Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family

Experimental Cell Research

Volumn 308, Issue 2, 2005, Pages 364-380

  Couceiro, José R ^a   Martín Bermudo, María D ^b,c   Bustelo, Xosé R ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^c UNIVERSIDAD PABLO DE OLAVIDE   (Spain)

Author keywords

Cell migration; Cytoskeleton; Development; Drosophila; GDP GTP exchange factors; Rho Rac GTPases; Vav oncoproteins

Indexed keywords

ONCOPROTEIN; VAV PROTEIN; CELL CYCLE PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; VAV1 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL FUSION; CELL MIGRATION; CELL MOTILITY; CELL TYPE; CYTOSKELETON; DROSOPHILA MELANOGASTER; EMBRYO; ENZYME ACTIVITY; EVOLUTION; MORPHOLOGY; MOUSE; MYOBLAST; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; TRACHEA; TRANSGENIC ANIMAL; AMINO ACID SEQUENCE; ANIMAL; ANIMAL EMBRYO; CELL DIFFERENTIATION; CELL MOTION; CELL STRAIN 3T3; CELL STRAIN COS1; CERCOPITHECUS; CYTOLOGY; EMBRYO DEVELOPMENT; GENETICS; METABOLISM; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; ORGANOGENESIS; PHYSIOLOGY; PRENATAL DEVELOPMENT; SIGNAL TRANSDUCTION;

ANIMALIA; DROSOPHILA MELANOGASTER; MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL MOVEMENT; CERCOPITHECUS AETHIOPS; CONSERVED SEQUENCE; COS CELLS; CYTOSKELETON; DROSOPHILA MELANOGASTER; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; EVOLUTION, MOLECULAR; MICE; NIH 3T3 CELLS; ORGANOGENESIS; PHYLOGENY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-VAV; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 24944488137     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexcr.2005.04.035     Document Type: Article

References (74)

