Sleep-related hypoventilation: The evolving role of leptin

Chest

Volumn 128, Issue 3, 2005, Pages 1079-1081

  Atwood, Charles W ^a,b  

^a University of Pittsburgh School of Medicine and the Veterans Affairs Pittsburgh Healthcare System ^*

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LEPTIN RECEPTOR;

BODY FAT; BODY WEIGHT; BREATHING; EDITORIAL; HORMONE ACTION; HUMAN; HYPERCAPNIA; HYPOVENTILATION; NONHUMAN; NONREM SLEEP; OBESITY HYPOVENTILATION SYNDROME; PATHOGENESIS; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SLEEP APNEA SYNDROME; SLEEP DISORDERED BREATHING;

EID: 24944573503     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.128.3.1079     Document Type: Editorial

References (14)

1. Llorens S, Jordan J, Nava E. The nitric oxide pathway in the cardiovascular system. J Physiol Biochem 2002; 58:179-188
2. Osorio J, Recchia F. The role of nitric oxide in metabolism regulation: from basic sciences to the clinical setting. Intensive Care Med 2000; 26:1395-1398
3. Mantzoros CS. The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med 1999; 130:671-680
4. Montague C, Prins J, Sanders L, et al. Depot- and sex-specific differences in human leptin mRNA expression. Diabetes 1997; 46:342-347
5. O'Donnell CP, Tankersley CG, Polotsky VP, et al. Leptin, obesity, and respiratory function. Respir Physiol 2000; 119: 163-170
6. Welt C, Chan J, Bullen J, et al. Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 2004; 351:987-997
7. Polotsky V, Wilson J, Smaldone M, et al. Female gender exacerbates respiratory depression in leptin-deficient obesity. Am J Respir Grit Care Med 2001; 164:1470-1475
8. O'Donnell GP, Schaub CD, Haines A, et al. Leptin prevents respiratory depression in obesity. Am J Respir Crit Care Med 1999; 159:1477-1484
9. Phipps P, Starritt E, Caterson I, et al. Association of serum leptin with hypoventilation in human obesity. Thorax 2002; 57:75-76
10. Schwab RJ, Gupta KB, Gefter WB, et al. Upper airway and soft tissue anatomy in normal subjects and patients with sleep-disordered breathing; significance of the lateral pharyngeal walls. Am J Respir Crit Care Med 1995; 152:1673-1689
11. Nowbar S, Burkart KM, Gonzales R, et al. Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome. Am J Med 2004; 116:1-7
12. Shimura R, Tatsumi K, Nakamura A, et al. Fat accumulation, leptin, and hypercapnia in obstructive sleep apnea-hypopnea syndrome. Chest 2005; 127:543-549
13. Caro J, Kolaczynski J, Nyce M, et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1997; 348:159-161
14. Schwartz MW, Seeley R. Neuroendocrine responses to starvation and weight loss. N Engl J Med 1997; 336:1802-1811