Healthy individuals that control a latent infection with Mycobacterium tuberculosis express high levels of Th1 cytokines and the IL-4 antagonist IL-4δ2

Journal of Immunology

Volumn 172, Issue 11, 2004, Pages 6938-6943

  Demissie, Abebech ^a   Abebe, Markos ^a   Aseffa, Abraham ^a   Rook, Graham ^b   Fletcher, Helen ^c   Zumla, Alimuddin ^c   Weldingh, Karin ^b   Brock, Inger ^b   Andersen, Peter ^b   Doherty, T Mark ^b   Chintu, Chifumbe ^d   Mulundu, Gina ^d   Mwaba, Peter ^d   McAdam, K P W J ^e   Owiafe, Patrick ^e   Warndorff, David ^e   Lienhardt, Christian ^e   Brookes, R ^e   Hill, Phillip ^e  

^a ARMAUER HANSEN RESEARCH INSTITUTE   (Ethiopia)

^b STATENS SERUM INSTITUT   (Denmark)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^d UNIVERSITY OF ZAMBIA   (Zambia)

^e MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 4DELTA2; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ADULT; ANTIGEN RECOGNITION; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENMARK; ENDEMIC DISEASE; ETHIOPIA; HUMAN; IMMUNITY; INFECTION CONTROL; INFECTION SENSITIVITY; MULTICENTER STUDY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; TUBERCULOSIS;

EID: 2442692860     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.11.6938     Document Type: Article

References (31)