1. X.R. Bustelo Regulatory and signaling properties of the Vav family Mol. Cell. Biol. 20 2000 1461 1477
2. S. Katzav, D. Martin-Zanca, and M. Barbacid Vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells EMBO J. 8 1989 2283 2290
3. K.E. Schuebel, X.R. Bustelo, D.A. Nielsen, B.J. Song, M. Barbacid, D. Goldman, and I.J. Lee Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes Oncogene 13 1996 363 371
4. N. Movilla, and X.R. Bustelo Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins Mol. Cell Biol. 19 1999 7870 7885
5. P. Crespo, K.E. Schuebel, A.A. Ostrom, J.S. Gutkind, and X.R. Bustelo Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product Nature 385 1997 169 172
6. K.E. Schuebel, N. Movilla, J.L. Rosa, and X.R. Bustelo Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2 EMBO J. 17 1998 6608 6621
7. N. Movilla, M. Dosil, Y. Zheng, and X.R. Bustelo How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc42 Oncogene 20 2001 8057 8065
8. M.J. Caloca, J.L. Zugaza, D. Matallanas, P. Crespo, and X.R. Bustelo Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1 EMBO J. 22 2003 3326 3336
9. J.L. Zugaza, M.J. Caloca, and X.R. Bustelo Inverted signaling hierarchy between RAS and RAC in T-lymphocytes Oncogene 23 2004 5823 5833
10. M.J. Caloca, J.L. Zugaza, M. Vicente-Manzanares, F. Sanchez-Madrid, and X.R. Bustelo F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2 J. Biol. Chem. 279 2004 20435 20446
11. Z.S. Ye, and D. Baltimore Binding of Vav to Grb2 through dimerization of Src homology 3 domains Proc. Natl. Acad. Sci. U. S. A. 91 1994 12629 12633
12. X.R. Bustelo, K.L. Suen, W.M. Michael, G. Dreyfuss, and M. Barbacid Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins Mol. Cell. Biol. 15 1995 1324 1332
13. X.R. Bustelo, P. Crespo, M. Lopez-Barahona, J.S. Gutkind, and M. Barbacid Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation Oncogene 15 1997 2511 2520
14. J. Wu, D.G. Motto, G.A. Koretzky, and A. Weiss Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation Immunity 4 1996 593 602
15. C. Wulfing, A. Bauch, G.R. Crabtree, and M.M. Davis The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte-antigen-presenting cell interface Proc. Natl. Acad. Sci. U. S. A. 97 2000 10150 10155
16. M. Turner, P.J. Mee, A.E. Walters, M.E. Quinn, A.L. Mellor, R. Zamoyska, and V.L. Tybulewicz A requirement for the Rho-family GTP exchange factor Vav in positive and negative selection of thymocytes Immunity 7 1997 451 460
17. L.F. Reynolds, L.A. Smyth, T. Norton, N. Freshney, J. Downward, D. Kioussis, and V.L. Tybulewicz Vav1 transduces T cell receptor signals to the activation of phospholipase C-gamma1 via phosphoinositide 3-kinase-dependent and-independent pathways J. Exp. Med. 195 2002 1103 1114
18. R. Zhang, F.W. Alt, L. Davidson, S.H. Orkin, and W. Swat Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene Nature 374 1995 470 473
19. M. Turner, and D.D. Billadeau VAV proteins as signal integrators for multi-subunit immune-recognition receptors Nat. Rev., Immunol. 2 2002 476 486
20. G.M. Doody, S.E. Bell, E. Vigorito, E. Clayton, S. McAdam, R. Tooze, C. Fernandez, I.J. Lee, and M. Turner Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation Nat. Immunol. 2 2001 542 547
21. K. Fujikawa, A.V. Miletic, F.W. Alt, R. Faccio, T. Brown, J. Hoog, J. Fredericks, S. Nishi, S. Mildiner, S.L. Moores, J. Brugge, F.S. Rosen, and W. Swat Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells J. Exp. Med. 198 2003 1595 1608
22. X.R. Bustelo Vav proteins, adaptors and cell signaling Oncogene 20 2001 6372 6381
