The systemic inflammatory response syndrome and cardiopulmonary bypass

International Journal of Surgery

Volumn 3, Issue 2, 2005, Pages 129-140

  Day, J R S ^a   Taylor, K M ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Cardiac surgery; Cardiopulmonary bypass; Inflammation; SIRS

Indexed keywords

APROTININ; COMPLEMENT INHIBITOR; GLUCOCORTICOID; HEPARIN; PEXELIZUMAB; RECOMBINANT ANTIBODY; SERINE PROTEINASE INHIBITOR;

ACUTE PANCREATITIS; CARBOHYDRATE METABOLISM; CARDIOPULMONARY BYPASS; COMPLEMENT SYSTEM; ENDOTHELIUM CELL; HEART SURGERY; HEMOSTASIS; HUMAN; INFLAMMATION; LEUKOCYTE; LIPID METABOLISM; MORBIDITY; NONHUMAN; OFF PUMP SURGERY; OPSONIZATION; PRIORITY JOURNAL; PROTEIN METABOLISM; REVIEW; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THROMBOCYTE;

EID: 24944517058     PISSN: 17439191     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijsu.2005.04.002     Document Type: Review

References (111)

1. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis Crit Care Med 20 6 1992 864 874
2. H.R. Roberts, D.M. Monroe, J.A. Oliver, J.Y. Chang, and M. Hoffman Newer concepts of blood coagulation Haemophilia 4 4 1998 331 334
3. E.W. Davie, K. Fujikawa, and W. Kisiel The coagulation cascade: initiation, maintenance, and regulation Biochemistry 30 43 1991 10363 10370
4. B.J. Hunt, R.N. Parratt, H.C. Segal, S. Sheikh, P. Kallis, and M. Yacoub Activation of coagulation and fibrinolysis during cardiothoracic operations Ann Thorac Surg 65 3 1998 712 718
5. A. Greinacher, P. Eichler, N. Lubenow, and V. Kiefel Drug-induced and drug-dependent immune thrombocytopenias Rev Clin Exp Hematol 5 3 2001 166 200
6. J.R.S. Day, A.N. Chaudhry, I. Hunt, and K.M. Taylor Heparin-induced hyperkalemia after cardiac surgery Ann Thorac Surg 74 5 2002 1698 1700
7. R.E. Jordan Antithrombin in vertebrate species: conservation of the heparin-dependent anticoagulant mechanism Arch Biochem Biophys 227 2 1983 587 595
8. R.D. Rosenberg, and P.S. Damus The purification and mechanism of action of human antithrombin-heparin cofactor J Biol Chem 248 18 1973 6490 6505
9. E.G. Levin, U. Marzec, J. Anderson, and L.A. Harker Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cells J Clin Invest 74 6 1984 1988 1995
10. E.M. Cramer, H. Lu, J.P. Caen, C. Soria, M.C. Berndt, and D. Tenza Differential redistribution of platelet glycoproteins Ib and IIb-IIIa after plasmin stimulation Blood 77 4 1991 694 699
11. M.J. Walport Complement. Second of two parts N Engl J Med 344 15 2001 1140 1144
12. M.J. Walport Complement. First of two parts N Engl J Med 344 14 2001 1058 1066
13. Y.T. Wachtfogel, P.C. Harpel, L.H. Edmunds Jr., and R.W. Colman Formation of C1s-C1-inhibitor, kallikrein-C1-inhibitor, and plasmin-alpha 2-plasmin-inhibitor complexes during cardiopulmonary bypass Blood 73 2 1989 468 471
14. N.E. Moat, D.F. Shore, and T.W. Evans Organ dysfunction and cardiopulmonary bypass: the role of complement and complement regulatory proteins Eur J Cardiothorac Surg 7 11 1993 563 573
15. O.W. van, M.D. Kazatchkine, B. scamps-Latscha, F. Maillet, E. Fischer, and A. Carpentier Deleterious effects of cardiopulmonary bypass. A prospective study of bubble versus membrane oxygenation J Thorac Cardiovasc Surg 89 6 1985 888 899
