How to interpret a CSF - The art and the science

Advances in Experimental Medicine and Biology

Volumn 568, Issue , 2005, Pages 199-216

  Connell, Tom ^a   Curtis, Nigel ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; BRAIN PROTEIN; CYTOKINE; GLUCOSE;

ALGORITHM; ART; BACTERIAL MENINGITIS; BLOOD CELL COUNT; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID CYTOLOGY; CEREBROSPINAL FLUID PRESSURE; CONVULSION; DISEASE MARKER; EOSINOPHILIA; GLUCOSE BRAIN LEVEL; HUMAN; LATEX AGGLUTINATION TEST; LEUKOCYTE COUNT; LUMBAR PUNCTURE; NEUTROPHIL COUNT; PLEOCYTOSIS; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; REVIEW; SCIENCE; SCORING SYSTEM; SENSITIVITY AND SPECIFICITY; SHUNT INFECTION; VIRUS MENINGITIS; ANIMAL; ARTICLE; BLOOD; MICROBIOLOGY; PHYSIOLOGY;

ANIMALS; BLOOD; CEREBROSPINAL FLUID; HUMANS; MENINGITIS, BACTERIAL;

EID: 25144523912     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (148)

1. Adinolfi, M. (1985). The development of the human blood-CSF-brain barrier. Dev. Med. Child Neurol. 27, 532-537.
2. Ahmed, A., Hickey, S.M., Ehrett, S., Trujillo, M., Brito, F., Goto, C. et al. (1996). Cerebrospinal fluid values in the term neonate. Pediatr. Infect. Dis. J. 15, 298-303.
3. Aminoff, M.J. and Simon, R.P. (1980). Status epilepticus. Causes, clinical features and consequences in 98 patients. Am. J. Med. 69, 657-666.
4. Anagnostakis, D., Messaritakis, J., Damianos, D., and Mandyla, H. (1992). Blood-brain barrier permeability in "healthy" infected and stressed neonates. J. Pediatr. 121, 291-294.
5. Archimbaud, C., Mirand, A., Chambon, M., Regagnon, C., Bailly, J.L., Peigue-Lafeuille, H. et al. (2004). Improved diagnosis on a daily basis of enterovirus meningitis using a one-step real-time RT-PCR assay. J. Med. Virol. 74, 604-611.
6. Backman, A., Lantz, P., Radstrom, P., and Olcen, P. (1999). Evaluation of an extended diagnostic PCR assay for detection and verification of the common causes of bacterial meningitis in CSF and other biological samples. Mol. Cell. Probes 13, 49-60.
7. Barry, E. and Hauser, W.A. (1994). Pleocytosis after status epilepticus. Arch. Neurol. 51, 190-193.
8. Biou, D., Benoist, J.F., Houng, C.N.H., Morel, P., and Marchand, M. (2000). Cerebrospinal fluid protein concentrations in children: Age-related values in patients without disorders of the central nervous system. Clin. Chem. 46, 399-403.
9. Blatter, D.D., Bigler, E.D., Gale, S.D., Johnson, S.C., Anderson, C.V., Burnett, B.M. et al. (1995). Quantitative volumetric analysis of brain MR: Normative database spanning 5 decades of life. Am. J. Neuroradiol. 16, 241-251.
10. Blazer, S., Berant, M., and Alon, U. (1983). Bacterial meningitis: Effect of antibiotic treatment on the cerbrospinal fluid. Am. J. Clin. Pathol. 80, 386-387.
11. Bonadio, W.A. (1988a). Acute bacterial meningitis. Cerebrospinal fluid differential count. Clin. Pediatr. (Phila.) 27, 445-447.
12. Bonadio, W.A. (1988b). Bacterial meningitis in children whose cerebrospinal fluid contains polymorphonuclear leukocytes without pleocytosis. Clin. Pediatr. (Phila.) 27, 198-200.
13. Bonadio, W.A. (1989). How rapidly is cerebrospinal fluid pleocytosis manifested with bacterial meningitis? Pediatr. Infect. Dis. J. 8, 337-338.
