Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produce IL-4 in high IgE-producer schistosomiasis patients

BMC Immunology

Volumn 3, Issue , 2002, Pages

  Dutra, Walderez O ^a   Correa Oliveira, Rodrigo ^b   Dunne, David ^c   Cecchini, Luiza Fosenca ^a   Fraga, Lúcia ^d   Roberts, Morven ^c   Soares Silveira, Alda Maria ^d   Webster, Michelle ^c   Yssel, Hans ^f,g   Gollob, Kenneth J ^a,e  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSIDADE VALE DO RIO DOCE   (Brazil)

^e CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^f MERCK RESEARCH LABORATORIES   (United States)

^g INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MONOCLONAL ANTIBODY;

ARTICLE; CELL POLARITY; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; FREQUENCY ANALYSIS; HELPER CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFECTION RESISTANCE; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; PHENOTYPE; PROTEIN EXPRESSION; REINFECTION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; T LYMPHOCYTE; TH0 CELL; TH2 CELL;

EID: 2542450296     PISSN: 14712172     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2172-3-8     Document Type: Article

References (38)

1. Todd CW, Colley DG, Ramzy RM, Habib M, Alamy El MA: Comparison of whole blood cultures and peripheral blood mononuclear cell cultures for evaluation of lymphocyte reactivity during chronic schistosomiasis. Trans. R. Soc. Trop. Med. Hyg. 1981, 75:783-7
2. Colley DG, Garcia AA, Lambertucci JR, Parra JC, Katz N, Rocha RS, Gazzinelli G: Immune responses during human schistosomiasis. XII. Differential responsiveness in patients with hepatosplenic disease. Am J Trop Med Hyg. 1986, 35:793-802
3. Butterworth AE, Dunne DW, Fulford AJ, Ouma JH, Sturrock RF: Immunity and morbidity in Schistosoma mansoni infection: quantitative aspects. Am. J. Trop. Med. Hyg. 1996, 55:109-15
4. Hagan P, Blumenthal UJ, Dunn D, Simpson AJ, Wilkins HA: Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium. Nature. 1991, 349:243-5
5. Dunne DW, Webster M, Smith P, Langley JG, Richardson BA, Fulford AJ, Butterworth AE, Sturrock RF, Kariuki HC, Ouma JH: The isolation of a 22 kDa band after SDS-PAGE of Schistosoma mansoni adult worms and its use to demonstrate that IgE responses against the antigen(s) it contains are associated with human resistance to reinfection. Parasite Immunol. 1997, 19:79-89
6. Webster M, Fallon PG, Fulford AJ, Butterworth AE, Ouma JH, Kimani G, Dunne DW: IgG4 and IgE responses to Schistosoma mansoni adult worms after treatment. J Infect Dis. 1997, 175:493-4
7. Webster M, Roberts M, Fulford AJ, Marguerite M, Gallisot MC, Diagne M, Niang M, Riveau G, Capron A, Dunne DW: Human IgE responses to rSm22.6 are associated with infection intensity rather than age per se, in a recently established focus of Schistomiasis mansoni. Trop Med Int Health. 1998, 3:318-26
8. Webster M, Fulford AJ, Braun G, Ouma JH, Kariuki HC, Havercroft JC, Gachuhi K, Sturrock RF, Butterworth AE, Dunne DW: Human immunoglobulin E responses to a recombinant 22.6-kilodalton antigen from Schistosoma mansoni adult worms are associated with low intensities of reinfection after treatment. Infect Immun 1996, 64:4042-6
9. Viana IR, Correa-Oliveira R, Carvalho O, dos S, Massara CL, Colosimo E, Colley DG, Gazzinelli G: Comparison of antibody isotype responses to Schistosoma mansoni antigens by infected and putative resistant individuals living in an endemic area. Parasite Immunol 1995, 17:297-304
10. Punnonen J, Yssel H, de Vries JE: The relative contribution of IL-4 and IL-13 to human IgE synthesis induced by activated CD4+ or CD8+ T cells. J Allergy Clin Immunol. 1997, 100:792-801
11. Gounni AS, Lamkhioued B, Delaporte E, Dubost A, Kinet JP, Capron A, Capron M: The high-affinity IgE receptor on eosinophils: from allergy to parasites or from parasites to allergy? J Allergy Clin Immunol. 1994, 94:1214-6
12. Capron M: Eosinophils and parasites. Ann Parasitol Hum Comp. 1991, 66 Suppl 1:41-5
13. Pearce EJ, Caspar P, Grzych JM, Lewis FA, Sher A: Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J Exp Med. 1991, 173:159-66
14. Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA: An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest. 1999, 104:777-85
15. King CL, Xianli J, Malhotra I, Liu S, Mahmoud AA, Oettgen HC: Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni. J Immunol. 1997, 158:294-300
16. Chiaramonte MG, Schopf LR, Neben TY, Cheever AW, Donaldson DD, Wynn TA: IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. J Immunol. 1999, 162:920-30
17. Yssel H, Groux H: Characterization of T cell subpopulations involved in the pathogenesis of asthma and allergic diseases. Int Arch Allergy Immunol. 2000, 121:10-8
18. Gazzinelli G, Katz N, Rocha RS, Colley DG: Immune responses during human schistosomiasis mansoni. X. Production and standardization of an antigen-induced mitogenic activity by peripheral blood mononuclear cells from treated, but not active cases of schistosomiasis. J Immunol. 1983, 130:2891-5
