Endogenous antipyretics: Neuropeptides and glucocorticoids

Frontiers in Bioscience

Volumn 9, Issue , 2004, Pages 816-826

  Roth, Joachim ^a   Zeisberger, Eugen ^b   Vybíral, Stanislav ^c   Janský, Ladislav ^b  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF SOUTH BOHEMIA   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

ACTH; Adrenocorticotropic Hormone; Arginine Vasopressin; Endogeous Antipyresis; Fever; Glucocorticoid; Melanocyte Stimulating Hormone; Reivew

Indexed keywords

ALPHA INTERMEDIN; ARGIPRESSIN; CORTICOTROPIN; CYTOKINE; GAMMA INTERMEDIN; GLUCOCORTICOID; NEUROPEPTIDE; PROSTAGLANDIN; ANALGESIC AGENT;

ANTERIOR HYPOTHALAMUS; ANTIPYRETIC ACTIVITY; BODY TEMPERATURE; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CORE TEMPERATURE; FEVER; HUMAN; LIMBIC SYSTEM; NERVE CELL; NONHUMAN; REVIEW; SEPTUM PELLUCIDUM; THERMOGENESIS; THERMOREGULATION; ANIMAL; DRUG EFFECT;

ANALGESICS, NON-NARCOTIC; ANIMALS; ARGININE VASOPRESSIN; BODY TEMPERATURE REGULATION; GLUCOCORTICOIDS; HUMANS; NEUROPEPTIDES;

EID: 2542441560     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/1277     Document Type: Review

References (102)

