The behavioral deficit observed following noncontingent shock in spinalized rats is prevented by the protein synthesis inhibitor cycloheximide

Behavioral Neuroscience

Volumn 118, Issue 3, 2004, Pages 653-658

  Patton, Brianne C ^a   Hook, Michelle A ^a   Ferguson, Adam R ^a   Crown, Eric D ^a   Grau, James W ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOHEXIMIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ELECTRIC SHOCK; INSTRUMENTAL CONDITIONING; LEARNING; MALE; NERVE CELL PLASTICITY; NONHUMAN; PROTEIN SYNTHESIS INHIBITION; RAT; SPINAL ANIMAL;

ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CONDITIONING, OPERANT; CYCLOHEXIMIDE; ELECTROSHOCK; LEARNING DISORDERS; MALE; MENTAL DISORDERS; PROTEIN SYNTHESIS INHIBITORS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD INJURIES; TIME FACTORS;

EID: 2542494998     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.118.3.653     Document Type: Article

References (43)

1. Barondes, S. H., & Cohen, H. D. (1967). Delayed and sustained effect of acetoxycycloheximide on memory in mice. Proceedings of the National Academy of Sciences, 58, 157-164.
2. Caudle, R. M., Chavkin, C., & Dubner, R. (1994). Kappa 2 opioid receptors inhibit NMDA receptor-mediated synaptic currents in guinea pig CA3 pyramidal cells. Journal of Neuroscience, 14, 5580-5589.
3. Chopin, S. F., & Buerger, A. A. (1976). Instrumental avoidance conditioning in the spinal rat. Brain Research Bulletin, 1, 177-183.
4. Coderre, T. J. (2001). Noxious stimulus-induced plasticity in spinal cord dorsal horn: Evidence and insights on mechanisms obtained using the formalin test. In M. M. Patterson & J. W. Grau (Eds.), Spinal cord plasticity: Alterations in reflex function (pp. 163-185). Norwell, MA: Kluwer Academic.
5. Crowe, M. J., Bresnahan, J. C., Shuman, S. L., Masters, J. N., & Beattie, M. S. (1997). Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nature Medicine, 3, 73-76.
6. Crown, E. D., Ferguson, A. R., Joynes, R. L., & Grau, J. W. (2002). Instrumental learning within the spinal cord: IV. Induction and retention of the behavioral deficit observed after noncontingent shock. Behavioral Neuroscience, 116, 1032-1051.
7. Davis, H. P., & Squire, L. R. (1984). Protein synthesis and memory: A review. Psychological Bulletin, 96, 518-559.
8. Dougherty, P. M., Palecek, J., Paleckova, V., Sorkin, L. S., & Willis, W. D. (1992). The role of NMDA and non-NMDA excitatory amino acid receptors in the excitation of primate spinothalamic tract neurons by mechanical, chemical, thermal, and electrical stimuli. Journal of Neuroscience, 12, 3025-3041.
9. Durkovic, R. G. (1975). Classical conditioning, sensitization and habituation in the spinal cat. Physiology and Behavior, 14, 297-304.
10. Ferguson, A. R., Crown, E. D., Patton, B. C., & Grau, J. W. (2002, November). Intrathecal administration of the NMDA antagonist MK-801 prevents the behavioral deficit observed after noncontingent shock in spinalized rats. Poster session presented at the annual meeting of the Society for Neuroscience, Orlando, FL (Program No. 166.7). Abstract retrieved June 9, 2003, from http://sfn.scholarone.com/itin2002/
11. Ferguson, A. R., Crown, E. D., Washburn, S. N., Miranda, R. C., & Grau, J. W. (2001, November). Instrumental learning in spinalized rats: Peripheral inflammation undermines behavioral potential in the spinal cord. Poster session presented at the annual meeting of the Society for Neuroscience, San Diego, CA (Program No. 220.2). Abstract retrieved June 9, 2003, from http://sfn.scholarone.com/itin2001/
12. A receptor activation is involved in the noncontingent shock inhibition of instrumental conditioning in spinal rat. Behavioral Neuroscience, 117, 799-812.
13. Grau, J. W., Barstow, D. G., & Joynes, R. L. (1998). Instrumental learning within the spinal cord: I. Behavioral properties. Behavioral Neuroscience, 112, 1366-1386.
14. Grau, J. W., Garcia, G., Ferguson, A. R., Crown, E. D., & Miranda, R. C. (2001). Exposure to a nociceptive stimulus impairs recovery after a contusion injury [Abstract]. Society for Neuroscience Abstracts, 27, 2039.
15. Grau, J. W., Joynes, R. L., & Penland, H. R. (1996). Inescapable shock disrupts spinal learning: Evidence for spinal mediation and naltrexone reversibility [Abstract]. Society for Neuroscience Abstracts, 21, 1840.
16. Grau, J. W., Washburn, S. N., Hook, M. A., Ferguson, A. R., Crown, E. D., Garcia, G., et al. (2003). Uncontrollable nociceptive stimulation undermines recovery after spinal cord injury. Manuscript submitted for publication.
17. Grillner, S., & Dubuc, R. (1988). Control of locomotion in vertebrates: Spinal and supraspinal mechanisms. Advances in Neurology, 47, 425-453.
18. Hodgson, J. A., Roy, R. R., de Leon, R., Dobkin, B., & Edgerton, V. R. (1994). Can the mammalian lumbar spinal cord learn a motor task? Medical Science: Sports Exercise, 26, 1491-1497.
