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Volumn 23, Issue 44, 2005, Pages 5177-5185

Investigation of nontypeable Haemophilus influenzae outer membrane protein P6 as a new carrier for lipooligosaccharide conjugate vaccines

Author keywords

Carrier; Conjugate vaccine; LOS; Nontypeable Haemophilus influenzae; P6

Indexed keywords

ADIPIC ACID DERIVATIVE; ADIPIC ACID DIHYDRAZIDE; ADJUVANT; BACTERIUM ANTIBODY; CARBOHYDRATE; EPITOPE; IMMUNOGLOBULIN G ANTIBODY; LIPOOLIGOSACCHARIDE; OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN P 6; RIBI; UNCLASSIFIED DRUG; ANTISERUM; CARRIER PROTEIN; HAEMOPHILUS VACCINE; LIPOPOLYSACCHARIDE; P6 OUTER MEMBRANE PROTEIN, HAEMOPHILUS; VACCINE;

EID: 25144449486     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2005.06.014     Document Type: Article
Times cited : (16)

References (43)
  • 1
    • 0037397842 scopus 로고    scopus 로고
    • Respiratory infections caused by non-typeable Haemophilus influenzae
    • T.F. Murphy Respiratory infections caused by non-typeable Haemophilus influenzae Curr Opin Infect Dis 16 2003 129 134
    • (2003) Curr Opin Infect Dis , vol.16 , pp. 129-134
    • Murphy, T.F.1
  • 2
    • 0031811255 scopus 로고    scopus 로고
    • Nontypeable Haemophilus influenzae: Pathogenesis and prevention
    • A.R. Foxwell, J.M. Kyd, and A.W. Cripps Nontypeable Haemophilus influenzae: pathogenesis and prevention Microbiol Mol Biol Rev 62 1998 294 308
    • (1998) Microbiol Mol Biol Rev , vol.62 , pp. 294-308
    • Foxwell, A.R.1    Kyd, J.M.2    Cripps, A.W.3
  • 3
    • 0027243733 scopus 로고
    • Evaluation of mixtures of purified Haemophilus influenzae outer membrane proteins in protection against challenge with nontypeable H. influenzae in the chinchilla otitis media model
    • B.A. Green, M.E. Vazquez, G.W. Zlotnick, G. Quigley-Reape, J.D. Swarts, and I. Green Evaluation of mixtures of purified Haemophilus influenzae outer membrane proteins in protection against challenge with nontypeable H. influenzae in the chinchilla otitis media model Infect Immun 61 1993 1950 1957
    • (1993) Infect Immun , vol.61 , pp. 1950-1957
    • Green, B.A.1    Vazquez, M.E.2    Zlotnick, G.W.3    Quigley-Reape, G.4    Swarts, J.D.5    Green, I.6
  • 4
    • 0030734568 scopus 로고    scopus 로고
    • Evaluation of the virulence of nontypeable Haemophilus influenzae lipooligosaccharide htrB and rfaD mutants in the chinchilla model of otitis media
    • T.F. DeMaria, M.A. Apicella, W.A. Nichols, and E.R. Leake Evaluation of the virulence of nontypeable Haemophilus influenzae lipooligosaccharide htrB and rfaD mutants in the chinchilla model of otitis media Infect Immunol 65 1997 4431 4435
    • (1997) Infect Immunol , vol.65 , pp. 4431-4435
    • Demaria, T.F.1    Apicella, M.A.2    Nichols, W.A.3    Leake, E.R.4
  • 5
    • 0029793893 scopus 로고    scopus 로고
    • Synthesis, characterization, and immunologic properties of detoxified lipooligosaccharide from nontypeable Haemophilus influenzae conjugated to proteins
    • X.X. Gu, C.M. Tsai, T. Ueyama, S.J. Barenkamp, J.B. Robbins, and D.J. Lim Synthesis, characterization, and immunologic properties of detoxified lipooligosaccharide from nontypeable Haemophilus influenzae conjugated to proteins Infect Immun 64 1996 4047 4053
