Fluorescent leukotriene B4: Potential applications

Journal of Lipid Research

Volumn 46, Issue 6, 2005, Pages 1339-1346

  Sabirsh, Alan ^a   Wetterholm, Anders ^a   Bristulf, Jesper ^b   Leffler, Hakon ^b   Haeggström, Jesper Z ^a   Owman, Christer ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

G protein coupled receptor; Method; Pharmacology

Indexed keywords

ANTIBODY; FLUORESCENT DYE; GREEN FLUORESCENT PROTEIN; LEUKOTRIENE B4; LEUKOTRIENE RECEPTOR STIMULATING AGENT; RADIOLIGAND; TRITIUM; LEUKOTRIENE B4 RECEPTOR; LEUKOTRIENE RECEPTOR; LIGAND; LTB4R PROTEIN, HUMAN; LUCIFERASE; PURINE P2 RECEPTOR;

ARTICLE; CONFOCAL MICROSCOPY; DRUG SYNTHESIS; FLOW CYTOMETRY; FLUORESCENCE; FLUORESCENCE POLARIZATION IMMUNOASSAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; ISOTOPE LABELING; PRIORITY JOURNAL; CELL MEMBRANE; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; FLUORESCENCE MICROSCOPY; HELA CELL; KINETICS; LIPID METABOLISM; METABOLISM; PROTEIN BINDING; REPORTER GENE;

CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT DYES; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; KINETICS; LEUKOTRIENE B4; LIGANDS; LIPID METABOLISM; LUCIFERASES; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MODELS, CHEMICAL; PROTEIN BINDING; RECEPTORS, LEUKOTRIENE; RECEPTORS, LEUKOTRIENE B4; RECEPTORS, PURINERGIC P2;

EID: 24944480063     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.D500005-JLR200     Document Type: Article

References (24)

1. Funk, C. D. 2001. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science. 294: 1871-1875.
2. Byrum, R. S., J. L. Goulet, J. N. Snouwaert, R. J. Griffiths, and B. H. Koller. 1999. Determination of the contribution of cysteinyl leukotrienes and leukotriene B4 in acute inflammatory responses using 5-lipoxygenase- and leukotriene A4 hydrolase-deficient mice. J. Immunol. 163: 6810-6819.
3. Haribabu, B., M. W. Verghese, D. A. Steeber, D. D. Sellars, C. B. Bock, and R. Snyderman. 2000. Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis. J. Exp. Med. 192: 433-438.
4. Tager, A. M., J. H. Dufour, K. Goodarzi, S. D. Bercury, U. H. von Andrian, and A. D. Luster. 2000. BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis. J. Exp. Med. 192: 439-446.
5. Flamand, L., P. Borgeat, R. Lalonde, and J. Gosselin. 2004. Release of anti-HIV mediators after administration of leukotriene B4 to humans. J. Infect. Dis. 189: 2001-2009.
6. Aiello, R. J., P. A. Bourassa, S. Lindsey, W. Weng, A. Freeman, and H. J. Showell. 2002. Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler. Thromb. Vasc. Biol. 22: 443-449.
7. Subbarao, K., V. R. Jala, S. Mathis, J. Suttles, W. Zacharias, J. Ahamed, H. Ali, M. T. Tseng, and B. Haribabu. 2003. Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms. Arterioscler. Thromb. Vasc. Biol. 24: 369-375.
8. Dwyer, J. H., H. Allayee, K. M. Dwyer, J. Fan, H. Wu, R. Mar, A. J. Lusis, and M. Mehrabian. 2004. Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. N. Engl. J. Med. 350: 29-37.
9. Helgadottir, A., A. Manolescu, G. Thorleifsson, S. Gretarsdottir, H. Jonsdottir, U. Thorsteinsdottir, N. J. Samani, G. Gudmundsson, S. F. Grant, G. Thorgeirsson, et al. 2004. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat. Genet. 36: 233-239.
10. Tager, A. M., S. K. Bromley, B. D. Medoff, S. A. Islam, S. D. Bercury, E. B. Friedrich, A. D. Carafone, R. E. Gerszten, and A. D. Luster. 2003. Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. Nat. Immunol. 4: 982-990.
11. Kamohara, M., J. Takasaki, M. Matsumoto, T. Saito, T. Ohishi, H. Ishii, and K. Furuichi. 2000. Molecular cloning and characterization of another leukotriene B4 receptor. J. Biol. Chem. 275: 27000-27004.
12. Tryselius, Y., N. E. Nilsson, K. Kotarsky, B. Olde, and C. Owman. 2000. Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor. Biochem. Biophys. Res. Commun. 274: 377-382.
13. Wang, S., E. Gustafson, L. Pang, X. Qiao, J. Behan, M. Maguire, M. Bayne, and T. Laz. 2000. A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. J. Biol. Chem. 275: 40686-40694.
14. Hwang, S. W., H. Cho, J. Kwak, S. Y. Lee, C. J. Kang, J. Jung, S. Cho, K. H. Min, Y. G. Suh, D. Kim, and U. Oh. 2000. Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances. Proc. Natl. Acad. Sci. USA. 97: 6155-6160.
15. Devchand, P. R., H. Keller, J. M. Peters, M. Vazquez, F. J. Gonzalez, and W. Wahli. 1996. The PPARalpha-leukotriene B4 pathway to inflammation control. Nature. 384: 39-43.
16. Pettersson, A., A. Boketoft, A. Sabirsh, N. E. Nilsson, K. Kotarsky, B. Olde, and C. Owman. 2000. First-generation monoclonal antibodies identifying the human leukotriene B(4) receptor-1. Biochem. Biophys. Res. Commun. 279: 520-525.
17. Harris, L. J., E. Skaletsky, and A. McPherson. 1998. Crystallographic structure of an intact IgG1 monoclonal antibody. J. Mol. Biol. 275:861-872.
18. Rudberg, P. C., F. Tholander, M. Andberg, M. M. Thunnissen, and J. Z. Haeggstrom. 2004. Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates. J. Biol. Chem. 279: 27376-27382.
19. Kotarsky, K., C. Owman, and B. Olde. 2001. A chimeric reporter gene allowing for clone selection and high-throughput screening of reporter cell lines expressing G-protein-coupled receptors. Anal. Biochem. 288: 209-215.
20. Sabirsh, A., J. Bristulf, and C. Owman. 2004. Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2. Eur. J. Pharmacol. 499: 53-65.
21. Prystay, L., M. Gosselin, and P. Banks. 2001. Determination of equilibrium dissociation constants in fluorescence polarization. J. Biomol. Screen. 6: 141-150.
22. Sabirsh, A., A. Pettersson, Å. Boketoft, K. Kotarsky, and C. Owman. 2003. Differential inhibition of receptor activation by two mouse monoclonal antibodies specific for the human leukotriene B4 receptor, BLT1. Int. Immunopharmacol. 3: 1829-1839.
23. Baneres, J. L., and J. Parello. 2003. Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein. J. Mol. Biol. 329: 815-829.
24. Goldman, D. W., L. A. Gifford, R. N. Young, T. Marotti, M. K. Cheung, and E. J. Goetzl. 1991. Affinity labeling of the membrane protein-binding component of human polymorphonuclear leukocyte receptors for leukotriene B4. J. Immunol. 146: 2671-2677.