Onchocerciasis modulates the immune response to mycobacterial antigens

Clinical and Experimental Immunology

Volumn 117, Issue 3, 1999, Pages 517-523

  Stewart, G R ^a,b   Boussinesq, M ^c   Coulson, T ^d   Elson, L ^e   Nutman, T ^e   Bradley, Janette E ^a,f  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^c Institut de Recherche pour le Developpement Cameroon   (Cameroon)

^d INSTITUTE OF ZOOLOGY   (United Kingdom)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^f UNIVERSITY OF SALFORD   (United Kingdom)

Author keywords

Helminth; Immune response; Mycobacterium; Onchocerca volvulus; PPD

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; MYCOBACTERIUM ANTIGEN; TUBERCULIN;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; HOST RESISTANCE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IMMUNOREGULATION; INTERFERON PRODUCTION; LYMPHOCYTE ACTIVATION; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; ANIMALS; ANTIGENS, HELMINTH; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; LEPROSY; LEUKOCYTES, MONONUCLEAR; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; ONCHOCERCA VOLVULUS; ONCHOCERCIASIS; TUBERCULIN; TUBERCULOSIS;

EID: 0032808890     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1999.01015.x     Document Type: Article

References (40)

1. 1 Duke BOL. Human onchocerciasis - an overview of the disease. Acta Leidensia 1990; 59:9-24.
2. 2 Schulz-Key H. Observations on the reproductive biology of Onchocerca volvulus. Acta Leidensia 1990; 59:27-44.
3. 3 Ward DJ, Nutman TB, Zea-Flores G et al. Onchocerciasis and immunity in humans: enhanced T cell responsiveness to parasite antigen in putatively immune individuals. J Infect Dis 1988; 157:536-43.
4. 4 Gallin M, Edmonds K, Ellner JJ et al. Cell mediated immune responses in human infection with Onchocerca volvulus. J Immunol 1988; 140:1406-19.
5. 5 Elkhalifa MY, Ghalib HW, Dafa'Alla T et al. Suppression of human lymphocyte responses to specific and non-specific stimuli in human onchocerciasis. Clin Exp Immunol 1991; 83:433-9.
6. 6 Soboslay PT, Dreweck CM, Hoffmann WH et al. Ivermectin-facilitated immunity in onchocerciasis. Reversal of lymphocytopenia, cellular anergy and deficient cytokine production after single treatment. Clin Exp Immunol 1992; 89:407-13.
7. 7 Elson L, Guderian R, Calvopena M et al. Immunity to Onchocerciasis: putative immune individuals produce a Th1-like response to Onchocerca volvulus. J Infect Dis 1995; 171:652-8.
8. 8 Mahanty S, King C, Kumaraswami V et al. IL-4 and lL-5-secreting lymphocyte populations are preferentially stimulated by parasite-derived antigens in human tissue invasive nematode infections. J Immunol 1993; 151:3704-11.
9. 9 Kirkwood B, Smith P, Marshall T et al. Variations in the prevalence and intensity of microfilarial infections by age, sex, place and time in the area of the Onchocerciasis Control Programme. Trans R Soc Trop Med Hyg 1983; 77:857-61.
10. 10 Steel C, Guinea A, McCarthy JS et al. Long-term effect of prenatal exposure to maternal microfilaracmia on immune responsiveness to filarial parasite antigens. Lancet 1994; 343:890-3.
11. 11 Wilson K, Grenfell B. Generalized linear modelling for parasitologists. Parasitol Today 1997; 13:33-38.
12. 12 Prost A, Nebout M, Rougemont A. Lepromatous leprosy and onchocerciasis. Br Med J 1979; 1:589-90.
13. 11 Greene BM, Gbakima AA, Albiez EJ et al. Humoral and cellular immune responses to Onchocercu volvulus infection in humans. Rev Infect Dis 1985; 7:789-95.
14. 14 Rougemont A, Bobson-Pontal ML, Pontal PG et al. Tuberculin skin tests and BCG vaccination in hyperendemic area of onchocerciasis. Lancet 1977; 2:309.
15. 15 Ottesen EA, Weller PF, Heck L. Specific cellular immune unresponsiveness in human filariasis. Immunology 1977; 33:413-21.
16. 16 Piessens WF, McGreevy PW, Piessens M et al. Immune responses in human infections with Brugia malayi: specific cellular unresponsiveness to filarial antigens. J Clin Invest 1980; 65:172-9.
