-
1
-
-
0027250487
-
Different biotransformation of morphine in isolated liver cells from guinea pig and rat
-
AASMUNDSTAD, T. A., RIPEL, Å., BODD, E., BJØNEBOE, A. and MØRLAND, J., 1993, Different biotransformation of morphine in isolated liver cells from guinea pig and rat. Biochemical Pharmacology, 46, 961-968.
-
(1993)
Biochemical Pharmacology
, vol.46
, pp. 961-968
-
-
Aasmundstad, T.A.1
Ripel, Å.2
Bodd, E.3
Bjøneboe, A.4
Mørland, J.5
-
2
-
-
0025352372
-
Sex differences and endocrine regulation of morphine oxidation in rat liver
-
BLANCK, A., HANSSON, T., NÄSLUND, B. and RANE, A., 1990, Sex differences and endocrine regulation of morphine oxidation in rat liver. Biochemical Pharmacology, 39, 1820-1822.
-
(1990)
Biochemical Pharmacology
, vol.39
, pp. 1820-1822
-
-
Blanck, A.1
Hansson, T.2
Näslund, B.3
Rane, A.4
-
3
-
-
0021252274
-
Morphine metabolism revisited. II. Isolation and chemical characterization of a glutathionylmorphine adduct from rat liver preparations
-
CORREIA, M. A., KROWECH, G., CALDERA-MUONZ, P., YEE, S. L., STRAUB, K. and CASTAGNOLI, N. J., 1984a, Morphine metabolism revisited. II. Isolation and chemical characterization of a glutathionylmorphine adduct from rat liver preparations. Chemico-Biological Interactions, 51, 13-24.
-
(1984)
Chemico-Biological Interactions
, vol.51
, pp. 13-24
-
-
Correia, M.A.1
Krowech, G.2
Caldera-Muonz, P.3
Yee, S.L.4
Straub, K.5
Castagnoli, N.J.6
-
4
-
-
0021250265
-
Morphine metabolism revisited. I. Metabolic activation of morphine to a reactive species in rats
-
CORREIA, M. A., WONG, J. A. and SOLVIEN, E., 1984b, Morphine metabolism revisited. I. Metabolic activation of morphine to a reactive species in rats. Chemico-Biological Interactions, 49, 255-268.
-
(1984)
Chemico-Biological Interactions
, vol.49
, pp. 255-268
-
-
Correia, M.A.1
Wong, J.A.2
Solvien, E.3
-
5
-
-
0022993971
-
On the mechanisms of glutathione depletion in hepatocytes exposed to morphine and ethylmorphine
-
EKLOW-LASTBOM, L., MOLDEUS, P. and ORRENIUS, S., 1986, On the mechanisms of glutathione depletion in hepatocytes exposed to morphine and ethylmorphine. Toxicology, 42, 13-21.
-
(1986)
Toxicology
, vol.42
, pp. 13-21
-
-
Eklow-Lastbom, L.1
Moldeus, P.2
Orrenius, S.3
-
6
-
-
0028904836
-
The disposition of morphine and its metabolites in the in-situ rat isolated perfused liver
-
EVANS, A. M. and SHANAHAN, K., 1995, The disposition of morphine and its metabolites in the in-situ rat isolated perfused liver. Journal of Pharmacy and Pharmacology, 47, 333-339.
-
(1995)
Journal of Pharmacy and Pharmacology
, vol.47
, pp. 333-339
-
-
Evans, A.M.1
Shanahan, K.2
-
7
-
-
0024602271
-
(8S)-(glutathione-S-yl)dihydromorphinone, a novel metabolite of morphine from guinea pig bile
-
ISHDA, T., KUMAGAI, Y., IKEDA, Y., YANO, M., TOKI, S., MIHASHI, K., FUJIOKA, T., IWASE, Y. and HACHIYAMA, S., 1989, (8S)-(glutathione-S-yl)dihydromorphinone, a novel metabolite of morphine from guinea pig bile. Drug Metabolism and Disposition, 17, 77-81.
