Myostatin and NF-κB regulate skeletal myogenesis through distinct signaling pathways

Signal Transduction

Volumn 5, Issue 4, 2005, Pages 202-210

  Bakkar, Nadine ^a   Wackerhage, Henning ^b   Guttridge, Denis C ^a,c  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Cachexia; Myogenesis; Myostatin; NF B; Wasting

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MYOSTATIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; MOUSE; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 24944566363     PISSN: 16154053     EISSN: None     Source Type: Journal    
DOI: 10.1002/sita.200400039     Document Type: Article

References (51)

1. Baldwin, A. S. (2001) Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J. Clin. Invest. 107(3): 241-246.
2. Ghosh, S., May, M. J., Kopp, E. B. (1998) NF-kappa B and Rel proteins: evolutionary conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225-260.
3. Karin, M., Ben-Neriah, Y. (2000) Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol. 18: 621-663.
4. Guttridge, D. C. (2004) Signaling pathways weigh in on decisions to make or break skeletal muscle. Curr. Opin. Clin. Nutr. Metab. Care. 7(4): 443-450.
5. Sabourin, L. A., Rudnicki, M. A. (2000) The molecular regulation of myogenesis. Clin. Genet. 57(1): 16-25.
6. Naya, F. S., Olson, E. (1999) MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation. Curr. Opin. Cell Biol. 11(6): 683-688.
7. Guttridge, D. C., Albanese, C., Reuther, J. Y., Pestell, R. G., Baldwin Jr., A. S. (1999) NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 19(8): 5785-5799.
8. Langen, R. C., Schols, A. M., Kelders, M. C., Wouters, E. F., Janssen-Heininger, Y. M. (2001) Inflammatory cytokines inhibit myogenic differentiation through activation of nuclear factor-kappaB. FASEB J. 15(7): 1169-1180.
9. Guttridge, D. C., Mayo, M. W., Madrid, L. V., Wang, C.-Y., Baldwin Jr., A. S. (2000) NF-kB-Induced Loss of MyoD Messenger RNA: Possible Role in Muscle Decay and Cachexia. Science 289(5488): 2363-2366.
10. Lee, K. H., Kim, D. G., Shin, N. Y., Song, W. K., Kwon, H., Chung, C. H., Kang, M. S. (1997) NF-kappaB-dependent expression of nitric oxide synthase is required for membrane fusion of chick embryonic myoblasts. Biochem. J. 324 (Pt 1): 237-242.
11. Kim, S. S., Rhee, S., Lee, K. H., Kim, J. H., Kim, H. S., Kang, M. S., Chung, C. H. (1998) Inhibitors of the proteasome block the myogenic differentiation of rat L6 myoblasts. FEBS Lett. 433(1-2): 47-50.
12. Kaliman, P., Canicio, J., Testar, X., Palacin, M., Zorzano, A. (1999) Insulin-like growth factor-II, phosphatidylinositol 3-kinase, nuclear factor-kappaB and inducible nitric-oxide synthase define a common myogenic signaling pathway. J. Biol. Chem. 274(25): 17437-17444.
13. Li, Y. P., Schwartz, R. J., Waddell, I. D., Holloway, B. R., Reid, M. B. (1998) Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha. FASEB J. 12(10): 871-880.
14. Li, Y. P., Reid, M. B. (2000) NF-kappaB mediates the protein loss induced by TNF-alpha in differentiated skeletal muscle myotubes. Am. J. Physiol. Regul. Integr. Comp. Physiol. 279(4): R11650-11670.
15. Acharyya, S., Ladner, K. J., Nelsen, L. L., Damrauer, J., Reiser, P. J., Swoap, S., Guttridge, D. C. (2004) Cancer cachexia is regulated by selective targeting of skeletal muscle gene products. J. Clin. Invest. 114(3): 370-378.
16. Ladner, K. J., Caligiuri, M. A., Guttridge, D. C. (2003) Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products. J. Biol. Chem. 278(4): 2294-2303.
17. Cai, D., Frantz, J. D., Tawa, N. E., Jr., Melendez, P. A., Oh, B.-C., Lidov, W. R., Hasselgren, P. O., Frontera, W. R., Lee, J., Glass, D. J., Shoelson, S. E. (2004) IKKbeta/NF-kB activation causes severe muscle wasting in mice. Cell 119: 285-298.
18. Sandri, M., Sandri, C., Gilbert, A., Skurk, C., Calabria, E., Picard, A., Walsh, K., Schiaffino, S., Lecker, S. H., Goldberg, A. L. (2004) Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117(3): 399-412.
19. Hunter, R. B., Kandarian, S. C. (2004) Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. J. Clin. Invest. 114(10): 1504-1511.
20. Kumar, A., Boriek, A. M. (2003) Mechanical stress activates the nuclear factor-kappaB pathway in skeletal muscle fibers: a possible role in Duchenne muscular dystrophy. FASEB J. 17(3): 386-396.
21. Monici, M. C., Aguennouz, M., Mazzeo, A., Messina, C., Vita, G. (2003) Activation of nuclear factor-kappaB in inflammatory myopathies and Duchenne muscular dystrophy. Neurology 60(6): 993-997.
22. Lee, S.-J. (2004) Regulation of Muscle Mass by Myostatin. Ann. Rev. Cell Dev. Biol. 20: 61-86.
23. Gonzalez-Cadavid, N. F, Bhasin, S. (2004) Role of myostatin in metabolism. Curr. Opin. Clin. Nutr. Metab. Care. 7(4): 451-457.
24. Schuelke, M., Wagner, K. R., Stolz, L. E., Hubner, C., Riebel, T., Komen, W., Braun, T., Tobin, J. F., Lee, S. J. (2004) Myostatin mutation associated with gross muscle hypertrophy in a child. N. Engl. J. Med. 350(26): 2682-2688.
25. Reardon, K. A., Davis, J., Kapsa, R. M., Choong, P., Byrne, E. (2001) Myostatin, insulin-like growth factor-1, and leukemia inhibitory factor mRNAs are upregulated in chronic human disuse muscle atrophy. Muscle Nerve. 24(7): 893-899.
26. Zachwieja, J. J., Smith, S. R., Sinha-Hikim, I., Gonzalez-Cadavid, N., Bhasin, S. (1999) Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration. J. Grav. Physiol. 6(2): 11-15.
27. Gonzalez-Cadavid, N. F., Taylor, W. E., Yarasheski, K., Sinha-Hikim, I., Ma, K., Ezzat, S., Shen, R., Lalani, R., Asa, S., Mamita, M., Nair, G., Arver, S., Bhasin, S. (1998) Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc. Natl. Acad Sci. U.S.A. 95(25): 14938-14943.
28. Whittemore, L. A., Song, K., Li, X., Aghajanian, J., Davies, M., Girgenrath, S., Hill, J. J., Jalenak, M., Kelley, P., Knight, A., Maylor, R., O'Hara, D., Pearson, A., Quazi, A., Ryerson, S., Tan, X. Y., Tomkinson, K. N., Veldman, G. M., Widom, A., Wright, J. F., Wudyka, S., Zhao, L., Wolfman, N. M. (2003) Inhibition of myostatin in adult mice increases skeletal muscle mass and strength. Biochem. Biophys. Res. Commun. 300(4): 965-971.
29. Wagner, K. R., McPherron, A. C., Winik, N., Lee, S. J. (2002) Loss of myostatin attenuates severity of muscular dystrophy in mdx mice. Ann. Neurol. 52(6): 832-836.
30. Bogdanovich, S., Krag, T. O., Barton, E. R., Morris, L. D., Whittemore, L. A., Ahima, R. S., Khurana, T. S. (2002) Functional improvement of dystrophic muscle by myostatin blockade. Nature 420(6914): 418-4121.
31. Zimmers, T. A., Davies, M. V., Koniaris, L. G., Haynes, P., Esquela, A. F., Tomkinson, K. N., McPherron, A. C., Wolfman, N. M., Lee, S. J. (2002) Induction of cachexia in mice by systemically administered myostatin. Science 296 (5572): 1486-1488.
32. Thomas, M., Langley, B., Berry, C., Sharma, M., Kirk, S., Bass, J., Kambadur, R. (2000) Myostatin, a negative regulator of muscle growth, functions by inhibiting myoblast proliferation. J. BiOl. Chem. 275(51): 40235-40243.
33. Rios, R., Carneiro, I., Arce, V. M., Devesa, J. (2002) Myostatin is an inhibitor of myogenic differentiation. Am. J. Physiol. Cell Physiol. 282(5): C993-C999.
34. Joulia, D., Bernardi, H., Garandel, V., Rabenoelina, F., Vernus, B., Cabello, G. (2003) Mechanisms involved in the inhibition of myoblast proliferation and differentiation by myostatin. Exp. Cell Res. 286(2): 263-275.
