Extracellular virulence factors of group B streptococci

Frontiers in Bioscience

Volumn 9, Issue , 2004, Pages 1794-1802

  Liu, George Yen Hsi ^a   Nizet, Victor ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

C5a peptidase; CAMP factor; Cytolysin; Group B Streptococcus; Hemolysin; Hyaluronate lyase; Protease; Review; Streptococcus agalactiae; Virulence factor

Indexed keywords

CARBOHYDRATE; CM 101; COMPLEMENT COMPONENT C5A; CYTOLYSIN; EXOTOXIN; HEMOLYSIN; HYALURONIDASE; LYASE; PEPTIDASE; PEPTIDE DERIVATIVE; VIRULENCE FACTOR;

BACTERIAL CELL WALL; BACTERIAL VIRULENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOMICS; NONHUMAN; PATHOGENESIS; PATHOGENICITY; REVIEW; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS PNEUMONIAE; GENETICS; HUMAN; MICROBIOLOGY; NEWBORN; PHYSIOLOGY; STREPTOCOCCUS INFECTION;

BACTERIA (MICROORGANISMS); STREPTOCOCCUS; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS SP. 'GROUP B';

HUMANS; INFANT, NEWBORN; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS AGALACTIAE; VIRULENCE FACTORS;

EID: 2442695616     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/1296     Document Type: Review

References (87)