16. J.K. Kirklin, D.E. Chenoweth, D.C. Naftel, E.H. Blackstone, J.W. Kirklin, and D.D. Bitran Effects of protamine administration after cardiopulmonary bypass on complement, blood elements, and the hemodynamic state Ann Thorac Surg 41 2 1986 193 199
17. D.E. Chenoweth, S.W. Cooper, T.E. Hugli, R.W. Stewart, E.H. Blackstone, and J.W. Kirklin Complement activation during cardiopulmonary bypass: evidence for generation of C3a and C5a anaphylatoxins N Engl J Med 304 9 1981 497 503
18. J. Butler, D. Parker, R. Pillai, S. Westaby, D.J. Shale, and G.M. Rocker Effect of cardiopulmonary bypass on systemic release of neutrophil elastase and tumor necrosis factor J Thorac Cardiovasc Surg 105 1 1993 25 30
19. C.S. Rinder, J.L. Bonan, H.M. Rinder, J. Mathew, R. Hines, and B.R. Smith Cardiopulmonary bypass induces leukocyte-platelet adhesion Blood 79 5 1992 1201 1205
20. B. Walcheck, K.L. Moore, R.P. McEver, and T.K. Kishimoto Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro J Clin Invest 98 5 1996 1081 1087
21. A. Shibamiya, N. Tabuchi, J. Chung, M. Sunamori, and T. Koyama Formation of tissue factor-bearing leukocytes during and after cardiopulmonary bypass Thromb Haemost 92 1 2004 124 131
22. A.K. Zimmermann, P. Simon, J. Seeburger, J. Hoffmann, G. Ziemer, and H. Aebert Cytokine gene expression in monocytes of patients undergoing cardiopulmonary bypass surgery evaluated by real-time PCR J Cell Mol Med 7 2 2003 146 156
23. S.K. Law, K.J. Micklem, J.M. Shaw, X.P. Zhang, Y. Dong, and A.C. Willis A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily Eur J Immunol 23 9 1993 2320 2325
24. M. Kristiansen, J.H. Graversen, C. Jacobsen, O. Sonne, H.J. Hoffman, and S.K. Law Identification of the haemoglobin scavenger receptor Nature 409 6817 2001 198 201
25. S.M. Sadrzadeh, E. Graf, S.S. Panter, P.E. Hallaway, and J.W. Eaton Hemoglobin. A biologic fenton reagent J Biol Chem 259 23 1984 14354 14356
26. S.K. Lim, H. Kim, S.K. Lim, A.A. bin, Y.K. Lim, and Y. Wang Increased susceptibility in Hp knockout mice during acute hemolysis Blood 92 6 1998 1870 1877
27. P. Philippidis, J.C. Mason, B.J. Evans, I. Nadra, K.M. Taylor, and D.O. Haskard Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery Circ Res 94 1 2004 119 126
28. K.D. Patel, S.L. Cuvelier, and S. Wiehler Selectins: critical mediators of leukocyte recruitment Semin Immunol 14 2 2002 73 81
29. T.A. Springer Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm Cell 76 2 1994 301 314
30. M.L. Arbones, D.C. Ord, K. Ley, H. Ratech, C. Maynard-Curry, and G. Otten Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin-deficient mice Immunity 1 4 1994 247 260
31. M.A. Labow, C.R. Norton, J.M. Rumberger, K.M. Lombard-Gillooly, D.J. Shuster, and J. Hubbard Characterization of E-selectin-deficient mice: demonstration of overlapping function of the endothelial selectins Immunity 1 8 1994 709 720
32. T.N. Mayadas, R.C. Johnson, H. Rayburn, R.O. Hynes, and D.D. Wagner Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice Cell 74 3 1993 541 554
33. J.R. Day, R.C. Landis, and K.M. Taylor Heparin is much more than just an anticoagulant J Cardiothorac Vasc Anesth 18 1 2004 93 100
34. V.A. Ferraris, S.P. Ferraris, A. Singh, W. Fuhr, D. Koppel, and D. McKenna The platelet thrombin receptor and postoperative bleeding Ann Thorac Surg 65 2 1998 352 358
