Young adult survivors of childhood acute lymphoblastic leukemia: Spontaneous GH secretion in relation to CNS radiation

Pediatric Blood and Cancer

Volumn 42, Issue 7, 2004, Pages 582-588

  Jarfelt, M ^a,c   Bjarnason, R ^a,b   Lannering, B ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^c QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

Author keywords

BMI; Childhood leukaemia; Cranial irradiation; Final height; GH secretion

Indexed keywords

GROWTH HORMONE; METHOTREXATE; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ANTHROPOMETRY; ARTICLE; BODY HEIGHT; BODY MASS; CANCER SURVIVAL; CHILDHOOD LEUKEMIA; CLINICAL ARTICLE; DRUG MEGADOSE; FEMALE; FOLLOW UP; GROWTH HORMONE RELEASE; HUMAN; HYPOTHALAMUS; MALE; PRIORITY JOURNAL; PROPHYLAXIS; RADIATION RESPONSE; REMISSION; SKULL IRRADIATION; STATISTICAL ANALYSIS; SWEDEN;

ADULT; BODY HEIGHT; BRAIN; FEMALE; FOLLOW-UP STUDIES; GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE;

EID: 2442690349     PISSN: 15455009     EISSN: None     Source Type: Journal    
DOI: 10.1002/pbc.20020     Document Type: Article

References (44)