23. X.R. Bustelo Regulation of Vav proteins by intramolecular events Front Biosci. 7 2002 d24 d30
24. B. Aghazadeh, W.E. Lowry, X.Y. Huang, and M.K. Rosen Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation Cell 102 2000 625 633
25. J.L. Zugaza, M.A. Lopez-Lago, M.J. Caloca, M. Dosil, N. Movilla, and X.R. Bustelo Structural determinants for the biological activity of Vav proteins J. Biol. Chem. 277 2002 45377 45392
26. M. Lopez-Lago, H. Lee, C. Cruz, N. Movilla, and X.R. Bustelo Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav Mol. Cell. Biol. 20 2000 1678 1691
27. I. Dekel, N. Russek, T. Jones, M.A. Mortin, and S. Katzav Identification of the Drosophila melanogaster homologue of the mammalian signal transducer protein, Vav FEBS Lett. 472 2000 99 104
28. I. Hornstein, M.A. Mortin, and S. Katzav DroVav, the Drosophila melanogaster homologue of the mammalian Vav proteins, serves as a signal transducer protein in the Rac and DER pathways Oncogene 22 2003 6774 6784
29. M.D. Adams, S.E. Celniker, R.A. Holt, C.A. Evans, J.D. Gocayne, P.G. Amanatides, S.E. Scherer, P.W. Li, R.A. Hoskins, R.F. Galle, R.A. George, S.E. Lewis, S. Richards, M. Ashburner, S.N. Henderson, G.G. Sutton, J.R. Wortman, M.D. Yandell, Q. Zhang, L.X. Chen, R.C. Brandon, Y.H. Rogers, R.G. Blazej, M. Champe, B.D. Pfeiffer, K.H. Wan, C. Doyle, E.G. Baxter, G. Helt, C.R. Nelson, G.L. Gabor, J.F. Abril, A. Agbayani, H.J. An, C. Andrews-Pfannkoch, D. Baldwin, R.M. Ballew, A. Basu, J. Baxendale, L. Bayraktaroglu, E.M. Beasley, K.Y. Beeson, P.V. Benos, B.P. Berman, D. Bhandari, S. Bolshakov, D. Borkova, M.R. Botchan, J. Bouck, P. Brokstein, P. Brottier, K.C. Burtis, D.A. Busam, H. Butler, E. Cadieu, A. Center, I. Chandra, J.M. Cherry, S. Cawley, C. Dahlke, L.B. Davenport, P. Davies, B. de Pablos, A. Delcher, Z. Deng, A.D. Mays, I. Dew, S.M. Dietz, K. Dodson, L.E. Doup, M. Downes, S. Dugan-Rocha, B.C. Dunkov, P. Dunn, K.J. Durbin, C.C. Evangelista, C. Ferraz, S. Ferriera, W. Fleischmann, C. Fosler, A.E. Gabrielian, N.S. Garg, W.M. Gelbart, K. Glasser, A. Glodek, F. Gong, J.H. Gorrell, Z. Gu, P. Guan, M. Harris, N.L. Harris, D. Harvey, T.J. Heiman, J.R. Hernandez, J. Houck, D. Hostin, K.A. Houston, T.J. Howland, M.H. Wei, C. Ibegwam, M. Jalali, F. Kalush, G.H. Karpen, Z. Ke, J.A. Kennison, K.A. Ketchum, B.E. Kimmel, C.D. Kodira, C. Kraft, S. Kravitz, D. Kulp, Z. Lai, P. Lasko, Y. Lei, A.A. Levitsky, J. Li, Z. Li, Y. Liang, X. Lin, X. Liu, B. Mattei, T.C. McIntosh, M.P. McLeod, D. McPherson, G. Merkulov, N.V. Milshina, C. Mobarry, J. Morris, A. Moshrefi, S.M. Mount, M. Moy, B. Murphy, L. Murphy, D.M. Muzny, D.L. Nelson, D.R. Nelson, K.A. Nelson, K. Nixon, D.R. Nusskern, J.M. Pacleb, M. Palazzolo, G.S. Pittman, S. Pan, J. Pollard, V. Puri, M.G. Reese, K. Reinert, K. Remington, R.D. Saunders, F. Scheeler, H. Shen, B.C. Shue, I. Siden-Kiamos, M. Simpson, M.P. Skupski, T. Smith, E. Spier, A.C. Spradling, M. Stapleton, R. Strong, E. Sun, R. Svirskas, C. Tector, R. Turner, E. Venter, A.H. Wang, X. Wang, Z.Y. Wang, D.A. Wassarman, G.M. Weinstock, J. Weissenbach, T. Woodage, K.C. Worley, D. Wu, S. Yang, Q.A. Yao, J. Ye, R.F. Yeh, J.S. Zaveri, M. Zhan, G. Zhang, Q. Zhao, L. Zheng, X.H. Zheng, F.N. Zhong, W. Zhong, X. Zhou, S. Zhu, X. Zhu, H.O. Smith, R.A. Gibbs, E.W. Myers, G.M. Rubin, and J.C. Venter The genome sequence of Drosophila melanogaster Science 287 2000 2185 2195
30. E.W. Myers, G.G. Sutton, A.L. Delcher, I.M. Dew, D.P. Fasulo, M.J. Flanigan, S.A. Kravitz, C.M. Mobarry, K.H. Reinert, K.A. Remington, E.L. Anson, R.A. Bolanos, H.H. Chou, C.M. Jordan, A.L. Halpern, S. Lonardi, E.M. Beasley, R.C. Brandon, L. Chen, P.J. Dunn, Z. Lai, Y. Liang, D.R. Nusskern, M. Zhan, Q. Zhang, X. Zheng, G.M. Rubin, M.D. Adams, and J.C. Venter A whole-genome assembly of Drosophila Science 287 2000 2196 2204