14. Bonadio, W.A. (1992). The cerebrospinal fluid: Physiologic aspects and alterations associated with bacterial meningitis. Pediatr. Infect. Dis. J. 11, 423-431.
15. Bonadio, W.A., Smith, D.S., Goddard, S., Burroughs, J., and Khaja, G. (1990). Distinguishing cerebrospinal fluid abnormalities in children with bacterial meningitis and traumatic lumbar puncture. J. Infect. Dis. 162, 251-254.
16. Bonadio, W.A., Stanco, L., Bruce, R., Barry, D., and Smith, D. (1992). Reference values of normal cerebrospinal fluid composition in infants ages 0 to 8 weeks. Pediatr. Infect. Dis. J. 11, 589-591.
17. Bonsu, B.K. and Harper, M.B. (2004a). Differentiating acute bacterial meningitis from acute viral meningitis among children with cerebrospinal fluid pleocytosis: A multivariable regression model. Pediatr. Infect. Dis. J. 23, 511-517.
18. Bonsu, B.K. and Harper, M.B. (2004b). Explanation of mathematical model. Pediatr. Infect. Dis. J. 23, 893.
19. Bosch, I. and Oehmichen, M. (1978). Eosinophilic granulocytes in the cerebrospinal fluid: Analysis of 94 cerebrospinal fluid specimens and review of the literature. J. Neurol. 219, 93-105.
20. Bryant, P.A., Li, H.Y., Zaia, A., Griffith, J., Hogg, G., Curtis, N. et al. (2004). Prospective study of a real-time PCR that is highly sensitive, specific, and clinically useful for diagnosis of meningococcal disease in children. J. Clin. Microbiol. 42, 2919-2925.
21. Cherian, T., Lalitha, M.K., Manoharan, A., Thomas, K., Yolken, R.H., and Steinhoff, M.C. (1998). PCR-enzyme immunoassay for detection of streptococcus pneumoniae DNA in cerebrospinal fluid samples from patients with culture-negative meningitis. J. Clin. Microbiol. 36, 3605-3608.
22. Clarke, D. and Cost, K. (1983). Use of serum C-reactive protein in differentiating septic from aseptic meningitis in children. J. Pediatr. 102, 718-720.
23. Coll, M.T., Uriz, M.S., Pineda, V., Fontanals, D., Bella, F., Nava, J.M. et al. (1994). Meningococcal meningitis with 'normal' cerebrospinal fluid. J. Infect. 29, 289-294.
24. Conly, J.M. and Ronald, A.R. (1983). Cerebrospinal fluid as a diagnostic body fluid. Am. J. Med. 75, 102-108.
25. Converse, G.M., Gwaltney, J.M., Jr., Strassburg, D.A., and Hendley, J.O. (1973). Alteration of cerebrospinal fluid findings by partial treatment of bacterial meningitis. J. Pediatr. 83, 220-225.
26. Corless, C.E., Guiver, M., Borrow, R., Edwards-Jones, V., Fox, A.J., and Kaczmarski, E.B. (2001). Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae in suspected cases of meningitis and septicemia using real-time PCR. J. Clin. Microbiol. 39, 1553-1558.
27. Cutler, R.W., Page, L., Galicich, J., and Watters, G.V. (1968). Formation and absorption of cerebrospinal fluid in man. Brain 91, 707-720.
28. Dalton, H.P. and Allison, M.J. (1968). Modification of laboratory results by partial treatment of bacterial meningitis. Am. J. Clin. Pathol. 49, 410-413.
29. Davson, H., Welch, K., and Segal, M.B. (1987). The physiology and pathophysiology of the cerebrospinal fluid. Edinburgh: Churchill Livingston.
30. De Beer, F.C., Kirsten, G.F., Gie, R.P., Beyers, N., and Strachan, A.F. (1984). Value of C-reactive protein measurements in tuberculous, bacterial and viral meningitis. Arch. Dis. Child. 59, 653-656.
31. Devinsky, O., Nadi, S., Theodore, W.H., and Porter, R.J. (1988). Cerebrospinal fluid pleocytosis following simple, complex partial, and generalized tonic-clonic seizures. Ann. Neurol. 23, 402-403.
