Molecular characterization of rat gastric mucosal response to potent acid inhibition

Physiological Genomics

Volumn 22, Issue , 2005, Pages 24-32

  Nørsett, Kristin G ^a   Lægreid, Astrid ^a   Langaas, Mette ^b   Wörlund, Sara ^a   Fossmark, Reidar ^a   Waldum, Helge L ^a   Sandvik, Arne K ^a,c  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

Author keywords

cDNA microarray; Gastrin; Omeprazole; Proliferation; Proton pump inhibitors

Indexed keywords

ALPHA 2 MACROGLOBULIN; ANGIOTENSINOGEN; CALPONIN; CARBONYL REDUCTASE; CHEMOKINE RECEPTOR; CONNECTIVE TISSUE GROWTH FACTOR; CYTOCHROME P450; EARLY GROWTH RESPONSE FACTOR 1; ELASTASE; FOLLISTATIN; GASTRIN; GLUTATHIONE TRANSFERASE; HISTONE DEACETYLASE; HISTONE H2B; INTEGRIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OMEPRAZOLE; PROTEIN KINASE SYK; PROTON PUMP INHIBITOR; STROMAL CELL DERIVED FACTOR 1; TAMM HORSFALL GLYCOPROTEIN; TYROSINE KINASE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; NONHUMAN; ONCOGENE C MYB; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; STOMACH ACID; STOMACH MUCOSA; STOMACH PH; STOMACH SECRETION; STRESS;

ANIMALS; BLOTTING, NORTHERN; GASTRIC ACID; GASTRIC MUCOSA; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICROARRAY ANALYSIS; OMEPRAZOLE; PARIETAL CELLS, GASTRIC; QUALITY CONTROL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CXCR4; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA;

ANIMALIA;

EID: 25144459381     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00245.2004     Document Type: Article

References (65)