    • (1996) Infect Immun , vol.64 , pp. 4047-4053
    • Gu, X.X.1    Tsai, C.M.2    Ueyama, T.3    Barenkamp, S.J.4    Robbins, J.B.5    Lim, D.J.6
  • 6
    • 0019222660 scopus 로고
    • Carrier-priming leads to hapten-specific suppression
    • L.A. Herzenberg, T. Tokuhisa, and L.A. Herzenberg Carrier-priming leads to hapten-specific suppression Nature 285 1980 664 667
    • (1980) Nature , vol.285 , pp. 664-667
    • Herzenberg, L.A.1    Tokuhisa, T.2    Herzenberg, L.A.3
  • 7
    • 0025942327 scopus 로고
    • Carrier-induced suppression of the antibody response to a 'self' hapten
    • S. Sad, H.M. Gupta, G.P. Talwar, and R. Raghupathy Carrier-induced suppression of the antibody response to a 'self' hapten Immunology 74 1991 223 227
    • (1991) Immunology , vol.74 , pp. 223-227
    • Sad, S.1    Gupta, H.M.2    Talwar, G.P.3    Raghupathy, R.4
  • 8
    • 0024494159 scopus 로고
    • Protective levels of serum antibodies stimulated in infants by two injections of Haemophilus influenzae type b capsular polysaccaride-tetanus toxoid conjugate
    • B.A. Claesson, R. Schneerson, J.B. Robbins, J. Johansson, T. Lagergard, and J. Taranger Protective levels of serum antibodies stimulated in infants by two injections of Haemophilus influenzae type b capsular polysaccaride-tetanus toxoid conjugate J Pediatr 114 1989 97 100
    • (1989) J Pediatr , vol.114 , pp. 97-100
    • Claesson, B.A.1    Schneerson, R.2    Robbins, J.B.3    Johansson, J.4    Lagergard, T.5    Taranger, J.6
  • 9
    • 0034036720 scopus 로고    scopus 로고
    • Elevated levels of maternal anti-tetanus toxin antibodies do not suppress the immune response to a Haemophilus influenzae type b polyribosylphosphate- tetanus toxoid conjugate vaccine
    • C. Panpitpat, U. Thisyakorn, T. Chotpitayasunondh, E. Furer, J.U. Que, and T. Hasler Elevated levels of maternal anti-tetanus toxin antibodies do not suppress the immune response to a Haemophilus influenzae type b polyribosylphosphate-tetanus toxoid conjugate vaccine Bull World Health Organ 78 2000 364 371
    • (2000) Bull World Health Organ , vol.78 , pp. 364-371
    • Panpitpat, C.1    Thisyakorn, U.2    Chotpitayasunondh, T.3    Furer, E.4    Que, J.U.5    Hasler, T.6
  • 10
    • 0032849756 scopus 로고    scopus 로고
    • Outer membrane proteins as a carrier for detoxified lipooligosaccharide conjugate vaccines for nontypeable Haemophilus influenzae
    • T.H. Wu, and X.X. Gu Outer membrane proteins as a carrier for detoxified lipooligosaccharide conjugate vaccines for nontypeable Haemophilus influenzae Infect Immunol 67 1999 5508 5513
    • (1999) Infect Immunol , vol.67 , pp. 5508-5513
    • Wu, T.H.1    Gu, X.X.2
  • 11
    • 1842411846 scopus 로고    scopus 로고
    • Detoxified lipooligosaccharide from nontypeable Haemophilus influenzae conjugated to proteins confers protection against otitis media in chinchillas
    • X.X. Gu, J. Sun, S. Jin, S.J. Barenkamp, D.J. Lim, and J.B. Robbins Detoxified lipooligosaccharide from nontypeable Haemophilus influenzae conjugated to proteins confers protection against otitis media in chinchillas Infect Immun 65 1997 4488 4493
    • (1997) Infect Immun , vol.65 , pp. 4488-4493
