Mast cell-specific genes - New drug targets/pathogenesis

Chemical Immunology and Allergy

Volumn 87, Issue , 2005, Pages 198-212

  Saito, Hirohisa ^a  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; PROTEOME; TRANSCRIPTOME; CYTOKINE; MESSENGER RNA;

ALLERGY; CELL ACTIVATION; CELL ACTIVITY; CELL FUNCTION; CELL TYPE; COMPUTER MODEL; DRUG TARGETING; GENETIC TRANSCRIPTION; GENOME; HUMAN; IN VITRO STUDY; MAST CELL; MOLECULAR BIOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; ANIMAL; BASOPHIL; BIOSYNTHESIS; CLASSIFICATION; COMPUTER SIMULATION; DNA MICROARRAY; DRUG EFFECT; EOSINOPHIL; GENE EXPRESSION PROFILING; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE;

ANIMALS; BASOPHILS; COMPUTER SIMULATION; CYTOKINES; EOSINOPHILS; GENE EXPRESSION PROFILING; GLUCOCORTICOIDS; HUMANS; MAST CELLS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEOME; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 25144465608     PISSN: 16602242     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000087645     Document Type: Review

References (64)

1. International Human Genome Sequencing Consortium: Finishing the euchromatic sequence of the human genome. Nature 2004;431:931-948.
2. Saito H: Translation of the human genome into clinical allergy. Allergol Int 2003;52:65-70.
3. Hunter PJ, Borg TK: Integration from proteins to organs: The Physiome Project. Nat Rev Mol Cell Biol 2003;4:237-243.
4. Silver RB, Reid AC, Mackins CJ, Askwith T, Schaefer U, Herzlinger D, Levi R: Mast cells: A unique source of renin. Proc Natl Acad Sci USA 2004;101:13607-13612.
5. Bochner BS: Systemic activation of basophils and eosinophils: Markers and consequences. J Allergy Clin Immunol 2000;106:8292-302.
6. Savage CO: The evolving pathogenesis of systemic vasculitis. Clin Med 2002:2:458-464.
7. Oehler R, Weingartmann G, Manhart N, Salzer U, Meissner M, Schlegel W, Spittler A, Bergmann M, Kandioler D, Oismuller C, Struse HM, Roth E: Polytrauma induces increased expression of pyruvate kinase in neutrophils. Blood 2000;95:1086-1092.
8. Bochner BS: Systemic activation of basophils and eosinophils: Markers and consequences. J Allergy Clin Immunol 2000;106:8292-8302.
9. Church MK, Pao GJ, Holgate ST: Characterization of histamine secretion from mechanically dispersed human lung mast cells: Effects of anti-IgE, calcium ionophore A23187, compound 48/80, and basic polypeptides. J Immunol 1982;129:2116-2121.
10. Lin CS, Boltz RC, Blake JT, Nguyen M, Talento A, Fischer PA, Springer MS, Sigal NH, Slaughter RS, Garcia ML, Kaczorowski GJ, Koo GC: Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation. J Exp Med 1993;177:637-645.
11. Saito H, Okajima F, Molski TF, Sha'afi RI, Ui M, Ishizaka T: Effects of ADP-ribosylation of GTP-binding protein by pertussis toxin on immunoglobulin E-dependent and -independent histamine release from mast cells and basophils. J Immunol 1987;138:3927-3934.
12. Ji TH, Grossmann M, Ji I: G protein-coupled receptors. I. Diversity of receptor-ligand interactions. J Biol Chem 1998;273:17299-17302.
13. Zambrowicz BP, Sands AT: Knockouts model the 100 best-selling drugs. Will they model the next 100? Nat Rev Drug Discov 2003;2:38-51.
14. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, et al: The sequence of the human genome. Science 2001;291:1304-1351.
15. Drews J: Drug discovery: A historical perspective. Science 2000;287:1960-1964.
16. Hopkins AL, Groom CR: The druggable genome. Nat Rev Drug Discov 2002;1:727-730.
17. Nakajima T, Iikura M, Okayama Y, Matsumoto K, Uchiyama C, Shirakawa T, Yang X, Adra CN, Hirai K, Saito H: Identification of granulocyte subtype-selective receptors and ion channels by high-density oligonucleotide probe array. J Allergy Clin Immunol 2004;113:528-535.
18. Gordon JR, Galli SJ: Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin. Nature 1990;346:274-276.
19. Okayama Y, Kobayashi H, Ashman LK, Dobashi K, Nakazawa T, Holgate ST, Church MK, Mori M: Human lung mast cells are enriched in the capacity to produce granulocyte-macrophage colony-stimulating factor in response to IgE-dependent stimulation. Eur J Immunol 1998;28: 708-715.
20. Burd PR, Rogers HW, Gordon JR, Martin CA, Jayaraman S, Wilson SD, Dvorak AM, Galli SJ, Dorf ME: Interleukin-3-dependent and -independent mast cells stimulated with IgE and antigen express multiple cytokines. J Exp Med 1989;170:245-257.