1. Farley M. M.: Group B streptococcal disease in nonpregnant adults. Clin Infect Dis 33, 556-561 (2001)
2. Schrag S. J., S. Zywicki, M. M. Farley, A. L. Reingold, L. H. Harrison, L. B. Lefkowitz, J. L. Hadler, R. Danila, P. R. Cieslak & A. Schuchat: Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N Engl J Med 342, 15-20 (2000)
3. Nizet V., P. Ferrieri & C. E. Rubens: Molecular pathogenesis of group B streptococcal disease in newborns. In: Streptococcal Infections: Clinical Aspects, Microbiology and Molecular Pathogenesis. Eds: Stevens DL, Kaplan EL. Oxford University Press, New York 180-221 (2000)
4. Nizet V. & C. E. Rubens: Pathogenic mechanisms and virulence factors of group B streptococci. In: The Gram- Positive Pathogens. Eds: Fischetti VA, Ferretti JJ, Portnoy DA, Rood JI. ASM Press, Washington, D.C. 125-136 (2000)
5. Paoletti L. C., L. C. Madoff & D. L. Kasper: Surface structures of group B streptococcus important in human immunity. In: The Gram-Positive Pathogens. Eds: Fischetti VA, Ferretti JJ, Portnoy DA, Rood JI. ASM Press, Washington, D.C. 137-153 (2000)
6. Spellerberg B.: Pathogenesis of neonatal Streptococcus agalactiae infections. Microbes Infect 2, 1733-1742 (2000)
7. Marchlewicz B. A. & J. L. Duncan: Lysis of erythrocytes by a hemolysin produced by a group B Streptococcus sp. Infect Immun 34, 787-794 (1981)
8. Tapsall J. W. & E. A. Phillips: The hemolytic and cytolytic activity of group B streptococcal hemolysin and its possible role in early onset group B streptococcal disease. Pathology 23, 139-144 (1991)
9. Nizet V., R. L. Gibson, E. Y. Chi, P. E. Framson, M. Hulse & C. E. Rubens: Group B streptococcal beta- hemolysin expression is associated with injury of lung epithelial cells. Infect Immun 64, 3818-3826 (1996)
10. Platt M. W.: In vivo hemolytic activity of group B streptococcus is dependent on erythrocyte-bacteria contact and independent of a carrier molecule. Curr Microbiol 31, 5-9 (1995)
11. Marchlewicz B. A. & J. L. Duncan: Properties of a hemolysin produced by group B streptococci. Infect Immun 30, 805-813 (1980)
12. Ferrieri P. Basic Concepts of Streptococci and Streptococcal Diseases. Surrey: Reedbooks, 1982.
13. Tsaihong J. & D. Wennerstrom: Effect of carrier molecules on production and properties of extracellular hemolysin produced by Streptococcus agalactiae. Curr Microbiol 9, 33-338 (1983)
14. Tapsall J.: Relationship between pigment production and haemoysin formation by Lancefield group B streptococci. J Med Microbiol 24, 83-87 (1987)
15. Spellerberg B., S. Martin, C. Brandt & R. Lutticken: The cyl genes of Streptococcus agalactiae are involved in the production of pigment. FEMS Microbiol Lett 188, 125-128 (2000)
16. Spellerberg B., B. Pohl, G. Haase, S. Martin, J. Weber- Heynemann & R. Lutticken: Identification of genetic determinants for the hemolytic activity of Streptococcus agalactiae by ISS1 transposition. J Bacteriol 181, 3212-3219 (1999)
17. Pritzlaff C. A., J. C. Chang, S. P. Kuo, G. S. Tamura, C. E. Rubens & V. Nizet: Genetic basis for the beta- haemolytic/cytolytic activity of group B Streptococcus. Mol Microbiol 39, 236-247 (2001)
18. Wennerstrom D. E.: Group B streptococcal type Ia sepsis in mice after intranasal inoculation and the effect of infection on lungs. Infect Immun 26, 287-293 (1979)
19. Nizet V., R. L. Gibson & C. E. Rubens: The role of group B streptococci beta-hemolysin expression in newborn lung injury. Adv Exp Med Biol 418, 627-630 (1997)
20. Puliti M., V. Nizet, C. von Hunolstein, F. Bistoni, P. Mosci, G. Orefici & L. Tissi: Severity of group B streptococcal arthritis is correlated with beta-hemolysin expression. J Infect Dis 182, 824-832 (2000)
21. Ring A., J. S. Braun, J. Pohl, V. Nizet, W. Stremmel & J. L. Shenep: Group B streptococcal beta-hemolysin induces mortality and liver injury in experimental sepsis. J Infect Dis 185, 1745-1753 (2002)
22. Gibson R. L., V. Nizet & C. E. Rubens: Group B streptococcal beta-hemolysin promotes injury of lung microvascular endothelial cells. Pediatr Res 45, 626-634 (1999)
23. Nizet V., K. S. Kim, M. Stins, M. Jonas, E. Y. Chi, D. Nguyen & C. E. Rubens: Invasion of brain microvascular endothelial cells by group B streptococci. Infect Immun 65, 5074-5081 (1997)
24. Ring A., J. S. Braun, V. Nizet, W. Stremmel & J. L. Shenep: Group B streptococcal beta-hemolysin induces nitric oxide production in murine macrophages. J Infect Dis 182, 150-157 (2000)