35. R. Mohr, U. Martinowitz, M. Golan, L. Ayala, D.A. Goor, and B. Ramot Platelet size and mass as an indicator for platelet transfusion after cardiopulmonary bypass Circulation 74 5 Pt 2 1986 III153 III158
36. J. Boldt, C. Knothe, I. Welters, F.L. Dapper, and G. Hempelmann Normothermic versus hypothermic cardiopulmonary bypass: do changes in coagulation differ? Ann Thorac Surg 62 1 1996 130 135
37. C.H. Gemmell, S.M. Ramirez, E.L. Yeo, and M.V. Sefton Platelet activation in whole blood by artificial surfaces: identification of platelet-derived microparticles and activated platelet binding to leukocytes as material-induced activation events J Lab Clin Med 125 2 1995 276 287
38. P. Gluszko, B. Rucinski, J. Musial, R.K. Wenger, A.H. Schmaier, and R.W. Colman Fibrinogen receptors in platelet adhesion to surfaces of extracorporeal circuit Am J Physiol 252 3 Pt 2 1987 H615 H621
39. A. Weerasinghe, and K.M. Taylor The platelet in cardiopulmonary bypass Ann Thorac Surg 66 6 1998 2145 2152
40. D.S. Holloway, L. Summaria, J. Sandesara, J.P. Vagher, J.C. Alexander, and J.A. Caprini Decreased platelet number and function and increased fibrinolysis contribute to postoperative bleeding in cardiopulmonary bypass patients Thromb Haemost 59 1 1988 62 67
41. C. Kondo, K. Tanaka, K. Takagi, T. Shimono, H. Shinpo, and I. Yada Platelet dysfunction during cardiopulmonary bypass surgery. With special reference to platelet membrane glycoproteins ASAIO J 39 3 1993 M550 M553
42. M.J. Metzelaar, J. Korteweg, J.J. Sixma, and H.K. Nieuwenhuis Comparison of platelet membrane markers for the detection of platelet activation in vitro and during platelet storage and cardiopulmonary bypass surgery J Lab Clin Med 121 4 1993 579 587
43. E. Larsen, A. Celi, G.E. Gilbert, B.C. Furie, J.K. Erban, and R. Bonfanti PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes Cell 59 2 1989 305 312
44. F.J. Neumann, N. Marx, M. Gawaz, K. Brand, I. Ott, and C. Rokitta Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets Circulation 95 10 1997 2387 2394
45. A.S. Weyrich, M.R. Elstad, R.P. McEver, T.M. McIntyre, K.L. Moore, and J.H. Morrissey Activated platelets signal chemokine synthesis by human monocytes J Clin Invest 97 6 1996 1525 1534
46. A. Celi, G. Pellegrini, R. Lorenzet, A. De Blasi, N. Ready, and B.C. Furie P-selectin induces the expression of tissue factor on monocytes Proc Natl Acad Sci U S A 91 19 1994 8767 8771
47. T. Palabrica, R. Lobb, B.C. Furie, M. Aronovitz, C. Benjamin, and Y.M. Hsu Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets Nature 359 6398 1992 848 851
48. V. Henn, J.R. Slupsky, M. Grafe, I. Anagnostopoulos, R. Forster, and G. Muller-Berghaus CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells Nature 391 6667 1998 591 594
49. G.D. Angelini, F.C. Taylor, B.C. Reeves, and R. Ascione Early and midterm outcome after off-pump and on-pump surgery in Beating Heart Against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomised controlled trials Lancet 359 9313 2002 1194 1199
50. R. Ascione, C.T. Lloyd, W.J. Gomes, M. Caputo, A.J. Bryan, and G.D. Angelini Beating versus arrested heart revascularization: evaluation of myocardial function in a prospective randomized study Eur J Cardiothorac Surg 15 5 1999 685 690
