Model based design of a biochemical cultivation process

Bioprocess Engineering

Volumn 18, Issue 3, 1998, Pages 227-234

  Galvanauskas, V ^a   Simutis, R ^a   Volk, N ^a   Lubbert A ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; GLUCOSE;

ARTICLE; BIOLOGICAL MODEL; BIOMASS; BIOPROCESS; BIOTECHNOLOGY; ESCHERICHIA COLI; FERMENTATION; METHODOLOGY; MODEL; NONHUMAN; PRIORITY JOURNAL;

EID: 0031939014     PISSN: 0178515X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004490050435     Document Type: Article

References (16)

1. Montgomery, D.C.: Design and analysis of experiments, New York: Wiley, (1991)
2. Glassey, J.; Montague, G.A.; Ward, A.C.; Kara, B.V.: Artificial neural network based experimental design procedures for enhancing fermentation development. Biotechnol. Bioeng. 44 (1994) 397-405
3. Goodwin, G.C.: Identification: Experiment design. In: G. Singh (Ed.) Systems and Control Encyclopedia, Vol. 4, Oxford: Pergamon (1987) 2257-2267
4. Munack, A.: Optimization of sampling. In: K. Schügerl (Ed.): Biotechnology, Vol. 4, Measuring, modelling and control, Weinheim: VCH (1991) 251-264
5. Baltes, M.; Schneider, R.; Sturm, C.; Reus, M.: Optimal experimental design for parameter estimation in unstructured growth models. Biotechnol. Prog. 10 (1994) 480-488
6. Simutis, R.; Oliveira, R.; Manikowski, M.; S. Feyo de Azevedo; Lübbert, A.: How to increase the performance of models for process optimization and control, J. Biotechnology (1997) submitted
7. Bajpai, R.: Control of bacterial fermentations. Annals of the New York Academy of Sciences 506 (1987) 446-458
8. Dors, M.; Simutis, R.; Lübbert, A.: Hybrid process modelling for advanced process state estimation, prediction and control examplified at a production scale mammalian cell culture. In: ACS Symposium Series: Biosensor and Chemical Sensor Technology. Process Monitoring and Control, (Eds) Rogers, K., Mulchandani, A., Zhou, W., ACS, Washington (1995) 144-145
9. Oliveira, R.; Simutis, R.; Azevedo, F.; Lübbert, A.: HYBNET, a new tool for advanced process modeling. In: B. Glennon et al. (Ed.): Proceedings of the 1st European Symposium on Biochemical Engineering Science, Dublin, Ireland: (1996) 182-183
10. Kell, D.B.; Sonnleitner, B.: GMB - Good modelling practice: an essential component of good manufacturing practice, Trends Biotechnol., 13 (1996) 481-492
11. Shuler, M.; L., Kargi, F.: Bioprocess engineering. Basic Concepts, New Jersey: Prentice Hall (1992)
12. Chattaway, T.; Demain, A.L.; Stephanopoulos, G.: Use of various measurements for biomass estimation, Biotechnol. Prog., 8 (1992) 81-84
13. Nielsen, J.; Villadsen, J.: Bioreaction Engineering Principles, New York: Plenum Press (1994)
14. Roels, J.: Energetics and kinetics in biotechnology, Amsterdam: Elsevier Biomedical Press (1983)
15. Heinzle, E.; Dunn, I.J.: Methods and instruments in fermentation gas analysis. In: K. Schügerl (Ed.): Biotechnology, Vol. 4, Measuring, modeling and control, Weinheim: VCH (1991) 27-74
16. Simutis, R., Lübbert, A.: A comparative study on random search algorithms for biotechnical process optimization, J. Biotechnology. 52 (1997) 245-256