-
(1989)
Drug Metabolism and Disposition
, vol.17
, pp. 77-81
-
-
Ishda, T.1
Kumagai, Y.2
Ikeda, Y.3
Yano, M.4
Toki, S.5
Mihashi, K.6
Fujioka, T.7
Iwase, Y.8
Hachiyama, S.9
-
8
-
-
84915613257
-
Detection of morphinone as a new metabolite of morphine in guinea pig urine
-
edited by H. Takagi and E. J. Simon (Tokyo: Kodansha)
-
ISHIDA, T., YAMANO, S. and TOKI, S., 1981, Detection of morphinone as a new metabolite of morphine in guinea pig urine. In Advances in Endogenous and Exogenous Opioids, edited by H. Takagi and E. J. Simon (Tokyo: Kodansha), p. 481.
-
(1981)
Advances in Endogenous and Exogenous Opioids
, pp. 481
-
-
Ishida, T.1
Yamano, S.2
Toki, S.3
-
9
-
-
0019991359
-
Hepatic glutathione and hepatoxicity: Changes induced by selected narcotics
-
JAMES, R. C., GOODMAN, D. R. and HARBISON, R. D., 1982, Hepatic glutathione and hepatoxicity: changes induced by selected narcotics. Journal of Pharmacology and Experimental Therapeutics, 221, 708-714.
-
(1982)
Journal of Pharmacology and Experimental Therapeutics
, vol.221
, pp. 708-714
-
-
James, R.C.1
Goodman, D.R.2
Harbison, R.D.3
-
10
-
-
0023729365
-
Centrally mediated opioid induced depression of hepatic glutathione: Effects of intracerbroventricular administration of mu, kappa, sigma, and delta agonists
-
JAMES, R. C., WESSINGER, W. D., ROBERTS, S. M., MILLNER, G. C. and PAULE, M. G., 1988, Centrally mediated opioid induced depression of hepatic glutathione: effects of intracerbroventricular administration of mu, kappa, sigma, and delta agonists. Toxicology, 51, 267-279.
-
(1988)
Toxicology
, vol.51
, pp. 267-279
-
-
James, R.C.1
Wessinger, W.D.2
Roberts, S.M.3
Millner, G.C.4
Paule, M.G.5
-
11
-
-
0016333915
-
A chromatographic investigation of morphine metabolism in rats. Confirmation of N-demethylation of morphine and isolation of a new metabolite
-
KLUTCH, A., 1974, A chromatographic investigation of morphine metabolism in rats. Confirmation of N-demethylation of morphine and isolation of a new metabolite. Drug Metabolism and Disposition, 2, 23-30.
-
(1974)
Drug Metabolism and Disposition
, vol.2
, pp. 23-30
-
-
Klutch, A.1
-
12
-
-
0023204905
-
Method for determination of morphinone in urine and bile of guinea-pig by high-performance liquid chromatography
-
KUMAGAI, Y., ISHIDA, T. and TOKI, S., 1987, Method for determination of morphinone in urine and bile of guinea-pig by high-performance liquid chromatography. Journal of Chromatography, 421, 155-160.
-
(1987)
Journal of Chromatography
, vol.421
, pp. 155-160
-
-
Kumagai, Y.1
Ishida, T.2
Toki, S.3
-
13
-
-
0025202080
-
A new metabolic pathway of morphine; in vivo and in vitro formation of morphinone and morphinone-glutathione adduct in guinea pig
-
KUMAGAI, Y., TODAKA, T. and TOKI, S., 1990, A new metabolic pathway of morphine; in vivo and in vitro formation of morphinone and morphinone-glutathione adduct in guinea pig. Journal of Pharmacology and Experimental Therapeutics, 225, 504-510.
-
(1990)
Journal of Pharmacology and Experimental Therapeutics
, vol.225
, pp. 504-510
-
-
Kumagai, Y.1
Todaka, T.2
Toki, S.3
-
14
-
-
0025758545
-
Species difference of site-selective glucuronidation of morphine
-
KUO, C. K., HANIOKA, N., HOSHIKAWA, Y., OGURI, K. and YOSHIMURA, H., 1991, Species difference of site-selective glucuronidation of morphine. Journal of Pharmacobio-Dyanamics, 14, 187-193.