51. R. Ascione, C.T. Lloyd, M.J. Underwood, W.J. Gomes, and G.D. Angelini On-pump versus off-pump coronary revascularization: evaluation of renal function Ann Thorac Surg 68 2 1999 493 498
52. C.T. Lloyd, R. Ascione, M.J. Underwood, F. Gardner, A. Black, and G.D. Angelini Serum S-100 protein release and neuropsychologic outcome during coronary revascularization on the beating heart: a prospective randomized study J Thorac Cardiovasc Surg 119 1 2000 148 154
53. R. Ascione, C.T. Lloyd, M.J. Underwood, A.A. Lotto, A.A. Pitsis, and G.D. Angelini Inflammatory response after coronary revascularization with or without cardiopulmonary bypass Ann Thorac Surg 69 4 2000 1198 1204
54. Z. Xiao, and P. Theroux Platelet activation with unfractionated heparin at therapeutic concentrations and comparisons with a low-molecular-weight heparin and with a direct thrombin inhibitor Circulation 97 3 1998 251 256
55. S. Svenmarker, S. Haggmark, E. Jansson, R. Lindholm, M. Appelblad, and E. Sandstrom Use of heparin-bonded circuits in cardiopulmonary bypass improves clinical outcome Scand Cardiovasc J 36 4 2002 241 246
56. L.B. Mongero, J.R. Beck, H.E. Manspeizer, E.J. Heyer, K. Lee, and T.A. Spanier Cardiac surgical patients exposed to heparin-bonded circuits develop less postoperative cerebral dysfunction than patients exposed to non-heparin-bonded circuits Perfusion 16 2 2001 107 111
57. P.G. Jansen, V.H. te, R.A. Huybregts, R. Paulus, E.R. Bulder, and H.I. van der Spoel Reduced complement activation and improved postoperative performance after cardiopulmonary bypass with heparin-coated circuits J Thorac Cardiovasc Surg 110 3 1995 829 834
58. C.B. Mahoney, and G.M. Lemole Transfusion after coronary artery bypass surgery: the impact of heparin-bonded circuits Eur J Cardiothorac Surg 16 2 1999 206 210
59. A. Belboul, C. Lofgren, C. Storm, and M. Jungbeck Heparin-coated circuits reduce occult myocardial damage during CPB: a randomized, single blind clinical trial Eur J Cardiothorac Surg 17 5 2000 580 586
60. H.L. Lazar, X. Zhang, T. Hamasaki, C.A. Memmelo, P. Treanor, and S. Rivers Heparin-bonded circuits decrease myocardial ischemic damage: an experimental study Ann Thorac Surg 63 6 1997 1701 1705
61. J.O. Defraigne, J. Pincemail, G. Dekoster, R. Larbuisson, M. Dujardin, and F. Blaffart SMA circuits reduce platelet consumption and platelet factor release during cardiac surgery Ann Thorac Surg 70 6 2000 2075 2081
62. M. Sudkamp, U. Mehlhorn, R.M. Reza, K. Hekmat, J. Easo, and H.J. Geissler Cardiopulmonary bypass copolymer surface modification reduces neither blood loss nor transfusions in coronary artery surgery Thorac Cardiovasc Surg 50 1 2002 5 10
63. T. Ikuta, H. Fujii, T. Shibata, K. Hattori, H. Hirai, and H. Kumano A new poly-2-methoxyethylacrylate-coated cardiopulmonary bypass circuit possesses superior platelet preservation and inflammatory suppression efficacy Ann Thorac Surg 77 5 2004 1678 1683
64. A.K. Zimmermann, H. Aebert, A. Reiz, M. Freitag, M. Husseini, and G. Ziemer Hemocompatibility of PMEA coated oxygenators used for extracorporeal circulation procedures ASAIO J 50 3 2004 193 199
65. H. Suhara, Y. Sawa, M. Nishimura, H. Oshiyama, K. Yokoyama, and N. Saito Efficacy of a new coating material, PMEA, for cardiopulmonary bypass circuits in a porcine model Ann Thorac Surg 71 5 2001 1603 1608