32. Dicuonzo, G., Lorino, D., Lilli, D., Rivanera, D., Guarino, P., Angeletti, S. et al. (1999). Polymerase chain reaction with sequencing, as a diagnostic tool in culture-negative meningitis. Clin. Microbiol. Infect. 5, 92-96.
33. Donald, P.R., Malan, C., and van der Walt, A. (1983). Simultaneous determination of cerebrospinal fluid glucose and blood glucose concentrations in the diagnosis of bacterial meningitis. J. Pediatr. 103, 413-415.
34. Edwards, R., Schmidley, J.W., and Simon, R.P. (1983). How often does a CSF pleocytosis follow generalized convulsions? Ann. Neurol. 13, 460-462.
35. Ellis, R., 3rd. (1994). Lumbar cerebrospinal fluid opening pressure measured in a flexed lateral decubitus position in children. Pediatrics 93, 622-623.
36. Feigin, R.D. (1981). Textbook of Pediatrice Infectious Diseases. Saunders, Philadelphia, pp. 293-307.
37. Feigin, R.D. and Shackelford, P.G. (1973). Value of repeat lumbar puncture in the differential diagnosis of meningitis. N. Engl. J. Med. 289, 571-574.
38. Fishbein, D.B., Palmer, D.L., Porter, K.M., and Reed, W.P. (1981). Bacterial meningitis in the absence of CSF pleocytosis. Arch. Intern. Med. 141, 1369-1372.
39. Fishman, R. (Ed.) (1980). Cerebrospinal fluid in diseases of the nervous system. Philadelphia: Saunders, 1980: 168-253.
40. Freedman, S.B., Marrocco, A., Pirie, J., and Dick, P.T. (2001). Predictors of bacterial meningitis in the era after Haemophilus influenzae. Arch. Pediatr. Adolesc. Med. 155, 1301-1306.
41. Freemont-Smith, F. and Dailey, M. (1925). Cerebrospinal fluid sugar. Arch. Neurol. Psychiatry 14, 390-395.
42. Freund, M., Adwan, M., Kooijman, H., Heiland, S., Thomsen, M., Hahnel, S. et al. (2001). Measurement of CSF flow in the spinal canal using MRI with an optimized MRI protocol: Experimental and clinical studies. Rofo 173, 306-314.
43. Frohna, J.G., Park, S.M., and Gopal, S. (2001). Diagnosing bacterial meningitis after the Haemophilus influenzae vaccine: Still a challenge. Arch. Pediatr. Adolesc. Med. 155, 1307-1310.
44. Fuchs, S. (1997). Paediatric Emergency Medicine. Mosby, St Louis.
45. Fujimaki, T., Takagi, K., and Nagata, K. (2003). Cerebrospinal fluid volume. J. Neurosurg. 98, 1144-1145, author reply 1145-1146.
46. Gendrel, D., Raymond, J., Assicot, M., Avenel, S., Lefevre, H., Ravilly, S. et al. (1998). Procalcitonin, C-reactive protein and interleukin 6 in bacterial and viral meningitis in children. Presse Med. 27, 1135-1139.
47. Gendrel, D., Raymond, J., Assicot, M., Moulin, F., Iniguez, J.L., Lebon, P. et al. (1997). Measurement of procalcitonin levels in children with bacterial or viral meningitis. Clin. Infect. Dis. 24, 1240-1242.
48. Gendrel, D., Raymond, J., Coste, J., Moulin, F., Lorrot, M., Guerin, S. et al. (1999). Comparison of procalcitonin with C-reactive protein, interleukin 6 and interferon-alpha for differentiation of bacterial vs. viral infections. Pediatr. Infect. Dis. J. 18, 875-881.
49. Goodwin, G.M. and Shelley, H.J. (1925). The sugar content of the cerebrospinal fluid and its relation to blood sugar. Arch. Intern. Med. 35, 242-258.
50. Gray, S.J., Sobanski, M.A., Kaczmarski, E.B., Guiver, M., Marsh, W.J., Borrow, R. et al. (1999). Ultrasound-enhanced latex immunoagglutination and PCR as complementary methods for non-culture-based confirmation of meningococcal disease. J. Clin. Microbiol. 37, 1797-1801.
