Computational design of receptors for an organophosphate surrogate of the nerve agent soman

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 21, 2004, Pages 7907-7912

  Allert, Malin ^a   Rizk, Shahir S ^a   Looger, Loren L ^a   Hellinga, Homme W ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Computational protein design; Fluorescent biosensor

Indexed keywords

ALANINE; METHYLPHOSPHONIC ACID DERIVATIVE; METHYLPHOSPHONIC ACID PINACOLYL ESTER; MUTANT PROTEIN; NERVE AGENT; ORGANOPHOSPHATE; RECEPTOR PROTEIN; SOMAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOSENSOR; CALCULATION; COMPUTER AIDED DESIGN; CONCENTRATION (PARAMETERS); CYTOPLASM; FLUORESCENCE; MATHEMATICAL ANALYSIS; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STRUCTURE; RANDOMIZATION; STRUCTURE ANALYSIS;

BINDING SITES; BIOSENSING TECHNIQUES; COMPUTER SIMULATION; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS; PROTEIN BINDING; RECEPTORS, CELL SURFACE; SOMAN; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 2542523113     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0401309101     Document Type: Article

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