66. C. Alexiou, A.A. Tang, S.V. Sheppard, D.C. Smith, R. Gibbs, and S.A. Livesey The effect of leucodepletion on leucocyte activation, pulmonary inflammation and respiratory index in surgery for coronary revascularisation: a prospective randomised study Eur J Cardiothorac Surg 26 2 2004 294 300
67. D.C. Stefanou, T. Gourlay, G. Asimakopoulos, and K.M. Taylor Leucodepletion during cardiopulmonary bypass reduces blood transfusion and crystalloid requirements Perfusion 16 1 2001 51 58
68. A.T. Tang, C. Alexiou, J. Hsu, S.V. Sheppard, M.P. Haw, and S.K. Ohri Leukodepletion reduces renal injury in coronary revascularization: a prospective randomized study Ann Thorac Surg 74 2 2002 372 377
69. A.H. Olivencia-Yurvati, C.A. Ferrara, N. Tierney, N. Wallace, and R.T. Mallet Strategic leukocyte depletion reduces pulmonary microvascular pressure and improves pulmonary status post-cardiopulmonary bypass Perfusion 18 Suppl. 1 2003 23 31
70. K.H. Teoh, C.A. Bradley, J. Gauldie, and H. Burrows Steroid inhibition of cytokine-mediated vasodilation after warm heart surgery Circulation 92 9 Suppl. 1995 II347 II353
71. M.P. Fillinger, A.J. Rassias, P.M. Guyre, J.H. Sanders, M. Beach, and J. Pahl Glucocorticoid effects on the inflammatory and clinical responses to cardiac surgery J Cardiothorac Vasc Anesth 16 2 2002 163 169
72. S. Wan, J.L. LeClerc, D. Schmartz, L. Barvais, C.H. Huynh, and J. Deviere Hepatic release of interleukin-10 during cardiopulmonary bypass in steroid-pretreated patients Am Heart J 133 3 1997 335 339
73. R.M. Engelman, J.A. Rousou, J.E. Flack III, D.W. Deaton, R. Kalfin, and D.K. Das Influence of steroids on complement and cytokine generation after cardiopulmonary bypass Ann Thorac Surg 60 3 1995 801 804
74. G.E. Hill, S. Snider, T.A. Galbraith, S. Forst, and R.A. Robbins Glucocorticoid reduction of bronchial epithelial inflammation during cardiopulmonary bypass Am J Respir Crit Care Med 152 6 Pt 1 1995 1791 1795
75. G.E. Hill, A. Alonso, J.R. Spurzem, A.H. Stammers, and R.A. Robbins Aprotinin and methylprednisolone equally blunt cardiopulmonary bypass-induced inflammation in humans J Thorac Cardiovasc Surg 110 6 1995 1658 1662
76. G.E. Hill, A. Alonso, G.M. Thiele, and R.A. Robbins Glucocorticoids blunt neutrophil CD11b surface glycoprotein upregulation during cardiopulmonary bypass in humans Anesth Analg 79 1 1994 23 27
77. T. Kawamura, K. Inada, H. Okada, K. Okada, and R. Wakusawa Methylprednisolone inhibits increase of interleukin 8 and 6 during open heart surgery Can J Anaesth 42 5 Pt 1 1995 399 403
78. P. Toft, K. Christiansen, E. Tonnesen, C.H. Nielsen, and S. Lillevang Effect of methylprednisolone on the oxidative burst activity, adhesion molecules and clinical outcome following open heart surgery Scand Cardiovasc J 31 5 1997 283 288
79. M.J. London, G.K. Grunwald, A.L. Shroyer, and F.L. Grover Association of fast-track cardiac management and low-dose to moderate-dose glucocorticoid administration with perioperative hyperglycemia J Cardiothorac Vasc Anesth 14 6 2000 631 638
80. M.A. Chaney, M.P. Nikolov, B. Blakeman, M. Bakhos, and S. Slogoff Pulmonary effects of methylprednisolone in patients undergoing coronary artery bypass grafting and early tracheal extubation Anesth Analg 87 1 1998 27 33
