Higher obesity risk associated with the exon-8 insertion of the UCP2 gene in a Spanish case-control study

Nutrition

Volumn 20, Issue 6, 2004, Pages 498-501

  Marti, Amelia ^a   Corbalán, Ma Soledad ^a   Forga L, Luis ^a   Martinez González, Miguel A ^a   Martinez, J Alfredo ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

case control study; exon 8 insertion; obesity; physical activity; UCP2

Indexed keywords

UNCOUPLING PROTEIN 2;

ADULT; AGE; ALLELE; ARTICLE; BODY MASS; CASE CONTROL STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DEMOGRAPHY; EXON; FEMALE; GENDER; GENE INSERTION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SCREENING; HEREDITY; HETEROZYGOTE; HIGH RISK PATIENT; HUMAN; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SITTING; SPAIN; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE;

ADULT; ANTHROPOMETRY; BODY COMPOSITION; CASE-CONTROL STUDIES; EXONS; HUMANS; ION CHANNELS; LOGISTIC MODELS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; MITOCHONDRIAL PROTEINS; MOTOR ACTIVITY; OBESITY; ODDS RATIO; POLYMORPHISM, GENETIC; RISK; SPAIN;

INSERTION SEQUENCES;

EID: 2542486426     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2004.03.019     Document Type: Article

References (24)

1. Krempler F., Esterbauer H., Weitgasser R., et al. A functional polymorphism in the promoter of UCP2 enhances obesity risk but reduces type 2 diabetes risk in obese middle-aged humans. Diabetes. 51:2002;3331
2. Esterbauer H., Schneitler C., Oberkofler H., et al. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet. 28:2001;178
3. Astrup A., Toubro S., Dalgaard L.T., Urhammer S.A., Sorensen T.I., Pedersen O. Impact of the v/v 55 polymorphism of the uncoupling protein 2 gene on 24-h energy expenditure and substrate oxidation. Int J Obes Relat Metab Disord. 23:1999;1030
4. Buemann B., Schierning B., Toubro S., et al. The association between the val/ala-55 polymorphism of the uncoupling protein 2 gene and exercise efficiency. Int J Obes Relat Metab Disord. 25:2001;467
5. Otabe S., Clement K., Rich N., et al. Mutation screening of the human UCP 2 gene in normoglycemic and NIDDM morbidly obese patients lack of association between new UCP 2 polymorphisms and obesity in French caucasians. Diabetes. 47:1998;840
6. Dalgaard L.T., Sorensen T.I., Andersen T., Hansen T., Pedersen O. An untranslated insertion variant in the uncoupling protein 2 gene is not related to body mass index and changes in body weight during a 26-year follow-up in Danish Caucasian men. Diabetologia. 42:1999;1413
7. van Rossum C.T., Hoebee B., Seidell J.C., et al. Genetic factors as predictors of weight gain in young adult Dutch men and women. Int J Obes Relat Metab Disord. 26:2002;517
8. Ukkola O., Tremblay A., Sun G., Chagnon Y.C., Bouchard C. Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding. Eur J Clin Nutr. 55:2001;1008
9. Shiinoki T., Suehiro T., Ikeda Y., et al. Screening for variants of the uncoupling protein 2 gene in Japanese patients with non-insulin-dependent diabetes mellitus. Metabolism. 48:1999;581
10. Nieters A., Becker N., Linseisen J. Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort. Eur J Nutr. 41:2002;210
11. Nordfors L., Heimburger O., Lonnqvist F., et al. Fat tissue accumulation during peritoneal dialysis is associated with a polymorphism in uncoupling protein 2. Kidney Int. 57:2001;1713
12. Cassell P.G., Neverova M., Janmohamed S., et al. An uncoupling protein 2 gene variant is associated with a raised body mass index but not type II diabetes. Diabetologia. 42:1999;688
13. Zheng Y., Xiang K., Zhang R., et al. The association between variant in UCP2 gene and body fat distribution, serum lipid profile in Chinese. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 17:2000;97
14. Evans D., Minouchehr S., Hagemann G., et al. Frequency of and interaction between polymorphisms in the beta3-adrenergic receptor and in uncoupling proteins 1 and 2 and obesity in Germans. Int J Obes Relat Metab Disord. 24:2000;1239
15. Yanovski J.A., Diament A.L., Sovik K.N., et al. Associations between uncoupling protein 2, body composition, and resting energy expenditure in lean and obese African American, white, and Asian children. Am J Clin Nutr. 71:2000;1405
16. Walder K., Norman R.A., Hanson R.L., et al. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians. Hum Mol Genet. 7:1998;1431
17. Ainsworth B.E., Haskell W.L., Whitt M.C., et al. Compendium of physical activities an update of activity codes and MET intensities. Med Sci Sports Exerc. 32:(suppl):2000;S498
18. Martinez-Gonzalez M.A., Varo J.J., Santos J.L., et al. Prevalence of physical activity during leisure time in the European Union. Med Sci Sports Exerc. 33:2001;1142
19. Brennan P. Design and analysis issues in case-control studies addressing genetic susceptibility. IARC Sci Publ. 148:1999;123
20. Marti A., Corbalan M.S., Martinez-Gonzalez M.A., Martinez J.A. TRP64ARG polymorphism of the beta3-adrenergic receptor gene and obesity risk effect modification by a sedentary lifestyle. Diabetes Obes Metab. 4:2002;428
21. Otabe S., Clement K., Dina C., et al. A genetic variation in the 5' flanking region of the UCP3 gene is associated with body mass index in humans in interaction with physical activity. Diabetologia. 43:2000;245
22. Corbalán M.S., Marti A., Martinez-Gonzalez M.A., Martinez J.A. The 27Glu polymorphism of the beta2-adrenergic receptor gene interacts with physical activity influencing obesity risk among female subjects. Clin Genet. 61:2002;305
23. Engert J.C., Vohl M.C., Williams S.M., et al. 5′ Flanking variants of resistin are associated with obesity. Diabetes. 51:2002;1629
24. Psaty B.M., Koepsell T.D., Lin D., et al. Assessment and control for confounding by indication in observational studies. J Am Geriatr Soc. 47:1999;749