The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases

Journal of Molecular Biology

Volumn 342, Issue 5, 2004, Pages 1583-1597

  Moroz, Olga V ^a   Harkiolaki, Maria ^a,b   Galperin, Michael Y ^c   Vagin, Alexei A ^a   González Pacanowska, Dolores ^d   Wilson, Keith S ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

bacteriophage; dCTPase; dUTPase; enzyme specificity; ligand complex

Indexed keywords

BACTERIAL ENZYME; BACTERIAL PROTEIN; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; DIMER; HELIX LOOP HELIX PROTEIN; ISOENZYME;

ARTICLE; BACTERIAL VIRULENCE; BACTERIOPHAGE; CAMPYLOBACTER JEJUNI; COMPLEX FORMATION; CRYSTAL STRUCTURE; DIMERIZATION; ENTEROBACTER; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GRAM NEGATIVE BACTERIUM; MOLECULAR BIOLOGY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR PHYLOGENY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN HYDROLYSIS; PROTEIN MOTIF; SEQUENCE HOMOLOGY; STRAIN DIFFERENCE; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI;

ANIMALIA; ARCHAEA; BACTERIA (MICROORGANISMS); CAMPYLOBACTER; CAMPYLOBACTER JEJUNI; ENTEROBACTERIACEAE; ESCHERICHIA COLI; EUKARYOTA; METHANOCALDOCOCCUS JANNASCHII; METHANOCOCCUS; NEGIBACTERIA; POSIBACTERIA; TRYPANOSOMA; TRYPANOSOMA CRUZI; UNIDENTIFIED BACTERIOPHAGE;

EID: 4444321494     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.07.050     Document Type: Article

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