Oncogene amplification in medulloblastoma: Analysis of a case by comparative genomic hybridization and fluorescence in situ hybridization

Pathology

Volumn 31, Issue 4, 1999, Pages 337-344

  Venita, Jay ^a   Squire, Jeremy ^a   Bayani, Jane ^a   Alkhani, Ahmed M ^a   Rutka, James T ^a   Zielenska, Maria ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Comparative genomic hybridization; Fluorescence in situ hybridization; Medulloblastoma; MYCC; MYCN; Oncogene

Indexed keywords

ANTINEOPLASTIC AGENT; SYNAPTOPHYSIN;

ARTICLE; CASE REPORT; CELL NUCLEUS; CEREBELLUM TUMOR; CHROMOSOME 17; CHROMOSOME 7; CLINICAL FEATURE; COMPARATIVE GENOMIC HYBRIDIZATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE AMPLIFICATION; GENE LOCUS; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOCHROMOSOME; KARYOTYPING; MALE; MEDULLOBLASTOMA; NUCLEOLUS; ONCOGENE; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD;

EID: 0033429115     PISSN: 00313025     EISSN: None     Source Type: Journal    
DOI: 10.1080/003130299104693     Document Type: Article

References (31)

1. 1. Giangaspero F, Rigobello L, Badiali M, et al. Large-cell medulloblastomas. A distinct variant with highly aggressive behavior. Am J Surg Pathol 1992; 16: 687-693.
2. 2. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning. A laboratory manual. Cold Spring Harbor: Cold Spring Harbor Laboratory, 1989.
3. 3. Boerner S, Squire J, Thorner P, et al. Assessment of MYCN amplification in neuroblastoma biopsies by differential polymerase chain reaction. Pediatr Pathol 1994; 14: 823-32.
4. 4. Squire JA, Thorner P, Marrano P, et al. Identification of MYCN copy number heterogeneity by direct FISH anlaysis of neuroblastoma preparations. Mol Diagn 1996; 1: 281-9.
5. 5. Kanda N TY, Hata J, Kohl NE, et al. Amplification of IMR 32 clones 8, G21, and N myc in human neuroblastoma xenografts. Cancer Res 1987; 47(12): 3291-5.
6. 6. Dracopoli NC, Haines JC, Korf BR, et al. Current protocols in human genetics. New York: John Wiley & Sons Inc, 1996.
7. 7. Kallioniemi A, Kallioniemi O-P, Sudar D, et al. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 1992; 258: 818-21.
8. 8. du Manoir S, Schrock E, Bentz M, et al. Quantitative analysis of comparative genomic hybridization. Cytometry 1995; 19: 27-41.
9. 9. Lundsteen C, Maahr J, Christensen B, et al. Image analysis in comparative genomic hybridization. Cytometry 1995; 19: 42-50.
10. 10. Monni O, Oinonen R, Elonen E, et al. Gain of 3q and deletion of 11q22 are frequent aberrations in mantle cell lymphoma. Genes Chromosomes Cancer 1998; 21: 298-307.
11. 11. Jay V. Pediatric brain tumors: an overview. J Histotechnol 1997; 20: 347-68.
12. 12. Bigner SH, Friedman HS, Vogelstein B, et al. Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. Cancer Res 1990; 50(8): 2347-50.
13. 13. Badiali M, Pession A, Basso G, et al. N-myc and c-myc oncogenes amplification in medulloblastomas. Evidence of particularly aggressive behavior in a tumor with c-myc amplification. Tumori 1991; 77: 118-21.
14. 14. Friedman HS, Burger PC, Bigner SH, et al. Phenotypic and genotypic analysis of human medulloblastoma cell line and transplantable xenograft (D 341 Med) demonstrating amplification of c-myc. Am J Pathol 1988; 130: 472-84.
15. 15. Fujimoto M, Sheridan PJ, Sharp ZD, et al. Proto-oncogene Analyses in Brain Tumors. J Neurosurg 1989; 70: 910-5.
16. 16. Jay V, Squire J, Zielenska M, et al. Molecular and cytogenetic analysis of a cerebellar primitive neuroectodermal tumor with prominent neuronal differentiation: detection of MYCN amplification by differential polymerase chain reaction and Southern blot analysis. Pediatr Pathol 1995; 15: 733-44.
17. 17. Rouah E, Wilson DR, Armstrong DL, Darlington GJ. N-myc amplification and neuronal differentiation in human primitive neuroectodermal tumors of the central nervous system. Cancer Res 1989; 49: 1797-801.
18. 18. Tomlinson FH, Jenkins RB, Scheithauer BW, et al. Aggressive medulloblastoma with high-level N-myc amplification. Mayo Clin Proc 1994; 69: 359-65.
19. 19. Wasson JC, Saylors RL III, Zelter P, et al. Oncogene amplification in pediatric brain tumors. Cancer Res 1990; 50: 2987-90.
20. 20. Bigner SH, Mark J, Friedman HS, et al. Structural chromosomal abnormalities in human medulloblastoma. Cancer Genet Cytogenet 1988; 30: 91-101.
21. 21. Jay V, MacNeill S, Zielenska M. MYCN amplfication in pediatric brain tumors. J Histotechnol 1997; 20: 115-8.
22. 22. Gray JW, Pinkel D, Brown JM. Fluorescence in situ hybridization in cancer and radiation biology. Radiat Res 1994; 137: 275-89.
23. 23. Kallioniemi OP, Kallioniemi A, Sudar D, et al. Comparative genomic hybridization: a rapid new method for detecting and mapping DNA amplification in tumors. Semin Cancer Biol 1993; 4: 41-6.
24. 24. Reardon DA, Michalkiewicz E, Boyett JM, et al. Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. Cancer Res 1997; 57: 4042-7.
25. 25. Schütz BR, Scheurlen W, Krauss J, et al. Mapping of chromosomal gains and losses in primitive neuroectodermal tumors by comparative genomic hybridization. Genes Chromosomes Cancer 1996; 16: 196-203.
26. 26. Bayani J, Thorner P, Zielenska M, et al. Application of a simplified comparative genomic hybridization technique to screen for gene amplification in pediatric solid tumors. Pediatr Pathol Lab Med 1995; 15: 831-44.
27. 27. Griffin CA, Hawkins AL, Packer RJ, et al. Chromosome abnormalities in pediatric brain tumors. Cancer Res 1988; 48(1): 175-80.
28. 28. Biegel JA, Rorke LB, Packer RJ, et al. Isochromosome 17q in primitive neuroectodermal tumors of the central nervous system. Genes Chromosomes Cancer 1989; I: 139-47.
29. 29. Karnes PS, Tran TN, Cui MY, et al. Cytogenetic analysis of 39 pediatric central nervous system tumors. Cancer Genet Cytogenet 1992; 59: 12-9.
30. 30. James CD, He J, Carlbom E, et al. Loss of genetic information in central nervous system tumors common to children and young adults. Genes Chromosom Cancer 1990; 2(2): 94-102.
31. 31. Chadduck WM, Boop FA, Sawyer JR. Cytogenetic studies of pediatric brain and spinal cord tumors. Pediatr Neurosurg 1991-92; 17: 57-65.