17. 17 Sartono K, Kruize TC, Kurniawan A et al. Elevated cellular immune responses and interferon-gamma release after long-term diethylcarbamazine treatment of patients with human lymphatic filariasis. J Infect Dis 1995; 17:1683-7.
18. 18 Mosmann TR, Cherwinski H, Bond MW et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986; 136:2348-57.
19. 19 Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989; 9:145-73.
20. 20 Salgame P, Abrams JS, Clayberger C et al. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T-cell clones. Science 1991; 254:279-82.
21. 21 Kemp M, Kurtzhals JA, Bendtzen K et al. Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis. Infect Immun 1993; 61:1069-73.
22. 22 Pearce EJ, Caspar P, Grzych J-M et al. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J Exp Med 1991; 173:159-66.
23. 23 Finkelman FD, Pearce EJ, Urban JF Jr et al. Regulation and biological function of helminth-induced cytokine responses. Immunol Today 1991; 12:A62-A66.
24. 24 Williams ME, Montenegro S, Domingues AL et al. Leukocytes of patients with Schistosoma mansoni respond with a Th2 pattern of cytokine production to mitogen or egg antigens but with a Th0 pattern to worm antigens. J Infect Dis 1994; 170:946-54.
25. 25 Yamamura M, Uyemura K, Deans RJ et al. Defining protective responses to pathogens - cytokine profiles in leprosy lesions. Science 1991; 254:277-9.
26. 26 Misra N, Murtaza A, Walker B et al. Cytokine profile of circulating cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae. Immunology 1995; 86:97-103.
27. 27 Sanchez FO, Rodriguez JI, Agudelo G et al. Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls. Infect Immun 1994; 62:5673-8.
28. 28 Surcel H-M, Troye-Blomberg M, Paulie S et al. Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens. Immunology 1994; 81:171-6.
29. 29 Zhang M, Lin Y, Iyer DV et al. T-cell cytokine responses in human infection with Mycobacterium tuberculosis. Infect Immun 1995; 63:3231-4.
30. 30 Kullberg MC, Pearce EJ, Hieny SE et al. Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen. J Immunol 1992; 148:3264-70.
31. 31 Pearlman E, Kazura JW, Hazlett FE et al. Modulation of murine cytokine responses to mycobacterial antigens hy helminth-induced T helper 2 responses. J Immunol 1993; 151:4857-64.
32. 32 Actor JK, Shirai M, Kullberg MC et al. Helminth infection results in decreased virus- specific CD8+ cytotoxic T-cell and Th1 cytokine responses as well as delayed virus clearance, Proc Natl Acad Sci USA 1993;90:948-52.
33. 33 Curry AJ, Else KJ, Jones F et al. Evidence that eytokine-mediated immune, interactions induced hy Schistosima mansoni alter disease outcome in mice concurrently infected with Trichuris muris. J Exp Med 1995; 181:769-74.
34. 34 Sabin EA, Araujo MI, Carvalho KM et al. Impairment of tetanus toxoid-specific Th1-like immune responses in humans infected with Schistosoma mansoni. J Infect Dis 1996; 173:269-72.
35. 35 Lawrence RA, Allen JE, Oshorne J et al. Adult and microfilarial stages of the filarial parasite Brugia malayi stimulate contrasting cytokine and Ig isotype responses in BALB/c mice. J Immunol 1994; 153:1216-24.
36. 36 Sartono E, Kruize YCM, Kurniawan A et al. In Th2-biased lymphatic filarial patients, responses to purified protein derivative of Mycobacterium tuberculosis remain Th1. Eur J Immunol 1996; 26:501-4.
37. 37 Malhotra I, Ouma J, Wamachi A et al. In utero exposure to helminth and mycobacterial antigens generates cytokine responses similar to that observed in adults. J Clin Invest 1997; 99:1759-66.
38. 38 Grzych J-M, Pearce E, Cheever A et al. Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J Immunol 1991; 146:1322-7.
39. 39 Kilian HD, Nielson G, Cell-mediated and humoral immune responses to BCG and rubella vaccinations and to recall antigens in onchocerciasis patients. Trop Med Parasit 1989; 40:285-91.
40. 40 Colditz GA, Brewer TF, Berkey CS et al. Efficacy of BCG vaccine in the prevention of tuberculosis. Meta-analysis of the published literature. JAMA 1994; 271:698-702.