    • Gu, X.X.1    Sun, J.2    Jin, S.3    Barenkamp, S.J.4    Lim, D.J.5    Robbins, J.B.6
  • 12
    • 0025915020 scopus 로고
    • Molecular conservation of the P6 outer membrane protein among strains of Haemophilus influenzae: Analysis of antigenic determinants, gene sequences, and restriction fragment length polymorphisms
    • M.B. Nelson, R.S. Munson Jr., M.A. Apicella, D.J. Sikkema, J.P. Molleston, and T.F. Murphy Molecular conservation of the P6 outer membrane protein among strains of Haemophilus influenzae: analysis of antigenic determinants, gene sequences, and restriction fragment length polymorphisms Infect Immun 59 1991 2658 2663
    • (1991) Infect Immun , vol.59 , pp. 2658-2663
    • Nelson, M.B.1    Munson Jr., R.S.2    Apicella, M.A.3    Sikkema, D.J.4    Molleston, J.P.5    Murphy, T.F.6
  • 13
    • 0024429459 scopus 로고
    • Nonculture detection of Haemophilus influenzae in sputum with monoclonal antibodies specific for outer membrane lipoprotein P6
    • K. Groeneveld, L. van Alphen, R.J. van Ketel, L. Geelen-van den Broek, P.P. Eijk, and H.C. Zanen Nonculture detection of Haemophilus influenzae in sputum with monoclonal antibodies specific for outer membrane lipoprotein P6 J Clin Microbiol 27 1989 2263 2267
    • (1989) J Clin Microbiol , vol.27 , pp. 2263-2267
    • Groeneveld, K.1    Van Alphen, L.2    Van Ketel, R.J.3    Geelen-Van Den Broek, L.4    Eijk, P.P.5    Zanen, H.C.6
  • 14
    • 0022389079 scopus 로고
    • Identification of a specific epitope of Haemophilus influenzae on a 16,600-dalton outer membrane protein
    • T.F. Murphy, M.B. Nelson, K.C. Dudas, J.M. Mylotte, and M.A. Apicella Identification of a specific epitope of Haemophilus influenzae on a 16,600-dalton outer membrane protein J Infect Dis 152 1985 1300 1307
    • (1985) J Infect Dis , vol.152 , pp. 1300-1307
    • Murphy, T.F.1    Nelson, M.B.2    Dudas, K.C.3    Mylotte, J.M.4    Apicella, M.A.5
  • 15
  • 16
    • 0023511528 scopus 로고
    • Biologic activities of antibody to a peptidoglycan-associated lipoprotein of Haemophilus influenzae against multiple clinical isolates of H. influenzae type b
    • B.A. Green, T. Quinn-Dey, and G.W. Zlotnick Biologic activities of antibody to a peptidoglycan-associated lipoprotein of Haemophilus influenzae against multiple clinical isolates of H. influenzae type b Infect Immunol 55 1987 2878 2883
    • (1987) Infect Immunol , vol.55 , pp. 2878-2883
    • Green, B.A.1    Quinn-Dey, T.2    Zlotnick, G.W.3
  • 17
    • 0025034303 scopus 로고
    • A recombinant non-fatty acylated form of the Hi-PAL (P6) protein of Haemophilus influenzae elicits biologically active antibody against both nontypeable and type b H. influenzae
    • B.A. Green, B.J. Metcalf, T. Quinn-Dey, D.H. Kirkley, S.A. Quataert, and R.A. Deich A recombinant non-fatty acylated form of the Hi-PAL (P6) protein of Haemophilus influenzae elicits biologically active antibody against both nontypeable and type b H. influenzae Infect Immun 58 1990 3272 3278
    • (1990) Infect Immun , vol.58 , pp. 3272-3278
    • Green, B.A.1    Metcalf, B.J.2    Quinn-Dey, T.3    Kirkley, D.H.4    Quataert, S.A.5    Deich, R.A.6
  • 18
    • 0029846855 scopus 로고    scopus 로고