1. Akimoto M, Hashimoto H, Maeda A, Shigemoto M, and Yamashita K. Roles of angiogenic factors and endothelin-1 in gastric ulcer healing. Clin Sci (Lond) 103, Suppl 48: 450S-454S, 2002.
2. Bakke I, Qvigstad G, Brenna E, Sandvik AK, and Waldum HL. Gastrin has a specific proliferative effect on the rat enterochromaffin-like cell, but not on the parietal cell: a study by elutriation centrifugation. Acta Physiol Scand 169: 29-37, 2000.
3. Balcz B, Kirchner L, Cairns N, Fountoulakis M, and Lubec G. Increased brain protein levels of carbonyl reductase and alcohol dehydrogenase in Down syndrome and Alzheimer's disease. J Neural Transm Suppl 61: 193-201, 2001.
4. Bjorkqvist M, Lindstrom E, Norlen P, Groenborg M, Hakanson R, and Gammeltoft S. Gastrin-induced gene expression in oxyntic mucosa and ECL cells of rat stomach. Regul Pept 84: 29-35, 1999.
5. Brasier AR and Li J. Mechanisms for inducible control of angiotensinogen gene transcription. Hypertension 27: 465-475, 1996.
6. Brazma A, Hingamp P, Quackenbush J, Sherlock G, Spellman P, Stoeckert C, Aach J, Ansorge W, Ball CA, Causton HC, Gaasterland T, Glenisson P, Holstege FC, Kim IF, Markowitz V, Matese JC, Parkinson H, Robinson A, Sarkans U, Schulze-Kremer S, Stewart J, Taylor R, Vilo J, and Vingron M. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat Genet 29: 365-371, 2001.
7. Campbell DJ, Kim CH, and Butcher EC. Chemokines in the systemic organization of immunity. Immunol Rev 195: 58-71, 2003.
8. Chaib H, Cocrell EK, Rubin MA, and Macoska JA. Profiling and verification of gene expression patterns in normal and malignant human prostate tissues by cDNA microarray analysis. Neoplasia 3: 43-52, 2001.
9. Dimaline R, Evans D, Forster ER, Sandvik AK, and Dockray GJ. Control of gastric corpus chromogranin A messenger RNA abundance in the rat. Am J Physiol Gastrointest Liver Physiol 264: G583-G588, 1993.
10. Dimaline R and Sandvik AK. Histidine decarboxylase gene expression in rat fundus is regulated by gastrin. FEBS Lett 281: 20-22, 1991.
11. Eissele R, Brunner G, Simon B, Solcia E, and Arnold R. Gastric mucosa during treatment with lansoprazole: Helicobacter pylori is a risk factor for argyrophil cell hyperplasia. Gastroenterology 112: 707-717, 1997.
12. Ekman L, Hansson E, Havu N, Carlsson E, and Lundberg C. Toxicological studies on omeprazole. Scand J Gastroenterol Suppl 108: 53-69, 1985.
13. Esteban I, Hannestad J, Levanti B, Del Valle ME, Naves FJ, and Vega JA. Neurotrophin receptor proteins immunoreactivity in human gastrointestinal endocrine cells. Brain Res Bull 38: 539-543, 1995.
14. +)ATPase. Nature 290: 159-161, 1981.
15. Ferkingstad EF, Langaas ML, and Lindqvist BL. Estimating the Proportion of True Null Hypotheses, with Application to DNA Microarray Data (Technical Report). Trondheim, Norway: Norwegian Univ. of Science and Technology, 2003, http://www.math.ntnu.no/preprint/statistics/2003/.
16. Garcia-Suarez O, Blanco-Gelaz MA, Lopez ML, Germana A, Cabo R, Diaz-Esnal B, Silos-Santiago I, Ciriaco E, and Vega JA. Massive lymphocyte apoptosis in the thymus of functionally deficient TrkB mice. J Neuroimmunol 129: 25-34, 2002.
17. Gough DB, Thompson GB, Crotty TB, Donohue JH, Kvols LK, Carney JA, Grant CS, and Nagorney DM. Diverse clinical and pathologic features of gastric carcinoid and the relevance of hypergastrinemia. World J Surg 18: 473-479, 1994.
18. Hakanson R, Larsson LI, Liedberg G, Oscarson J, Sundler F, and Vang J. Effects of antrectomy or porta-caval shunting on the histamine-storing endocrine-like cells in oxyntic mucosa of rat stomach. A fluorescence histochemical, electron microscopic and chemical study. J Physiol 259: 785-800, 1976.
19. Hakanson R, Larsson LI, Liedberg G, and Sundler F. The histamine-storing enterochromaffin-like cells of the rat stomach. In: Chromaffin, Enterochromaffin and Related Cells, edited by Coupland RE and Fujita T. Amsterdam, The Netherlands: Elsevier, 1976, p. 243-263.