35. McCroskery, S., Thomas, M., Maxwell, L., Sharma, M., Kambadur, R. (2003) Myostatin negatively regulates satellite cell activation and self-renewal. J. Cell Biol. 162(6): 1135-1147.
36. Langley, B., Thomas, M., Bishop, A., Sharma, M., Gilmour, S., Kambadur, R. (2002) Myostatin inhibits myoblast differentiation by down-regulating MyoD expression. J Biol. Chem. 277(51): 49831-49840.
37. Zhu, X., Topouzis, S., Liang, L. F., Stotish, R. L. (2004) Myostatin signaling through Smad2, Smad3 and Smad4 is regulated by the inhibitory Smad7 by a negative feedback mechanism. Cytokine 26(6): 262-272.
38. Kon, A., Vindevoghel, L., Kouba, D. J., Fujimura, Y., Uitto, J., Mauviel, A. (1999) Cooperation between SMAD and NF-kappaB in growth factor regulated type VII collagen gene expression. Oncogene 18(10): 1837-1844.
39. Huber, M. A., Azoitei, N., Baumann, B., Grunert, S., Sommer, A., Pehamberger, H., Kraut, N., Beug, H., Wirth, T. (2004) NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J. Clin. Invest. 114(4): 569-581.
40. Ma, K., Mallidis, C., Artaza, J., Taylor, W., Gonzalez-Cadavid, N., Bhasin, S. (2001) Characterization of 5′-regulatory region of human myostatin gene: regulation by dexamethasone in vitro. Am. J. Physiol. Endocrinol. Metab. 281(6): E1128-E1136.
41. Arsura, M., Wu, M., Sonenshein, G. E. (1996) TGF beta 1 inhibits NF-kappa B/Rel activity inducing apoptosis of B cells: transcriptional activation of I kappa B alpha. Immunity 5(1): 31-40.
42. Bitzer, M., von Gersdorff, G., Liang, D., Dominguez-Rosales, A., Beg, A. A., Rojkind, M., Bottinger, E. P. (2000) A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA. Genes Dev. 14(2): 187-197.
43. Conejo, R., Valverde, A. M., Benito, M., Lorenzo, M. (2001) Insulin produces myogenesis in C2C12 myoblasts by induction of NF-kappaB and downregulation of AP-1 activities. J. Cell. Physiol. 186(1): 82-94.
44. Madrid, L. V., Wang, C. Y., Guttridge, D. C., Schottelius, A. J., Baldwin Jr., A. S., Mayo, M.W. (2000) Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol. Cell. Biol. 20(5): 1626-1638.
45. Arsura, M., Panta, G. R., Bilyeu, J. D., Cavin, L. G., Sovak, M. A., Oliver, A. A., Factor, V., Heuchel, R., Mercurio, F., Thorgeirsson, S. S., Sonenshein, G. E. (2003) Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation. Oncogene 22(3): 412-425.
46. McKinnell, I. W., Rudnicki, M. A. (2004) Molecular mechanisms of muscle atrophy. Cell 119(7): 907-910.
47. Rios, R., Fernandez-Nocelos, S., Carneiro, I., Arce, V. M., Devesa, J. (2004) Differential response to exogenous and endogenous myostatin in myoblasts suggests that myostatin acts as an autocrine factor in vivo. Endocrinology 145(6): 2795-2803.
48. Bengal, E., Ransone, L., Scharfmann, R., Dwarki, V. J., Tapscott, S. J., Weintraub, H., Verma, I. M. (1992) Functional antagonism between c-Jun and MyoD proteins: a direct physical association. Cell. 68(3): 507-519.
49. Hirsinger, E., Malapert, P., Dubrulle, J., Delfini, M. C., Duprez, D., Henrique, D., Ish-Horowicz, D., Pourquie, O. (2001) Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation. Development 128(1): 107-116.
50. Spiller, M. P., Kambadur, R., Jeanplong, F., Thomas, M., Martyn, J. K., Bass, J. J., Sharma, M. (2002) The myostatin gene is a downstream target gene of basic helix-loop-helix transcription factor MyoD. Mol. Cell. Biol. 22(20): 7066-7082.
51. Kocamis, H., Gulmez, N., Aslan, S., Nazli, M. (2004) Follistatin alters myostatin gene expression in C2C12 muscle cells. Acta Vet. Hung. 52(2): 135-141.