31. A.J. van der Eb, and F.L. Graham Assay of transforming activity of tumor virus DNA Methods Enzymol. 65 1980 826 839
32. S.V. Kulkarni, G. Gish, P. van der Geer, M. Henkemeyer, and T. Pawson Role of p120 Ras-GAP in directed cell movement J. Cell Biol. 149 2000 457 470
33. G. Keller, M. Kennedy, T. Papayannopoulou, and M.V. Wiles Hematopoietic commitment during embryonic stem cell differentiation in culture Mol. Cell. Biol. 13 1993 473 486
34. A.C. Spradling, and G.M. Rubin Transposition of cloned P elements into Drosophila germ line chromosomes Science 218 1982 341 347
35. A.H. Brand, and N. Perrimon Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Development 118 1993 401 405
36. L. Luo, Y.J. Liao, L.Y. Jan, and Y.N. Jan Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion Genes Dev. 8 1994 1787 1802
37. C. Georgias, M. Wasser, and U. Hinz A basic-helix-loop-helix protein expressed in precursors of Drosophila longitudinal visceral muscles Mech Dev. 69 1997 115 124
38. M. Sato, and T.B. Kornberg FGF is an essential mitogen and chemoattractant for the air sacs of the Drosophila tracheal system Dev. Cell 3 2002 195 207
39. J. Coppola, S. Bryant, T. Koda, D. Conway, and M. Barbacid Mechanism of activation of the vav protooncogene Cell Growth Differ. 2 1991 95 105
40. M.J. Hart, A. Eva, D. Zangrilli, S.A. Aaronson, T. Evans, R.A. Cerione, and Y. Zheng Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product J. Biol. Chem. 269 1994 62 65
41. M.J. Hart, A. Eva, T. Evans, S.A. Aaronson, and R.A. Cerione Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product Nature 354 1991 311 314
42. M. van Triest, and J.L. Bos Pull-down assays for guanoside 5′-triphosphate-bound Ras-like guanosine 5′-triphosphatases Methods Mol. Biol. 250 2004 97 102
43. S. Etienne-Manneville, and A. Hall Rho GTPases in cell biology Nature 420 2002 629 635
44. L. Van Aelst, and C. D'Souza-Schorey Rho GTPases and signaling networks Genes Dev. 11 1997 2295 2322
45. P.E. Young, A.M. Richman, A.S. Ketchum, and D.P. Kiehart Morphogenesis in Drosophila requires nonmuscle myosin heavy chain function Genes Dev. 7 1993 29 41
46. K.A. Edwards, M. Demsky, R.A. Montague, N. Weymouth, and D.P. Kiehart GFP-moesin illuminates actin cytoskeleton dynamics in living tissue and demonstrates cell shape changes during morphogenesis in Drosophila Dev. Biol. 191 1997 103 117
47. A. Jacinto, W. Wood, T. Balayo, M. Turmaine, A. Martinez-Arias, and P. Martin Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure Curr. Biol. 10 2000 1420 1426
48. A. Jacinto, W. Wood, S. Woolner, C. Hiley, L. Turner, C. Wilson, A. Martinez-Arias, and P. Martin Dynamic analysis of actin cable function during Drosophila dorsal closure Curr. Biol. 12 2002 1245 1250
49. N. Harden, H.Y. Loh, W. Chia, and L. Lim A dominant inhibitory version of the small GTP-binding protein Rac disrupts cytoskeletal structures and inhibits developmental cell shape changes in Drosophila Development 121 1995 903 914
50. S. Hakeda-Suzuki, J. Ng, J. Tzu, G. Dietzl, Y. Sun, M. Harms, T. Nardine, L. Luo, and B.J. Dickson Rac function and regulation during Drosophila development Nature 416 2002 438 442
51. N.H. Patel, P.M. Snow, and C.S. Goodman Characterization and cloning of fasciclin III: a glycoprotein expressed on a subset of neurons and axon pathways in Drosophila Cell 48 1987 975 988
52. M.J. Wakelam The fusion of myoblasts Biochem. J. 228 1985 1 12