-
(1991)
Journal of Pharmacobio-Dyanamics
, vol.14
, pp. 187-193
-
-
Kuo, C.K.1
Hanioka, N.2
Hoshikawa, Y.3
Oguri, K.4
Yoshimura, H.5
-
15
-
-
0029738663
-
The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine
-
MILNE, R. W., NATION, R. L. and SOMOGYI, A. A., 1996, The disposition of morphine and its 3- and 6-glucuronide metabolites in humans and animals, and the importance of the metabolites to the pharmacological effects of morphine. Drug Metabolism Reviews, 28, 345-472.
-
(1996)
Drug Metabolism Reviews
, vol.28
, pp. 345-472
-
-
Milne, R.W.1
Nation, R.L.2
Somogyi, A.A.3
-
16
-
-
0026772058
-
Covalent binding of morphine to isolated rat hepatocytes
-
NAGAMATSU, K. and HASEGAWA, A., 1992, Covalent binding of morphine to isolated rat hepatocytes. Biochemical Pharmacology, 43, 2631-2635.
-
(1992)
Biochemical Pharmacology
, vol.43
, pp. 2631-2635
-
-
Nagamatsu, K.1
Hasegawa, A.2
-
17
-
-
0020028129
-
Protective effect of sulfhydral compounds on acute toxicity of morphinone
-
NAGAMATSU, K., KIDO, Y., TERAO, T., ISHIDA, T. and TOKI, S., 1982a, Protective effect of sulfhydral compounds on acute toxicity of morphinone. Life Sciences, 30, 1121-1127.
-
(1982)
Life Sciences
, vol.30
, pp. 1121-1127
-
-
Nagamatsu, K.1
Kido, Y.2
Terao, T.3
Ishida, T.4
Toki, S.5
-
18
-
-
0020418993
-
Effect of morphinone on opiate binding and morphine-elicited analgesia
-
NAGAMATSU, K., KIDO, Y., TERAO, T., ISHIDA, T. and TOKI, S., 1982b, Effect of morphinone on opiate binding and morphine-elicited analgesia. Life Sciences, 31, 1451-1457.
-
(1982)
Life Sciences
, vol.31
, pp. 1451-1457
-
-
Nagamatsu, K.1
Kido, Y.2
Terao, T.3
Ishida, T.4
Toki, S.5
-
19
-
-
0020582785
-
Studies on the mechanism of covalent binding of morphine metabolites to proteins in mouse
-
NAGAMATSU, K., KIDO, Y., TERAO, T., ISHIDA, T. and TOKI, S., 1983, Studies on the mechanism of covalent binding of morphine metabolites to proteins in mouse. Drug Metabolism and Disposition, 11, 190-194.
-
(1983)
Drug Metabolism and Disposition
, vol.11
, pp. 190-194
-
-
Nagamatsu, K.1
Kido, Y.2
Terao, T.3
Ishida, T.4
Toki, S.5
-
20
-
-
0023010970
-
Morphine metabolism in isolated rat hepatocytes and implications for hepatotoxicity
-
NAGAMATSU, K., OHNO, Y., IKEBUCHI, H., TAKAHASHI, A., TERAO, T. and TAKANAKA, A., 1986, Morphine metabolism in isolated rat hepatocytes and implications for hepatotoxicity. Biochemical Pharmacology, 35, 3543-3548.
-
(1986)
Biochemical Pharmacology
, vol.35
, pp. 3543-3548
-
-
Nagamatsu, K.1
Ohno, Y.2
Ikebuchi, H.3
Takahashi, A.4
Terao, T.5
Takanaka, A.6
-
21
-
-
0001122930
-
Morphinone
-
RAPOPORT, H., BAKER, D. R. and REIST, H. N., 1957, Morphinone. Journal of Organic Chemistry, 22, 1489-1492.
-
(1957)
Journal of Organic Chemistry
, vol.22
, pp. 1489-1492
-
-
Rapoport, H.1
Baker, D.R.2
Reist, H.N.3
-
22
-
-
0021051883
-
Sex differences in the excretion of glucuronide conjugates: Role of internal glucuronidation
-
RUSH, G. F., NEWTON, J. F. and HOOK, J. B., 1983, Sex differences in the excretion of glucuronide conjugates: role of internal glucuronidation. Journal of Pharmacology and Experimental Therapeutics, 227, 658-662.