20. Hamadeh HK, Bushel P, Tucker CJ, Martin K, Paules R, and Afshari CA. Detection of diluted gene expression alterations using cDNA microarrays. Biotechniques 32: 322-329, 2002.
21. Havu N. Enterochromaffin-like cell carcinoids of gastric mucosa in rats after life-long inhibition of gastric secretion. Digestion 35: 42-55, 1986.
22. Inatome R, Yanagi S, Takano T, and Yamamura H. A critical role for Syk in endothelial cell proliferation and migration. Biochem Biophys Res Commun 286: 195-199, 2001.
23. Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JC, Trent JM, Staudt LM, Hudson JJ, Boguski MS, Lashkari D, Shalon D, Botstein D, and Brown PO. The transcriptional program in the response of human fibroblasts to serum. Science 283: 83-87, 1999.
24. Jones FS, Meech R, Edelman DB, Oakey RJ, and Jones PL. Prx1 controls vascular smooth muscle cell proliferation and tenascin-C expression and is upregulated with Prx2 in pulmonary vascular disease. Circ Res 89: 131-138, 2001.
25. Kil BJ, Kim IW, Shin CY, Jeong JH, Jun CH, Lee SM, Kim DY, Huh IH, and Sohn UD. Comparison of IY81149 with omeprazole in rat reflux oesophagitis. J Auton Pharmacol 20: 291-296, 2000.
26. Kim KH, Park GT, Lim YB, Rue SW, Jung JC, Sonn JK, Bae YS, Park JW, and Lee YS. Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-β-mediated signaling pathway. Biochem Biophys Res Commun 318: 819-825, 2004.
27. Kinoshita Y, Ishihara S, Kadowaki Y, Fukui H, and Chiba T. Reg protein is a unique growth factor of gastric mucosal cells. J Gastroenterol 39: 507-513, 2004.
28. 125I-gastrin, using Iodo-gen as oxidizing agent, and the use of this tracer in receptor studies. Scand J Gastroenterol 20: 569-576, 1985.
29. Krones-Herzig A, Adamson E, and Mercola D. Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence. Proc Natl Acad Sci USA 100: 3233-3238, 2003.
30. +-ATPase inhibitors and other xenobiotics. Xenobiotica 33: 107-118, 2003.
31. Lapenna D, de Gioia S, Ciofani G, Festi D, and Cuccurullo F. Antioxidant properties of omeprazole. FEBS Lett 382: 189-192, 1996.
32. Larsen M, Ressler SJ, Gerdes MJ, Lu B, Byron M, Lawrence JB, and Rowley DR. The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in multiple cancers. Mamm Genome 11: 767-773, 2000.
33. Livak KJ and Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔC(T)) method. Methods 25: 402-408, 2001.
34. Martinsen TC, Taylor DM, Johnsen R, and Waldum HL. Gastric acidity protects mice against prion infection? Scand J Gastroenterol 37: 497-500, 2002.
35. McCabe DR, Kent TH, and Hogben CA. Distribution and weights of various cell types in the rat stomach. Anat Rec 163: 555-561, 1969.
36. McMahon SB and Monroe JG. The role of early growth response gene 1 (egr-1) in regulation of the immune response. J Leukoc Biol 60: 159-166, 1996.
37. Miyaoka Y, Kadowaki Y, Ishihara S, Ose T, Fukuhara H, Kazumori H, Takasawa S, Okamoto H, Chiba T, and Kinoshita Y. Transgenic overexpression of Reg protein caused gastric cell proliferation and differentiation along parietal cell and chief cell lineages. Oncogene 23: 3572-3579, 2004.
38. Moritani NH, Kubota S, Nishida T, Kawaki H, Kondo S, Sugahara T, and Takigawa M. Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line. Cancer Lett 192: 205-214, 2003.
39. Mowat C, Carswell A, Wirz A, and McColl KE. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 116: 813-822, 1999.
40. Nassenstein C, Kerzel S, and Braun A. Neurotrophins and neurotrophin receptors in allergic asthma. Prog Brain Res 146: 347-367, 2004.
41. Natale G, Lazzeri G, Lubrano V, Colucci R, Vassalle C, Fornai M, Blandizzi C, and Del Tacca M. Mechanisms of gastroprotection by lansoprazole pretreatment against experimentally induced injury in rats: role of mucosal oxidative damage and sulfhydryl compounds. Toxicol Appl Pharmacol 195: 62-72, 2004.