1. Gustafsson GK, Schmiegelow K, Forestier E, et al. Improving outcome through two decades in childhood ALL in the Nordic countries: The impact of high-dose methotrexate in the reduction of CNS irradiation. Nordic Society of Pediatric Haematology and Oncology (NOPHO). Leukemia 2000;14(12):2267-2275.
2. Lannering B, Rosberg S, Marky I, et al. Reduced growth hormone secretion with maintained periodicity following cranial irradiation in children with acute lymphoblastic leukaemia. Clin Endocrinol (Oxf) 1995;42(2):153-159.
3. Sklar CA, Constine LS. Chronic neuroendocrinological sequelae of radiation therapy. Int J Radiat Oncol Biol Phys 1995;31(5):1113-1121.
4. Birkebaek NH, Fisker S, Clausen N, et al. Growth and endocrinological disorders up to 21 years after treatment for acute lymphoblastic leukemia in childhood. Med Pediatr Oncol 1998;30(6):351-356.
5. Holmes SJ, Economou G, Whitehouse RW, et al. Reduced bone mineral density in patients with adult onset growth hormone deficiency. J Clin Endocrinol Metab 1994;78(3):669-674.
6. Beshyah SA, Freemantle C, Thomas E, et al. Abnormal body composition and reduced bone mass in growth hormone deficient hypopituitary adults. Clin Endocrinol (Oxf) 1995;42(2):179-189.
7. Amato G, Carella C, Fazio S, et al. Body composition, bone metabolism, and heart structure and function in growth hormone (GH)-deficient adults before and after GH replacement therapy at low doses. J Clin Endocrinol Metab 1993;77(6):1671-1676.
8. Jorgensen JO, Pedersen SA, Thuesen L, et al. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1989;1(8649):1221-1225.
9. Gibney J, Wallace JD, Spinks T, et al. The effects of 10 years of recombinant human growth hormone (GH) in adult GH-deficient patients. J Clin Endocrinol Metab 1999;84(8):2596-2602.
10. Merola B, Cittadini A, Colao A, et al. Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency. J Clin Endocrinol Metab 1993;77(6):1658-16561.
11. Rosen T, Eden S, Larson G, et al. Cardiovascular risk factors in adult patients with growth hormone deficiency. Acta Endocrinol (Copenh) 1993;129(3):195-200.
12. Cuneo RC, Salomon F, Watts GF, et al. Growth hormone treatment improves serum lipids and lipoproteins in adults with growth hormone deficiency. Metabolism 1993;42(12):1519-1523.
13. Talvensaari KK, Lanning M, Tapanainen P, et al. Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome. J Clin Endocrinol Metab 1996;81(8): 3051-3055.
14. Rosen T, Wiren L, Wilhelmsen L, et al. Decreased psychological well-being in adult patients with growth hormone deficiency. Clin Endocrinol (Oxf) 1994;40(1):111-116.
15. Gustafsson G, Kreuger A, Dohlwitz A. Acute lymphoblastic leukemia in Swedish children 1973-1978. Acta Paediatr Scand 1981;70(5):609-614.
16. Wikland KA, Luo ZC, Niklasson A, et al. Swedish population-based longitudinal reference values from birth to 18 years of age for height, weight and head circumference. Acta Paediatr 2002;91(7):739-754.
17. Karlberg P, Taranger J, Engstrom I, et al. I. Physical growth from birth to 16 years and longitudinal outcome of the study during the same age period. Acta Paediatr Scand Suppl 1976;XX(258): 7-76.
18. Merriam GR, Wachter KW. Algorithms for the study of episodic hormone secretion. Am J Physiol 1982;243(4):E310-E318.
19. Albertsson-Wikland K, Rosberg S, Libre E, et al. Growth hormone secretory rates in children as estimated by deconvolution analysis of 24-h plasma concentration profiles. Am J Physiol 1989;257 (6 Pt 1):E809-E814.
20. Blum WF, Breier BH. Radioimmunoassays for IGFs and IGFBPs. Growth Regul 1994;4(Suppl 1):11-19.
21. Brennan BM, Rahim A, Mackie EM, et al. Growth hormone status in adults treated for acute lymphoblastic leukaemia in childhood. Clin Endocrinol (Oxf) 1998;48(6):777-783.
22. Blatt J, Bercu BB, Gillin JC, et al. Reduced pulsatile growth hormone secretion in children after therapy for acute lymphoblastic leukemia. J Pediatr 1984;104(2):182-186.
23. Reutens AT, Veldhuis JD, Hoffman DM, et al. A highly sensitive growth hormone (GH) enzyme-linked immunosorbent assay uncovers increased contribution of a tonic mode of GH secretion in adults with organic GH deficiency. J Clin Endocrinol Metab 1996;81(4):1591-1597.
24. Hartman ML. The growth hormone research society consensus guidelines for the diagnosis and treatment of adult GH deficiency. Growth Horm IGF Res 1998;8(Suppl A):25-29.
25. Hoffman DM, O'Sullivan AJ, Baxter RC, et al. Diagnosis of growth-hormone deficiency in adults. Lancet 1994;343(8905): 1064-1068.
26. Ho KY, Evans WS, Blizzard RM, et al. Effects of sex and age on the 24-hour profile of growth hormone secretion in man: Importance of endogenous estradiol concentrations. J Clin Endocrinol Metab 1987;64(1):51-58.
27. Albertsson-Wikland K, Rosberg S, Karlberg J, et al. Analysis of 24-hour growth hormone profiles in healthy boys and girls of normal stature: Relation to puberty. J Clin Endocrinol Metab 1994;78(5):1195-1201.
28. Fors H, Matsuoka H, Bosaeus I, et al. Serum leptin levels correlate with growth hormone secretion and body fat in children. J Clin Endocrinol Metab 1999;84(10):3586-3590.
29. Toogood AA, Jones J, O'Neill PA, et al. The diagnosis of severe growth hormone deficiency in elderly patients with hypothalamic-pituitary disease. Clin Endocrinol (Oxf) 1998;48(5):569-576.
30. Svensson J, Johannsson G, Bengtsson BA. Insulin-like growth factor-I in growth hormone-deficient adults: Relationship to population-based normal values, body composition and insulin tolerance test. Clin Endocrinol (Oxf) 1997;46(5):579-586.
31. Holm K, Nysom K, Hertz H, et al. Normal final height after treatment for acute lymphoblastic leukemia without irradiation. Acta Paediatr 1994;83(12):1287-1290.
32. Moell C, Marky I, Hovi L, et al. Cerebral irradiation causes blunted pubertal growth in girls treated for acute leukemia. Med Pediatr Oncol 1994;22(6):375-379.
33. van der Sluis IM, van den Heuvel-Eibrink MM, Hahlen K, et al. Bone mineral density, body composition, and height in long-term survivors of acute lymphoblastic leukemia in childhood. Med Pediatr Oncol 2000;35(4):415-420.
34. Birkebaek NH, Clausen N. Height and weight pattern up to 20 years after treatment for acute lymphoblastic leukaemia. Arch Dis Child 1998;79(2):161-164.
35. Didi M, Didcock E, Davies HA, et al. High incidence of obesity in young adults after treatment of acute lymphoblastic leukemia in childhood. J Pediatr 1995;127(1):63-67.
36. Nysom K, Holm K, Michaelsen KF, et al. Degree of fatness after treatment for acute lymphoblastic leukemia in childhood. J Clin Endocrinol Metab 1999;84(12):4591-4596.
37. Odame I, Reilly JJ, Gibson BE, et al. Patterns of obesity in boys and girls after treatment for acute lymphoblastic leukaemia. Arch Dis Child 1994;71(2):147-149.
38. Sklar CA, Mertens AC, Walter A, et al. Changes in body mass index and prevalence of overweight in survivors of childhood acute lymphoblastic leukemia: Role of cranial irradiation. Med Pediatr Oncol 2000;35(2):91-95,
39. Van Dongen-Melman JE, Hokken-Koelega AC, Hahlen K, et al. Obesity after successful treatment of acute lymphoblastic leukemia in childhood. Pediatr Res 1995;38(1):86-90.
40. Zee P, Chen CH. Prevalence of obesity in children after therapy for acute lymphoblastic leukemia. Am J Pediatr Hematol Oncol 1986;8(4):294-299.
41. Oeffinger KC, Mertens AC, Sklar CA, et al. Obesity in adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study. J Clin Oncol 2003;21(7):1359-1365.
42. Craig F, Leiper AD, Stanhope R, et al. Sexually dimorphic and radiation dose dependent effect of cranial irradiation on body mass index. Arch Dis Child 1999;81(6):500-504.
43. Bengtsson BA, Eden S, Lonn L, et al. Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab 1993;76(2):309-317.
44. Jorgensen JO, Vahl N, Hansen TB, et al. Growth hormone versus placebo treatment for one year in growth hormone deficient adults: Increase in exercise capacity and normalization of body composition. Clin Endocrinol (Oxf) 1996;45(6):681-688.