51. Greenlee, J.E. (1990). Approach to diagnosis of meningitis. Cerebrospinal fluid evaluation. Infect. Dis. Clin. North Am. 4, 583-598.
52. Guney, C., Ozkaya, E., Yapar, M., Gumus, I., Kubar, A., and Doganci, L. (2003). Laboratory diagnosis of enteroviral infections of the central nervous system by using a nested RT-polymerase chain reaction (PCR) assay. Diagn. Microbiol. Infect. Dis. 47, 557-562.
53. Gyllesward, A., and Malmstrom, L. (1962). The cerebrospinal fluid in immature infants. Acta Paediatr. 51(suppl 135):54-62.
54. Hall, L.M., Duke, B., and Urwin, G. (1995). An approach to the identification of the pathogens of bacterial meningitis by the polymerase chain reaction. Eur. J. Clin. Microbiol. Infect. Dis. 14, 1090-1094.
55. Harrison, S.A. and Risser, W.L. (1988). Repeat lumbar puncture in the differential diagnosis of meningitis. Pediatr. Infect. Dis. J. 7, 143-145.
56. Herndon, R.M. and R.A. Brumback (1989). The Cerebrospinal fluid. Boston, Kluwer Academic Publishers.
57. Hoen, B., Viel, J.F., Paquot, C., Gerard, A., and Canton, P. (1995). Multivariate approach to differential diagnosis of acute meningitis. Eur. J. Clin. Microbiol. Infect. Dis. 14, 267-274.
58. Hristeva, L., Bowler, I., Booy, R., King, A., and Wilkinson, A.R. (1993). Value of cerebrospinal fluid examination in the diagnosis of meningitis in the newborn. Arch. Dis. Child. 69, 514-517.
59. Kotilainen, P., Jalava, J., Meurman, O., Lehtonen, O.P., Rintala, E., Seppala, O.P. et al. (1998). Diagnosis of meningococcal meningitis by broad-range bacterial PCR with cerebrospinal fluid. J. Clin. Microbiol. 36, 2205-2209.
60. Kuberski, T., Bart, R.D., Briley, J.M., and Rosen, L. (1979). Recovery of Angiostrongylus cantonensis from cerebrospinal fluid of a child with eosinophilic meningitis. J. Clin. Microbiol. 9, 629-631.
61. Leblebicioglu, H., Esen, S., Bedir, A., Gunaydin, M., and Sanic, A. (1996). The validity of Spanos' and Hoen's models for differential diagnosis of meningitis. Eur. J. Clin. Microbiol. Infect. Dis. 15, 252-254.
62. Levinson, A. (1928). Cerebrospinal fluid in infants and children. Am. J. Dis. Child. 36, 799-818.
63. Lo Re, V., 3rd and Gluckman, S.J. (2001). Eosinophilic meningitis due to Angiostrongylus cantonensis in a returned traveler: Case report and review of the literature. Clin. Infect. Dis. 33, e112-e115.
64. Lo Re, V., 3rd and Gluckman, S.J. (2002). Eosinophilic meningitis due to Gnathostoma spinigerum. J. Infect. 45, 117-120.
65. Lo Re, V., 3rd and Gluckman, S.J. (2003). Eosinophilic meningitis. Am. J. Med. 114, 217-223.
66. Lorino, G., Angeletti, S., Gherardi, G., De Cesaris, M., Gherardi, L., Battistoni, F. et al. (2000). Diagnostic value of cytokine assays in cerebrospinal fluid in culture-negative, polymerase chain reaction-positive bacterial meningitis. Eur. J. Clin. Microbiol. Infect. Dis. 19, 388-392.
67. Lott, J.A. and Warren, P. (1989). Estimation of reference intervals for total protein in cerebrospinal fluid. Clin. Chem. 35, 1766-1770.
68. Lu, J.J., Perng, C.L., Lee, S.Y., and Wan, C.C. (2000). Use of PCR with universal primers and restriction endonuclease digestions for detection and identification of common bacterial pathogens in cerebrospinal fluid. J. Clin. Microbiol. 38, 2076-2080.
