Identification of a novel region in the proximal promoter of the mouse renin gene critical for expression

American Journal of Physiology - Renal Physiology

Volumn 286, Issue 6 55-6, 2004, Pages

  Pan, Li ^a   Jones, Craig A ^a   Glenn, Sean T ^a   Gross, Kenneth W ^a  

^a ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

As4.1 cells; Endothelin; Transcription factor

Indexed keywords

ENDOTHELIN 1; NUCLEAR FACTOR I; NUCLEOTIDE; RENIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR SP3;

ARTICLE; BINDING SITE; ELECTROPHORETIC MOBILITY; ENHANCER REGION; GENE; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 2442640276     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00319.2003     Document Type: Article

References (41)

1. Abel KJ, Howles PN, and Gross KW. DNA insertions distinguish the duplicated renin genes of DBA/2 and M. hortulanus mice. Mamm Genome 2: 32-40, 1992.
2. Abonia JP, Howles PN, Abel KJ, Black TA, Jones CA, and Gross KW. Evaluating a model of an NRE mediated tissue-specific expression of murine renin genes. Hypertension 37: 105-109, 2001.
3. Ackermann M, Ritthaler T, Riegger G, Kurtz A, and Kramer BK. Endothelin inhibits cAMP-induced renin release from isolated renal juxtaglomerular cells. J Cardiovasc Pharmacol 26, Suppl 3: S135-S137, 1995.
4. Barrett G, Horiuchi M, Paul M, Pratt RE, Nakamura N, and Dzau VJ. Identification of a negative regulatory element involved in tissue-specific expression of mouse renin genes. Proc Natl Acad Sci USA 89: 885-889, 1992.
5. Black AR, Black JD, and Azizkhan-Clifford J. Sp1 and Kruppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 188: 143-160, 2001.
6. Borensztein P, Germain S, Fuchs S, Philippe J, Corvol P, and Pinet F. Cis-regulatory elements and trans-acting factors directing basal and cAMP-stimulated human renin gene expression in chrorionic cells. Circ Res 74: 764-773, 1994.
7. Bruggemeier U, Rogge L, Winnacker EL, and Beato M. Nuclear factor I acts as a transcription factor on the MMTV promoter but competes with steroid hormone receptors for DNA binding. EMBO J 9: 2233-2239, 1990.
8. Ducy P. Cbfa1: a molecular switch in osteoblast biology. Dev Dyn 219: 461-471, 2000.
9. Gronostajski RM. Roles of the NFI/CTF gene family in transcription and development. Gene 249: 31-45, 2000.
10. Hilger-Eversheim K, Moser M, Schorle H, and Buettner R. Regulatory roles of AP-2 transcription factors in vertebrate development, apoptosis and cell-cycle control. Gene 260: 1-12, 2000.
11. Horiuchi M, Pratt RE, Nakamura N, and Dzau VJ. Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression. J Clin Invest 92: 1805-1811, 1993.
12. Jones CA, Fabian JR, Abel KJ, Sigmund CD, and Gross KW. The regulation of renal and extrarenal renin gene expression in the mouse. In: Cellular and Molecular Biology of the Renin-Angiotensin System, edited by Raizada MK, Phillips MI, and Sumners C. Boca Raton, FL: CRC, 1993, p. 33-57.
13. Jones CA, Petrovic N, Novak EK, Swank RT, Sigmund CD, and Gross KW. Biosynthesis of renin in mouse kidney tumor As4.1 cells. Eur J Biochem 243: 181-190, 1997.
14. Kennett SB, Udvadia AJ, and Horowitz JM. Sp3 encodes multiple proteins that differ in their capacity to stimulate or repress transcription. Nucleic Acids Res 25: 3110-3117, 1997.
15. Konoshita T, Germain S, Philippe J, Corvol P, and Pinet F. Evidence that renal and chotionic tissues contain similar nuclear binding proteins that recognize the human renin promoter. Kidney Int 50: 1515-1524, 1996.
16. 3 is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 110: 229-238, 2002.
17. Liu X, Huang X, and Sigmund CD. Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription. Circ Res 92: 1033-1040, 2003.
18. Nakamura N, Burt DW, Paul M, and Dzau VJ. Negative control elements and cAMP responsive sequences in the tissue-specific expression of mouse renin genes. Proc Natl Acad Sci USA 86: 56-59, 1989.