    • Immunization with outer membrane protein P6 from nontypeable Haemophilus influenzae induces bactericidal antibody and affords protection in the chinchilla model of otitis media
    • T.F. DeMaria, D.M. Murwin, and E.R. Leake Immunization with outer membrane protein P6 from nontypeable Haemophilus influenzae induces bactericidal antibody and affords protection in the chinchilla model of otitis media Infect Immunol 64 1996 5187 5192
    • (1996) Infect Immunol , vol.64 , pp. 5187-5192
    • Demaria, T.F.1    Murwin, D.M.2    Leake, E.R.3
  • 19
    • 0034100828 scopus 로고    scopus 로고
    • Induction of specific immunoglobulin a and Th2 immune responses to P6 outer membrane protein of nontypeable Haemophilus influenzae in middle ear mucosa by intranasal immunization
    • S. Kodama, S. Suenaga, T. Hirano, M. Suzuki, and G. Mogi Induction of specific immunoglobulin A and Th2 immune responses to P6 outer membrane protein of nontypeable Haemophilus influenzae in middle ear mucosa by intranasal immunization Infect Immun 68 2000 2294 2300
    • (2000) Infect Immun , vol.68 , pp. 2294-2300
    • Kodama, S.1    Suenaga, S.2    Hirano, T.3    Suzuki, M.4    Mogi, G.5
  • 20
    • 0035058393 scopus 로고    scopus 로고
    • Intranasal immunization enhances clearance of nontypeable Haemophilus influenzae and reduces stimulation of tumor necrosis factor alpha production in the murine model of otitis media
    • A. Sabirov, S. Kodama, T. Hirano, M. Suzuki, and G. Mogi Intranasal immunization enhances clearance of nontypeable Haemophilus influenzae and reduces stimulation of tumor necrosis factor alpha production in the murine model of otitis media Infect Immun 69 2001 2964 2971
    • (2001) Infect Immun , vol.69 , pp. 2964-2971
    • Sabirov, A.1    Kodama, S.2    Hirano, T.3    Suzuki, M.4    Mogi, G.5
  • 21
    • 0037009227 scopus 로고    scopus 로고
    • Intranasal immunization with recombinant outer membrane protein P6 induces specific immune responses against nontypeable Haemophilus influenzae
    • M. Hotomi, N. Yamanaka, J. Shimada, M. Suzumoto, Y. Ikeda, and A. Sakai Intranasal immunization with recombinant outer membrane protein P6 induces specific immune responses against nontypeable Haemophilus influenzae Int J Pediatr Otorhinolaryngol 65 2002 109 116
    • (2002) Int J Pediatr Otorhinolaryngol , vol.65 , pp. 109-116
    • Hotomi, M.1    Yamanaka, N.2    Shimada, J.3    Suzumoto, M.4    Ikeda, Y.5    Sakai, A.6
  • 22
    • 0027183256 scopus 로고
    • Local antibody response to P6 of nontypable Haemophilus influenzae in otitis-prone and normal children
    • N. Yamanaka, and H. Faden Local antibody response to P6 of nontypable Haemophilus influenzae in otitis-prone and normal children Acta Otolaryngol 113 1993 524 529
    • (1993) Acta Otolaryngol , vol.113 , pp. 524-529
    • Yamanaka, N.1    Faden, H.2
  • 23
    • 0024339586 scopus 로고
    • Epidemiology of otitis media during the first seven years of life in children in greater Boston: A prospective, cohort study
    • D.W. Teele, J.O. Klein, and B. Rosner Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort study J Infect Dis 160 1989 83 94
    • (1989) J Infect Dis , vol.160 , pp. 83-94
    • Teele, D.W.1    Klein, J.O.2    Rosner, B.3
  • 24
    • 0035902482 scopus 로고    scopus 로고
    • Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells
    • T. Shuto, H. Xu, B. Wang, J. Han, H. Kai, and X.X. Gu Activation of NF-kappa B by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKK alpha /beta-I kappa B alpha and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells Proc Natl Acad Sci USA 98 2001 8774 8779
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8774-8779
    • Shuto, T.1    Xu, H.2    Wang, B.3    Han, J.4    Kai, H.5    Gu, X.X.6
  • 25
    • 0032934263 scopus 로고    scopus 로고
    • Identification of common lipooligosaccharide types in isolates from patients with otitis media by monoclonal antibodies against nontypeable Haemophilus influenzae 9274
    • T. Ueyama, X.X. Gu, C.M. Tsai, A.B. Karpas, and D.J. Lim Identification of common lipooligosaccharide types in isolates from patients with otitis media by monoclonal antibodies against nontypeable Haemophilus influenzae 9274 Clin Diagn Lab Immunol 6 1999 96 100
    • (1999) Clin Diagn Lab Immunol , vol.6 , pp. 96-100
    • Ueyama, T.1    Gu, X.X.2    Tsai, C.M.3    Karpas, A.B.4    Lim, D.J.5
  • 26
    • 0023156173 scopus 로고
    • Antigenic diversity of lipo-oligosaccharides of nontypable Haemophilus influenzae
    • A.A. Campagnari, M.R. Gupta, K.C. Dudas, T.F. Murphy, and M.A. Apicella Antigenic diversity of lipo-oligosaccharides of nontypable Haemophilus influenzae Infect Immun 55 1987 882 887
    • (1987) Infect Immun , vol.55 , pp. 882-887
    • Campagnari, A.A.1    Gupta, M.R.2    Dudas, K.C.3    Murphy, T.F.4    Apicella, M.A.5
  • 27
    • 0029084577 scopus 로고
    • Quantitation and biological properties of released and cell-bound lipooligosaccharides from nontypeable Haemophilus influenzae
    • X.X. Gu, C.M. Tsai, M.A. Apicella, and D.J. Lim Quantitation and biological properties of released and cell-bound lipooligosaccharides from nontypeable Haemophilus influenzae Infect Immunol 63 1995 4115 4120
    • (1995) Infect Immunol , vol.63 , pp. 4115-4120
    • Gu, X.X.1    Tsai, C.M.2    Apicella, M.A.3    Lim, D.J.4
  • 28
    • 0026734654 scopus 로고
    • Synthesis, characterization, and some immunological properties of conjugates composed of the detoxified lipopolysaccharide of Vibrio cholerae O1 serotype Inaba bound to cholera toxin
    • R.K. Gupta, S.C. Szu, R.A. Finkelstein, and J.B. Robbins Synthesis, characterization, and some immunological properties of conjugates composed of the detoxified lipopolysaccharide of Vibrio cholerae O1 serotype Inaba bound to cholera toxin Infect Immunol 60 1992 3201 3208
    • (1992) Infect Immunol , vol.60 , pp. 3201-3208
    • Gupta, R.K.1    Szu, S.C.2    Finkelstein, R.A.3    Robbins, J.B.4
  • 29
    • 0027286295 scopus 로고
    • Preparation, characterization, and immunogenicity of meningococcal lipooligosaccharide-derived oligosaccharide-protein conjugates
    • X.X. Gu, and C.M. Tsai Preparation, characterization, and immunogenicity of meningococcal lipooligosaccharide-derived oligosaccharide-protein conjugates Infect Immunol 61 1993 1873 1880
    • (1993) Infect Immunol , vol.61 , pp. 1873-1880
    • Gu, X.X.1    Tsai, C.M.2
  • 30
    • 0020055346 scopus 로고
    • A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels
    • C.M. Tsai, and C.E. Frasch A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels Anal Biochem 119 1982 115 119
    • (1982) Anal Biochem , vol.119 , pp. 115-119
    • Tsai, C.M.1    Frasch, C.E.2
  • 31
    • 0023019930 scopus 로고
    • Antigenic characterization of the P6 protein of nontypeable Haemophilus influenzae
    • T.F. Murphy, L.C. Bartos, A.A. Campagnari, M.B. Nelson, and M.A. Apicella Antigenic characterization of the P6 protein of nontypeable Haemophilus influenzae Infect Immun 54 1986 774 779
    • (1986) Infect Immun , vol.54 , pp. 774-779
    • Murphy, T.F.1    Bartos, L.C.2    Campagnari, A.A.3    Nelson, M.B.4    Apicella, M.A.5
  • 33
    • 33749946901 scopus 로고
    • Colorimetric method for determination of sugars and related substances
    • M. Dubois, K.A. Gilles, J.K. Hamilton, A.A. Rebers, and R. Smith Colorimetric method for determination of sugars and related substances Anal Chem 28 1956 350 356
    • (1956) Anal Chem , vol.28 , pp. 350-356
    • Dubois, M.1    Gilles, K.A.2    Hamilton, J.K.3    Rebers, A.A.4    Smith, R.5
  • 34
    • 0031030047 scopus 로고    scopus 로고
    • Bactericidal antibody responses of juvenile rhesus monkeys immunized with group B Neisseria meningitidis capsular polysaccharide-protein conjugate vaccines
    • W.D. Zollinger, E.E. Moran, S.J. Devi, and C.E. Frasch Bactericidal antibody responses of juvenile rhesus monkeys immunized with group B Neisseria meningitidis capsular polysaccharide-protein conjugate vaccines Infect Immunol 65 1997 1053 1060
    • (1997) Infect Immunol , vol.65 , pp. 1053-1060
    • Zollinger, W.D.1    Moran, E.E.2    Devi, S.J.3    Frasch, C.E.4
  • 35
    • 0032921891 scopus 로고    scopus 로고
    • Alpha C protein as a carrier for type III capsular polysaccharide and as a protective protein in group B streptococcal vaccines
    • C. Gravekamp, D.L. Kasper, L.C. Paoletti, and L.C. Madoff Alpha C protein as a carrier for type III capsular polysaccharide and as a protective protein in group B streptococcal vaccines Infect Immunol 67 1999 2491 2496
    • (1999) Infect Immunol , vol.67 , pp. 2491-2496
    • Gravekamp, C.1    Kasper, D.L.2    Paoletti, L.C.3    Madoff, L.C.4
  • 36
    • 0031954139 scopus 로고    scopus 로고
    • Synthesis and characterization of lipooligosaccharide-based conjugates as vaccine candidates for Moraxella (Branhamella) catarrhalis
    • X.X. Gu, J. Chen, S.J. Barenkamp, J. Robbins, B. Tsai, and C.M. Lim Synthesis and characterization of lipooligosaccharide-based conjugates as vaccine candidates for Moraxella (Branhamella) catarrhalis Infect Immun 66 1998 1891 1987
    • (1998) Infect Immun , vol.66 , pp. 1891-1987
    • Gu, X.X.1    Chen, J.2    Barenkamp, S.J.3    Robbins, J.4    Tsai, B.5    Lim, C.M.6
  • 37
    • 0033849901 scopus 로고    scopus 로고
    • Enhancement of clearance of bacteria from murine lungs by immunization with detoxified lipooligosaccharide from Moraxella catarrhalis conjugated to proteins
    • W.G. Hu, J. Chen, J.F. Battey, and X.X. Gu Enhancement of clearance of bacteria from murine lungs by immunization with detoxified lipooligosaccharide from Moraxella catarrhalis conjugated to proteins Infect Immunol 68 2000 4980 4985
    • (2000) Infect Immunol , vol.68 , pp. 4980-4985
    • Hu, W.G.1    Chen, J.2    Battey, J.F.3    Gu, X.X.4