19. de Jesus AM, Almeida RP, Bacellar O, Araujo MI, Demeure C, Bina JC, Dessein AJ, Carvalho EM: Correlation between cell-mediated immunity and degree of infection in subjects living in an endemic area of schistosomiasis. Eur J Immunol 1993, 23:152-8
20. Parra JC, Lima MS, Gazzinelli G, Colley DG: Immune responses during human schistosomiasis mansoni. XV. Anti-idiotypic T cells can recognize and respond to anti-SEA idiotypes directly. J Immunol. 1988, 140:2401-5
21. Marguerite M, Gallissot MC, Diagne M, Moreau C, Diakkhate MM, Roberts M, Remoue F, Thiam A, Decam C, Rogerie F, Cottrez F, Neyrinck JL, Butterworth AE, Sturrock RF, Piau JP, Daff B, Niang M, Wolowczuk I, Riveau G, Auriault C, Capron A: Cellular immune responses of a Senegalese community recently exposed to Schistosoma mansoni: correlations of infection level with age and inflammatory cytokine production by soluble egg antigen-specific cells. Trop Med Int Health. 1999, 4:530-43
22. Bahia-Oliveira LM, Gazzinelli G, Eloi-Santos SM, Cunha-Melo JR, Alves-Oliveira LF, Silveira AM, Viana IR, Carmo J, Souza A, Correa-Oliveira R: Differential cellular reactivity to adult worm antigens of patients with different clinical forms of schistosomiasis mansoni. Trans R Soc Trop Med Hyg. 1992, 86:57-61
23. Sabin EA, Araujo MI, Carvalho EM, Pearce EJ: Impairment of tetanus toxoid-specific Th I-like immune responses in humans infected with Schistosoma mansoni. J Infect Dis. 1996, 173:269-72
24. Falcao PL, Malaquias LC, Martins-Filho OA, Silveira AM, Passos VM, Prata A, Gazzinelli G, Coffman RL, Correa-Oliveira R: Human Schistosomiasis mansoni: IL-10 modulates the in vitro granuloma formation. Parasite Immunol. 1998, 20:447-54
25. Martins-Filho OA, Dutra WO, Freeman GL, Silveira AM, Rabello A, Colley DG, Prata A, Gazzinelli G, Correa-Oliveira R, Carvalho-Parra J: Flow cytometric study of blood leucocytes in clinical forms of human schistosomiasis. Scand J Immunol. 1997, 46:304-11
26. Gollob KJ, Coffman RL: A minority subpopulation of CD4+ T cells directs the development of naive CD4+ T cells into IL-4-secreting cells. J Immunol. 1994, 152:5180-8
27. Dutra WO, Martins-Filho OA, Cancado JR, Pinto-Dias JC, Brener Z, Freeman Junior GL, Colley DG, Gazzinelli G, Parra JC: Activated T and B lymphocytes in peripheral blood of patients with Chagas' disease. Int Immunol. 1994, 6:499-506
28. Dutra WO, Gollob KJ, Pinto-Dias JC, Gazzinelli G, Correa-Oliveira R, Coffman RL, Carvalho-Parra JF: Cytokine mRNA profile of peripheral blood mononuclear cells isolated from individuals with Trypanosoma cruzi chronic infection. Scand J Immunol. 1997, 45:74-80
29. Naus CW, Kimani G, Ouma JH, Fulford AJ, Webster M, van Dam GJ, Deelder AM, Butterworth AE, Dunne DW: Development of antibody isotype responses to Schistosoma mansoni in an immunologically naive immigrant population: influence of infection duration, infection intensity, and host age. Infect Immun. 1999, 67:3444-51
30. Zhang Z, Wu H, Chen S, Hu L, Xie Z, Qiu Y, Su C, Cao JP, Wu Y, Zhang S, Wu G: Association between IgE antibody against soluble egg antigen and resistance to reinfection with Schistosoma japonicum. Trans R Soc Trop Med Hyg. 1997, 91:606-8
31. Grogan JL, Kremsner PG, van Dam GJ, Metzger W, Mordmuller B, Deelder AM, Yazdanbakhsh M: Antischistosome IgG4 and IgE responses are affected differentially by chemotherapy in children versus adults. J Infect Dis. 1996, 173:1242-7
32. Schuerwegh AJ, De Clerck LS, De Schutter L, Bridts CH, Verbruggen A, Stevens WJ: Flow cytometric detection of type 1 (IL-2, IΦN-γ amma) and type 2 (IL-4, IL-5) cytokines in T-helper and T-suppressor/cytotoxic cells in rheumatoid arthritis, allergic asthma and atopic dermatitis. Cytokine. 1999, 11(10):783-8
33. Jason J, Iarned J: Single-cell cytokine profiles in normal humans: comparison of flow cytometric reagents and stimulation protocols. J Immunol Methods. 1997, 207:13-22
34. Gollob KJ, Dutra WO, Coffman RL: Early message expression of interleukin-4 and interferon-gamma, but not of interleukin-2 and interleukin-10, reflects later polarization of primary CD4+ T cell cultures. Eur J Immunol. 1996, 26:1565-70
35. Mahanty S, Abrams JS, King CL, Limaye AP, Nutman TB: Parallel regulation of IL-4 and IL-5 in human helminth infections J Immunol 1992, 148:3567-3571
36. Webster M, Correa-Oliveira R, Gazzinelli G, Viana IR, Fraga LA, Silveira AM, Dunne DW: Factors affecting high and low human IgE responses to schistosome worm antigens in an area of Brazil endemic for Schistosoma mansoni and hookworm. Am J Trop Med Hyg. 1997, 57:487-94
37. Sornasse T, Larenas PV, Davis KA, de Vries JE, Yssel H: Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level. J Exp Med. 1996, 184:473-83
38. Yssel H, Spits H: Generation and maintenance of cloned human T cell lines. In Current Protocols in Immunology, John Wiley & Sons, New York. 2002, Unit 7.19: