Effect of acute hyperhomocysteinemia on methylation potential of erythrocytes and on DNA methylation of lymphocytes in healthy male volunteers

American Journal of Physiology - Renal Physiology

Volumn 289, Issue 4 58-4, 2005, Pages

  Fux, R ^a   Kloor, D ^a   Hermes, M ^a   Rock T ^a   Proksch, B ^a   Grenz, A ^a   Delabar, U ^a   Bucheler R ^a   Igel, S ^a   Morike K ^a   Gleiter, C H ^a   Osswald, H ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYTOSINE; DNA; HOMOCYSTEINE; INULIN; PLACEBO; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE;

ADULT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DNA METHYLATION; ERYTHROCYTE; GENOTYPE; GLOMERULUS FILTRATION RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; HYPERHOMOCYSTEINEMIA; INULIN CLEARANCE; LYMPHOCYTE; MALE; METABOLITE; METHYLATION; NORMAL HUMAN; PRIORITY JOURNAL; URINALYSIS; URINE LEVEL;

EID: 24944541423     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00465.2004     Document Type: Article

References (37)

1. Bostom A, Brosnan JT, Hall B, Nadeau MR, and Selhub J. Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis 116: 59-62, 1995.
2. Bostom AG and Culleton BF. Hyperhomocysteinemia in chronic renal disease. J Am Soc Nephrol 10: 891-900, 1999.
3. Brattström L, Wilcken DE, Ohrvik J, and Brudin L. Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation 98: 2520-2526, 1998.
4. Brosnan JT, Jacobs RL, Stead LM, and Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol 51: 405-413, 2004.
5. Clarke S and Banfield K. S-adenosylmethionine-dependent methyltransferases. In: Homocysteine in Health and Disease, edited by Carmel R and Jacobson DW. Cambridge, UK: Cambridge University Press. 2001, p. 63-78.
6. Delabar U, Kloor D, Luippold G, and Mühlbauer B. Simultaneous determination of adenosine, S-adenosylhomocysteine and S-adenosylmethionine in biological samples using solid-phase extraction and high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 724: 231-238, 1999.
7. Du Bois D and du Bois EF. A formula to estimate the approximate surface area if height and weight be known. Arch Int Med 17: 863-871, 1916.
8. Finkelstein JD. Pathways and regulation of homocysteine metabolism in mammals. Semin Thromb Hemost 26: 219-225, 2000.
9. Fux R, Biedermann T, Sander-Wiecker T, Mörike K, and Gleiter CH. Anaphylaxis to intravenous sinistrin. Ann Pharmacother 38: 2175-2176, 2004.
10. Guttormsen AB, Mansoor AM, Fiskerstrand T, Ueland PM, and Refsum H. Kinetics of plasma homocysteine in healthy subjects after peroral homocysteine loading. Clin Chem 39: 1390-1397, 1993.
11. Guttormsen AB, Schneede J, Fiskerstrand T, Ueland PM, and Refsum HM. Plasma concentrations of homocysteine and other aminothiol compounds are related to food intake in healthy human subjects. J Nutr 124: 1934-1941, 1994.
12. Guttormsen AB, Schneede J, Ueland PM, and Refsum H. Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency. Am J Clin Nutr 63: 194-202, 1996.
13. Hankey GJ and Eikelboom JW. Homocysteine and vascular disease. Lancet 354: 407-413, 1999.
14. Hermes M, Osswald H, Mattar J, and Kloor D. Influence of an altered methylation potential on mRNA methylation and gene expression in HepG2 cells. Exp Cell Res 294: 325-334, 2004.
15. House JD, Brosnan ME, and Brosnan JT. Renal uptake and excretion of homocysteine in rats with acute hyperhomocysteinemia. Kidney Int 54: 1601-1607, 1998.
16. Jacob RA, Gretz DM, Taylor PC, James SJ, Pogribny IP, Miller BJ, Henning SM, and Swendseid ME. Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr 128: 1204-1212, 1998.
17. Kloor D, Fuchs S, Petroktistis F, Delabar U, Mühlbauer B, Quast U, and Osswald H. Effects of ions on adenosine binding and enzyme activity of purified S-adenosylhomocysteine hydrolase from bovine kidney. Biochem Pharmacol 56: 1493-1496, 1998.
