Hyperthermic and neurotoxic effect of 3,4-methylenedioxymethamphetamine (MDMA) in guinea pigs

Psychopharmacology

Volumn 173, Issue 3-4, 2004, Pages 452-453

  Saadat, Kathryn S ^a   Elliott, J Martin ^d   Colado, M Isabel ^b   Green, A Richard ^a,c  

^a DE MONTFORT UNIVERSITY   (United Kingdom)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c ASTRAZENECA   (United Kingdom)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; DOPAMINE; SEROTONIN;

ANIMAL EXPERIMENT; DOPAMINERGIC NERVE CELL; GUINEA PIG; HYPERTHERMIA; LETTER; MALE; NERVE CELL LESION; NERVE ENDING; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SEROTONINERGIC NERVE CELL;

ANIMALS; CORPUS STRIATUM; DOPAMINE; DOPAMINE AGENTS; FEVER; GUINEA PIGS; MALE; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; NEUROTOXICITY SYNDROMES; SEROTONIN; SEROTONIN AGENTS;

EID: 2542529172     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1653-1     Document Type: Letter

References (10)

1. Battaglia G, Brooks BP, Kulsakdinun C, De Souza EB (1988) Pharmacologic profile of MDMA (3,4-methylenedioxymethamphetamine) at various brain recognition sites. Eur J Pharmacol 149:159-163
2. Broening HW, Bowyer JF, Slikker Jr W (1995) Age-dependent sensitivity of rats to the long-term effects of the serotonergic neurotoxicant (±)-3,4-methylenedioxymethamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response. J Pharmacol Exp Ther 275:325-333
3. Commins DL, Vosmer G, Virus RM, Woolverton WL, Schuster CR, Seiden LS (1987) Biochemical and histological evidence that methylenedioxymethamphetamine (MDMA) is toxic to neurons in the rat brain. J Pharmacol Exp Ther 241:338-345
4. Green AR, Mechan AO, Elliott JM, O'Shea E, Colado MI (2003) The pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Pharmacol Rev 55:463-508
5. Malberg JE, Seiden LS (1998) Small changes in ambient temperature cause large changes in 3,4-methylenedioxymethamphetamine (MDMA)-induced serotonin neurotoxicity and core body temperature in the rat. J Neurosci 18:5086-5094
6. O'Shea E, Granados R, Esteban B, Colado MI, Green AR (1998) The relationship between the degree of neurodegeneration of rat brain 5-HT nerve terminals and the dose and frequency of administration of MDMA ("ecstasy"). Neuropharmacology 37:919-926
7. O'Shea E, Esteban B, Camarero J, Green AR, Colado MI (2001) Effect of GBR 12909 and fluoxetine on the acute and long term changes induced by MDMA ("ecstasy") on the 5-HT and dopamine concentrations in mouse brain. Neuropharmacology 40:65-74
8. Ricaurte GA, Yuan J, Hatzidimitriou G, Cord BJ, McCann UD (2002) Severe dopaminergic neurotoxicity in primates after a single recreational dose regimen of MDMA ("Ecstasy"). Science (Wash) 297:2260-2263
9. Ricaurte GA, Yuan J, Hatzidimitriou G, Cord BJ, McCann UD (2003) Retraction. Science (Wash) 301:1479
10. Sanchez V, Camarero J, O'Shea E, Green AR, Colado MI (2003) Differential effect of dietary selenium on the long term neurotoxicity induced by MDMA in mice and rats. Neuropharmacology 44:449-461