Downregulation of the PTH/PTHrP receptor by vitamin D3 in the osteoblast-like ROS 17/2.8 cells

American Journal of Physiology - Endocrinology and Metabolism

Volumn 270, Issue 4 33-4, 1996, Pages

  Xie, Lin Y ^a   Leung, Albert ^a   Segre, Gino V ^a   Yamamoto, Itsuo ^a   Abou Samra, Abdul B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Dihydroxyvitamin D3; Parathyroid hormone; Parathyroid hormone related peptide

Indexed keywords

CALCITRIOL; MESSENGER RNA; PARATHYROID HORMONE; PARATHYROID HORMONE RECEPTOR; PARATHYROID HORMONE RELATED PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HALF LIFE TIME; IMMUNOREACTIVITY; NONHUMAN; OSTEOBLAST; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CALCITRIOL; CELL MEMBRANE; DOWN-REGULATION; MOLECULAR SEQUENCE DATA; OSTEOBLASTS; PEPTIDE FRAGMENTS; RATS; RECEPTOR, PARATHYROID HORMONE, TYPE 1; RECEPTORS, PARATHYROID HORMONE; RNA, MESSENGER; TUMOR CELLS, CULTURED;

EID: 0029990436     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.270.4.e654     Document Type: Article

References (30)

1. Abou-Samra, A. B., H. Jüppner, T. Force, M. W. Freeman, X. F. Kong, E. Schipani, P. Urena, J. Richards, J. V. Bonventre, J. T. Potts, Jr., H. M. Kronenberg, and G. V. Segre. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc. Natl. Acad. Sci. USA 89: 2732-2736, 1992.
2. Abou-Samra, A. B., H. Jüppner, D. Westerberg, J. T. Potts, Jr., and G. V. Segre. Parathyroid hormone causes translocation of protein kinase-C from cytosol to membranes in rat osteosarcoma cells. Endocrinology 124: 1107-1113, 1989.
3. Abou-Samra, A. B., J. D. Zajac, A. D. Schiffer, R. Skurat, A. Kearns, G. V. Segre, and F. R. Bringhurst. Cyclic adenosine 3′,5′-monophosphate (cAMP)-dependent and cAMP-independent regulation of parathyroid hormone receptors on UMR 106-01 osteoblastic osteosarcoma cells. Endocrinology 129: 2547-2554, 1991.
4. 3 and its interaction with glucocorticoids. Calcif. Tissue Int. 36: 580-585, 1984.
5. Chen, T. L., and D. Feldman. Glucocorticoid modulation of cell proliferation in cultured osteoblast-like bone cells: differences between rat and mouse. Endocrinology 112: 1739-1745, 1983.
6. Chomczynski, P., and N. Sacchi. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
7. Civitelli, R., A. Fujimori, S. M. Bernier, P. M. Warlow, D. Goltzman, K. A. Hruska, and L. V. Avioli. Heterogeneous intracellular free calcium responses to parathyroid hormone correlate with morphology and receptor distribution in osteogenic sarcoma cells. Endocrinology 130: 2392-2400, 1992.
8. Cosman, F., B. Morrow, M. Kopal, and J. P. Bilezikian. Stimulation of inositol phosphate formation in ROS 17/2.8 cell membranes by guanine nucleotide, calcium and parathyroid hormone. J. Bone Miner. Res. 4: 413-420, 1989.
9. Donahue, H. J., M. J. Fryer, E. F. Eriksen, and H. Heath. Differential effects of parathyroid hormone and its analogues on cytosolic calcium ion and cAMP levels in cultured osteoblast-like cells. J. Biol. Chem. 263: 13522-13527, 1988.
10. Dunlay, R., and K. Hruska. PTH receptor coupling to phospholipase C is an alternate pathway of signal transduction in bone and kidney Am. J. Physiol. 258 (Renal Fluid Electrolyte Physiol. 27): F223-F231, 1990.
11. Hanai, H., D. P. Brennan, L. Cheng, M. E. Goldman, M. Chorev, M. A. Levine, B. Sacktor, and C. T. Liang. Downregulation of parathyroid hormone receptors in renal membranes from aged rats. Am. J. Physiol. 259 (Renal Fluid Electrolyte Physiol. 28): F444-F450, 1990.
12. Jaaskelainen, T., A. Pirskanen, S. Ryhanen, J. J. Palvimo, H. F. Deluca, and P. H. Maenpaa. Functional interference between AP-1 and the vitamin D receptor on osteocalcin gene expression in human osteosarcoma cells. Eur. J. Biochem. 224: 11-20, 1994.
13. Jüppner, H., A. B. Abou-Samra, M. Freeman, X. F. Kong, E. Schipani, J. Richards, L. F. J. Kolakowski, J. Hock, J. T. Potts, Jr., H. M. Kronenberg, and G. V. Segre. A G protein-linked receptor for parathyroid hormone, and parathyroid hormone-related peptide. Science Wash. DC 254: 1024-1026, 1991.
14. Jüppner, H., A. B. Abou-Samra, S. Uneno, W. X. Gu, J. T. Potts, Jr., and G. V. Segre. The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells. J. Biol. Chem. 263: 8557-8560, 1988.