1. Anon. 2002. Global Tuberculosis Control. WHO Report 2002. World Health Organization., Geneva, Switzerland, p. 181.
2. Colditz, G. A., C. S. Berkey, F. Mosteller, T. F. Brewer, M. E. Wilson, E. Burdick, and H. V. Fineberg. 1995. The efficacy of bacillus Calmette-Guérin vaccination of newborns and infants in the prevention of tuberculosis: meta-analyses of the published literature. Pediatrics 96:29.
3. Cooper, A. M., D. K. Dalton, T. A. Stewart, J. P. Griffin, D. G. Russell, and I. M. Orme. 1993. Disseminated tuberculosis in interferon γ gene-disrupted mice. J. Exp. Med. 178:2243.
4. de Jong, R., F. Altare, I. A. Haagen, D. G. Elferink, T. Boer, P. J. van Breda Vriesman, P. J. Kabel, J. M. Draalsma, J. T. van Dissel, F. P. Kroon, et al. 1998. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science 280:1435.
5. Jouanguy, E., F. Altare, S. Lamhamedi, P. Revy, J. F. Emile, M. Newport, M. Levin, S. Blanche, E. Seboun, A. Fischer, and J. L. Casanova. 1996. Interferon-γ-receptor deficiency in an infant with fatal bacille Calmette-Guérin infection. N. Engl. J. Med. 335:1956.
6. Agger, E. M., and P. Andersen. 2001. Tuberculosis subunit vaccine development: on the role of interferon-γ. Vaccine 19:2298.
7. Andersen, P., M. E. Munk, J. M. Pollock, and T. M. Doherty. 2000. Specific immune-based diagnosis of tuberculosis. Lancet 356:1099.
8. Ulrichs, T., P. Anding, S. Porcelli, S. H. Kaufmann, and M. E. Munk. 2000. Increased numbers of ESAT-6- and purified protein derivative-specific γ interferon-producing cells in subclinical and active tuberculosis infection. Infect. Immun. 68:6073.
9. Doherty, T. M., A. Demissie, J. Olobo, D. Wolday, S. Britton, T. Eguale, P. Ravn, and P. Andersen. 2002. Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients. J. Clin. Microbiol. 40:704.
10. Seah, G. T., and G. A. Rook. 1999. A sensitive, non-radioactive quantitative method for measuring IL-4 and IL-4δ2 mRNA in unstimulated cells from multiple clinical samples, using nested RT-PCR. J. Immunol. Methods 228:139.
11. Arinobu, Y., S. P. Atamas, T. Otsuka, H. Niiro, K. Yamaoka, H. Mitsuyasu, Y. Niho, N. Hamasaki, B. White, and K. Izuhara. 1999. Antagonistic effects of an alternative splice variant of human IL-4, IL-4δ2, on IL-4 activities in human monocytes and B cells. Cell. Immunol. 191:161.
12. Vasiliev, A. M., R. N. Vasilenko, N. L. Kulikova, S. M. Andreev, I. O. Chikileva, G. Y. Puchkova, I. V. Kosarev, A. V. Khodyakova, V. S. Khlebnikov, L. R. Ptitsyn, et al. 2003. Structural and functional properties of IL-4δ2, an alternative splice variant of human IL-4. J. Proteome Res. 2:273.
13. Vekemans, J., C. Lienhardt, J. S. Sillah, J. G. Wheeler, G. P. Lahai, M. T. Doherty, T. Corrah, P. Andersen, K. P. McAdam, and A. Marchant. 2001. Tuberculosis contacts but not patients have higher γ interferon responses to ESAT-6 than do community controls in The Gambia. Infect. Immun. 69:6554.
14. Lalvani, A., P. Nagvenkar, Z. Udwadia, A. A. Pathan, K. A. Wilkinson, J. S. Shastri, K. Ewer, A. V. Hill, A. Mehta, and C. Rodrigues. 2001. Enumeration of T cells specific for RD1-encoded antigens suggests a high prevalence of latent Mycobacterium tuberculosis infection in healthy urban Indians. J. Infect. Dis. 183:469.
15. Ekerfelt, C., J. Ernerudh, and M. C. Janmalm. 2002. Detection of spontaneous and antigen-induced human interleukin-4 responses in vitro: comparison of ELISPOT, a novel ELISA and real-time RT-PCR. J. Immunol. Methods 260:55.
16. Seah, G. T., and G. A. Rook. 2001. High levels of mRNA encoding IL-4 in unstimulated peripheral blood mononuclear cells from tuberculosis patients revealed by quantitative nested reverse transcriptase-polymerase chain reaction; correlations with serum IgE levels. Scand. J. Infect. Dis. 33:106.
17. Lienhardt, C., A. Azzurri, A. Amedei, K. Fielding, J. Sillah, O. Y. Sow, B. Bah, M. Benagiano, A. Diallo, R. Manetti, et al. 2002. Active tuberculosis in Africa is associated with reduced Th1 and increased Th2 activity in vivo. Eur. J. Immunol. 32:1605.
18. Seah, G. T., G. M. Scott, and G. A. Rook. 2000. Type 2 cytokine gene activation and its relationship to extent of disease in patients with tuberculosis. J. Infect. Dis. 181:385.
19. Lillebaek, T., A. Dirksen, E. Vynnycky, I. Baess, V. O. Thomsen, and A. B. Andersen. 2003. Stability of DNA patterns and evidence of Mycobacterium tuberculosis reactivation occurring decades after the initial infection. J. Infect. Dis. 188:1032.
20. Corbett, E. L., and K. M. De Cock. 1996. Tuberculosis in the HIV-positive patient. Br. J. Hosp. Med. 56:200.
21. Wu-Hsieh, B. A., C. K. Chen, J. H. Chang, S. Y. Lai, C. H. Wu, W. C. Cheng, P. Andersen, and T. M. Doherty. 2001. Long-lived immune response to early secretory antigenic target 6 in individuals who had recovered from tuberculosis. Clin. Infect. Dis. 33:1336.
22. Demissie, A., P. Ravn, J. Olobo, T. M. Doherty, T. Eguale, M. Geletu, W. Hailu, P. Andersen, and S. Britton. 1999. T-cell recognition of Mycobacterium tuberculosis culture filtrate fractions in tuberculosis patients and their household contacts. Infect. Immun. 67:5967.
23. Jo, E. K., J. K. Park, and H. M. Dockrell. 2003. Dynamics of cytokine generation in patients with active pulmonary tuberculosis. Curr. Opin. Infect. Dis. 16:205.
24. Turner, J., T. Corrah, S. Sabbally, H. Whittle, and H. M. Dockrell. 2000. A longitudinal study of in vitro IFNγ production and cytotoxic T cell responses of tuberculosis patients in The Gambia. Tubercle Lung Dis. 80:161.
25. Marchant, A., A. Amedei, A. Azzuri, J. Vekemans, M. Benagiano, C. Tamburini, C. Lienhardt, T. Corrah, K. P. McAdam, S. Romagnani, M. M. D'Elios, and G. Del Prete. 2001. Polarization of PPD-specific T-cell response of patients with tuberculosis from Th0 to Th1 profile after successful antimycobacterial therapy or in vitro conditioning with interferon-α or interleukin-12. Am. J. Respir. Cell Mol. Biol. 24:187.
26. Olobo, J. O., M. Geletu, A. Demissie, T. Eguale, K. Hiwot, G. Aderaye, and S. Britton. 2001. Circulating TNF-α, TGF-β, and IL-10 in tuberculosis patients and healthy contacts. Scand. J. Immunol. 53:85.
27. Elias, D., D. Wolday, H. Akuffo, B. Petros, U. Bronner, and S. Britton. 2001. Effect of deworming on human T cell responses to mycobacterial antigens in helminth-exposed individuals before and after bacille Calmette-Guérin (BCG) vaccination. Clin. Exp. Immunol. 123:219.
28. Stewart, G. R., M. Boussinesq, T. Coulson, L. Elson, T. Nutman, and J. E. Bradley. 1999. Onchocerciasis modulates the immune response to mycobacterial antigens. Clin. Exp. Immunol. 117:517.
29. Orsini, B., B. Ottanelli, A. Amedei, E. Surrenti, M. Capanni, G. Del Prete, A. Amorosi, S. Milani, M. M. D'Elios, and C. Surrenti. 2003. Helicobacter pylori cag pathogenicity island is associated with reduced expression of interleukin-4 (IL-4) mRNA and modulation of the IL-4δ2 mRNA isoform in human gastric mucosa. Infect. Immun. 71:6664.
30. Chiaramonte, M. G., M. Mentink-Kane, B. A. Jacobson, A. W. Cheever, M. J. Whitters, M. E. Goad, A. Wong, M. Collins, D. D. Donaldson, M. J. Grusby, and T. A. Wynn. 2003. Regulation and function of the interleukin 13 receptor α 2 during a T helper cell type 2-dominant immune response. J. Exp. Med. 197:687.
31. Seah, G. T., P. S. Gao, J. M. Hopkin, and G. A. Rook. 2001. Interleukin-4 and its alternatively spliced variant (IL-4δ2) in patients with atopic asthma. Am. J. Respir. Crit. Care Med. 164:1016.