69. Marc, E., Menager, C., Moulin, F., Stos, B., Chalumeau, M., Guerin, S. et al. (2002). Procalcitonin and viral meningitis: Reduction of unnecessary antibiotics by measurement during an outbreak. Arch. Pediatr. 9, 358-364.
70. Marks, V. (1960). True glucose content of Lumbar and Ventricular cerebrospinal fluid. J. Clin. Pathol. 13, 82-84.
71. Marton, K.I. and Gean, A.D. (1986). The spinal tap: A new look at an old test. Ann. Intern. Med. 104, 840-848.
72. Mayefsky, J.H. and Roghmann, K.J. (1987). Determination of leukocytosis in traumatic spinal tap specimens. Am. J. Med. 82, 1175-1181.
73. Mazor, S.S., McNulty, J.E., and Roosevelt, G.E. (2003). Interpretation of traumatic lumbar punctures: Who can go home? Pediatrics 111, 525-528.
74. McClinton, D., Carraccio, C., and Englander, R. (2001). Predictors of ventriculoperitoneal shunt pathology. Pediatr. Infect. Dis. J. 20, 593-597.
75. Mehl, A.L. (1986). Interpretation of traumatic lumbar puncture. Predictive value in the presence of meningitis. Clin. Pediatr. (Phila.) 25, 575-577.
76. Meldrum, B.S. and Breirley, J.B. (1973). Prolonged epileptic seizures in primates. Arch. Neurol. 28, 10-17.
77. Meritt, H.H. and Fremont-Smith, F. (eds.) (1937). The Cerebrospinal Fluid. Saunders, Philadelphia.
78. Michael, M., Barrett, D.J., and Mehta, P. (1986). Infants with meningitis without cerebrospinal fluid pleocytosis. Am. J. Dis. Child. 140, 851.
79. Mohamed, N., Elfaitouri, A., Fohlman, J., Friman, G., and Blomberg, J. (2004). A sensitive and quantitative single-tube real-time reverse transcriptase-PCR for detection of enteroviral RNA. J. Clin. Virol. 30, 150-156.
80. Moore, C.M. and Ross, M. (1973). Acute bacterial meningitis with absent or minimal cerebrospinal fluid abnormalities. Clin. Pediatr. 12, 117-118.
81. Mulford, W.S., Buller, R.S., Arens, M.Q., and Storch, G.A. (2004). Correlation of cerebrospinal fluid (CSF) cell counts and elevated CSF protein levels with enterovirus reverse transcription-PCR results in pediatric and adult patients. J. Clin. Microbiol. 42, 4199-4203.
82. Munro, D. (1928). Cerebrospinal fluid pressure in the new-born. J. Am. Med. Assoc. 90, 1688-1689.
83. Naidoo, B. (1982). The cerebrospinal fluid in the healthy newborn infant. S. Afr. Med. J. 42, 933-935.
84. Negrini, B., Kelleher, K.J., and Wald, E.R. (2000). Cerebrospinal fluid findings in aseptic versus bacterial meningitis. Pediatrics 105, 316-319.
85. Nigrovic, L.E., Kuppermann, N., and Malley, R. (2002). Development and validation of a multivariable predictive model to distinguish bacterial from aseptic meningitis in children in the post-Haemophilus influenzae era. Pediatrics 110, 712-719.
86. Novak, R.W. (1984). Lack of validity of standard corrections for white blood cell counts of blood-contaminated cerebrospinal fluid in infants. Am. J. Clin. Pathol. 82, 95.
87. Nye, F.J. (1983). The value of initial laboratory investigations in the management of meningitis. J. Infect. 7, 31-38.
88. Onorato, I.M., Wormser, G.P., and Nicholas, P. (1980). "Normal" CSF in bacterial meningitis. J. Am. Med. Assoc. 244, 1469-1471.
89. Osborne, J.P. and Pizer, B. (1981). Effect on the white cell count of contaminating cerebrospinal fluid with blood. Arch. Dis. Child. 56, 400-401.
