Ligand discrimination in soluble guanylate cyclase and the H-NOX family of heme sensor proteins

Current Opinion in Chemical Biology

Volumn 9, Issue 5, 2005, Pages 441-446

  Boon, Elizabeth M ^a   Marletta, Michael A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; GUANYLATE CYCLASE; NITRIC OXIDE; PROTEIN; PROTEIN H NOX; UNCLASSIFIED DRUG;

BINDING AFFINITY; DROSOPHILA MELANOGASTER; EUKARYOTE; KINETICS; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; REVIEW;

AMINO ACID SEQUENCE; ANIMALS; GUANYLATE CYCLASE; HEMEPROTEINS; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; OXYGEN; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TYROSINE;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 25144497879     PISSN: 13675931     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbpa.2005.08.015     Document Type: Review

References (21)

1. J.W. Denninger, and M.A. Marletta Guanylate cyclase and the NO/cGMP signaling pathway Biochim Biophys Acta 1411 1999 334 350
2. J.M. Hare, and W.S. Colucci Role of nitric oxide in the regulation of myocardial function Prog Cardiovasc Dis 38 1995 155 166
3. A.M. Shah, and P.A. MacCarthy Paracrine and autocrine effects of nitric oxide on myocardial function Pharmacol Ther 86 2000 49 86
4. N. Toda, and T. Okamura The pharmacology of nitric oxide in the peripheral nervous system of blood vessels Pharmacol Rev 55 2003 271 324
5. M.A. Gilles-Gonzalez, and G. Gonzalez Heme-based sensors: defining characteristics, recent developments, and regulatory hypotheses J Inorg Biochem 99 2005 1 22 This review provides a current overview of heme-based sensors including their defining characteristics, recent developments and regulatory hypotheses.
6. A.J. Hobbs, and L.J. Ignarro Nitric oxide cyclic GMP signal transduction system Methods Enzymol 269 1996 134 148
7. Y. Zhao, P.E. Brandish, D.P. Ballou, and M.A. Marletta A molecular basis for nitric oxide sensing by soluble guanylate cyclase Proc Natl Acad Sci USA 96 1999 14753 14758
8. J.R. Stone, and M.A. Marletta Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states Biochemistry 33 1994 5636 5640
9. L.M. Iyer, V. Anantharaman, and L. Aravind Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteins BMC Genomics 4 2003 5 By sequence mining, Iyer et al. report for the first time a family of heme proteins with significant homology to the heme domain from sGC, suggesting a bacterial origin for this important eukaryotic NO sensor. In the same report they find a high coincidence of a second conserved domain homologous to a different domain of sGC associated with the conserved heme domain.
10. D.S. Karow, D. Pan, R. Tran, P. Pellicena, A. Presley, R.A. Mathies, and M.A. Marletta Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from Vibrio cholerae and Thermoanaerobacter tengcongensis Biochemistry 43 2004 10203 10211
11. P.M. Schmidt, M. Schramm, H. Schroder, F. Wunder, and J.P. Stasch Identification of residues crucially involved in the binding of the heme moiety of soluble guanylate cyclase J Biol Chem 279 2004 3025 3032 Prior to structural characterization of a heme domain related to sGC, this paper identifies for the first time a tyrosine and an arginine residue that are critical to heme binding by sGC. These residues are part of an invariant Y-S/T-R motif found in all H-NOX domains.
12. P. Schmidt, C. Rothkegel, F. Wunder, H. Schroder, and J. Stasch Residues stabilizing the heme moiety of the nitric oxide sensor soluble guanylate cyclase Eur J Pharmacol 513 2005 67 74
13. P. Pellicena, D.S. Karow, E.M. Boon, M.A. Marletta, and J. Kuriyan Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases Proc Natl Acad Sci USA 101 2004 12854 12859 This paper provides the very first structural characterization of the H-NOX domain with a crystal structure refined to 1.77 Å resolution. The fold is unique and unrelated to known protein structures. Furthermore, comparison of the heme group in two different crystal forms suggests a mechanism of signal transduction for H-NOX heme sensors.
14. 2 and NO using a kinetic selection.
15. R. Jain, and M.K. Chan Mechanisms of ligand discrimination by heme proteins J Biol Inorg Chem 8 2003 1 11
16. 2, NO, and CO by electrostatic interactions with the bound ligand J Biol Inorg Chem 2 1997 544 552
17. G.N. Phillips, M.L. Teodoro, T.S. Li, B. Smith, and J.S. Olson Bound CO is a molecular probe of electrostatic potential in the distal pocket of myoglobin J Phys Chem B 103 1999 8817 8829
18. J.R. Stone, and M.A. Marletta The ferrous heme of soluble guanylate cyclase: formation of hexacoordinate complexes with carbon monoxide and nitrosomethane Biochemistry 34 1995 16397 16403
19. P. Nioche, V. Berka, J. Vipond, N. Minton, A.L. Tsai, and C.S. Raman Femtomolar sensitivity of a NO sensor from Clostridium botulinum Science 306 2004 1550 1553
20. J.M. Gray, D.S. Karow, H. Lu, A.J. Chang, J.S. Chang, R.E. Ellis, M.A. Marletta, and C.I. Bargmann Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue Nature 430 2004 317 322
21. D.B. Morton Atypical soluble guanylyl cyclases in Drosophila can function as molecular oxygen sensors J Biol Chem 279 2004 50651 50653