21. Baghestanian M, Hofbauer R, Kiener HP, Bankl HC, Wimazal F, Willheim M, Scheiner O, Fureder W Muller MR, Bevec D, Lechner K, Valent P: The c-kit ligand stem cell factor and anti-IgE promote expression of monocytes chemoattractant protein-1 in human lung mast cells. Blood 1997;90:4438-4449.
22. Tachimoto H, Ebisawa M, Hasegawa T, Kashiwabara T, Ra C, Bochner BS, Miura K, Saito H: Reciprocal regulation of cultured human mast cell cytokine production by IL-4 and IFN-α. J Allergy Clin Immunol 2000;106:141-149.
23. Lorentz A, Schwengberg S, Sellge G, Manns MP, Bischoff SC: Human intestinal mast cells are capable of producing different cytokine profiles: Role of IgE receptor cross-linking and IL-4. J Immunol 2000;164:43-48.
24. Bradding P, Feather IH, Wilson S, Bardin PG, Heusser CH, Holgate ST, Howarth PH: Immunolocalization of cytokines in the nasal mucosa of normal and perennial rhinitic subjects. The mast cell as a source of IL-4, IL-5, and IL-6 in human allergic mucosal inflammation. J Immunol 1993;151:3853-3865.
25. Jaffe JS, Glaum MC, Raible DG, Post TJ, Dimitry E, Govindarao D, Wang Y, Schulman ES: Human lung mast cell IL-5 gene and protein expression: Temporal analysis of upregulation following IgE-mediated activation. Am J Respir Cell Mol Biol 1995;13:665-675.
26. Ochi H, Hirani WM, Yuan Q, Friend DS, Austen KF, Boyce JA: T-helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J Exp Med 1999;190:267-280.
27. Ishizuka T, Okayama Y, Kobayashi H, Mori M: Interleukin-10 is localized to and released by human lung mast cells. Clin Exp Allergy 1999;29:1424-1432.
28. Kobayashi H, Okayama Y, Ishizuka T, Pawankar R, Ra C, Mori M: Production of IL-13 by human lung mast cells in response to Fcε receptor cross-linkage. Clin Exp Allergy 1998;28:1219-1227.
29. Toru H, Pawankar R, Ra C, Yata J, Nakahata T: Human mast cells produce IL-13 by high-affinity IgE receptor cross-linking: Enhanced IL-13 production by IL-4-primed human mast cells. J Allergy Clin Immunol 1998;102:491-502.
30. Mekori YA, Metcalfe DD: Mast cell-T cell interactions. J Allergy Clin Immunol 1999;104:517-523.
31. Sayama K, Diehn M, Matsuda K, Lunderius C, Tsai M, Tam SY, Botstein D, Brown PO, Galli SJ: Transcriptional response of human mast cells stimulated via the FcεRI and identification of mast cells as a source of IL-11. BMC Immunol 2002;3:5.
32. Nakajima T, Inagaki N, Tanaka H, Tanaka A, Yoshikawa M, Tamari M, Hasegawa K, Matsumoto K, Tachimoto H, Ebisawa M, Tsujimoto G, Matsuda H, Nagai H, Saito H: Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcε receptor I cross-linking: An interspecies comparison. Blood 2002;100:3861-3868.
33. Takeda K, Kaisho T, Akira S: Toll-like receptors. Annu Rev Immunol 2003;21:335-376.
34. Supajatura V, Ushio H, Nakao A, Okumura K, Ra C, Ogawa H: Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J Immunol 2001;167:2250-2256.
35. Masuda A, Yoshikai Y, Aiba K, Matsuguchi T: Th2 cytokine production from mast cells is directly induced by lipopolysaccharide and distinctly regulated by c-Jun N-terminal kinase and p38 pathways. J Immunol 2002;169:3801-3810.
36. Supajatura V, Ushio H, Nakao A, Akira S, Okumura K, Ra C, Ogawa H: Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity. J Clin Invest 2002;109: 1351-1359.
37. McCurdy JD, Olynych TJ, Maher LH, Marshall JS: Cutting edge: distinct Toll-like receptor-2 activators selectively induce different classes of mediator production from human mast cells. J Immunol 2003;170:1625-1629.
38. Varadaradjalou S, Feger F, Thieblemont N, Hamouda NB, Pleau JM, Dy M, Arock M: Toll-like receptor (TLR)2 and TLR4 differentially activate human mast cells. Eur J Immunol 2003;33:899-906.
39. Okumura S, Kashiwakura J, Tomita H, Matsumoto K, Nakajima T, Saito H, Okayama Y: Identification of specific gene expression profiles in human mast cells mediated by Toll-like receptor-4 and FcεRI. Blood 2003;102:2547-2554.
40. Verthelyi D, Zeuner RA: Differential signaling by CpG DNA in DCs and B cells: Not just TLR9. Trends Immunol 2003;24:519-522.
41. + cytotoxic T lymphocytes. Int Immunol 2004;16:55-63.
42. Eklund KK, Humphries DE, Xia Z, Ghildyal N, Friend DS, Gross V, Stevens RL: Glucocorticoids inhibit the cytokine-induced proliferation of mast cells, the high affinity IgE receptor-mediated expression of TNF-α, and the IL-10-induced expression of chymases. J Immunol 1997;158:4373-4380.
