1,25-Dihydroxyvitamin D3 stimulated protein kinase C phosphorylation of type VI adenylyl cyclase inhibits parathyroid hormone signal transduction in rat osteoblastic UMR 106-01 cells

Journal of Cellular Biochemistry

Volumn 94, Issue 5, 2005, Pages 1017-1027

  Cheung, Ricky ^a   Erclik, Mary S ^a   Mitchell, Jane ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

1,25 dihydroxyvitamin D3; Adenylyl cyclase type VI; Osteoblast; Parathyroid hormone; Phosphatidylinositol 3 kinase; Protein kinase C

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ADENYLATE CYCLASE; CALCITRIOL; CALPHOSTIN C; CYCLIC AMP; FORSKOLIN; MESSENGER RNA; PARATHYROID HORMONE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOLIPASE C INHIBITOR; PROTEIN KINASE C; PROTEIN KINASE C BETA; PROTEIN KINASE C BETA1; PROTEIN KINASE C DELTA; PROTEIN KINASE C ZETA; UNCLASSIFIED DRUG; WORTMANNIN; PHOSPHOLIPASE C;

ANIMAL CELL; ARTICLE; CELL LINE; CELL MEMBRANE TRANSPORT; CELL STRAIN UMR 106 01; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HORMONE ACTION; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENYLATE CYCLASE; ANIMALS; CALCITRIOL; CELL LINE; OSTEOBLASTS; PARATHYROID HORMONE; PHOSPHOLIPASE C; PHOSPHORYLATION; PROTEIN KINASE C; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 24944580795     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.20366     Document Type: Article

References (45)