25. Doran K. S., J. C. Chang, V. M. Benoit, L. Eckmann & V. Nizet: Group B streptococcal beta-hemolysin/cytolysin promotes invasion of human lung epithelial cells and the release of interleukin-8. J Infect Dis 185, 196-203 (2002)
26. Doran K, G. Y. Liu, V.: Group B streptococcal beta- hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. J Clin Invest 112, 736-744 (2003)
27. Fettucciari K., E. Rosati, L. Scaringi, P. Cornacchione, G. Migliorati, R. Sabatini, I. Fetriconi, R. Rossi & P. Marconi: Group B Streptococcus induces apoptosis in macrophages. J Immunol 165, 3923-3933 (2000)
28. Henneke P., O. Takeuchi, R. Malley, E. Lien, R. R. Ingalls, M. W. Freeman, T. Mayadas, V. Nizet, S. Akira, D. L. Kasper & D. T. Golenbock: Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol 169, 3970-3977 (2002)
29. Talati A. J., D. T. Crouse, B. K. English, C. Newman, L. Harrison & E. Meals: Immunomodulation by exogenous surfactant: effect on TNF-alpha secretion and luminol- enhanced chemiluminescence activity by murine macrophages stimulated with group B streptococci. Microbes Infect 3, 267-273 (2001)
30. Herting E., O. Gefeller, M. Land, L. van Sonderen, K. Harms & B. Robertson: Surfactant treatment of neonates with respiratory failure and group B streptococcal infection. Members of the Collaborative European Multicenter Study Group. Pediatrics 106, 957-964; discussion 1135 (2000)
31. Dal M.-C. & H. Monteil: Hemolysin produced by group B Streptococcus agalactiae. FEMS Microbiol Lett 16, 89-94 (1983)
32. Qui G. N., T. H., T. Toida, I. Koshiishi & I. T: Compositional analysis of hyaluronan, chondroitin sulfate and dermatan sulfate: HPLC of disaccharides produced from the glycosaminoglycans by solvolysis. Chem. Pharm. Bull. (Tokyo) 44, 1017-1020 (1996)
33. Baker J. R., H. Yu, K. Morrison, W. F. Averett & D. G. Pritchard: Specificity of the hyaluronate lyase of group-B streptococcus toward unsulphated regions of chondroitin sulphate. Biochem J 327 (Pt 1), 65-71 (1997)
34. Baker J. R. & D. G. Pritchard: Action pattern and substrate specificity of the hyaluronan lyase from group B streptococci. Biochem J 348 Pt 2, 465-471 (2000)
35. Lin B., S. K. Hollingshead, J. E. Coligan, M. L. Egan, J. R. Baker & D. G. Pritchard: Cloning and expression of the gene for group B streptococcal hyaluronate lyase. J Biol Chem 269, 30113-30116 (1994)
36. Gase K., J. Ozegowski & H. Malke: The Streptococcus agalactiae hylB gene encoding hyaluronate lyase: completion of the sequence and expression analysis. Biochim Biophys Acta 1398, 86-98 (1998)
37. Pritchard D. G. & B. Lin: Group B streptococcal neuraminidase is actually a hyaluronidase. Infect Immun 61, 3234-3239 (1993)
38. Pritchard D. G., B. Lin, T. R. Willingham & J. R. Baker: Characterization of the group B streptococcal hyaluronate lyase. Arch Biochem Biophys 315, 431-437 (1994)
39. Mello L. V., B. L. De Groot, S. Li & M. J. Jedrzejas: Structure and flexibility of Streptococcus agalactiae hyaluronate lyase complex with its substrate. Insights into the mechanism of processive degradation of hyaluronan. J Biol Chem 277, 36678-36688 (2002)
40. Li S. & M. J. Jedrzejas: Hyaluronan binding and degradation by Streptococcus agalactiae hyaluronate lyase. J Biol Chem 276, 41407-41416 (2001)
41. Miyake K., C. B. Underhill, J. Lesley & P. W. Kincade: Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J Exp Med 172, 69-75 (1990)
42. Haynes B. F., M. J. Telen, L. P. Hale & S. M. Denning: CD44-a molecule involved in leukocyte adherence and T-cell activation. Immunol Today 10, 423-428 (1989)
43. Milligan T. W., C. J. Baker, D. C. Straus & S. J. Mattingly: Association of elevated levels of extracellular neuraminidase with clinical isolates of type III group B streptococci. Infect Immun 21, 738-746 (1978)
44. Juul S. E., M. G. Kinsella, W. E. Truog, R. L. Gibson & G. J. Redding: Lung hyaluronan decreases during group B streptococcal pneumonia in neonatal piglets. Am J Respir Crit Care Med 153, 1567-1570 (1996)
45. Strunk R. C., D. M. Eidlen & R. J. Mason: Pulmonary alveolar type II epithelial cells synthesize and secrete proteins of the classical and alternative complement pathways. J Clin Invest 81, 1419-1426 (1988)
46. Fernandez H. N. & T. E. Hugli: Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a. J Biol Chem 253, 6955-6964 (1978)