1. The Commission for Thermal Physiology of the International Union of Physiological Sciences (IUPS Thermal Commission): Glossary of terms for thermal physiology. Jpn J Physiol 51, 245-280 (2001)
2. Cooper K.E.: Fever and Antipyresis - The Role of the Nervous System. Cambridge University Press, Cambridge (1995)
3. Vane J.R.: Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 23, 232-235 (1971)
4. Milton A.S.: Prostaglandins and fever. Progr Brain Res 115, 129-139 (1998)
5. Roth J., T. Hübschle, U. Pehl, G. Ross & R. Gerstberger: Influence of systemic treatment with cyclooxygenase inhibitors on lipopolysaccharide-induced fever and circulating levels of cytokines and cortisol in guinea pigs. Pflügers Arch - Eur J Physiol 443, 411-417 (2002)
6. Du Bois E.F.: Why are fever temperatures over 106°F rare? Am. J. Med. Sci. 217: 361-368 (1949)
7. Pittman Q.J., K.E. Cooper, W.L. Veale & G.R. Van Petten: Observations on the development of the febrile response to pyrogens in sheep. Clin Sci Molec Med 46, 591-602 (1974)
8. Kasting N.W. W.L. Veale & K.E. Cooper: Development of fever in the newborn lamb. Am J Physiol 236, R184- R187 (1979)
9. Kasting N.W., W.L. Veale & K.E. Cooper: Suppression of fever at term of pregnancy. Nature 271, 245-246 (1978)
10. Zeisberger E., G. Merker & S. Blähser: Fever response in the guinea pig before and after parturition. Brain Res 212, 379-392 (1981)
11. Roth J. & P. Persson: What suppresses fever in pregnancy near term? Am J Physiol 283, R798-R799 (2002)
12. Tatro J.B.: Endogenous antipyresis. Clin Inf Dis 31, S190-S201 (2000)
13. Besedovsky H., A. Del Rey, E. Sorkin & C.A. Dinarello: Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science 233, 652-654 (1986)
14. Franchimont D., K. Kino, J. Galon, G.U. Meduri & G. Chrousos: Glucocorticoids and inflammation revisited: the state of the art. Neuroimmunomodulation 10, 247-260 (2003)
15. Alexander D.P., R.A. Bashore, R.A. Britton & M.A. Forsling: Maternal and fetal arginine vasopressin in the chronically catheterized sheep. Biol Neonate 25, 242-248 (1974)
16. Stark R.I., S.S. Daniel, K.M. Husain, L.S. James & R.L. Van de Wiele: Arginine vasopressin during gestation and parturition in sheep fetus. Biol. Neonate 35, 235-241 (1979)
17. Cooper K.E., N.W. Kasting, K. Lederis & W.L. Veale: Evidence supporting a role for endogenous vasopressin in natural suppression of fever in the sheep. J Physiol. 295, 33-45 (1979)
18. Federico P., W.L. Veale & Q.J. Pittman: Vasopressin- induced antipyresis in the medial amygdaloid nucleus of the conscious rat. Am. J. Physiol. 262, R901-R908 (1992).
19. Kasting N.W.: Criteria for establishing a physiological role for brain peptides. A case in point: the role of vasopressin in thermoregulation during fever and antipyresis. Brain Res Rev 14, 143-153 (1989)
20. Kluger M.J.: Fever: role of pyrogens and cryogens. Physiol Rev 71, 93-127 (1991)
21. Naylor A.M., W.D. Ruwe, A.F. Kohut & W.L. Veale: Perfusion of vasopressin within the ventral septum of the rabbit suppresses endotoxin fever. Brain Res Bull 15, 209-213 (1985)
22. Cooper K.E., A.M. Naylor & W.L. Veale: Evidence supporting a role for endogenous vasopressin in fever suppression in the rat. J Physiol 387, 163-172 (1987)
23. Zeisberger E.: Antipyretic action of vasopressin in the in the ventral septal area of the guinea pig's brain. In: Schönbaum E. & P. Lomax (eds.) Thermoregulation: Research and Clinical Applications, Karger, Basel, pp. 65-68 (1989)
24. De Vries G.J., R.M. Buijs, F.W. Van Leuwen, A.R. Caffe & D.F. Swaab: The vasopressinergic innervation of the brain in normal and castrated rats. J Comp Neurol 233, 236-254 (1985)
25. Staiger J.F. & F. Nürnberger: Pattern of afferents to the lateral septum in the guinea pig. Cell Tissue Res 257, 471-490 (1989)
26. Merker G., S. Blähser & E. Zeisberger: Reactivity pattern of vasopressin containing neurons and its relation to the antipyretic reaction in the pregnant guinea pig. Cell Tissue Res 212, 47-61 (1980)
27. Cooper K.E., S. Blähser, T.J. Malkinson, G. Merker, J. Roth & E. Zeisberger: Changes in body tempreature and vasopressin content of brain neurons, in pregnant and non-pregnant guinea pigs, during fevers produced by Poly I: Poly C. Pflügers Arch - Eur J Physiol 412, 292-296 (1988).
28. Merker G., J. Roth & E. Zeisberger: Thermoadaptive influence on reactivity pattern of vasopressinergic neurons in the guinea pig. Experientia 45, 722-726 (1989).