1. Bandyopadhyay G, Standaert ML, Galloway L, Moscat J, Farese RV. 1997. Evidence for involvement of protein kinase C (PKC)-ζ and noninvolvement of diacylglycerol-sensitive PKCs in insulin-stimulated glucose transport in L6 myotubes. Endocrinology 138:4721-4731.
2. 3. J Cell Biochem 78:34-46.
3. Bek MJ, Zheng S, Xu J, Yamaguchi I, Asico LD, Sun XG, Jose PA. 2001. Differential expression of adenylyl cyclases in the rat nephron. Kidney Int 60:890-899.
4. 3 in osteoblasts. Steroids 67:235-246.
5. Catherwood BD. 1985. 1,25-Dihydroxycholecalciferol and glucocorticosteroid regulation of adenylate cyclase in an osteoblast-like cell line. J Biol Chem 260:736-743.
6. 3 and its interaction with glucocorticoids. Calcif Tissue Int 36:580-585.
7. Chern Y, Chiou JY, Lai HL, Tsai MH. 1995. Regulation of adenylyl cyclase type VI activity during desensi AMP AMP tization of the A2a adenosine receptor-mediated cyclic AMP response: Role for protein phosphatase 2A. Mol Pharmacol 48:1-8.
8. Civitelli R, Kim YS, Gunsten SL, Fujimori A, Huskey M, Avioli LV, Hruska KA. 1990. Nongenomic activation of the calcium message system by vitamin D metabolites in osteoblast-like cells. Endocrinology 127:2253-2262.
9. Erclik MS, Mitchell J. 2002. The role of protein kinase C-δ in PTH stimulation of IGF-binding protein-5 mRNA in UMR-106-01 cells. Am J Physiol Endocrinol Metab 282: E534-E541.
10. Haussler MR, Whitfleld GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH, Dominguez CE, Jurutka PW. 1998. The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed. J Bone Miner Res 13:325-349.
11. 3-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complex. J Exp Med 190:1583-1594.
12. Jacobowitz O, Chen J, Iyengar R. 1994. Transient expression assays for mammalian adenylyl cyclases. Methods Enzymol 238:108-116.
13. 3 stimulates activator protein 1 DNA-binding activity by a phosphatidylinositol 3-kinase/Ras/MEK/ extracellular signal regulated kinase 1/2 and c-Jun N-terminal kinase 1-dependent increase in c-Fos, Fra1, and c-Jun expression in human keratinocytes. J Invest Dermatol 120:561-570.
14. Jones G, Strugnell SA, DeLuca HF. 1998. Current understanding of the molecular actions of vitamin D. Physiol Rev 78:1193-1231.
15. Kotani K, Ogawa W, Matsumoto M, Kitamura T, Sakaue H, Hino Y, Miyake K, Sano W, Akimoto K, Ohno S, Kasuga M. 1998. Requirement of atypical protein kinase Cl for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol Cell Biol 18:6971-6982.
16. Krupinski J, Lehman TC, Frankenfield CD, Zwaagstra JC, Watson PA. 1992. Molecular diversity in the adenylylcyclase family. Evidence for eight forms of the enzyme and cloning of type VI. J Biol Chem 267:24858-24862.
17. 3 on cyclic AMP responses to hormones in clonal osteogenic sarcoma cells. Biochem J 231:11-17.
18. Lai HL, Yang TH, Messing RO, Ching YH, Lin SC, Chern Y. 1997. Protein kinase C inhibits adenylyl cyclase type VI activity during desensitization of the A2a-adenosine receptor-mediated cAMP response. J Biol Chem 272:4970-4977.
19. Lai HL, Lin TH, Kao YY, Lin WJ, Hwang MJ, Chern Y. 1999. The N terminus domain of type VI adenylyl cyclase mediates its inhibition by protein kinase C. Mol Pharmacol 56:644-650.
20. Lee SK, Lorenzo JA. 1999. Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: Correlation with osteoclast-like cell formation. Endocrinology 140:3552-3561.
21. Lin TH, Lai HL, Kao YY, Sun CN, Hwang MJ, Chern Y. 2002. Protein kinase C inhibits type VI adenylyl cyclase by phosphorylating the regulatory N domain and two catalytic C1 and C2 domains. J Biol Chem 277:15721-15728.
22. Liu Q, Ning W, Dantzer R, Freund GG, Kelley KW. 1998. Activation of protein kinase C-ζ and phosphatidylinositol 3′-kinase and promotion of macrophage differentiation by insulin-like growth factor-I. J Immunol 160:1393-1401.
23. Mendez R, Kollmorgen G, White MF, Rhoads RE. 1997. Requirement of protein kinase C ζ for stimulation of protein synthesis by insulin. Mol Cell Biol 17:5184-5192.
24. Mitchell J, Bansal A. 1997. Dexamethasone increases G alpha q-11 expression and hormone-stimulated phospholipase C activity in UMR-106-01 cells. Am J Physiol 273: E528-E535.
25. 3 which mediates rapid activation of protein kinase C. J Bone Miner Res 13:1353-1359.
26. Offermanns S, Iida-Klein A, Segre GV, Simon MI. 1996. Gαq family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells. Mol Endocrinol 10:566-574.
27. Rebsamen MC, Sun J, Norman AW, Liao JK. 2002. 1α,25- dihydroxyvitamin D3 induces vascular smooth muscle cell migration via activation of phosphatidylinositol 3-kinase. Circ Res 91:17-24.
28. Reinhardt TA, Horst RL. 1990. Parathyroid hormone down-regulates 1,25-dihydroxyvitamin D receptors (VDR) and VDR messenger ribonucleic acid in vitro and blocks homologous up-regulation of VDR in vivo. Endocrinology 127:942-948.
29. 3 selectively translocates PKCα to nuclei in ROS 17/2.8 cells. Mol Cell Endocrinol 188:227-239.
30. Salomon Y, Londos C, Rodbell M. 1974. A highly sensitive adenylate cyclase assay. Anal Biochem 58:541-548.
31. Schaffner W, Weissmann C. 1973. A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal Biochem 56:502-514.
32. 3 is mediated by phospholipase C. Steroids 66:683-694.
33. Silver J, Russell J, Sherwood LM. 1985. Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc Natl Acad Sci USA 82:4270-4273.
34. 3-induced monocyte antimycobacterial activity is regulated by phosphatidylinositol 3-kinase and mediated by the NADPH-dependent phagocyte oxidase. J Biol Chem 276:35482-35493.
35. 3, retinoic acid and TPA augment forskolin-induced cyclic AMP accumulation in the absence of altered isozyme expression. Arch Dermatol Res 290:407-412.
36. 3 in bone. J Biol Chem 267:12562-12569.
37. Varga EV, Stropova D, Rubenzik M, Waite S, Roeske WR, Yamamura HI. 1999. Phosphorylation of adenylyl cyclase VI upon chronic δ-opioid receptor stimulation. Eur J Pharmacol 364:R1-R3.
38. 3 stimulates membrane phosphoinositide turnover, activates protein kinase C, and increases cytosolic calcium in rat colonic epithelium. J Clin Invest 85:1296-1303.
39. 3 to increase intracellular calcium and activate protein kinase C in mouse osteoblasts. J Cell Biochem 88:794-801.
40. Watson PA, Krupinski J, Kempinski AM, Frankenfield CD. 1994. Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells. J Biol Chem 269:28893-28898.
41. Winchester SK, Bloch SR, Fiacco GJ, Partridge NC. 1999. Regulation of expression of collagenase-3 in normal, differentiating rat osteoblasts. J Cell Physiol 181:479-488.
42. Wu Y, Kumar R. 2000. Parathyroid hormone regulates transforming growth factor β1 and β2 synthesis in osteoblasts via divergent signaling pathways. J Bone Miner Res 15:879-884.
43. 3 in the osteoblast-like ROS 17/2.8 cells. Am J Physiol 270:E654-E660.
44. Yasuda I, Kishimoto A, Tanaka S, Tominaga M, Sakurai A, Nishizuka Y. 1990. A synthetic peptide substrate for selective assay of protein kinase C. Biochem Biophys Res Commun 166:1220-1227.
45. 2+-inhibitable adenylyl cyclase from NCB-20 cells. Proc Natl Acad Sci USA 89:6716-6720.