Prolonged recovery of retinal structure/function after gene therapy in an Rs1h-deficient mouse model of X-Linked juvenile retinoschisis

Molecular Therapy

Volumn 12, Issue 4, 2005, Pages 644-651

  Min, Seok H ^a   Molday, Laurie L ^b   Seeliger, Mathias W ^c   Dinculescu, Astra ^a   Timmers, Adrian M ^a   Janssen, Andreas ^d   Tonagel, Felix ^c   Tanimoto, Naoyuki ^c   Weber, Bernhard H F ^d   Molday, Robert S ^b   Hauswirth, William W ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

AAV vector; Electroretinogram; Gene therapy; Knockout mouse; Opsin promoter; Retinoschisis

Indexed keywords

CELL PROTEIN; COMPLEMENTARY DNA; PARVOVIRUS VECTOR; RETINOSCHISIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY LABELING; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ELECTRORETINOGRAPHY; IMMUNOFLUORESCENCE; IN VIVO STUDY; MOUSE; NONHUMAN; PHOTORECEPTOR CELL; PROMOTER REGION; PROTEIN EXPRESSION; RETINA; RETINA CONE; RETINA MACULA DEGENERATION; RETINA ROD; RETINOSCHISIS; SCANNING LASER OPHTHALMOSCOPY; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WESTERN BLOTTING; WILD TYPE; X CHROMOSOME LINKED DISORDER;

ANIMALS; CELL ADHESION MOLECULES; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; EYE PROTEINS; GENE THERAPY; GENETIC VECTORS; HUMANS; LINKAGE (GENETICS); MALE; MICE; MICE, KNOCKOUT; RETINA; RETINAL DEGENERATION; RETINOSCHISIS; TRANSFECTION;

EID: 25144501446     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.06.002     Document Type: Article

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