43. Okumura S, Sagara H, Fukuda T, Saito H, Okayama Y: FcεRI-mediated amphiregulin production by human mast cells increases mucin gene expression in epithelial cells. J Allergy Clin Immunol 2005;115:272-279.
44. Cook PW, Piepkorn M, Clegg CH, Plowman GD, DeMay JM, Brown JR, Pittelkow MR: Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. J Clin Invest 1997;100:2286-2294.
45. 2 from cord blood mononuclear cells. J Immunol 1996;157:343-350.
46. Ahn K, Takai S, Pawankar R, Kuramasu A, Ohtsu H, Kempuraj D, Tomita H, Matsumoto K, Akasawa A, Miyazaki M, Saito H: Regulation of chymase production in human mast cell progenitors. J Allergy Clin Immunol 2000;106:321-328.
47. Iida M, Matsumoto K, Tomita H, Nakajima T, Akasawa A, Ohtani NY, Yoshida NL, Matsui K, Nakada A, Sugita Y, Shimizu Y, Wakahara S, Nakao T, Fujii Y, Ra C, Saito H: Selective down-regulation of high affinity IgE receptor (FcεRI) α-chain messenger RNA among transcriptome in cord blood-derived versus adult peripheral blood-derived cultured human mast cells. Blood 2001;97:1016-1022.
48. Debili N, Robin C, Schiavon V, Letestu R, Pflumio F, Mitjavila-Garcia MT, Coulombel L, Vainchenker W: Different expression of CD41 on human lymphoid and myeloid progenitors from adults and neonates. Blood 2001;97:2023-2030.
49. Bracho F, van de Ven C, Areman E, Hughes RM, Davenport V, Bradley MB, Cai JW, Cairo MS: A comparison of ex vivo expanded DCs derived from cord blood and mobilized adult peripheral blood plastic-adherent mononuclear cells: Decreased alloreactivity of cord blood DCs. Cytotherapy 2003;5:349-361.
50. Kashiwakura JI, Yokoi H, Saito H, Okayama Y: T cell proliferation by direct cross-talk between OX40 ligand on human mast cells and OX40 on human T cells. J Immunol 2004;173:5247-5257.
51. Tedla N, Wang HW, McNeil HP, Di Girolamo N, Hampartzoumian T, Wakefield D, Lloyd A: Regulation of T lymphocyte trafficking into lymph nodes during an immune response by the chemokines macrophage inflammatory protein (MIP)-1α and MIP-1β. J Immunol 1998;161:5663-5672.
52. McLachlan JB, Hart JP, Pizzo SV, Shelburne CP, Staats HF, Gunn MD, Abraham SN: Mast cell-derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection. Nat Immunol 2003;4:1199-1205.
53. Irani AM, Bradford TR, Kepley CL, Schechter NM, Schwartz LB: Detection of MCT and MCTC types of human mast cells by immunohistochemistry using new monoclonal anti-tryptase and anti-chymase antibodies. J Histochem Cytochem 1989;37:1509-1515.
54. Kambe N, Kambe M, Kochan JP, Schwartz LB: Human skin-derived mast cells can proliferate while retaining their characteristic functional and protease phenotypes. Blood 2001;97:2045-2052.
55. Bradding P, Okayama Y, Kambe N, Saito H: Ion channel gene expression in human lung, skin and cord blood-derived mast cells. J Leukoc Biol 2003;73:614-620.
56. Jippo T, Lee YM, Ge Y, Kim DK, Okabe M, Kitamura Y: Tissue-dependent alteration of protease expression phenotype in murine peritoneal mast cells that were genetically labeled with green fluorescent protein. Am J Pathol 2001;158:1695-1701.
57. Borish L, Steinke JW: Beyond transcription factor. Allergy Clin Immunol Int 2004;16:2-27.
58. Persson CGA: Mice are not a good model of human airway disease. Am J Respir Crit Care Med 2002;166:6-7.
59. Gelfand EW: Mice are a good model of human airway disease. Am J Respir Crit Care Med 2002;166:5-6.
60. Hamelmann E, Oshiba A, Loader J, Larsen GL, Gleich G, Lee J, Gelfand EW: Anti-interleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization. Am J Respir Crit Care Med 1997;155:819-825.
61. Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, Mathur AK, Cowley HC, Chung KF, Djukanovic R, Hansel TT, Holgate ST, Sterk PJ, Barnes PJ: Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2144-2148.
62. Shichijo M, Inagaki N, Nakai N, Kimata M, Nakahata T, Serizawa I, Iikura Y, Saito H, Nagai H: The effects of anti-asthma drugs on mediator release from cultured human mast cells. Clin Exp Allergy 1998;28:1228-1236.
63. Okayama Y, Church MK: Comparison of the modulatory effect of ketotifen, sodium cromoglycate, procaterol and salbutamol in human skin, lung and tonsil mast cells. Int Arch Allergy Immunol 1992;97:216-225.
64. Tomita M: Whole-cell simulation: A grand challenge of the 21st century. Trends Biotechnol 2001;19:205-210.