81. E.D. Verrier, S.K. Shernan, K.M. Taylor, W.F. Van de, M.F. Newman, and J.C. Chen Terminal complement blockade with pexelizumab during coronary artery bypass graft surgery requiring cardiopulmonary bypass: a randomized trial JAMA 291 19 2004 2319 2327
82. G.C. Castiglioni, L. Lojacono, and G. Tamborini Effects of trypsin and kallikrein inhibition in acute pancreatitis Arch Ital Chir 91 4 1965 365 376
83. D. Royston, B.D. Bidstrup, K.M. Taylor, and R.N. Sapsford Aprotinin decreases the need for post-operative blood transfusions in patients having open heart surgery Bibl Cardiol 43 1988 73 82
84. D. Royston, B.P. Bidstrup, K.M. Taylor, and R.N. Sapsford Effect of aprotinin on need for blood transfusion after repeat open-heart surgery Lancet 2 8571 1987 1289 1291
85. B.P. Bidstrup, D. Royston, R.N. Sapsford, and K.M. Taylor Reduction in blood loss and blood use after cardiopulmonary bypass with high dose aprotinin (Trasylol) J Thorac Cardiovasc Surg 97 3 1989 364 372
86. B.P. Bidstrup, J. Harrison, D. Royston, K.M. Taylor, and T. Treasure Aprotinin therapy in cardiac operations: a report on use in 41 cardiac centers in the United Kingdom Ann Thorac Surg 55 4 1993 971 976
87. M.P. Savage, D.L. Fischman, R. Rake, M.B. Leon, R.A. Schatz, and I. Penn Efficacy of coronary stenting versus balloon angioplasty in small coronary arteries. Stent Restenosis Study (STRESS) Investigators J Am Coll Cardiol 31 2 1998 307 311
88. W. van Oeveren, N.J. Jansen, B.P. Bidstrup, D. Royston, S. Westaby, and H. Neuhof Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass Ann Thorac Surg 44 6 1987 640 645
89. R.J. Porte, I.Q. Molenaar, B. Begliomini, T.H. Groenland, A. Januszkiewicz, and L. Lindgren Aprotinin and transfusion requirements in orthotopic liver transplantation: a multicentre randomised double-blind study. EMSALT Study Group Lancet 355 9212 2000 1303 1309
90. R. Jeserschek, H. Clar, C. Aigner, P. Rehak, B. Primus, and R. Windhager Reduction of blood loss using high-dose aprotinin in major orthopaedic surgery: a prospective, double-blind, randomised and placebo-controlled study J Bone Joint Surg Br 85 2 2003 174 177
91. A. von Berghoff, and U. Glatzel Inhibition of the fibrinolytic potential by Trasylol Med Klin 12 1963 476
92. H. Nagaoka, R. Innami, F. Murayama, N. Funakoshi, K. Hirooka, and M. Watanabe Effects of aprotinin on prostaglandin metabolism and platelet function in open heart surgery J Cardiovasc Surg (Torino) 32 1 1991 31 37
93. W. van Oeveren, M.P. Harder, K.J. Roozendaal, L. Eijsman, and C.R. Wildevuur Aprotinin protects platelets against the initial effect of cardiopulmonary bypass J Thorac Cardiovasc Surg 99 5 1990 788 796
94. C.R. Wildevuur, L. Eijsman, K.J. Roozendaal, M.P. Harder, M. Chang, and W. van Oeveren Platelet preservation during cardiopulmonary bypass with aprotinin Eur J Cardiothorac Surg 3 6 1989 533 537
95. Y.T. Wachtfogel, C. Kettner, C.E. Hack, J.H. Nuijens, T.M. Reilly, and R.M. Knabb Thrombin and human plasma kallikrein inhibition during simulated extracorporeal circulation block platelet and neutrophil activation Thromb Haemost 80 4 1998 686 691
96. I. Weide, J. Romisch, and T. Simmet Contact activation triggers stimulation of the monocyte 5-lipoxygenase pathway via plasmin Blood 83 7 1994 1941 1951