47. Hemming V. G., D. W. McCloskey & H. R. Hill: Pneumonia in the neonate associated with group B streptococcal septicemia. Am J Dis Child 130, 1231-1233 (1976)
48. Quirante J., R. Ceballos & G. Cassady: Group B beta-hemolytic streptococcal infection in the newborn. I. Early onset infection. Am J Dis Child 128, 659-665 (1974)
49. Hill H. R.: Biochemical, structural, and functional abnormalities of polymorphonuclear leukocytes in the neonate. Pediatr Res 22, 375-382 (1987)
50. Hill H. R., J. F. Bohnsack, E. Z. Morris, N. H. Augustine, C. J. Parker, P. P. Cleary & J. T. Wu: Group B streptococci inhibit the chemotactic activity of the fifth component of complement. J Immunol 141, 3551-3556 (1988)
51. Bohnsack J. F., K. W. Mollison, A. M. Buko, J. C. Ashworth & H. R. Hill: Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus. Biochem J 273 (Pt 3), 635-640 (1991)
52. Mollison K. W., W. Mandecki, E. R. Zuiderweg, L. Fayer, T. A. Fey, R. A. Krause, R. G. Conway, L. Miller, R. P. Edalji, M. A. Shallcross & et al.: Identification of receptor-binding residues in the inflammatory complement protein C5a by site-directed mutagenesis. Proc Natl Acad Sci U S A 86, 292-296 (1989)
53. Chmouryguina I., A. Suvorov, P. Ferrieri & P. P. Cleary: Conservation of the C5a peptidase genes in group A and B streptococci. Infect Immun 64, 2387-2390 (1996)
54. Cleary P. P., J. Handley, A. N. Suvorov, A. Podbielski & P. Ferrieri: Similarity between the group B and A streptococcal C5a peptidase genes. Infect Immun 60, 4239-4244 (1992)
55. Chmouryguina, II, A. N. Suvorov, B. Carlson & P. Cleary: Structural and functional similarity of C5a-ase enzymes from group A and B streptococci. Adv Exp Med Biol 418, 757-759 (1997)
56. Bohnsack J. F., X. N. Zhou, P. A. Williams, P. P. Cleary, C. J. Parker & H. R. Hill: Purification of the proteinase from group B streptococci that inactivates human C5a. Biochim Biophys Acta 1079, 222-228 (1991)
57. Bohnsack J. F., X. N. Zhou, J. N. Gustin, C. E. Rubens, C. J. Parker & H. R. Hill: Bacterial evasion of the antibody response: human IgG antibodies neutralize soluble but not bacteria-associated group B streptococcal C5a-ase. J Infect Dis 165, 315-321 (1992)
58. Glaser P., C. Rusniok, C. Buchrieser, F. Chevalier, L. Frangeul, T. Msadek, M. Zouine, E. Couve, L. Lalioui, C. Poyart, P. Trieu-Cuot & F. Kunst: Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease. Mol Microbiol 45, 1499-1513 (2002)
59. Bohnsack J. F., J. K. Chang & H. R. Hill: Restricted ability of group B streptococcal C5a-ase to inactivate C5a prepared from different animal species. Infect Immun 61, 1421-1426 (1993)
60. Bohnsack J. F., K. Widjaja, S. Ghazizadeh, C. E. Rubens, D. R. Hillyard, C. J. Parker, K. H. Albertine & H. R. Hill: A role for C5 and C5a-ase in the acute neutrophil response to group B streptococcal infections. J Infect Dis 175, 847-855 (1997)
61. Kishimoto T. K., M. A. Jutila, E. L. Berg & E. C. Butcher: Neutrophil Mac-1 and MEL-14 adhesion proteins inversely regulated by chemotactic factors. Science 245, 1238-1241 (1989)
62. Cheng Q., D. Stafslien, S. S. Purushothaman & P. Cleary: The group B streptococcal C5a peptidase is both a specific protease and an invasin. Infect Immun 70, 2408-2413 (2002)
63. Beckmann C., J. D. Waggoner, T. O. Harris, G. S. Tamura & C. E. Rubens: Identification of novel adhesins from Group B streptococci by use of phage display reveals that C5a peptidase mediates fibronectin binding. Infect Immun 70, 2869-2876 (2002)
64. Sugano N., H. Tanaka, K. Ito & S. Murai: Arg-Gly-Asp(RGD) peptides inhibit Streptococcus mitis to adhere to fibronectin. J Nihon Univ Sch Dent 39, 154-155 (1997)
65. Cheng Q., S. Debol, H. Lam, R. Eby, L. Edwards, Y. Matsuka, S. B. Olmsted & P. P. Cleary: Immunization with C5a peptidase or peptidase-type III polysaccharide conjugate vaccines enhances clearance of group B streptococci from lungs of infected mice. Infect Immun 70, 6409-6415 (2002)
66. Cheng Q., B. Carlson, S. Pillai, R. Eby, L. Edwards, S. B. Olmsted & P. Cleary: Antibody against surface-bound C5a peptidase is opsonic and initiates macrophage killing of group B streptococci. Infect Immun 69, 2302-2308 (2001)
67. Christie R., N. Atkins & E. Munch-Peterson: A note on a lytic phenomenon shown by group B streptococci. Aust J Exp Biol Med Sci 22, 197-200 (1944)