42. Nwokolo CU, Loft DE, Holder R, and Langman MJS. Increased incidence of bacterial diarrhoea in patients taking gastric acid antisecretory drugs. Eur J Gastroenterol Hepatol 6: 697-699, 1994.
43. Ott C, Iwanciw D, Graness A, Giehl K, and Goppelt-Struebe M. Modulation of the expression of connective tissue growth factor by alterations of the cytoskeleton. J Biol Chem 278: 44305-44311, 2003.
44. Park SK, Kim J, Seomun Y, Choi J, Kim DH, Han IO, Lee EH, Chung SK, and Joo CK. Hydrogen peroxide is a novel inducer of connective tissue growth factor. Biochem Biophys Res Commun 284: 966-971, 2001.
45. R Development Core Team. R: A Language and Environment for Statistical Computing (Conference Proceeding). Vienna, Austria: R Foundation for Statistical Computing, 2004.
46. Rudi J, Kuck D, Strand S, von Herbay A, Mariani SM, Krammer PH, Galle PR, and Stremmel W. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest 102: 1506-1514, 1998.
47. Sakurai K and Yamasaki K. Protective effect of rebamipide against hydrogen peroxide-induced hemorrhagic mucosal lesions in rat stomach. Jpn J Pharmacol 64: 229-234, 1994.
48. Sandvik AK and Waldum HL. CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion. Am J Physiol Gastrointest Liver Physiol 260: G925-G928, 1991.
49. Schiller MR, Mains RE, and Eipper BA. A novel neuroendocrine intracellular signaling pathway. Mol Endocrinol 11: 1846-1857, 1997.
50. Scortegagna M, Ding K, Oktay Y, Gaur A, Thurmond F, Yan LJ, Marck BT, Matsumoto AM, Shelton JM, Richardson JA, Bennett MJ, and Garcia JA. Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet 35: 331-340, 2003.
51. Sergeant GP, Large RJ, Beckett EAH, McGeough CM, Ward SM, and Horowitz B. Microarray comparison of normal and W/Wv mice in the gastric fundus indicates a supersensitive phenotype. Physiol Genomics 11: 1-9, 2002.
52. Smith JM, Johanesen PA, Wendt MK, Binion DG, and Dwinell MB. CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity. Am J Physiol Gastrointest Liver Physiol 288: G316-G326, 2005.
53. Smyth GK. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: article3, 2004.
54. Stockbruegger RW. Bacterial overgrowth as a consequence of reduced gastric acidity. Scand J Gastroenterol Suppl 111: 7-16, 1985.
55. Storey JD. A direct approach to false discovery rates. J Royal Stat Soc 64: 479-498, 2002.
56. Su SJ and Yeh TM. The dynamic responses of pro-inflammatory and anti-inflammatory cytokines of human mononuclear cells induced by uromodulin. Life Sci 65: 2581-2590, 1999.
57. Tohyama Y, Takano T, and Yamamura H. B cell responses to oxidative stress. Curr Pharm 10: 835-839, 2004.
58. Ueyama T, Saika M, Koreeda C, and Senba E. Water immersion-restraint stress induces expression of immediate-early genes in gastrointestinal tract of rats. Am J Physiol Gastrointest Liver Physiol 275: G287-G295, 1998.
59. Ulanova M, Puttagunta L, Kim MK, Schreiber AD, and Befus AD. Antisense oligonucleotides to Syk kinase: a novel therapeutic approach for respiratory disorders. Curr Opin Investig Drugs 4: 552-555, 2003.
60. Ulanova M, Puttagunta L, Marcet-Palacios M, Duszyk M, Steinhoff U, Duta F, Kim MK, Indik ZK, Schreiber AD, and Befus AD. Syk tyrosine kinase participates in β1-integrin signaling and inflammatory responses in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 288: L497-L507, 2005.
61. von Herbay A and Rudi J. Role of apoptosis in gastric epithelial turnover. Microsc Res Tech 48: 303-311, 2000.
62. Walsh JH and Grossman MI. Gastrin. N Engl J Med 292: 1324-1332, 1975.
63. Xiao H, Chung J, Kao HY, and Yang YC. Tip60 is a co-repressor for STAT3. J Biol Chem 278: 11197-11204, 2003.
64. Yadetie F, Laegreid A, Bakke I, Kusnierczyk W, Komorowski J, Waldum HL, and Sandvik AK. Liver gene expression in rats in response to the peroxisome proliferator-activated receptor α agonist ciprofibrate. Physiol Genomics 15: 9-19, 2003.
65. Yang YH, Dudoit S, Luu P, Lin DM, Peng V, Ngai J, and Speed TP. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res 30: e15, 2002.