29. Unger M., G. Merker, J. Roth & E. Zeisberger; Influence of noradrenergic input into the hypothalamic paraventricular nucleus on fever in the guinea-pig. Pflügers Arch - Eur J Physiol 419, 394-400 (1991)
30. Zeisberger E. & J. Roth: Neurobiological concepts of fever generation and suppression. Neuropsychobiology 28, 106-109 (1993)
31. Naylor A.M., Q.J. Pittman & W.L. Veale: Stimulation of vasopressin release in the ventral septum of the brain suppresses prostaglandin E1 fever. J Physiol 399, 177-189 (1988)
32. Bock M., J. Roth, M.J. Kluger & E. Zeisberger: Antipyresis caused by stimulation of vasopressinergic neurons and intraseptal or systemic infusions of γ-MSH. Am J Physiol 266, R614-R621 (1994)
33. Kasting N.W.: Potent stimuli for vasopressin release, hypertonic saline and hemorrhage cause antipyresis in the rat. Regul Pept 15, 293-300 (1986)
34. Roth J., K. Schulze, E. Simon & E. Zeisberger: Alteration of endotoxin fever and release of arginine vasopressin by dehydration in the guinea pig. Neuroendocrinology 56, 680-686 (1992)
35. Zeisberger E. & G. Merker: The role of OVLT in fever and antipyresis. Progr Brain Res 91, 403-408 (1992)
36. Staiger J.F. & F.G. Wouterlood: Efferent projections from the lateral septal nucleus to the anterior hypothalamus in the rat: a study combining Phaseolus vulgaris-leucoagglutinin tracing with vasopressin immunocytochemistry. Cell Tissue Res 261, 17-23 (1990)
37. Disturnal J.E., W.L. Veale & Q.J. Pittman: Electrophysiological analysis of potential arginine vasopressin projections to the ventral septal area of the rat. Brain Res 342, 162-167 (1985)
38. Disturnal J.E., W.L. Veale & Q.J. Pittman: The ventral septal area: electrophysiological evidence for putative arginine vasopressin projections onto thermoresponsive neurons. Neuroscience 19, 795-802 (1986)
39. Disturnal J.E., W.L. Veale & Q.J. Pittman: Modulation by arginine vasopressine of glutamate excitation in the ventral septal area of the rat brain. Can J Physiol Pharmacol 65, 30-35 (1987)
40. Poulin P., K. Lederis & Q.J. Pittman: Subcellular localization and characterization of vasopressin binding sites in the ventral septal area, lateral septum and hippocampus of the rat brain. J Neurochem 50, 889-898 (1988)
41. Gerstberger R. & F. Fahrenholz: Autoradiographic localization of V1 vasopressin binding sites in rat brain and kidney. Eur J Pharmacol 167, 105-116 (1989)
42. Landgraf R., T.J. Malkinson, W.L. Veale, K. Lederis & Q.J. Pittman: Vasopressin and oxytocin in rat brain in response to prostaglandin fever. Am J Physiol 259, R1056- R1062 (1990)
43. Kiss J.Z.: Dymanism of chemoarchitecture in the hypothalamic paraventricular nucleus. Brain Res Bull 20: 699-708 (1988)
44. Eliason H.L. & J.E. Fewell: AVP mediates the attenuated febrile response to administration of PGE1 in rats near term of pregnancy. Am J Physiol 275, R691-R696 (1998)
45. Eliason H.L. & J.E. Fewell: Arginine vasopressin does not mediate the attenuated febrile response to intravenous IL-1β in pregnant rats. Am J Physiol 276, R450-R454 (1999)
46. Zeisberger E.: The role of septal peptides in thermoregulation and fever. In: Bligh J. & K. Voigt (eds) Thermoreception and Temperature Regulation, Springer, Heidelberg, pp 273-283 (1990)
47. Roth J.: Immunological and neuroendocrine modulation of fever in stress. Progr Brain Res 115, 177-192 (1998)
48. Milton N.G.N., E.W. Hillhouse & A.S. Milton: Does endogenous peripheral arginine vasopressin have a role in the febrile responses of conscious rabbits ? J Physiol 469, 525-534 (1993)
49. Paro F.M., M.C. Almeida, E.C. Carnio & L.G.S. Branco: Role of L-glutamate in systemic AVP-induced hypothermia. J Appl Physiol 94, 271-277 (2003)
50. Eagen P.C., N.W. Kasting, W.L. Veale & K.E. Cooper: Absence of endotoxin fever but not prostaglandin E2 fever in the Brattleboro rat. Am J Physiol 242: R116-R120 (1982)
51. Stitt J.T. & S.G. Shimada: A comparison of the febrile responses of the Brattleboro and Sprague-Dawley strains of rats to endotoxin and endogenous pyrogens. Can J Physiol Pharmacol 65, 1377-1381 (1987)
52. Glyn J.R. & J.M. Lipton: Hypothermic and antipyretic effects of centrally administered ACTH (1-24) and α-melanotropin. Peptides 2, 177-187 (1981)
53. Glyn-Ballinger J.R., G.L. Bernadini & J.M. Lipton: α-MSH injected into the septal region reduces fever in rabbits. Peptides 4, 199-203 (1983)
