Structural elucidation of lemonomycin, a potent antibiotic from Streptomyces candidus

Tetrahedron Letters

Volumn 41, Issue 13, 2000, Pages 2067-2071

  He, Haiyin ^a   Shen, Bo ^a   Carter, Guy T ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; DYE; LEMONOMYCIN; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHIRALITY; DRUG ISOLATION; DRUG PURIFICATION; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTRAL SENSITIVITY; STEREOCHEMISTRY; STREPTOMYCES; STRUCTURE ACTIVITY RELATION;

EID: 0034719702     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)00116-7     Document Type: Article

References (9)

1. Whaley, H. A.; Patterson, E. L.; Dann, M.; Shay, A. J.; Porter, J. N. Antimicrob. Agents Chemother. 1964, 8, 83-86.
2. Chopra, I. J.; Hodgson, B. M.; Poste, G. Antimicrob. Agents Chemother. 1997, 41, 497-503.
3. -1 3403, 2942, 1655, 1600, 1465, 1451, 1381, 1347, 1234.
4. The absolute stereochemistry of lemonomycin has not been determined experimentally, but the configuration of the aglycon was depicted according to the absolute stereochemistry of the isoquinoline antibiotics, saframycins (Ref. 6).
5. 3's on isopropoxy's).
6. (a) Arai, T.; Takahashi, K.; Kubo, A.; Nakahara, S.; Sato, S.; Aiba, K.; Tamura, C. Tetrahedron Lett. 1979, 25, 2355-2358.
7. (b) Myers, A. G.; Kung, D. W. J. Am. Chem. Soc. 1999, 121, 10828-10829.
8. He, H.; Faulkner, D. J. J. Org. Chem. 1989, 54, 5822-5824.
9. Arai, T.; Yazawa, K.; Takahashi, K.; Maeda, A.; Mikami, Y. Antimicrob. Agents Chemother. 1985, 28, 5-11.