90. Otila, E. (1948). Studies on the Cerebrospinal fluid in Premature Infants. Acta Paediatr Vol 35(suppl 8).
91. Pappu, L.D., Purohit, D.M., Levkoff, A.H., and Kaplan, B. (1982). CSF cytology in the neonate. Am. J. Dis. Child. 136, 297-298.
92. Paul, R., Koedel, U., Winkler, F., Kieseier, B.C., Fontana, A., Kopf, M. et al. (2003). Lack of IL-6 augments inflammatory response but decreases vascular permeability in bacterial meningitis. Brain 126, 1873-1882.
93. Petito, C.K., Schaefer, J.A., and Plum, F. (1977). Ultrastructural characteristics of the brain and blood-brain barrier in experimental seizures. Brain Res. 127, 251-267.
94. Petola, H. and Jaakola, M. (1988). C-reactive protein in the early detection of bacteremic versus viral infections in immunocompetent and compromised children. J. Pediatr. 113, 641-646.
95. Polk, D.B. and Steele, R.W. (1987). Bacterial meningitis presenting with normal cerebrospinal fluid. Pediatr. Infect. Dis. J. 6, 1040-1042.
96. Porritt, R.J., Mercer, J.L., and Munro, R. (2003). Ultrasound-enhanced latex immunoagglutination test (USELAT) for detection of capsular polysaccharide antigen of Neisseria meningitidis from CSF and plasma. Pathology 35, 61-64.
97. Portnoy, J.M. and Olson, L.C. (1985). Normal cerebrospinal fluid values in children: Another look. Pediatrics 75, 484-487.
98. Powers, W. (1981). Cerebrospinal fluid to serum glucose ratios in diabetes mellitus and bacterial meningitis. Am. J. Med. 71, 217.
99. Powers, W.J. (1985). Cerebrospinal fluid lymphocytosis in acute bacterial meningitis. Am. J. Med. 79, 216-220.
100. Prokesch, R.C., Rimland, D., Petrini, J.L., and Fein, A.B. (1983). Cerebrospinal fluid pleocytosis after seizures. South. Med. J. 76, 322-327.
101. Quick, D.T., Thompson, J.M., and Bond, J.O. (1965). The 1962 Epidemic of St. Louis encephalitis in Florida. Clinical features of cases occuring in the Tampa Bay area. Am. J. Epidemiol. 81, 415-427.
102. Ramers, C., Billman, G., Hartin, M., Ho, S., and Sawyer, M.H. (2000). Impact of a diagnostic cerebrospinal fluid enterovirus polymerase chain reaction test on patient management. J. Am. Med. Assoc. 283, 2680-2685.
103. Rantakokko-Jalava, K., Nikkari, S., Jalava, J., Eerola, E., Skurnik, M., Meurman, O. et al. (2000). Direct amplification of rRNA genes in diagnosis of bacterial infections. J. Clin. Microbiol. 38, 32-39.
104. Rao, S.P., Schmalzer, E., and Kaufmann, M. (1983). Meningitis in patients with sickle cell anaemia. Am. J. Pediatr. Haematol. Oncol. 12, 101-103.
105. Remington, J.S. and Klein, O.J. (Eds.) (2001). Infectious Diseases of the Fetus and Newborn Infant, Philadelphia: W.B.Saunders.
106. Rider, L.G., Thapa, P.B., Del Beccaro, M.A., Gale, J.L., Foy, H.M., Farwell, J.R. et al. (1995). Cerebrospinal fluid analysis in children with seizures. Pediatr. Emerg. Care 11, 226-229.
107. Rodriguez, A.F., Kaplan, S.L., and Mason, E.O., Jr. (1990). Cerebrospinal fluid values in the very low birth weight infant. J. Pediatr. 116, 971-974.
108. Rubenstein, J.S. and Yogev, R. (1985). What represents pleocytosis in blood-contaminated ("traumatic tap") cerebrospinal fluid in children? J. Pediatr. 107, 249-251.
109. Rutledge, J., Benjamin, D., Hood, L., and Smith, A. (1981). Is the CSF lactate measurement useful in the management of children with suspected bacterial meningitis? J. Pediatr. 98, 20-24.