19. Hook, M. A., Garcia, G., Crown, E. D., Ferguson, A. R., Miranda, R. C., & Grau, J. W. (2002, November). Uncontrollable nociceptive stimulation undermines locomotor recovery in spinally contused rats. Poster session presented at the annual meeting of the Society for Neuroscience, Orlando, FL (Program No. 204.1). Abstract retrieved June 9, 2003, from http://sfn.scholarone.com/itin2002/
20. Horridge, G. A. (1962). Learning of the leg position by the ventral nerve cord in headless insects. Proceedings of the Royal Society of London, 157, 33-52.
21. Joynes, R. L., Ferguson, A. R., Crown, E. D., Patton, B. C., & Grau, J. W. (2003). Instrumental learning within the spinal cord: V. Evidence the behavioral deficit observed after noncontingent nociceptive stimulation reflects an intraspinal modification. Behavioral Brain Research, 141, 159-170.
22. Joynes, R. L., & Grau, J. W. (1996). Mechanisms of Pavlovian conditioning: Role of protection from habituation in spinal conditioning. Behavioral Neuroscience, 110, 1375-1387.
23. Joynes, R. L., & Grau, J. W. (in press). Instrumental learning within the spinal cord: III. Prior exposure to noncontingent shock induces a behavioral deficit that is blocked by an opioid antagonist. Behavioral Brain Research.
24. Joynes, R. L., Janjua, K. R., & Grau, J. W. (1995). Operant learning at the level of the spinal cord is blocked by the NMDA antagonist APV [Abstract]. Society for Neuroscience Abstracts, 21, 415.
25. Laughlin, T. M., Bethea, J. R., Yezierski, R. P., & Wilcox, G. L. (2000). Cytokine involvement in dynorphin-induced allodynia. Pain, 84, 159-167.
26. Liu, G. T., Miranda, R. C., Wilkie, J. M., Washburn, S. N., Bolding, K. A., Hook, M. A., et al. (2003, November). Exposure to uncontrollable nociceptive stimulation increases vulnerability to apoptosis in spinally transected rats [Abstract]. Poster session presented at the annual meeting of the Society for Neuroscience, New Orleans, LA.
27. Liu, X. G., & Sandkuhler, J. (1995). Long-term potentiation of C-fiber-evoked potentials in the rat spinal dorsal horn is prevented by spinal N-methyl-D-aspartic acid receptor blockage. Neuroscience Letters, 191, 43-46.
28. McNaughton, B. L. (1983). Activity-dependent modulation of hippocampal synaptic efficacy: Some implications for memory processes. In W. Siefert (Ed.), Neurobiology of the hippocampus (pp. 233-252). London: Academic Press.
29. Millan, M. J. (1986). Multiple opioid systems and pain. Pain, 27, 303-347.
30. Millan, M. J. (1999). The induction of pain: An integrative review. Progress in Neurobiology, 57, 1-164.
31. Moser, E. I., & Moser, M. B. (1999). Is learning blocked by saturation of synaptic weights in the hippocampus? Neuroscience and Biobehavioral Reviews, 23, 661-672.
32. Nakada, K., Hodgson, J. A., de Leon, R., Roy, R. R., & Edgerton, V. R. (1994). Prolonged modification of the mechanics of the step cycle by single and repetitive mechanical stimuli in chronic spinal cats [Abstract]. Society for Neuroscience Abstracts, 20, 1755.
33. Nguyen, P. V., & Kandel, E. R. (1996). A macromolecular synthesis-dependent late phase of long-term potentiation requiring cAMP in the medial perforant pathway of rat hippocampal slices. Journal of Neuroscience, 16, 3189-3198.
34. Porreca, F., Burgess, S. E., Gardell, L. R., Vanderah, T. W., Malan, T. P., Jr., Ossipov, M. H., et al. (2001). Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor. Journal of Neuroscience, 21, 5281-5288.
35. Ressler, K. J., Paschall, G., Zhou, X. L., & Davis, M. (2002). Regulation of synaptic plasticity genes during consolidation of fear conditioning. Journal of Neuroscience, 22, 7892-7902.
36. Rossignol, S., Drew, T., Brustein, E., & Jiang, W. (1999). Locomotor performance and adaptation after partial or complete spinal cord lesions in the cat. Progress in Brain Research, 123, 349-365.
37. Segal, R. L., & Wolf, S. L. (1994). Operant conditioning of spinal stretch reflexes in patients with spinal cord injuries. Experimental Neurology, 130, 202-213.
38. Sluka, K. A., Willis, W. D., & Westlund, K. N. (1993). Joint inflammation and hyperalgesia are reduced by spinal bicuculline. Neuro Report, 5, 109-112.
39. Sluka, K. A., Willis, W. D., & Westlund, K. N. (1994). Inflammation-induced release of excitatory amino acids is prevented by spinal administration of a GABAA but not by a GABAB receptor antagonist in rats. Journal of Pharmacology and Experimental Therapeutics, 271, 76-82.
40. Willis, W. D. (2002). Long-term potentiation in spinothalamic neurons. Brain Research Reviews, 40, 202-214.
41. Woolf, C. J., & Costigan, M. (1999). Transcriptional and posttranslational plasticity and the generation of inflammatory pain. Proceedings of the National Academy of Science, USA, 96, 7723-7730.
42. Yaksh, T. H., & Rudy, T. A. (1976). Chronic catheterization of the spinal cord subarachnoid space. Physiology and Behavior, 17, 1031-1036.
43. Zimmermann, M. (2001). Pathobiology of neuropathic pain. European Journal of Pharmacology, 429, 23-37.