15. Katz, M. S., G. E. Gutierrez, G. R. Mundy, T. K. Hymer, M. P. Caulfield, and R. L. McKee. Tumor necrosis factor and interleukin 1 inhibit parathyroid hormone-responsive adenylate cyclase in clonal osteoblast-like cells by down-regulating parathyroid hormone receptors. J. Cell Physiol. 153: 206-213, 1992.
16. Mitchell, J., and D. Goltzman. Mechanisms of homologous and heterologous regulation of parathyroid hormone receptors in the rat osteosarcoma cell line UMR-106. Endocrinology 126: 2650-2660, 1990.
17. Pernalete, N., J. C. Garcia, C. R. Betts, and K. J. Martin. Inhibitors of protein kinase-C modulate desensitization of the parathyroid hormone receptor-adenylate cyclase system in opossum kidney cells. Endocrinology 126: 407-413, 1990.
18. Rappaport, M. S., and P. H. Stern. Parathyroid hormone and calcitonin modify phospholipid metabolism in fetal rat limb bones. J. Bone Miner. Res. 2: 173-179, 1986.
19. Rizzoli, R., and H. Fleisch. Heterologous desensitization by 1,25-dihydroxyvitamin D-3 of cyclic AMP response to parathyroid hormone in osteoblast-like cells and the role of the stimulatory guanine nucleotide regulatory protein. Biochim. Biophys. Acta 887: 214-221, 1986.
20. Rodan, G. A., and S. B. Rodan. The effect of dexamethasone on parathyroid hormone stimulation of adenylate cyclase in ROS 17/2.8 cells. Endocrinology 115: 951-958, 1984.
21. Rodan, S. B., Y. Imai, M. A. Thiede, G. Wesolowski, D. Thompson, S. Z. Bar, S. Shull, K. Mann, and G. A. Rodan. Effects of retinoic acid on alkaline phosphatase messenger ribonucleic acid, catecholamine receptors, and G proteins in ROS 17/2.8 cells. Endocrinology 122: 456-463, 1988.
22. Schepmoes, G., E. Breen, T. A. Owen, M. A. Aronow, G. S. Stein, and J. B. Lian. Influence of dexamethasone on the vitamin D-mediated regulation of osteocalcin gene expression. J. Cell Biochem. 47: 184-196, 1991.
23. Schneider, H. G., E. H. Allan, J. M. Moseley, T. J. Martin, and D. M. Findlay. Specific down-regulation of parathyroid hormone (PTH) receptors and responses to PTH by tumour necrosis factor alpha and retinoic acid in UMR106-06 osteoblast-like osteosarcoma cells. Biochem. J. 280: 451-457, 1991.
24. Segre, G. V., M. Rosenblatt, B. L. Reiner, J. E. Mahaffey, and J. T. Potts, Jr. Characterization of parathyroid hormone receptors in canine renal cortical plasma membranes using a radioiodinated sulfur-free hormone analogue: correlation of binding with adenylate cylase activity. J. Biol. Chem. 254: 6980-6986, 1979.
25. Silver, J., J. Russell, and L. M. Sherwood. Regulation by vitamin D metabolites of messenger ribonucleic acid for preproparathyroid hormone in isolated bovine parathyroid cells. Proc. Natl. Acad. Sci. USA 82: 4270-4273, 1985.
26. Titus, L., E. Jackson, M. S. Nanes, J. E. Rubin, and B. D. Catherwood. 1,25-Dihydroxyvitamin D reduces parathyroid hormone receptor number in ROS 17/2.8 cells and prevents the glucocorticoid-induced increase in these receptors: relationship to adenylate cyclase activation. J. Bone Miner. Res. 6: 631-637, 1991.
27. Urena, P., A. Iida-Klein, X. F. Kong, H. Jüppner, H. M. Kronenberg, A. B. Abou-Samra, and G. V. Segre. Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor mRNA by glucocorticoids and PTH in ROS 17/2.8 and OK cells. Endocrinology 134: 451-456, 1994.
28. Yamaguchi, T. D., T. J. Hahn, A. Iida-Klein, C. R. Kleeman, and S. Muallem. Parathyroid hormone-activated calium channels in an osteoblast-like clonal osteosarcoma cell line. cAMP-independent calcium channels. J. Biol. Chem. 262: 7711-7718, 1987.
29. Yamamoto, I., C. Shigeno, J. J. Potts, and G. V. Segre. Characterization and agonist-induced down-regulation of parathyroid hormone receptors in clonal rat osteosarcoma cells. Endocrinology 122: 1208-1217, 1988.
30. Zajac, J. D., S. A. Livesey, V. P. Michelangeli, S. B. Rodan, G. A. Rodan, and T. J. Martin. Glucocorticoid treatment facilitates cyclic adenosine 3′,5′- monophosphate-dependent protein kinase response in parathyroid hormone-responsive osteogenic sarcoma cells. Endocrinology 118: 2059-2064, 1986.