110. Sabel, K.C. and Hanson, L.A. (1974). The clinical usefulness of C-reactive protein (CRP) determinations in bacterial meningitis and septicaemia in infancy. Acta. Paediatr. Scand. 63, 381-388.
111. Saravolatz, L.D., Manzor, O., VanderVelde, N., Pawlak, J., and Belian, B. (2003). Broad-range bacterial polymerase chain reaction for early detection of bacterial meningitis. Clin. Infect. Dis. 36, 40-45.
112. Sarff, L.D., Platt, L.H., and McCracken, G.H., Jr. (1976). Cerebrospinal fluid evaluation in neonates: Comparison of high-risk infants with and without meningitis. J. Pediatr. 88, 473-477.
113. Sato, M., Hosoya, M., Honzumi, K., Watanabe, M., Ninomiya, N., Shigeta, S. et al. (2003). Cytokine and cellular inflammatory sequence in enteroviral meningitis. Pediatrics 112, 1103-1107.
114. Saunders, N.B., Shoemaker, D.R., Brandt, B.L., and Zollinger, W.D. (1997). Confirmation of suspicious cases of meningococcal meningitis by PCR and enzyme-linked immunosorbent assay. J. Clin. Microbiol. 35, 3215-3219.
115. Scheld, W.M., Whitley, R.J. and Durack, D.T. (eds.) (1997). Infections of the central nervous system. Philadelphia: Lippincott-Raven.
116. Schmidley, J.W. and Simon, R.P. (1981). Postictal pleocytosis. Ann. Neurol. 9, 81-84.
117. Schulte, C., Krebs, B., Jelinek, T., Nothdurft, H.D., von Sonnenburg, F., and Loscher, T. (2002). Diagnostic significance of blood eosinophilia in returning travelers. Clin. Infect. Dis. 34, 407-411.
118. Schuurman, T., de Boer, R.F., Kooistra-Smid, A.M., and van Zwet, A.A. (2004). Prospective study of use of PCR amplification and sequencing of 16S ribosomal DNA from cerebrospinal fluid for diagnosis of bacterial meningitis in a clinical setting. J. Clin. Microbiol. 42, 734-740.
119. Schwarz, S., Bertram, M., Schwab, S., Andrassy, K., and Hacke, W. (2000). Serum procalcitonin levels in bacterial and abacterial meningitis. Crit. Care Med. 28, 1828-1832.
120. Seehusen, D.A., Reeves, M.M., and Fomin, D.A. (2003). Cerebrospinal fluid analysis. Am. Fam. Phys. 68, 1103-1108.
121. Seeler, R.A., Metzger, W., Mufson, A. (1972). Diplococcus pneumoniae infections in children with sickle cell anemia. Am J Dis Child Jan. 123(1): 8-10.
122. Seward, R.J. and Towner, K.J. (2000). Use of an automated DNA analysis system (DARAS) for sequence-specific recognition of Neisseria meningitidis DNA. Clin. Microbiol. Infect. 6, 29-33.
123. Sidbury, J.B. (1920). The importance of lumbar puncture in the intra-cranial heaemorrhage of the new born. Report of a case with recovery. Arch. Pediatr. 37, 545-553.
124. Simon, R.P. (1985). Physiological consequences of status epilepticus. Epilepsia 26, S58-S66.
125. Sobanski, M.A., Vince, R., Biagini, G.A., Cousins, C., Guiver, M., Gray, S.J. et al. (2002). Ultrasound enhanced detection of individual meningococcal serogroups by latex immunoassay. J. Clin. Pathol. 55, 37-40.
126. Solomon, P., Dailey, M., and Freemont-Smith, F. (1934). Contamination of the cerobrospinal fluid with blood. Arch. Neurol. Psychiatry 31, 1222-1234.
127. Sormunen, P., Kallio, M.J., Kilpi, T., and Peltola, H. (1999). C-reactive protein is useful in distinguishing Gram stain-negative bacterial meningitis from viral meningitis in children. J. Pediatr. 134, 725-759.
128. Spanos, A., Harrell, F.E., Jr., and Durack, D.T. (1989). Differential diagnosis of acute meningitis. An analysis of the predictive value of initial observations. J. Am. Med. Assoc. 262, 2700-2707.
