Genetic regulation of endothelial function

Heart

Volumn 91, Issue 10, 2005, Pages 1275-1277

  Jones, L C ^a   Hingorani, Aroon D ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TETRAHYDROBIOPTERIN; ARGININE; DIMETHYLARGININE; DRUG DERIVATIVE;

ATHEROSCLEROSIS; CELL FUNCTION; CONFERENCE PAPER; DNA POLYMORPHISM; ENDOTHELIUM CELL; GENETIC REGULATION; GENETIC VARIABILITY; HUMAN; PRIORITY JOURNAL; ARTERIOSCLEROSIS; FORECASTING; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETICS; PATHOPHYSIOLOGY; REVIEW; VASCULAR ENDOTHELIUM;

ARGININE; ARTERIOSCLEROSIS; ENDOTHELIUM, VASCULAR; FORECASTING; GENE EXPRESSION REGULATION; HUMANS; NADPH OXIDASE; NITRIC OXIDE; POLYMORPHISM, GENETIC;

EID: 25144434375     PISSN: 13556037     EISSN: None     Source Type: Journal    
DOI: 10.1136/hrt.2005.061325     Document Type: Conference Paper

References (30)

1. Vallance P, Chan N. Endothelial function and nitric oxide: clinical relevance. Heart 2001;85:342-50.
2. Corretti MC, Anderson TJ, Benjamin EJ, et al for the International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the international brachial artery reactivity task force [erratum in: J Am Coll Cordial 2002;39:1082]. J Am Coll Cardiol 2002;39:257-65.
3. Chan NN, Colhoun HM, Vallance P. Cardiovascular risk factors as determinants of endothelium-dependent and endothelium-independent vascular reactivity in the general population. J Am Coll Cardiol 2001;38:1814-20.
4. Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 2001;104:191-6.
5. Celermajer DS, Sorensen K, Ryalls M, et al. Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents. J Am Coll Cardiol 1993;22:854-8.
6. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-5.
7. Marenberg ME, Risch N, Berkman LF, et al. Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med 1994;330:1041-6.
8. Gaeta G, De Michele M, Cuomo S, et al. Arterial abnormalities in the offspring of patients with premature myocardial infarction. N Engl J Med 2000;343:840-6.
9. Clarkson P, Celermajor DS, Powe AJ, et al. Endothelium-dependent dilatation is impaired in young healthy subjects with a family history of premature coronary disease. Circulation 1997;96:3378-83.
10. Hingorani A. Resolving inconsistency in the results of genetic association studies of cardiovascular disease. Clin Sci (Lond) 2004;107:251-3.
11. Hingorani AD. Polymorphisms in endothelial nitric oxide synthase and atherogenesis: John French Lecture 2000. Atherosclerosis 2001;154:521-7.
12. Nakayama M, Yasue H, Yoshimura M, et al. T-786→C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 1999;99:2864-70.
13. Cattaruzza M, Guzik TJ, Slodowski W, et al. Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease. Circ Res 2004;95:841-7.
14. Casas JP, Hingorani AD, Humphries SE, et al. Do meta-analyses of association studies of endothelial nitric oxide synthase variants and ischemic heart disease provide conclusive answers? Circulation 2004;110:e305-6.
15. Persu A, Stoenoiu MS, Messiaen T, et al. Modifier effect of ENOS in autosomal dominant polycystic kidney disease. Hum Mol Genet 2002;11:229-41.
16. McDonald DM, Alp NJ, Channon KM. Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells. Pharmacogenetics 2004;14:831-9.
17. Hingorani AD. Endothelial nitric oxide synthase polymorphisms and hypertension. Curr Hypertens Rep 2003;5:19-25.
18. Guzik TJ, Black E, West NE, et al. Relationship between the G894T polymorphism (Glu298Asp variant) in endothelialnitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis. Am J Med Genet 2001;100:130-7.
19. Casas JP, Bautista LE, Humphries S, et al. Endothelial nitric oxide synthase genotype and ischaemic heart disease: meta-analysis of 30 studies, involving 23,028 subjects. Circulation 2004;109:1359-65.
20. Vallance P, Leiper J. Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol 2004;24:1023-30.
21. Jones LC, Tran CTL, Leiper JM, et al. Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells. Biochem Biophys Res Comm 2003;310:836-43.
22. Alp NJ, Channon KM. Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. Arterioscler Thromb Vasc Biol 2004;24:413-20.
23. Griendling KK, Sorescu D, Ushio-Fukai M. NADPH oxidase. Role in cardiovascular biology and disease. Circulation Res 2000;86:494-501.
24. Guzik TJ, West NE, Black E, McDonald D, et al. Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox gene on vascular superoxide production in atherosclerosis. Circulation 2000;102:1744-7.
25. Schachinger V, Britten MB, Dimmeler S, et al. NADH/NADPH oxidase p22 phox gene polymorphism is associated with improved coronary endothelial vasodilator function. Eur Heart J 2001;22:96-101.
26. Inoue N, Kawashima S, Kanazawa K, et al. Polymorphism of the NADH/ NADPH oxidase p22 phox gene in patients with coronary artery disease. Circulation 1998;97:135-7.
27. Murase Y, Yamada Y, Hirashiki A, et al. Genetic risk and gene-environment interaction in coronary artery spasm in Japanese men and women. Eur Heart J 2004;25:970-7.
28. Cahilly C, Ballantyne CM, Lim DS, et al. A variant of p22(phox), involved in generation of reactive oxygen species in the vessel wall, is associated with progression of coronary atherosclerosis. Circ Res 2000;86:391-5.
29. Cai H, Duarte N, Wilcken DE, et al. NADH/NADPH oxidase p22 phox C242T polymorphism and coronary artery disease in the Australian population. Eur J Clin Invest 1999;29:744-8.
30. Schneider MP, Hilgers KF, Huang Y, et al. The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia. Clin Sci (Lond) 2003;105:97-103.