53. S.K. Doberstein, R.D. Fetter, A.Y. Mehta, and C.S. Goodman Genetic analysis of myoblast fusion: blown fuse is required for progression beyond the prefusion complex J. Cell Biol. 136 1997 1249 1261
54. M.D. Martin-Bermudo, O.M. Dunin-Borkowski, and N.H. Brown Specificity of PS integrin function during embryogenesis resides in the alpha subunit extracellular domain EMBO J. 16 1997 4184 4193
55. N. Kaufmann, Z.P. Wills, and D. Van Vactor Drosophila Rac1 controls motor axon guidance Development 125 1998 453 461
56. J. Ng, T. Nardine, M. Harms, J. Tzu, A. Goldstein, Y. Sun, G. Dietzl, B.J. Dickson, and L. Luo Rac GTPases control axon growth, guidance and branching Nature 416 2002 442 447
57. G. Grenningloh, E.J. Rehm, and C.S. Goodman Genetic analysis of growth cone guidance in Drosophila: fasciclin II functions as a neuronal recognition molecule Cell 67 1991 45 57
58. I. Canal, and A. Ferrus The expression of Ultrabithorax (Ubx) during development of the nervous system of Drosophila J. Neurogenet. 4 1987 161 177
59. J.A. Lengyel, and D.D. Iwaki It takes guts: the Drosophila hindgut as a model system for organogenesis Dev. Biol. 243 2002 1 19
60. A. Ghabrial, S. Luschnig, M.M. Metzstein, and M.A. Krasnow Branching morphogenesis of the Drosophila tracheal system Annu. Rev. Cell Dev. Biol. 19 2003 623 647
61. C. Ribeiro, V. Petit, and M. Affolter Signaling systems, guided cell migration, and organogenesis: insights from genetic studies in Drosophila Dev. Biol. 260 2003 1 8
62. A. Uv, R. Cantera, and C. Samakovlis Drosophila tracheal morphogenesis: intricate cellular solutions to basic plumbing problems Trends Cell Biol. 13 2003 301 309
63. M. Boube, M.D. Martin-Bermudo, N.H. Brown, and J. Casanova Specific tracheal migration is mediated by complementary expression of cell surface proteins Genes Dev. 15 2001 1554 1562
64. B. Glise, and S. Noselli Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis Genes Dev. 11 1997 1738 1747
65. X.R. Bustelo Understanding Rho/Rac biology in T-cells using animal models BioEssays 24 2002 602 612
66. G.M. Doody, D.D. Billadeau, E. Clayton, A. Hutchings, R. Berland, S. McAdam, P.J. Leibson, and M. Turner Vav-2 controls NFAT-dependent transcription in B-but not T-lymphocytes EMBO J. 19 2000 6173 6184
67. S. Zakaria, T.S. Gomez, D.N. Savoy, S. McAdam, M. Turner, R.T. Abraham, and D.D. Billadeau Differential regulation of TCR-mediated gene transcription by Vav family members J. Exp. Med. 199 2004 429 434
68. T.P. Newsome, S. Schmidt, G. Dietzl, K. Keleman, B. Asling, A. Debant, and B.J. Dickson Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila Cell 101 2000 283 294
69. K. Zhou, Y. Wang, J.L. Gorski, N. Nomura, J. Collard, and G.M. Bokoch Guanine nucleotide exchange factors regulate specificity of downstream signaling from Rac and Cdc42 J. Biol. Chem. 273 1998 16782 16786
70. R.J. Buchsbaum, B.A. Connolly, and L.A. Feig Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin J. Biol. Chem. 278 2003 18833 18841
71. R.J. Buchsbaum, B.A. Connolly, and L.A. Feig Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade Mol. Cell. Biol. 22 2002 4073 4085
72. J. Bubeck Wardenburg, R. Pappu, J.Y. Bu, B. Mayer, J. Chernoff, D. Straus, and A.C. Chan Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76 Immunity 9 1998 607 616
73. N. King, C.T. Hittinger, and S.B. Carroll Evolution of key cell signaling and adhesion protein families predates animal origins Science 301 2003 361 363
74. D.J. Hibberd Observations on the ultrastructure of the choanoflagellate Codosiga botrytis (Ehr.) Saville-Kent with special reference to the flagellar apparatus J. Cell. Sci. 17 1975 191 219