54. Bell R.C. & J.M. Lipton: Pulsatile release of antipyretic neuropeptide α-MSH from septum of rabbit during fever. Am J Physiol 252, R1152-R1157 (1987)
55. Feng J.D., T. Dao & J.M. Lipton: Effects of preoptic microinjection of alpha-MSH on fever and normal temperature control in rabbits. Brain Res Bull 18, 473-477 (1987)
56. Shih S.T., O. Khorram, J.M. Lipton & S.M. McCann: Central administration of α-MSH antiserum augments fever in the rabbit. Am J Physiol 250, R803-R806 (1987)
57. Martin S.M., T.J. Malkinson, W.L. Veale & Q.J. Pittman: Depletion of brain α-MSH alters prostaglandin and interleukin fever in rats. Brain Res 526, 351-354 (1990)
58. Shih S.T. & J.M. Lipton: Intravenous α-MSH reduces fever in squirrel monkeys. Peptides 6, 685-687 (1985)
59. Goelst K., D. Mitchell & H. Laburn: Effects of α-melanocyte stimulating hormone on fever caused by endotoxin in rabbits. J Physiol 441, 469-476 (1991)
60. Davidson J., A.S. Milton & D. Rotondo: α-Melanocyte stimulating hormone suppresses fever and increase in plasma levels of prostaglandin E2 in rabbits. J Physiol 451, 491-502 (1992)
61. Huang Q.H., V.J. Hruby & J.B. Tatro: Systemic α-MSH suppresses LPS fever via central melanocortin receptors independently of its suppression of corticosterone and IL-6 release. Am J Physiol 275, R524-R530 (1998)
62. Al-Dujalili E.A.S., J. Hope, F.E. Estivaritz, P.J. Lowry & C.R.W. Edwards: Circulating human pituitary pro-γ-melanotropin enhances the adrenal response to ACTH. Nature 291, 156-159 (1981)
63. Roth J. Harré E.M., Rummel C., R. Gerstberger & T. Hübschle: Signaling the brain in systemic inflammation: role of sensory circumventricular organs. Front Biosci 9, 290-300 (2004)
64. Zimmer J.A. & J.M. Lipton: Central and peripheral injections of ACTH (1-24) reduce fever in adrenalectomized rabbits. Peptides 2, 419-423 (1981)
65. Kawai Y.S., S. Inagaki, S. Shiosaka, T. Shibasaki, N. Ling, M. Tohyama & Y. Shiotani: The distribution and projection of γ-melanocyte stimulating hormone in the rat brain: an immunohistochemical analysis. Brain Res 297: 21-32 (1984)
66. Catania A. & J.M. Lipton: α-Melanocyte stimulating hormone in the modulation of host reactions. Endocrine Rev 14, 564-576 (1993)
67. Tatro J.B.: Receptor biology of the melanocortins, a family of neuroimmunomodulatory peptides. Neuroimmunomodulation 3, 259-284 (1996)
68. Fan W., B.A. Boston, R.A. Kesterson, V.J. Hruby & R.D. Cone: Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385, 165-168 (1997)
69. Lawrence C.B. & N.J. Rothwell: Anorexic but not pyrogenic actions of interleukin-1 are modulated by central melanocortin-3/4 receptors in the rat. J Neuroendocrin 13, 490-495 (2001)
70. Huang Q.H., M.L. Entwistle, J.D. Alvaro, R.S. Duman V.J. Hruby & J.B. Tatro: Antipyretic role of endogenous melanocortins mediated by central melanocortin receptors during endotoxin-induced fever. J Neurosci 17, 3343-3351 (1997)
71. Sinha P.S., Schiöth H.B. & J.B. Tatro: Activation of central melanocortin-4 receptor suppresses lipopoly-saccharide-induced fever in rats. Am J Physiol 284, R1595-R1603 (2002)
72. Kass E.H. & M. Finland: Effect of ACTH on induced fever. N Engl J Med 243, 693-695 (1950)
73. Inomoto T., J.B. Mercer & E. Simon: Opposing effects of hypothalamic cooling on threshold and sensitivity of metabolic response to body cooling in rabbits. J Physiol 322, 139-150 (1982)
74. Janský L, W. Riedel, E. Simon, C. Simon-Oppermann & S Vyíral: Effect of bombesin on thermoregulation of the rabbit. Pflügers Arch - Eur J Physiol 409, 318-322 (2002)
75. Janský L., S. Vybíral, J. Moravec, J. Nacházel, W. Riedel, E. Simon & C. Simon-Oppermann: Neuropeptides and temperature regulation. J Therm Biol 11, 79-83 (1986)
76. Janský L.: Neuropeptides and central regulation of body temperature during fever and hibernation. J Therm Biol 15, 232-247 (1990)
77. Vybíral S., M. Szekely, L. Janský & L. Cerný: Thermoregulation of the rabbit during during the late phase of endotoxin fever. Pflügers Arch - Eur J Physiol 410, 220-222 (1987)
78. Vybíral S., L. Cerný & L. Janský: Mode of ACTH antipyretic action. Brain Res Bull 21: 557-562 (1988)
79. Janský L. & S. Vybíral: Neuropeptides and body temperature control during normothermia and fever. Acta Physiol Pol 41, 1-3 (1990)