97. J.M. Murkin, J. Maurer, and S. Niemcryk Full dose aprotinin administration is associated with a significant decrease in perioperative stroke in patients undergoing elective cardiac surgery: a meta-analysis Ann Thorac Surg 73 1 2002 S374
98. J.R. Day, P.P. Punjabi, A.M. Randi, D.O. Haskard, R.C. Landis, and K.M. Taylor Clinical inhibition of the seven-transmembrane thrombin receptor (PAR1) by intravenous aprotinin during cardiothoracic surgery Circulation 2004
99. M. Poullis, R. Manning, M. Laffan, D.O. Haskard, K.M. Taylor, and R.C. Landis The antithrombotic effect of aprotinin: actions mediated via the proteaseactivated receptor 1 J Thorac Cardiovasc Surg 120 2 2000 370 378
100. T.K. Vu, D.T. Hung, V.I. Wheaton, and S.R. Coughlin Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation Cell 64 6 1991 1057 1068
101. C.E. Junge, T. Sugawara, G. Mannaioni, S. Alagarsamy, P.J. Conn, and D.J. Brat The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia Proc Natl Acad Sci U S A 100 22 2003 13019 13024
102. K. Jurk, U.R. Jahn, H. Van Aken, C. Schriek, D.W. Droste, and M.A. Ritter Platelets in patients with acute ischemic stroke are exhausted and refractory to thrombin, due to cleavage of the seven-transmembrane thrombin receptor (PAR-1) Thromb Haemost 91 2 2004 334 344
103. G. Asimakopoulos, R. Thompson, S. Nourshargh, E.A. Lidington, J.C. Mason, and C.P. Ratnatunga An anti-inflammatory property of aprotinin detected at the level of leukocyte extravasation J Thorac Cardiovasc Surg 120 2 2000 361 369
104. T. Ege, C. Arar, S. Canbaz, M. Cikirikcioglu, H. Sunar, and V. Yuksel The importance of aprotinin and pentoxifylline in preventing leukocyte sequestration and lung injury caused by protamine at the end of cardiopulmonary bypass surgery Thorac Cardiovasc Surg 52 1 2004 10 15
105. P.E. Greilich, C.F. Brouse, C.W. Whitten, L. Chi, J.M. Dimaio, and M.E. Jessen Antifibrinolytic therapy during cardiopulmonary bypass reduces proinflammatory cytokine levels: a randomized, double-blind, placebo-controlled study of epsilon-aminocaproic acid and aprotinin J Thorac Cardiovasc Surg 126 5 2003 1498 1503
106. G.E. Hill, R.P. Diego, A.H. Stammers, S.M. Huffman, and R. Pohorecki Aprotinin enhances the endogenous release of interleukin-10 after cardiac operations Ann Thorac Surg 65 1 1998 66 69
107. G.E. Hill, R. Pohorecki, A. Alonso, S.I. Rennard, and R.A. Robbins Aprotinin reduces interleukin-8 production and lung neutrophil accumulation after cardiopulmonary bypass Anesth Analg 83 4 1996 696 700
108. G. Asimakopoulos, A. Kohn, D.C. Stefanou, D.O. Haskard, R.C. Landis, and K.M. Taylor Leukocyte integrin expression in patients undergoing cardiopulmonary bypass Ann Thorac Surg 69 4 2000 1192 1197
109. D.C. Altieri, J.H. Morrissey, and T.S. Edgington Adhesive receptor Mac-1 coordinates the activation of factor X on stimulated cells of monocytic and myeloid differentiation: an alternative initiation of the coagulation protease cascade Proc Natl Acad Sci U S A 85 20 1988 7462 7466
110. D.C. Altieri, R. Bader, P.M. Mannucci, and T.S. Edgington Oligospecificity of the cellular adhesion receptor Mac-1 encompasses an inducible recognition specificity for fibrinogen J Cell Biol 107 5 1988 1893 1900
111. T. Ueda, P. Rieu, J. Brayer, and M.A. Arnaout Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18) Proc Natl Acad Sci U S A 91 22 1994 10680 10684