Bioactivation of morphine in human liver: Isolation and identification of morphinone, a toxic metabolite

Biological and Pharmaceutical Bulletin

Volumn 28, Issue 7, 2005, Pages 1275-1280

  Todaka, Takashi ^a   Ishida, Takashi ^a   Kita, Hideki ^a   Narimatsu, Shizuo ^b   Yamano, Shigeru ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Human liver; Metabolic activation; Morphine 6 dehydrogenase; Morphine metabolism; Morphinone

Indexed keywords

5BETA ANDROSTANOLONE; ANDROSTANOLONE; ANDROSTERONE; BARBITAL; CHENODEOXYCHOLIC ACID; CHOLIC ACID; EPIANDROSTERONE; ESTRADIOL; INDOMETACIN; KETAMINE; LITHOCHOLIC ACID; MERCAPTOETHANOL; MORPHINE; MORPHINONE; NALOXONE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PYRAZOLE; STEROID; TESTOSTERONE;

ADULT; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME MECHANISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; MASS SPECTROMETRY; MICROSOME; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SUPERNATANT;

EID: 24944505992     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.28.1275     Document Type: Article

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