GABAA receptor activation is involved in noncontingent shock inhibition of instrumental conditioning in spinal rats

Behavioral Neuroscience

Volumn 117, Issue 4, 2003, Pages 799-812

  Ferguson, Adam R ^a   Washburn, Stephanie N ^a   Crown, Eric D ^a,b   Grau, James W ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; BICUCULLINE; MUSCIMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONDITIONING; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; LEARNING; MOTOR PERFORMANCE; NERVE CELL PLASTICITY; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; RAT; RECEPTOR UPREGULATION; SHOCK; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION; TIME SERIES ANALYSIS;

ANIMALS; BICUCULLINE; CONDITIONING, OPERANT; ELECTRIC STIMULATION; GABA AGONISTS; GABA ANTAGONISTS; MUSCIMOL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; REINFORCEMENT (PSYCHOLOGY); SPINAL CORD;

EID: 0043167887     PISSN: 07357044     EISSN: None     Source Type: Journal    
DOI: 10.1037/0735-7044.117.4.799     Document Type: Article

References (53)

1. Abraham, W. C., & Tate, W. P. (1997). Metaplasticity: A new vista across the field of synaptic plasticity. Progress in Neurobiology, 52, 303-323.
2. Anderson, M. F., & Winterson, B. J. (1995). Properties of peripherally induced persistent hindlimb flexion in rat: Involvement of N-methyl-D-aspartate receptors and capsaicin-sensitive afferents. Brain Research, 678, 140-150.
3. Barbeau, H., & Rossignol, S. (1987). Recovery of locomotion after chronic spinalization in the adult cat. Brain Research, 412, 84-95.
4. Basbaum, A. I., & Fields, H. L. (1979). The origin of descending pathways in the dorsolateral funiculus of the spinal cord of the cat and rat: Further studies on the anatomy of pain modulation. Journal of Comparative Neurology, 187, 513-532.
5. Bertrand, S., & Cazalets, J. R. (1999). Presynaptic GABAergic control of the locomotor drive in the isolated spinal cord of neonatal rats. European Journal of Neuroscience, 11, 583-592.
6. Bouyer, L., & Rossignol, S. (2001). Spinal cord plasticity associated with locomotor compensation to peripheral nerve lesions in the cat. In M. Patterson, & J. Grau (Eds.), Spinal cord plasticity: Alterations in reflex function (pp. 207-224). Boston: Kluwer.
7. Castro-Lopes, J. M., Tavares, I., Tolle, T. R., & Coimbra, A. (1994). Carrageenan-induced inflammation of the hind foot provokes a rise of GABA-immunoreactive cells in the rat spinal cord that is prevented by peripheral neurectomy or neonatal capsaicin treatment. Pain, 56, 193-201.
8. Cazalets, J. R., Bertrand, S., Sqalli-Houssaini, Y., & Clarac, F. (1998). GABAergic control of spinal locomotor networks in the neonatal rat. In O. Kiehn, R. M. Harris-Warrick, L. M. Jordan, H. Hultborn, & N. Kodo (Eds.), Annals of the New York Academy of Science: Vol. 860. Neuronal mechanisms for generating locomotor activity (pp. 168-180). New York: New York Academy of Sciences.
9. Coderre, T. J., & Melzack, R. (1992). The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. Journal of Neuroscience, 12, 3665-3670.
10. Crown, E. D., Ferguson, A. R., Dhruv, S., Patton, B. C., & Grau, J. W. (2001, November). Descending noradrenergic systems protect spinal cord neurons from the deleterious effects of nociceptive stimulation (Poster session presented at the annual meeting of the Society for Neuroscience, San Diego, CA, Program No. 363.3 [Abstract]). Retrieved May 20, 2003, from http://sfn.scholarone.com/itin/2001/
11. Crown, E. D., Ferguson, A. R., Joynes, R. L., & Grau, J. W. (2002a). Instrumental learning within the spinal cord: II. Evidence for central mediation. Physiology & Behavior, 77, 259-267.
12. Crown, E. D., Ferguson, A. R., Joynes, R. L., Grau, J. W. (2002b). Instrumental learning within the spinal cord: IV. Induction and retention of the behavioral deficit observed after noncontingent shock. Behavioral Neuroscience, 116, 1032-1051.
13. Crown, E. D., & Grau, J. W. (2001). Preserving and restoring behavioral potential within the spinal cord using an instrumental training paradigm. Journal of Neurophysiology, 86, 845-855.
14. de Leon, R. D., Hodgson, J. A., Roy, R. R., & Edgerton, V. R. (1998). Locomotor capacity attributable to step training versus spontaneous recovery after spinalization in adult cats. Journal of Neurophysiology, 79, 1329-1340.