19. Pan L, Black TA, Shi Q, Jones CA, Petrovic N, Loudon J, Kane C, Sigmund CD, and Gross KW. Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. J Biol Chem 276: 45530-45538, 2001.
20. Pan L, Glenn ST, Jones CA, Gronostajski RM, and Gross KW. Regulation of renin enhancer activity by nuclear factor I and Sp1/Sp3: Biochim Biophys Acta 1625: 280-290, 2003.
21. c gene. J Biol Chem 276: 32489-32494, 2001.
22. Petrovic N, Black TA, Fabian JR, Kane C, Jones CA, Loudon JA, Abonia JP, Sigmund CD, and Gross KW. Role of proximal promoter elements in regulation of renin gene transcription. J Biol Chem 271: 22499-22505, 1996.
23. Rafty LA, Santiago FS, and Khachigian LM. NFI/X represses PDGF A-chain transcription by interacting with Sp1 and antagonizing Sp1 occupancy of the promoter. EMBO J 21: 334-343, 2002.
24. Ritthaler T, Scholz H, Ackermann M, Riegger G, Kurtz A, and Kramer BK. Effects of endothelins on renin secretion from isolated mouse renal juxtaglomerular cells. Am J Physiol Renal Fluid Electrolyte Physiol 268: F39-F45, 1995.
25. Rubanyi GM and Polokoff MA. Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev 46: 325-415, 1994.
26. Ryan MJ, Black TA, Millard SL, Gross KW, and Hajduczok G. Endothelin-1 increases calcium and attenuates renin gene expression in As4.1 cells. Am J Physiol Heart Circ Physiol 283: H2458-H2465, 2002.
27. Santoro C, Mermod N, Andrews PC, and Tjian R. A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs. Nature 334: 218-224, 1988.
28. Shi Q, Black TA, Gross KW, and Sigmund CD. Species-specific differences in positive and negative regulatory elements in the renin gene enhancer. Circ Res 85: 479-488, 1999.
29. Shi Q, Gross KW, and Sigmund CD. Retinoic acid-mediated activation of the mouse renin enhancer. J Biol Chem 276: 3597-3603, 2001.
30. Shi Q, Gross KW, and Sigmund CD. NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. Hypertention 38: 332-336, 2001.
31. 3. J Clin Invest 110: 155-156, 2002.
32. Sigmund CD and Gross KW. Structure, expression and regulation of murine renin genes. Hypertension 18: 446-457, 1991.
33. Sigmund CD, Okuyama K, Ingelfinger J, Jones CA, Mullins JJ, Kane C, Kim U, Wu C, Kenny L, Rustum Y, Dzau VJ, and Gross KW. Isolation and characterization of renin expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct. J Biol Chem 265: 19916-19922, 1990.
34. Sokolovsky M. Endothelin receptor subtypes and their role in transmembrane signaling mechanisms. Pharmacol Ther 68: 435-471, 1995.
35. Tamura K, Chen YE, Horiuchi M, Chen Q, Daviet L, Yang Z, Lopez-Ilasaca M, Mu H, Pratt RE, and Dzau VJ. LXRα functions as a cAMP-responsive transcriptional regulator of gene expression. Proc Natl Acad Sci USA 97: 8513-8518, 2000.
36. Tamura K, Tanimoto K, Murakami K, and Fukamizu A. A combination of upstream and proximal elements is required for efficient expression of the mouse renin promoter in cultured cells. Nucleic Acids Res 20: 3617-3623, 1992.
37. Todorov VT, Volkl S, Muller M, Bohla A, Klar J, Kunz-Schughart LA, Hehlgans T, and Kurtz A. TNF-α activates NF-κB to inhibit renin transcription by targeting cAMP responsive element. J Biol Chem 279: 1458-1467, 2003.
38. Yamada T, Horiuchi M, Morishita R, Zhang L, Pratt RE, and Dzau VJ. In vivo indentification of a negative regulatory element in the mouse renin gene using direct gene transfer. J Clin Invest 96: 1230-1237, 1995.
39. Yan Y, Jones CA, Sigmund CD, Gross KW, and Catanzaro DF. Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells. Circ Res 81: 558-566, 1997.
40. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, and Masaki Y. A novel potent vasoconstrictor peptide producing vascular endothelial cells. Nature 332: 411-415, 1988.
41. Yoon JB, Li G, and Roeder RG. Characterization of a family of related cellular transcription factors which can modulate human immunodeficiency virus type 1 transcription in vitro. Mol Cell Biol 14: 1776-1785, 1994.