18. Kramer DL, Porter CW, Borchardt RT, and Sufrin JR. Combined modulation of S-adenosylmethionine biosynthesis and S-adenosylhomocysteine metabolism enhances inhibition of nucleic acid methylation and L1210 cell growth. Cancer Res 50: 3838-3842, 1990.
19. Massy ZA. Hyperhomocyst(e)inaemia in renal failure-what are the implications? Nephrol Dial Transplant 11: 2392-2393, 1996.
20. Nygård O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, and Vollset SE. Plasma homocysteine levels and mortality in patients with coronary artery disease. N Engl J Med 337: 230-236, 1997.
21. Perna AF, Ingrosso D, De Santo NG, Galletti P, and Zappia V. Mechanism of erythrocyte accumulation of methylation inhibitor S-adenosylhomocysteine in uremia. Kidney Int 47: 247-253, 1995.
22. Perna AF, Ingrosso D, Satta E, Lombardi C, Acanfora F, and De Santo NG. Homocysteine metabolism in renal failure. Curr Opin Clin Nutr Metab Care 7: 53-57, 2004.
23. Pogribny I, Yi P, and James SJ. A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands. Biochem Biophys Res Commun 262: 624-628, 1999.
24. Refsum H, Helland S, and Ueland PM. Radioenzymic determination of homocysteine in plasma and urine. Clin Chem 31: 624-628, 1985.
25. Selhub J and Miller JW. The pathogenesis of homocysteinemia: interruption of the coordinate regulation by S-adenosylmethionine of the remethylation and transsulfuration of homocysteine. Am J Clin Nutr 55: 131-138, 1992.
26. Stam F, van Guldener C, ter Wee PM, Kulik W, Smith DE, Jakobs C, Stehouwer CD, and de Meer K. Homocysteine clearance and methylation flux rates in health and end-stage renal disease: association with S-adenosylhomocysteine. Am J Physiol Renal Physiol 287: F215-F223, 2004.
27. Thambyrajah J, Landray MJ, McGlynn FJ, Jones HJ, Wheeler DC, and Townend JN. Does folic acid decrease plasma homocysteine and improve endothelial function in patients with predialysis renal failure? Circulation 102: 871-875, 2000.
28. Toole JF, Malinow MR, Chambless LE, Spence JD, Pettigrew LC, Howard VJ, Sides EG, Wang CH, and Stampfer M. Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial. JAMA 291: 565-575, 2004.
29. Tsai JC, Perrella MA, Yoshizumi M, Hsieh CM, Haber E, Schlegel R, and Lee ME. Promotion of vascular smooth muscle cell growth by homocysteine: a link to atherosclerosis. Proc Natl Acad Sci USA 91: 6369-6373, 1994.
30. Ubbink JB, Vermaak WJ, van der Merwe A, and Becker PJ. The effect of blood sample aging and food consumption on plasma total homocysteine levels. Clin Chim Acta 207: 119-128, 1992.
31. Ueland PM. Pharmacological and biochemical aspects of S-adenosylhomocysteine and S-adenosylhomocysteine hydrolase. Pharmacol Rev 34: 223-253, 1982.
32. Van Guldener C, Donker AJ, Jakobs C, Teerlink T, de Meer K, and Stehouwer CD. No net renal extraction of homocysteine in fasting humans. Kidney Int 54: 166-169, 1998.
33. Van Guldener C, Kulik W, Berger R, Dijkstra DA, Jakobs C, Reijngoud DJ, Donker AJ, Stehouwer CD, and De Meer K. Homocysteine and methionine metabolism in ESRD: a stable isotope study. Kidney Int 56: 1064-1071, 1999.
34. Wahler BE. Determination of 2-20 micrograms of insulin in animal tissue. Hoppe Seylers Z Physiol Chem 306: 84-89, 1956.
35. Winkelmayer WC, Kramar R, Curhan GC, Chandraker A, Endler G, Födinger M, Hörl WH, and Sunder-Plassmann G. Fasting plasma total homocysteine levels and mortality and allograft loss in kidney transplant recipients: a prospective study. J Am Soc Nephrol 16: 255-260, 2005.
36. Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, and James SJ. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. J Biol Chem 275: 29318-29323, 2000.
37. Zhang Z, Liu W, Jia X, Gao Y, Hemminki K, and Lindholm B. Use of pyrosequencing to detect clinically relevant polymorphisms of genes in basal cell carcinoma. Clin Chim Acta 342: 137-143, 2004.