The effect of mycophenolate acid on hepatitis B virus replication in vitro

Hepatobiliary and Pancreatic Diseases International

Volumn 2, Issue 3, 2003, Pages 410-413

  Wu, Jian ^a   Xie, Hai Yang ^a   Jiang, Guo Ping ^a   Xu, Xiao ^a   Zheng, Shu Sen ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Cell line; Hepatitis B virus; Mycophenolate acid

Indexed keywords

HEPATITIS B SURFACE ANTIGEN; HEPATITIS B(E) ANTIGEN; MYCOPHENOLIC ACID; VIRUS DNA; VIRUS PROTEIN;

ANIMAL CELL; ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; CELL LINE; CELL SURVIVAL; CONTROLLED STUDY; DNA DETERMINATION; DOSE RESPONSE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS B VIRUS; IN VITRO STUDY; INHIBITION KINETICS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; QUANTITATIVE ANALYSIS; SLOT BLOT HYBRIDIZATION; SUPERNATANT; VIRUS REPLICATION;

CELL LINE; COLORING AGENTS; DNA, VIRAL; ENZYME INHIBITORS; HEPATITIS B; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; MYCOPHENOLIC ACID; TETRAZOLIUM SALTS; THIAZOLES; VIRUS REPLICATION;

EID: 0042913088     PISSN: 14993872     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Samuel D, Muller R, Alexander G, et al. Liver transplantation in European patients with the hepatitis B surface antigen. N Engl J Med 1993;329:1842-1847.
2. McMillan JS, Shaw T, Angus PW, et al. Effect of immunosuppressive and antiviral agents on hepatitis B virus replication in vitro. Hepatology 1995;22:36-43.
3. Guidotti LG, Ishikawa T, Hobbs MV, et al. Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 1996;4:25-36.
4. George M, Siegbert R, Patrizia C, et al. Immunopathogenesis of hepatitis B virus recurrence after liver transplantation. Transplantation 2000;69:559-568.
5. Lau JYN, Bain VG, Smith HM, et al. Modulation of hepatitis B virus antigen expression by immunosuppressive drugs in primary hepatocyte culture. Transplantation 1992;53:894-898.
6. Bian XY. MTT Assay and its application. Foreign Medical Science: Section of Clinical Biochemistry and Laboratory Science 1998;19:83-85 (in Chinese).
7. Gong ZJ, De Meyer S, Clarysse C, et al. Mycophenolic acid, an immunosuppressive agent, inhibits HBV replication in vitro. J Viral Hepat 1999;6:229-236.
8. Markland W, McQuaid TJ, Jain J, et al. Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral activity with alpha interferon. Antimicrob Agents Chemother 2000;44:566-859.
9. Ichimura H, Levy JA. Polymerase substrate depletion: a novel strategy for inhibiting the replication of the human immunodeficiency virus. Virology 1995;211:554-560.
10. Everson GT. Impact of immunosuppressive therapy on recurrence of hepatitis C. Liver Transpl 2002;8:S19-27.
11. Zhou S, Liu R, Baroudy BM, et al. The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA. Virology 2003;310:333-342.
12. Sterneck M, Fischer L, Gahlemann C, et al. Mycophenolate mofetil for prevention of liver allograft rejection:initial results of a controlled clinical trial. Ann Transplant 2000;5:43-46.