Determination of the folding transition states of barnase by using ΦI-value-restrained simulations validated by double mutant ΦIJ-values

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 35, 2005, Pages 12389-12394

  Salvatella, Xavier ^a   Dobson, Christopher M ^a   Fersht, Alan R ^a,b   Vendruscolo, Michele ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MRC CENTRE FOR PROTEIN ENGINEERING   (United Kingdom)

Author keywords

value; Protein folding; Restrained molecular dynamics simulations

Indexed keywords

BARNASE;

ALPHA CHAIN; ARTICLE; BETA SHEET; CALCULATION; ENERGY; ENZYME DENATURATION; ENZYME STRUCTURE; HYDROPHOBICITY; MOLECULAR DYNAMICS; MUTANT; POINT MUTATION; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN FOLDING; SIMULATION; VALIDATION PROCESS;

BIOPHYSICS; MODELS, MOLECULAR; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN FOLDING; RIBONUCLEASES; THERMODYNAMICS;

EID: 24644462765     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0408226102     Document Type: Article

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