Effect of IL-18 on peripheral blood mononuclear cells of chronic hepatitis B and hepatitis B virus DNA released by HepG2.2.15 cell lines

Hepatobiliary and Pancreatic Diseases International

Volumn 3, Issue 2, 2004, Pages 230-234

  Sun, Ying ^a   Chen, Huan Yong ^a   Xin, Shao Jie ^b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b BEIJING 302 HOSPITAL   (China)

Author keywords

Chronic hepatitis B; HBV DNA; HepG2.2.15 cells; Interferon ; Interleukin 18; Peripheral blood mononuclear cells

Indexed keywords

ALPHA1 INTERFERON; GAMMA INTERFERON; HEPATITIS B CORE ANTIGEN; INTERLEUKIN 12; INTERLEUKIN 18; VIRUS DNA;

ADOLESCENT; ADULT; ARTICLE; CANCER CELL CULTURE; CELL ISOLATION; CENTRIFUGATION; CHRONIC HEPATITIS; CLINICAL ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA DETERMINATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC TRANSFECTION; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; IN VITRO STUDY; LEUKOCYTE ACTIVATION; LEUKOCYTE CULTURE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; QUANTITATIVE ANALYSIS; SUPERNATANT;

ADJUVANTS, IMMUNOLOGIC; ADOLESCENT; ADULT; CELL LINE; DNA, VIRAL; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; INTERLEUKIN-18; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; TRANSFECTION;