  • 38
    • 0025955177 scopus 로고
    • Minimal oligosaccharide structures required for induction of immune responses against meningococcal immunotype L1, L2, and L3,7,9 lipopolysaccharides determined by using synthetic oligosaccharide-protein conjugates
    • A.F. Verheul, G.J. Boons, G.A. Van der Marel, J.H. Van Boom, H.J. Jennings, and H. Snippe Minimal oligosaccharide structures required for induction of immune responses against meningococcal immunotype L1, L2, and L3,7,9 lipopolysaccharides determined by using synthetic oligosaccharide-protein conjugates Infect Immun 59 1991 3566 3573
    • (1991) Infect Immun , vol.59 , pp. 3566-3573
    • Verheul, A.F.1    Boons, G.J.2    Van Der Marel, G.A.3    Van Boom, J.H.4    Jennings, H.J.5    Snippe, H.6
  • 40
    • 0029920391 scopus 로고    scopus 로고
    • Activation of soluble polysaccharides with 1-cyano-4- dimethylaminopyridinium tetrafluoroborate for use in protein-polysaccharide conjugate vaccines and immunological reagents
    • A. Lees, B.L. Nelson, and J.J. Mond Activation of soluble polysaccharides with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate for use in protein-polysaccharide conjugate vaccines and immunological reagents Vaccine 14 1996 190 198
    • (1996) Vaccine , vol.14 , pp. 190-198
    • Lees, A.1    Nelson, B.L.2    Mond, J.J.3
  • 41
    • 2442507111 scopus 로고    scopus 로고
    • Exploration of Moraxella Catarrhalis outer membrane proteins, CD and UspA, as new carriers for lipooligosaccharide-based conjugates
    • W-H. Hu, J. Berry, J. Chen, and X-X. Gu Exploration of Moraxella Catarrhalis outer membrane proteins, CD and UspA, as new carriers for lipooligosaccharide-based conjugates FEMS Immunol Med Mic 35 2004 1 10
    • (2004) FEMS Immunol Med Mic , vol.35 , pp. 1-10
    • Hu, W.-H.1    Berry, J.2    Chen, J.3    Gu, X.-X.4
  • 42
    • 0024551362 scopus 로고
    • Effect of oligosaccharide chain length, exposed terminal group, and hapten loading on the antibody response of human adults and infants to vaccines consisting of Haemophilus influenzae type b capsular antigen unterminally coupled to the diphtheria protein CRM197
    • P.W. Anderson, M.E. Pichichero, E.C. Stein, S. Porcelli, R.F. Betts, and D.M. Connuck Effect of oligosaccharide chain length, exposed terminal group, and hapten loading on the antibody response of human adults and infants to vaccines consisting of Haemophilus influenzae type b capsular antigen unterminally coupled to the diphtheria protein CRM197 J Immunol 142 1989 2464 2468
    • (1989) J Immunol , vol.142 , pp. 2464-2468
    • Anderson, P.W.1    Pichichero, M.E.2    Stein, E.C.3    Porcelli, S.4    Betts, R.F.5    Connuck, D.M.6
  • 43
    • 0037449090 scopus 로고    scopus 로고
    • Phase I study of a lipooligosaccharide-based conjugate vaccine against nontypeable Haemophilus influenzae
    • X.X. Gu, S.F. Rudy, C. Chu, L. McCullagh, HN. Kim, and J. Chen Phase I study of a lipooligosaccharide-based conjugate vaccine against nontypeable Haemophilus influenzae Vaccine 21 2003 2107 2114
    • (2003) Vaccine , vol.21 , pp. 2107-2114
    • Gu, X.X.1    Rudy, S.F.2    Chu, C.3    McCullagh, L.4    Kim, H.N.5    Chen, J.6


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