15. de Leon, R. D., Hodgson, J. A., Roy, R. R., & Edgerton, V. R. (1999). Retention of hindlimb stepping ability in adult spinal cats after the cessation of step training. Journal of Neurophysiology, 81, 85-94.
16. Drugan, R. C., & Holmes, P. V. (1991). Central and peripheral benzodiazepine receptors: Involvement in an organism's response to physical and psychological stress. Neuroscience and Biobehavioral Reviews, 15, 277-298.
17. Drugan, R. C., & Maier, S. F. (1983). Analgesia and opioid involvement in the shock-elicited activity and escape deficits produced by inescapable shock. Learning and Motivation, 14, 30-47.
18. Drugan, R. C., Morrow, A. L., Weizman, R., Weizman, A., Deutsch, S. I., Crawley, J. N., & Paul, S. M. (1989). Stress-induced behavioral depression in the rat is associated with a decrease in GABA receptor-mediated chloride ion flux and brain benzodiazepine receptor occupancy. Brain Research, 487, 45-51.
19. Edgerton, V. R., de Leon, R. D., Harkema, S. J., Hodgson, J. A., London, N., Reinkensmeyer, D. J., et al. (2001). Retraining the injured spinal cord. Journal of Physiology, 533, 15-22.
20. Edgerton, V. R., de Leon, R. D., Tillakaratne, N., Recktenwald, M. R., Hodgson, J. A., & Roy, R. R. (1997). Use-dependent plasticity in spinal stepping and standing. Advances in Neurology, 72, 233-247.
21. Edgerton, V. R., Roy, R. R., & de Leon, R. D. (2001). Neural Darwinism in the mammalian spinal cord. In M. Patterson, & J. Grau (Eds.), Spinal cord plasticity: Alterations in reflex function (pp. 185-206). Boston: Kluwer.
22. Ferguson, A. R., Crown, E. D., Dhruv, S., Washburn, S. N., & Grau, J. W. (2000, November). Instrumental learning in spinalized rats: The GABA antagonist bicuculline prevents the behavioral deficit observed after noncontingent shock (Poster session presented at the annual meeting of the Society for Neuroscience, New Orleans, LA, Program No. 830.13 [Abstract]). Retrieved May 20, 2003, from http://sfn.scholarone.com/ itin/2000/
23. Ferguson, A. R., Crown, E. D., Washburn, S. N., & Grau, J. W. (2002). Intrathecal administration of the NMDA antagonist MK-801 prevents the behavioral deficit observed after noncontingent shock in spinalized rats. Society for Neuroscience Abstracts, 28.
24. Ferguson, A. R., Crown, E. D., Washburn, S. N., Miranda, R. C., & Grau, J. W. (2001). Instrumental learning in spinalized rats: Inflammation induces a behavioral deficit similar to the one induced by noncontingent shock. Society for Neuroscience Abstracts, 27.
25. Grau, J. W., Barstow, D. G., & Joynes, R. L. (1998). Instrumental learning within the spinal cord: I. Behavioral properties. Behavioral Neuroscience, 112, 1366-1386.
26. Grau, J. W., Garcia, G., Ferguson, A. R., Crown, E. D., Olson, J., & Miranda, R. C. (2001). Exposure to a nociceptive stimulus impairs recovery after a contusion injury. Society for Neuroscience Abstracts, 27, 2039.
27. Grau, J. W., & Joynes, R. L. (2002). Learning and memory without a brain. In M. Bekoff, C. Allen, & G. M. Burghardt (Eds.), The cognitive animal: Empirical and theoretical perspectives on animal cognition. Cambridge, MA: MIT Press.
28. Grau, J. W., Salinas, J. A., Illich, P. A., & Meagher, M. W. (1990). Associative learning and memory for an antinociceptive response in the spinalized rat. Behavioral Neuroscience, 104, 489-494.
29. Guinan, M. J., Rothfield, J. M., Pretel, S., Culhane, E. S., Cartens, E., & Watkins, L. R. (1989). Electrical stimulation of the rat ventral midbrain elicits antinociception via the dorsolateral funiculus. Brain Research, 485, 333-348.
30. Harkema, S. J. (2001). Neural plasticity after human spinal cord injury: Application of locomotor training to the rehabilitation of walking. Neuroscientist, 7, 455-468.
31. Illich, P. A., Salinas, J. A., & Grau, J. W. (1994). Latent inhibition, overshadowing, and blocking of a conditioned antinociceptive response in spinalized rats. Behavioral and Neural Biology, 62, 140-150.
32. Joynes, R. L., Ferguson, A. R., Crown, E. D., Patton, B. C., & Grau, J. W. (2003). Instrumental learning within the spinal cord: V. Evidence the behavioral deficit observed after noncontingent nociceptive stimulation reflects an intraspinal modification. Behavioural Brain Research, 141, 159-170.