68. Bernheimer A. W., R. Linder & L. S. Avigad: Nature and mechanism of action of the CAMP protein of group B streptococci. Infect Immun 23, 838-844 (1979)
69. Ruhlmann J., B. Wittmann-Liebold, D. Jurgens & F. Fehrenbach: Complete amino acid sequence of protein B. FEBS microbiol Lett 235, 262-266 (1988)
70. Schneewind O., K. Friedrich & R. Lutticken: Cloning and expression of the CAMP factor of group B streptococci in Escherichia coli. Infect Immun 56, 2174-2179 (1988)
71. Podbielski A., O. Blankenstein & R. Lutticken: Molecular characterization of the cfb gene encoding group B streptococcal CAMP-factor. Med Microbiol Immunol (Berl) 183, 239-256 (1994)
72. Gase K., J. J. Ferretti, C. Primeaux & W. M. McShan: Identification, cloning, and expression of the CAMP factor gene (cfa) of group A streptococci. Infect Immun 67, 4725-4731 (1999)
73. Lang S. & M. Palmer: Characterization of Streptococcus agalactiae CAMP factor as a pore-forming toxin. J Biol Chem 2003)
74. Jurgens D., B. Sterzik & F. J. Fehrenbach: Unspecific binding of group B streptococcal cocytolysin (CAMP factor) to immunoglobulins and its possible role in pathogenicity. J Exp Med 165, 720-732 (1987)
75. Skalka B. & J. Smola: Lethal effect of CAMP-factor and UBERIS-factor - a new finding about diffusible exosubstances of Streptococcus agalactiae and Streptococcus uberis. Zentralbl Bakteriol A 249, 190-194 (1981)
76. Jackson R. J., M. L. Dao & D. V. Lim: Cell-associated collagenolytic activity by group B streptococci. Infect Immun 62, 5647-5651 (1994)
77. Lin B., W. F. Averett, J. Novak, W. W. Chatham, S. K. Hollingshead, J. E. Coligan, M. L. Egan & D. G. Pritchard: Characterization of PepB, a group B streptococcal oligopeptidase. Infect Immun 64, 3401-3406 (1996)
78. Hellerqvist C. G., J. Rojas, R. S. Green, S. Sell, H. Sundell & M. T. Stahlman: Studies on group B beta- hemolytic Streptococcus. I. Isolation and partial characterization of an extracellular toxin. Pediatr Res 15, 892-898 (1981)
79. Rojas J., L. E. Larsson, C. G. Hellerqvist, K. L. Brigham, M. E. Gray & M. T. Stahlman: Pulmonary hemodynamic and ultrastructural changes associated with Group B streptococcal toxemia in adult sheep and newborn lambs. Pediatr Res 17, 1002-1008 (1983)
80. Hellerqvist C. G., H. Sundell & P. Gettins: Molecular basis for group B beta-hemolytic streptococcal disease. Proc Natl Acad Sci U S A 84, 51-55 (1987)
81. Sundell H. W., H. Yan, C. E. Carter, B. D. Wamil, K. Wu, R. Gaddipati, D. Li & C. G. Hellerqvist: Isolation and identification of the group B streptococcal toxin CM101 from infants with sepsis. J Pediatr 137, 338-344 (2000)
82. Tettelin H., V. Masignani, M. J. Cieslewicz, J. A. Eisen, S. Peterson, M. R. Wessels, I. T. Paulsen, K. E. Nelson, I. Margarit, T. D. Read, L. C. Madoff, A. M. Wolf, M. J. Beanan, L. M. Brinkac, S. C. Daugherty, R. T. DeBoy, A. S. Durkin, J. F. Kolonay, R. Madupu, M. R. Lewis, D. Radune, N. B. Fedorova, D. Scanlan, H. Khouri, S. Mulligan, H. A. Carty, R. T. Cline, S. E. Van Aken, J. Gill, M. Scarselli, M. Mora, E. T. Iacobini, C. Brettoni, G. Galli, M. Mariani, F. Vegni, D. Maione, D. Rinaudo, R. Rappuoli, J. L. Telford, D. L. Kasper, G. Grandi & C. M. Fraser: Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc Natl Acad Sci U S A 99, 12391-12396 (2002)
83. Tong H. H., L. E. Blue, M. A. James & T. F. DeMaria: Evaluation of the virulence of a Streptococcus pneumoniae neuraminidase-deficient mutant in nasopharyngeal colonization and development of otitis media in the chinchilla model. Infect Immun 68, 921-924 (2000)
84. Holmes A. R., R. McNab, K. W. Millsap, M. Rohde, S. Hammerschmidt, J. L. Mawdsley & H. F. Jenkinson: The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence. Mol Microbiol 41, 1395-1408 (2001)
85. Chhatwal G. S.: Anchorless adhesins and invasins of Gram-positive bacteria: a new class of virulence factors. Trends Microbiol 10, 205-208 (2002)
86. Jones A. L., K. M. Knoll & C. E. Rubens: Identification of Streptococcus agalactiae virulence genes in the neonatal rat sepsis model using signature-tagged mutagenesis. Mol Microbiol 37, 1444-1455 (2000)
87. Hughes M. J., J. C. Moore, J. D. Lane, R. Wilson, P. K. Pribul, Z. N. Younes, R. J. Dobson, P. Everest, A. J. Reason, J. M. Redfern, F. M. Greer, T. Paxton, M. Panico, H. R. Morris, R. G. Feldman & J. D. Santangelo: Identification of major outer surface proteins of Streptococcus agalactiae. Infect Immun 70, 1254-1259 (2002)