80. Janský L., Vybíral, S. Pospisilova, D. Roth, J. Dornand, J. E. Zeisberger & J. Kaminkova: Production of systemic and hypothalamic cytokines during the early phase of endotoxin fever. Neuroendocrinology 62, 55-61 (1995)
81. Vybíral S., Z. Pesanová, L. Barczayová & L. Jansky: Pyrogenic effects of cytokines (IL-β, IL-6, TNFα) and their mode of action on thermoregulatory centers and functions. Experimental Physiol, in press (2003)
82. Xin L. & C.M. Blatteis: Hypothalamic neuronal responses to interleukin-6 in tissue slices: effects of indomethacin and naloxone. Brain Res Bull 29, 27-35 (1992)
83. Ehymayed H.M. & L. Janský: A discrete mode of the antipyretic effect of AVP, α-MSH and ACTH. Physiol Res 41, 57-61 (1992)
84. Vybíral S. & R. Veselá: Can haloperidol disguise fever? Physiol Res 43, 359-363 (1994)
85. Vybíral S. & L. Janský: The role of dopaminergic pathways in the thermoregulation in the rabbit. Neuropharmacology 28, 15-20 (1989)
86. Shibata M. & C.M. Blatteis: Differential effects of cytokines on thermosensitive neurons in guinea pig preoptic area slices. Am J Physiol 261, R1096-R1102 (1991)
87. Moravec J. & F.K. Pierau: Arginine vasopressin modifies the firing rate and thermosensitivity of neurons in slices of the rat PO/AH area. In: Pleschka K. & R. Gerstberger (eds) Integrative and cellular aspects of autonomic functions: tempreature and osmoregulation, John Libbey and Comp. Ltd. London, 143-152 (1994)
88. Kass E.M.& M. Finland: Corticosteroids in infectious diseases. Adv intern Med 84, 304-315 (1958)
89. Willies G.H. & C.J. Woolf: The site of action of corticosteroid antipyresis in the rabbit. J Physiol 300, 1-6 (1980)
90. Chai Z., Alheim K., Lundkvist J., S. Gatti & T. Bartfai: Subchronic glucocorticoid pretreatment reversibly attenuates IL-1β induced fever in rats: IL-6 mRNA is elevated while IL-1α and IL-1β mRNAs are suppressed in the CNS. Cytokine 8, 227-237 (1996)
91. Kutteh W.H., W.E. Rainey & B.R. Carr: Glucocorticoids inhibit lipopolysaccharide-induced production of tumor necrosis factor-α by human fetal Kupffer cells. J Clin Endocrin Metab 73, 296-301 (1991)
92. Barber A.E., S.M Coyle, M.A. Marano, E. Fischer, S.E. Galvano, Y. Fong, L.L. Moldawer & S.F. Lowry: Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man. J Immunol 150, 1999-2006 (1993)
93. Morrow L.E., J.L. McClellan, C.A. Conn & M.J. Kluger: Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide. Am J Physiol 264, R1010-R1016 (1993)
94. Coelho M.M., G.E.P. Souza & IR. Pelá: Endotoxin fever is modulated by by endogenous glucocorticoids in rats. Am J Physiol 263, R423-R427 (1992)
95. Briegel J., W. Kellermann, H. Forst, M. Haller, M. Bittl, G.E. Hoffmann, M. Büchler, W. Uhl & K. Peter: Low-dose hydrocorticone infusion attenuates the systemic inflammatory response syndrome. Clin Invest 72, 782-787 (1994)
96. McClellan J.L., J.J. Klir, L.E. Morrow & M.J. Kluger: Central effects of glucocorticoid receptor antagonist RU-38486 on lipopolysaccharide and stress-induced fever. Am J Physiol 264, R705-R711 (1993)
97. Morrow L.E., J.L. McClellan, J.J. Klir & M.J. Kluger: The CNS site of glucocorticoid negative feedback during LPS- and psychological stress-induced fevers. Am J Physiol 271, R732-R737 (1996)
98. Carey F., R. Forder, M.D. Edge, A.R. Greene, M.A. Horan, PJ.L.M. Strijbos & N.J. Rothwell: Lipocortin-1 fragment modifies pyrogenic actions of cytokines in rats. Am J Physiol 259, R266-R269 (1990)
99. Minghetti L., A. Nicolini, E. Polazzi, A. Greco, M. Perretti, L. Parente & G. Levi: Down-regulation of microglial cyclooxygenase-2 and inducible nitric oxide synthase expression by lipocortin-1. Br J Pharmacol 126, 1307-1314 (1999)
100. Mouihate A., M.S. Clerget-Froidevaux, K. Nakamura, M. Negeshi, J.L. Wallace & Q.J. Pittman: Suppression of fever at near term is associated with reduced COX-2 protein expression in rat hypothalamus. Am J Physiol 283, R800-R805 (2002)
101. Imai-Matsumura K., K. Matsumura, A. Terao & Y. Watanabe: Attenuated fever in pregnant rats is associated with blunted synthesis of brain cyclooxygenase-2 and PGE2. Am J Physiol 283, R1346-R1353 (2002)
102. Zeisberger E., J. Roth & M.J. Kluger: Interactions between the immune system and the hypothalamic neuroendocrine system during fever and endogenous antipyresis. In: Pleschka K. & R. Gerstberger (eds) Integrative and cellular aspects of autonomic functions: tempreature and osmoregulation, John Libbey and Comp. Ltd. London, 181-190 (1994)