Model based calculation of substrate/inducer feed-rate profiles in fed-batch processes for recombinant protein production

Biotechnology Techniques

Volumn 13, Issue 1, 1999, Pages 37-42

  Levisauskas, D ^a   Galvanauskas, V ^a,b   Simutis, R ^a,b   Lubbert A ^b  

^a KAUNAS UNIVERSITY OF TECHNOLOGY   (Lithuania)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

E. coli; Fed batch cultivation; Model based optimization; Recombinant protein

Indexed keywords

FED BATCH REACTOR; MODEL; PROTEIN ENGINEERING; RECOMBINANT PROTEIN;

EID: 0033042539     PISSN: 0951208X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008887514011     Document Type: Article

References (16)

1. Brinkmann U, Mattes RE, Buckel P (1989) Gene 85: 109-114.
2. Chen Q, Bentley WE, Weigand WA (1995) Appl. Biochem. Biotechnol. 51/52: 449-461.
3. Fogel DJ (1995) Evolutionary Computation: Toward a New Philosophy of Machine Intelligence. New York: IEEE Press.
4. Galvanauskas V, Oliveira R, Volk N, Simutis R, Lübbert A (1998a) Chem. Eng. Sci. (submitted).
5. Galvanauskas V, Simutis R, Lübbert A (1998b) Proc. Contr. Qual. 11:119-124.
6. Galvanauskas V, Simutis R, Volk N, Lübbert A (1998c) Bioproc. Eng. 18: 227-234.
7. Hellmuth K, Korz DJ, Sanders EA, Deckwer WD (1994) J. Biotechnol. 32: 289-298.
8. Lee J, Ramirez F (1992) Biotech. Bioeng. 39: 635-646.
9. Levisauskas D, Reuss M (1992) A method for optimal feed rate profile calculation in fed-batch culture. DECHEMA Biotechnol. Conf., Karlsruhe, Germany. Frankfurt(M), ISBN 3-527-28534-2, 5, Part A., pp. 409-413.
10. Lim HC, Tayeb YI, Modak IM, Bonte P (1986) Biotech. Bioeng. 28: 1408-1420.
11. Merriam CW (1967) Optimization Theory and the Design of Feedback Control Systems. New York: General Electric Research Laboratory.
12. Modak IM, Lim HC, Tayeb YI (1986) Biotech. Bioeng. 28: 1396-1407.
13. Neubauer P, Hofmann K (1994) FEMS Micmbiol. Rev 14: 99-102.
14. Rudolph R, Böhin G, Lilie H, Jaenicke R (1996) Folding proteins. In: Creighton TE, ed. Protein Function: A Practical Approach, Chapter 3, Oxford University Press.
15. Simutis R, Lübbert A (1997) J. Biotechnol. 52: 245-256.
16. Yoon SK, Kwon SH, Park MG, Kang WK, Park TH (1995) Biotechnol. Lett. 16: 1119-1124.