-
(1983)
Journal of Pharmacology and Experimental Therapeutics
, vol.227
, pp. 658-662
-
-
Rush, G.F.1
Newton, J.F.2
Hook, J.B.3
-
23
-
-
0024348564
-
Depression of hepatic glutathione by opioid analgesic drugs in mice
-
SKOULIS, N. P., JAMES, R. C., HARBISON, R. D. and ROBERTS, S. M., 1989a, Depression of hepatic glutathione by opioid analgesic drugs in mice. Toxicology and Applied Pharmacology, 99, 139-147.
-
(1989)
Toxicology and Applied Pharmacology
, vol.99
, pp. 139-147
-
-
Skoulis, N.P.1
James, R.C.2
Harbison, R.D.3
Roberts, S.M.4
-
24
-
-
0024322842
-
Perturbation of glutathione by a central action of morphine
-
SKOULIS, N. P., JAMES, R. C., HARBISON, R. D. and ROBERTS, S. M., 1989b, Perturbation of glutathione by a central action of morphine. Toxicology, 57, 287-302.
-
(1989)
Toxicology
, vol.57
, pp. 287-302
-
-
Skoulis, N.P.1
James, R.C.2
Harbison, R.D.3
Roberts, S.M.4
-
25
-
-
0023710823
-
Biomedical basis of sex differences in drug metabolism
-
SKETT, P., 1988, Biomedical basis of sex differences in drug metabolism. Pharmacological Therapeutics, 38, 269-304.
-
(1988)
Pharmacological Therapeutics
, vol.38
, pp. 269-304
-
-
Skett, P.1
-
26
-
-
0021872250
-
Purification and characterization of guinea pig liver morphine 6-dehydrogenase
-
YAMANO, S., KAGEURA, E., ISHIDA, T. and TOKI, S., 1985, Purification and characterization of guinea pig liver morphine 6-dehydrogenase. Journal of Biological Chemistry, 260, 5259-5264.
-
(1985)
Journal of Biological Chemistry
, vol.260
, pp. 5259-5264
-
-
Yamano, S.1
Kageura, E.2
Ishida, T.3
Toki, S.4
-
27
-
-
0023019574
-
Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase
-
YAMANO, S., NISHIDA, F. and TOKI, S., 1986, Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase. Biochemical Pharmacology, 35, 4321-4326.
-
(1986)
Biochemical Pharmacology
, vol.35
, pp. 4321-4326
-
-
Yamano, S.1
Nishida, F.2
Toki, S.3
-
28
-
-
0018376437
-
Isolation and identification of morphine N-oxide, α- and β-dihydromorphines, β- or γ-isomorphine, and hydroxylated morphine as morphine metabolites in several mammalian species
-
YEH, S. Y., KREBS, H. A. and GORODETTZKY, C. W., 1979, Isolation and identification of morphine N-oxide, α- and β-dihydromorphines, β- or γ-isomorphine, and hydroxylated morphine as morphine metabolites in several mammalian species, Journal of Pharmaceutical Sciences, 68, 133-140.
-
(1979)
Journal of Pharmaceutical Sciences
, vol.68
, pp. 133-140
-
-
Yeh, S.Y.1
Krebs, H.A.2
Gorodettzky, C.W.3
-
29
-
-
0017605342
-
Biotransformation of morphine to dihydromorphinone and normorphine in the mouse, rat, rabbit, guinea pig, cat, dog, and monkey
-
YEH, S. Y., MCQUINN, R. L. and GORODETTZKY, C. W., 1977, Biotransformation of morphine to dihydromorphinone and normorphine in the mouse, rat, rabbit, guinea pig, cat, dog, and monkey. Drug Metabolism and Disposition, 5, 335-342.
-
(1977)
Drug Metabolism and Disposition
, vol.5
, pp. 335-342
-
-
Yeh, S.Y.1
Mcquinn, R.L.2
Gorodettzky, C.W.3
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