33. Joynes, R. L., & Grau, J. W. (1996). Mechanisms of Pavlovian conditioning: Role of protection from habituation in spinal conditioning. Behavioral Neuroscience, 110, 1375-1387.
34. Joynes, R. L., & Grau, J. W. (in press). Instrumental learning within the spinal cord: III. Prior exposure to noncontingent shock induces a behavioral deficit that is blocked by an opioid antagonist. Behavioural Brain Research.
35. Joynes, R. L., Janjua, K. R., & Grau, J. W. (in press). Instrumental learning within the spinal cord: VI. Disruption of learning by the NMDA antagonist APV. Neurobiology of Learning and Memory.
36. Maier, S. F., & Seligman, M. E. P. (1976). Learned helplessness: Theory and evidence. Journal of Experimental Psychology: General, 105, 3-46.
37. McNaughton, B. L., Barnes, C. A., Rao, G., Baldwin, J., & Rasmussen, M. (1986). Long-term enhancement of hippocampal synaptic transmission and the acquisition of spatial information. Journal of Neuroscience, 6, 563-571.
38. Morris, R. G. (1989). Synaptic plasticity and learning: Selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. Journal of Neuroscience, 9, 3040-3057.
39. Moser, E. I., Krobert, K. A., Moser, M. B., & Morris, R. G. (1998, September 25). Impaired spatial learning after saturation of long-term potentiation. Science, 281, 2038-2042.
40. Nakada, K., Hodgson, J. A., de Leon, R., Roy, R. R., & Edgerton, V. R. (1994). Prolonged modification of the mechanics of the step cycle by single and repetitive mechanical stimuli in chronic spinal cats. Society for Neuroscience Abstracts, 20, 1755.
41. Patterson, M. M. (2001). Spinal fixation: Long-term alterations in spinal reflex excitability with altered or sustained sensory inputs. In M. Patterson & J. Grau (Eds.), Spinal cord plasticity: Alterations in reflex function (pp. 77-99). Boston: Kluwer.
42. Patterson, M. M., & Grau, J. W. (2001). Spinal cord plasticity: Alterations in reflex function. Boston: Kluwer.
43. Petty, F., & Sherman, A. D. (1981). GABAergic modulation of learned helplessness. Pharmacology Biochemistry and Behavior, 15, 567-570.
44. Robinson, G. A., & Goldberger, M. E. (1986). The development and recovery of motor function in spinal cats: II. Pharmacological enhancement of recovery. Experimental Brain Research, 62, 387-400.
45. Sandkuhler, J., & Liu, X. (1998). Induction of long-term potentiation at spinal synapses by noxious stimulation or nerve injury. European Journal of Neuroscience, 10, 2476-2480.
46. Sluka, K. A., Willis, W. D., & Westlund, K. N. (1993). Joint inflammation and hyperalgesia are reduced by spinal bicuculline, NeuroReport, 5, 109-112.
47. Sluka, K. A., Willis, W. D., & Westlund, K. N. (1994). Inflammation-induced release of excitatory amino acids is prevented by spinal administration of a GABAA but not by a GABAB receptor antagonist in rats. Journal of Pharmacology and Experimental Therapeutics, 271, 76-82.
48. Tillakaratne, N. J., de Leon, R. D., Hoang, T. X., Roy, R. R., Edgerton, V. R., & Tobin, A. J. (2002). Use-dependent modulation of inhibitory capacity in the feline lumbar spinal cord. Journal of Neuroscience, 22, 3130-3143.
49. Wernig, A., Müller, S., Nanassy, A., Cagol, E. (1995). Laufband therapy based on 'rules of spinal locomotion' is effective in spinal cord injured persons. European Journal of Neuroscience, 7, 823-829.
50. Wernig, A., Nanassy, A., & Müller, S. (2001). Laufband (treadmill) therapy in incomplete para- and tetraplegia. In M. Patterson, & J. Grau (Eds.), Spinal cord plasticity: Alterations in reflex function (pp. 225-239). Boston: Kluwer.
51. Whitehouse, W. G., Walker, J., Margules, D. L., & Bersh, P. J. (1983). Opiate antagonists overcome the learned helplessness effect but impair competent escape performance. Physiology & Behavior, 30, 731-734.
52. Williams, J. L., & Maier, S. F. (1977). Transsituational immunization and therapy of learned helplessness in the rat. Journal of Experimental Psychology: Animal Behavior Processes, 3, 240-253.
53. Xu, X., Elfvin, A., & Wiesenfeld-Hallin, Z. (1995). Subcutaneous carrageenan, but not formalin, increases the excitability of the nociceptive flexor reflex in the rat. Neuroscience Letters, 196, 116-118.