Fatty acid synthase expression and clinicopathological findings in endometrial cancer

Acta Obstetricia et Gynecologica Scandinavica

Volumn 83, Issue 6, 2004, Pages 586-590

  Tsuji, Takahiro ^a   Yoshinaga, Mitsuhiro ^a   Togami, Shinichi ^a   Douchi, Tsutomu ^a   Nagata, Yukihiro ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Body fat distribution; Cancer progression; Endometrial cancer; Fatty acid synthase; Percentage of body fat

Indexed keywords

FATTY ACID SYNTHASE;

ADULT; ARTICLE; BLOOD VESSEL PERMEABILITY; BODY FAT; BODY MASS; BODY WEIGHT; DUAL ENERGY X RAY ABSORPTIOMETRY; ENDOMETRIOID CARCINOMA; ENDOMETRIUM CANCER; FEMALE; HEIGHT; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MENOPAUSE; METASTASIS; ONSET AGE; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UTERUS CONTRACTILITY;

ADIPOSE TISSUE; AGED; ANTHROPOMETRY; CARCINOMA, ENDOMETRIOID; DENSITOMETRY, X-RAY; ENDOMETRIAL NEOPLASMS; FATTY ACID SYNTHETASE COMPLEX; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; NEOPLASM STAGING;

EID: 2542512304     PISSN: 00016349     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0001-6349.2004.00511.x     Document Type: Article

References (20)

1. Alo PL, Visca P, Trombetta G, Mangoni A, Lenti L, Manaco S et al. Fatty acid synthase (FAS) predictive strength in poorly differentiated early breast carcinomas. Tumori 1999; 85: 35-40.
2. Jensen V, Ladkarl M, Holm-Nielsen P, Melsen F, Soerensen FB. The prognostic value of oncogenic antigen 519 (OA 519) expression and proliferative activity detected by antibody MIB-1 in mode negative breast cancer. J Pathol 1995; 176: 343-52.
3. Alo PL, Visca P, Marci A, Mangoni A, Botti C, Di-Tondo U. Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage 1 breast carcinoma patients. Cancer 1996; 77: 474-82.
4. Nakamura I, Kimijima I, Zhang GJ, Onogi H, Endo Y et al. Fatty acid synthase expression in Japanese breast carcinoma patients. Int J Mol Med 1999; 4: 381-7.
5. Gansler TS, Hardman W, Hunt DA, Schaffel S, Hennigar RA. Increased expression of fatty acid synthase (OA-519) in ovarian neoplasms predicts shorter survival. Hum Pathol 1997; 27: 917-21.
6. Pizer ES, Lax SF, Kuhajda FP, Pasternack GR, Kurman RJ. Fatty acid synthase expression in endometrial carcinoma: correlation with cell proliferation and hormone breceptors. Cancer 1998; 83: 528-37.
7. Rashid A, Pizer ES, Moga M, Hamilton SR. Elevation of fatty acid synthase expression and fatty acid synthetic activity in colorectal neoplasia. Am J Pathol 1997; 150: 201-8.
8. Shurbaji MS, Kalbfleisch JH, Thurmond TS. Immunohistochemical detection of fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. Hum Pathol 1996; 27: 917-21.
9. Epstein JI, Carmichael M, Partin AW. OA-519 (fatty acid synthase) as an independent predictor of pathologic stage in adenocarcinoma of the prostate. Urology 1995; 45: 81-6.
10. Piyathilake CJ, Frost AR, Manne U, Bell WC, Weiss H. Heimburger DC et al. The expression of fatty acid synthase (FASE) is an early event in the development and progression of squamous cell carcinoma of the lung. Hum Pathol 2000; 31: 1068-73.
11. Kusakabe T, Nashimoto A, Honma K, Suzuki T. Fatty acid synthase is highly expressed in carcinoma, adenoma and in regenerative epithelium and intestinal metaplasia of the stomach. Histopathology 2002; 40: 71-9.
12. Henderson BE, Casagrande JT, Pick MC, Mack T, Rosario I, Duke A. The epidemiology of endometrial cancer in young women. Br J Obstet Gynecol 1983; 47: 749-56.
13. Douchi T, Ijuin H, Nakamura S, Oki T, Maruta K, Nagata Y. Correlation of body fat distribution with grade of endometrial cancer. Gynecol Oncol 1997; 65: 138-42.
14. Ley CJ, Lees B, Stevenson JC. Sex- and menopause-associated changes in body-fat distribution. Am J Clin Nutr 1992; 55: 950-4.
15. Lapidus L, Helgesson C, Merck C, Bjorntorp P. Adipose tissue distribution and female carcinoma: a 12-year follow up of participants in the population study of women in Gothenburg, Sweden. Int J Obesity 1988; 12: 361-8.
16. Elliott EA, Matanoski GM, Rosenshein NB, Grumbine FC, Diamond EL. Body fat patterning in women with endometrial cancer. Gynecol Oncol 1990; 39: 253-8.
17. Swanson CA, Potischman N, Wilbanks GD, Twiggs LB, Mortel R, Berman ML et al. Relation of endometrial cancer risk to post contemporary body size and body fat distribution. Cancer Epidemiol Biomarkers Prev 1993; 2: 321-7.
18. Schapiro DV, Kumar NB, Lyman GH, Cavanagh DC, Robert WS, Lapolla J. Upper-body fat distribution and endometrial cancer risk. JAMA 1991; 266: 1808-11.
19. Kirschner MA, Samojlik E. Sex hormone metabolism in upper and lower body obesity. Int J Obes 1991; 2: 101-8.
20. Pizer ES, Kurman RJ, Pasternack GR, Kuhajda FP. Expression of fatty acid synthase is closely linked to proliferation and decidualization in cycling endometrium. Int J Gynecol Pathol 1997; 16: 45-51.