129. Statz, A. and Felgenhauer, K. (1983). Development of the blood-CSF barrier. Dev. Med. Child Neurol. 25, 152-161.
130. Steele, R.W., Marmer, D.J., O'Brien, M.D., Tyson, S.T., and Steele, C.R. (1986). Leukocyte survival in cerebrospinal fluid. J. Clin. Microbiol. 23, 965-966.
131. Stellrecht, K.A., Harding, I., Woron, A.M., Lepow, M.L., and Venezia, R.A. (2002). The impact of an enteroviral RT-PCR assay on the diagnosis of aseptic meningitis and patient management. J. Clin. Virol. 25 (Suppl 1), S19-S26.
132. Stewart, D. (1928). The normal cerebrospinal fluid in children. Arch. Dis. Child. 3, 96-108.
133. Taha, M.K. (2000). Simultaneous approach for nonculture PCR-based identification and serogroup prediction of Neisseria meningitidis. J. Clin. Microbiol. 38, 855-857.
134. Tarafdar, K., Rao, S., Recco, R.A., and Zaman, M.M. (2001). Lack of sensitivity of the latex agglutination test to detect bacterial antigen in the cerebrospinal fluid of patients with culture-negative meningitis. Clin. Infect. Dis. 33, 406-408.
135. Thompson, J. and Salinsky, M. (1988). The utility of cerebrospinal fluid examination in patients with partial epilepsy. Epilepsia 29, 195-197.
136. Tibbling, G., Link, H., and Ohman, S. (1977). Principles of albumin and IgG analyses in neurological disorders. Scand. J. Clin. Lab. Invest. 37, 385-390.
137. Tung, H., Corey, R., and Mc Comb, J.G. (1991). Ventricular cerebrospinal fluid eosinophilia in children with ventricularperitoneal shunts. J. Neurosurg. 75, 541-544.
138. Tzvetanova, E.M. and Tzekoc, C.T. (1986). Eosinophilia in the cerebrospinal fluid of children with shunts implanted for the treatment of internal hydrocephalus. Acta. Cytol. 30, 277-280.
139. Vinchon, M., Vallee, L., Prin, L., Desreumaux, P., and Dhellemmes, P. (1992). Cerebro-spinal fluid eosinophilia in shunt infections. Neuropediatrics 23, 235-240.
140. Wenzel, D., Statz, A., and Felgenhauer, K. (1980). Convulsions and the blood-brain barrier. Monatsschr. Kinderheilkd. 128, 376-377.
141. Wiersbitzky, S.K.W., Ahern, N., Becker, T., Panzig, B., Abel, J., and Stenger, R.D. (1998). The diagnositc importance of eosinophil granulocytes in the CSF of children with ventricul-peritoneal shunt systems. Acta. Neurol. Scand. 97, 201-203.
142. Wolf, J. (1961). The cerebrospinal fluid in the newborn and premature infant. World Neurol. 2, 871-876.
143. Wong, M., Schlaggar, B.L., Buller, R.S., Storch, G.A., and Landt, M. (2000). Cerebrospinal fluid protein concentration in pediatric patients: Defining clinically relevant reference values. Arch. Pediatr. Adolesc. Med. 154, 827-831.
144. Wong, M., Schlaggar, B.L., and Landt, M. (2001). Postictal cerebrospinal fluid abnormalities in children. J. Pediatr. 138, 373-377.
145. Wong, V.K., Hitchcock, W., and Mason, W.H. (1989). Meningococcal infections in children: A review of 100 cases. Pediatr. Infect. Dis. J. 8, 224-227.
146. Wood, J. (1983). Neurobiology of the Cerebrospinal Fluid. Plenum, New York, pp. 1-17.
147. Woody, R.C., Yamauchi, T., and Bolyard, K. (1988). Cerebrospinal fluid cell counts in childhood idiopathic status epilepticus. Pediatr. Infect. Dis. J. 7, 298-299.
148. Yogev, R. (2002). Meningitis. Saunders, Philadelphia, pp. 630-650.