EID: 2442657887     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Milich DR, Schodel F, Hughes JL, Jones JE, Peterson DL. The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype. J Virol 1997;71:2192-2201.
2. Parr MB, Parr EL. The role of gamma interferon in immune resistance to vaginal infection by herpes simplex virus type 2 in mice. Virology 1999;258:282-294.
3. Xing Z, Zganiacz A, Wang J, Divangahi M, Nawaz F. IL-12-independent Th1-type immune responses to respiratory viral infection: requirement of IL-18 for IFN-γ release in the lung but not for the differentiation of viral-reactive Th1-type lymphocytes. J Immunol 2000;164:2575-2584.
4. Dinarello CA. IL-18: a Th1-inducing, proinflammatory cytokine and new member of the IL-1 family. J Allergy Clin Immunol 1999;103 (1 Pt 1):11-24.
5. Tang LL, Liu KZ. Recent advances in DNA vaccine of hepatitis virus. Hepatobiliary Pancreat Dis Int 2002;1:228-231.
6. Kim JJ, Nottingham LK, Tsai A, Lee DJ, Maguire HC, Oh J, et al. Antigen-specific humoral and cellular immune responses can be modulated in rhesus macaques through the use of IFN-gamma, IL-12, or IL-18 gene adjuvants. J Med Primatol 1999;28:214-223.
7. Arena A, Iannello D, Gazzara D, Speranza A, Bonina L, Mastroeni P. Role of interleukin-18 in peripheral blood mononuclear cells infected with human herpes virus type 6. Intervirology 2001;44:250-254.
8. Reading PC, Smith GL. Vaccinia virus interleukin-18-binding protein promotes virulence by reducing gamma interferon production and natural killer and T-cell activity. J Virol 2003;77: 9960-9968.
9. Gherardi MM, Ramirez JC, Esteban M. IL-12 and IL-18 act in synergy to clear vaccinia virus infection: involvement of innate and adaptive components of the immune system. J Gen Virol 2003;84(Pt 8):1961-1972.
10. Mori I, Hossain MJ, Takeda K, Okamura H, Imai Y, Kohsaka S, et al. Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection. Virology 2001;287:163-170.
11. Tovey MG, Meritet JF, Guymarho J, Maury C. Mucosal cytokine therapy: marked antiviral and antitumor activity. J Interferon Cytokine Res 1999;19:911-921.
12. Fujioka N, Akazawa R, Ohashi K, Fujii M, Ikeda M, Kurimoto M. Interleukin-18 protects mice against acute herpes simplex virus type 1 infection. J Virol 1999;73:2401-2409.
13. Tanaka-Kataoka M, Kunikata T, Takayama S. In vivo antiviral effect of interleukin 18 in a mouse model of vaccinia virus infection. Cytokine 1999;11:593-599.
14. Wen W, Zhang L, Xiao H. The transcription and expression of IL-18 gene in HBV infectors. Zhonghua Yi Xue Za Zhi 2001;81:655-658.
15. Jia HY, Du J, Zhu SH, Ma YJ, Chen HY, Yang BS, et al. The roles of serum IL-18, IL-10, TNF-alpha and sIL-2R in patients with chronic hepatitis C. Hepatobiliary Pancreat Dis Int 2002;1:378-382.
16. Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV. Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice. J Virol 2002;76:10702-10707.
17. Chinese Medical Association, Infectious Diseases and Verminosis Branch, Heptology Branch. Prophylaxis and treatment program to viral hepatitis. Zhonghua Gan Zang Bing Za Zhi 2000; 8:324-329.
18. Wu J, Xie HY, Jiang GP, Xu X, Zheng SS. The effect of mycophenolate acid on hepatitis B virus replication in vitro. Hepatobiliary Pancreat Dis Int 2003;2:410-413.
19. Tsuji-Takayama K, Aizawa Y, Okamoto I, Kojima H, Koide K, Takeuchi M, et al. Interleukin-18 induces interferon-gamma production through NF-kappa B and NFAT activation in murine T helper type 1 cells. Cell Immunol 1999;196:41-50.
20. Okamura H, Tsutsui H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, et al. Cloning of a new cytokine that induces interferon-g production by T cells. Nature 1995;378:88-91.
21. Chan WL, Pejnovic N, Lee CA, Al-Ali NA. Human IL-18 receptor and ST2L are stable and selective markets for the respective type 1 and type 2 circulating lymphocytes. J Immunol 2001;167:1238-1244.
22. Micallef MJ, Ohtsuke T, Kohno K, Tanabe F, Ushio S, Namba M, et al. Interferon-gamma-inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin-12 for interferon-gamma production. Eur J Immunol 1996;26:1647-1651.
23. Sareneva T, Julkunen I, Matikainen S. IFN-alpha and IL-12 induce IL-18 receptor gene expression in human NK and T cells. J Immunol 2000;165:1933-1938.
24. Sareneva T, Matikainen S, Kurimoto M, Julkunen I. Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells. J Immunol 1998;160:6032-6038.
25. Malmgaard L, Paludan SR. Interferon (IFN) -alpha/beta, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2. J Gen Virol 2003;84(Pt 9):2497-2500.
26. Torigoe K, Ushio S, Okura T, Kobayashi S, Taniai M, Kunikata T, et al. Purification and characterization of the human interleukin-18 receptor. J Biol Chem 1997;272:25737-25742.
27. Born TL, Thomassen E, Bird TA, Sims JE. Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J Biol Chem 1998;273:29445-29450.
28. Kim SH, Reznikov LL, Stuyt RJ, Selzman CH, Fantuzzi G, Hoshino, T, et al. Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain. J Immunol 2001;166: 148-154.
29. Yoshimoto T, Takeda K, Tanaka T, Ohkusu K, Kashiwamura S, Okamura H, et al. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-gamma production. J Immunol 1998; 161: 3400-3407.
30. Matsumoto S, Tsuji-Takayama K, Aizawa Y, Koide K, Takeuchi M, Ohta T, et al. Interleukin-18 activates NF-kappa B in murine T helper type 1 cells. Biochem Biophys Res Commun 1997;234:454-457.
31. Robinson D, Shibuya K, Mui A, Zonin F, Murphy E, Sana T, et al. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NF-kappa B. Immunity 1997;7:571-581.