The antigenic tip GPGRAFY of the V3 loop on HIV-1 gp120: Genetic variability and subtypes

Immunology Letters

Volumn 101, Issue 1, 2005, Pages 112-114

  Dong, Xiao Nan ^a   Wu, Yi ^a   Ying, Jian ^a   Chen, Ying Hua ^a  

^a TSINGHUA UNIVERSITY   (China)

Author keywords

Genetic variability; GPGRAFY; Restricted mutation; Subtype; V3

Indexed keywords

ANTIBODY; ANTIGEN; EPITOPE; GLYCOPROTEIN GP 120; GLYCYLPROLYLGLYCYLARGINYLALANYLPHENYLALANYLTYROSINE; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CORRELATION ANALYSIS; GENETIC VARIABILITY; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTATION; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; SYNCYTIUM; VIRUS INFECTIVITY;

AMINO ACID MOTIFS; EPITOPES; HIV ENVELOPE PROTEIN GP120; HIV-1; VARIATION (GENETICS);

EID: 24744457947     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2005.04.008     Document Type: Article

References (18)

1. S.S. Hwang, T.J. Boyle, H.K. Lyerly, and B.R. Cullen Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1 Science 253 5015 1991 71 74
2. F. Cocchi, A.L. DeVico, A. Garzino-Demo, A. Cara, R.C. Gallo, and P. Lusso The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection Nat Med 2 11 1996 1244 1247
3. C.D. Rizzuto, R. Wyatt, N. Hernandez-Ramos, Y. Sun, P.D. Kwong, and W.A. Hendrickson A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding Science 280 5371 1998 1949 1953
4. X.N. Dong, X. Chen, Y. Chen, A. Ablimit, Z. Ye, Y. Wu, and Y.H. Chen HIV-1 phenotype, tropism and sequence patterns: the association and preference AIDS Res Hum Retroviruses 21 3 2005 234 238
5. M.K. Gorny, K. Revesz, C. Williams, B. Volsky, M.K. Louder, and C.A. Anyangwe The V3 loop is accessible on the surface of most human immunodeficiency virus type 1 primary isolates and serves as a neutralization epitope J Virol 78 5 2004 2394 2404
6. E.A. Emini, W.A. Schleif, J.H. Nunberg, A.J. Conley, Y. Eda, and S. Tokiyoshi Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody Nature 355 6362 1992 728 730
7. A.J. Conley, M.K. Gorny, J.A. Kessler II, L.J. Boots, M. Ossorio-Castro, and S. Koenig Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D J Virol 68 11 1994 6994 7000
8. J.P. Moore, A. Trkola, B. Korber, L.J. Boots, J.A. Kessler II, and F.E. McCutchan A human monoclonal antibody to a complex epitope in the V3 region of gp120 of human immunodeficiency virus type 1 has broad reactivity within and outside clade B J Virol 69 1 1995 122 130
9. C.E. Hioe, S. Xu, P. Chigurupati, S. Burda, C. Williams, and M.K. Gorny Neutralization of HIV-1 primary isolates by polyclonal and monoclonal human antibodies Int Immunol 9 9 1997 1281 1290
10. C.P. Krachmarov, S.C. Kayman, W.J. Honnen, O. Trochev, and A. Pinter V3-specific polyclonal antibodies affinity purified from sera of infected humans effectively neutralize primary isolates of human immunodeficiency virus type 1 AIDS Res Hum Retroviruses 17 18 2001 1737 1748
11. M.K. Gorny, C. Williams, B. Volsky, K. Revesz, S. Cohen, and V.R. Polonis Human monoclonal antibodies specific for conformation-sensitive epitopes of V3 neutralize human immunodeficiency virus type 1 primary isolates from various clades J Virol 76 18 2002 9035 9045
12. S. Harada Human immunodeficiency virus type 1 neutralization by a single molecule of V3-targeted antibody Microbiol Immunol 46 12 2002 857 862
13. A.N. Lekkerkerker, I.S. Ludwig, S.J. van Vliet, Y. van Kooyk, and T.B. Geijtenbeek Potency of HIV-1 envelope glycoprotein gp120 antibodies to inhibit the interaction of DC-SIGN with HIV-1 gp120 Virology 329 2 2004 465 476
14. J.M. Rini, R.L. Stanfield, E.A. Stura, P.A. Salinas, A.T. Profy, and I.A. Wilson Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen Proc Natl Acad Sci USA 90 1993 6325 6329
15. J.B. Ghiara, E.A. Stura, R.L. Stanfield, A.T. Profy, and I.A. Wilson Crystal structure of the principal neutralization site of HIV-1 Science 264 1994 82 85
16. J.B. Ghiara, D.C. Ferguson, A.C. Satterthwait, H.J. Dyson, and I.A. Wilson Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site J Mol Biol 266 1997 31 39
17. S. Zolla-Pazner, P. Zhong, K. Revesz, B. Volsky, C. Williams, and P. Nyambi The cross-clade neutralizing activity of a human monoclonal antibody is determined by the GPGR V3 motif of HIV type 1 AIDS Res Hum Retroviruses 20 11 2004 1254 1258
18. H. Tian, Y. Xiao, L. Qin, and Y.H. Chen Antigenicity and predefined specificities of the multi-epitope vaccine in candidate consisting of neutralizing epitope and mutated epitopes suggested a new way against HIV-1 mutation Immunobiology 204 4 2001 434 441