Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription

Circulation Research

Volumn 92, Issue 9, 2003, Pages 1033-1040

  Liu, Xuebo ^b   Huang, Xiaodong ^b   Sigmund, Curt D ^a  

^a UNIVERSITY OF IOWA   (United States)

^b NONE

Author keywords

Gel shift; Nuclear receptor; Repression; Transcription; Transfection

Indexed keywords

CELL NUCLEUS RECEPTOR; COMPLEMENTARY DNA; DNA BINDING PROTEIN; NUCLEAR PROTEIN; PROTEIN EAR2; RECOMBINANT PROTEIN; RENIN; RETINOID; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA LIBRARY; DNA SCREENING; ENHANCER REGION; GENE MUTATION; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HYBRID; MOUSE; NONHUMAN; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PURIFICATION; REGULATORY MECHANISM; TRANSCRIPTION REGULATION; YEAST;

ANIMALS; BASE SEQUENCE; CELL LINE; DNA-BINDING PROTEINS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RENIN; RESPONSE ELEMENTS; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 0037687975     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000071355.82009.43     Document Type: Article

References (46)

1. Sinn PL, Sigmund CD. Human renin mRNA stability is increased in response to cAMP in Calu-6 cells. Hypertension. 1999;33:900-905.
2. Ying L, Morris BJ, Sigmund CD. Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both CREB-dependent and CREB-independent mechanisms in Calu-6 cells. J Biol Chem. 1997;272:2412-2420.
3. Gilbert MT, Sun J, Yan Y, Oddoux C, Lazarus A, Tansey WP, Lavin TN, Catanzaro DF. Renin gene promoter activity in GC cells is regulated by cAMP and thyroid hormone through Pit-1-dependent mechanisms. J Biol Chem. 1994;269:1-6.
4. Pan L. Xie Y, Black TA, Jones CA, Pruitt SC, Gross KW. An Abd-B class HOX. PBX recognition sequence is required for expression from the mouse Ren-1c gene. J Biol Chem. 2001;276:32489-32494.
5. Tamura K, Chen YE, Horiuchi M, Chen Q, Daviet L, Yang Z, Lopez-Ilasaca M, Mu H, Pratt RE, Dzau VJ. LXRα functions as a cAMP-responsive transcriptional regulator of gene expression. Proc Natl Acad Sci USA. 2000;97:8513-8518.
6. Petrovic N, Black TA, Fabian JR, Kane CM, Jones CA, Loudon JA, Abonia JP, Sigmund CD, Gross KW. Role of proximal promoter elements in regulation of renin gene transcription. J Biol Chem. 1996;271:22499-22505.
7. Yan Y, Jones CA, Sigmund CD, Gross KW, Catanzaro DF. Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells. Circ Res. 1997;81:558-566.
8. Shi Q, Black TA, Gross KW, Sigmund CD. Species-specific differences in positive, and negative regulatory elements in the renin gene enhancer. Circ Res. 1999;85:479-488.
9. Shi Q, Gross KW, Sigmund CD. Retinoic acid-mediated activation of the mouse renin enhancer. J Biol Chem. 2001;276:3597-3603.
10. Shi Q, Gross KW, Sigmund CD. NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. Hypertension. 2001;38:332-336.
11. Pan L, Black TA, Shi Q, Jones CA, Petrovic N, Loudon J, Kane C, Sigmund CD, Gross KW. Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. J Biol Chem. 2001;276:45530-45538.
12. 3 is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest. 2002;110:229-238.
13. Willson TM, Moore JT. Minireview: genomics versus orphan nuclear receptors-a half-time report. Mol Endocrinol. 2002;16:1135-1144.
14. Tsai SY, Tsai MJ. Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age. Endocr Rev. 1997;18:229-240.
15. Sigmund CD, Okuyama K, Ingelfinger J, Jones CA, Mullins JJ, Kim U, Kane-Haas C, Wu C, Kenney L, Rustum Y, Dzau V, Gross KW. Isolation and characterization of renin expressing cell lines from transgenic mice containing a renin promoter viral oncogene fusion construct. J Biol Chem. 1990;265:19916-19922.
16. Zhu XG, Park KS, Kaneshige M, Bhat MK, Zhu Q, Mariash CN, McPhie P, Cheng SY. The orphan nuclear receptor Ear-2 is a negative coregulator for thyroid hormone nuclear receptor function. Mol Cell Biol. 2000;20:2604-2618.
17. Zhang Y, Dufau ML. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. J Biol Chem. 2000;275:2763-2770.
18. Sinn PL, Davis DR, Sigmund CD. Highly regulated cell-type restricted expression of human renin in mice containing 140 Kb or 160 Kb P1 phage artificial chromosome transgenes. J Biol Chem. 1999;274:35785-35793.
19. Barnhart KM, Mellon PL. The sequence of a murine cDNA encoding Ear-2, a nuclear orphan receptor. Gene. 1994;142:313-314.
20. Chambliss KL, Yuhanna IS, Mineo C, Liu P, German Z, Sherman TS, Mendelsohn ME, Anderson RG, Shaul PW. Estrogen receptor α and endothelial nitric oxide synthase are organized into a functional signaling module in caveolae. Circ Res. 2000;87:e44-e52.
21. Razandi M, Alton G, Pedram A, Ghonshani S, Webb P, Levin ER. Identification of a structural determinant necessary for the localization and function of estrogen receptor α at the plasma membrane. Mol Cell Biol. 2003;23:1633-1646.
22. Dene H, McIlwain C, Rapp JP. Quantitation of renal renin and renin mRNA in Dah1 rats in response to provocative stimuli. Clin Exp Hypertens A. 1989;11:1585-1594.
23. Barrett G, Horiuchi M, Paul M, Pratt RE, Nakamura N, Dzau VJ. Identification of a negative regulatory element involved in tissue-specific expression of mouse renin genes. Proc Natl Acad Sci USA. 1992;89:885-889.
24. Abel KJ, Howles PN, Gross KW. DNA insertions distinguish the duplicated renin genes of DBA/2 and M. hortulanus mice. Mamm Gen. 1992;2:32-40.
25. Abonia JP, Howles PN, Abel KJ, Black TA, Jones CA, Gross KW. Evaluating a model of an NRE mediated tissue-specific expression of murine renin genes. Hypertension. 2001;37:105-109.
26. Jones CA, Sigmund CD, McGowan R, Kane-Haas C, Gross KW. Temporal and spatial expression of the murine renin genes during fetal development. Mol Endocrinol. 1990;4:375-383.
27. Gomez RA. Molecular biology of components of the renin-angiotensin system during development. Pediatr Nephrol. 1990;4:421-423.
28. Kastner P, Mark M, Chambon P. Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life? Cell. 1995;83:859-869.
29. Mangelsdorf DJ, Evans RM. The RXR heterodimers and orphan receptors. Cell. 1995;83:841-850.
30. Leng X, Cooney AJ, Tsai SY, Tsai MJ. Molecular mechanisms of COUP-TF-mediated transcriptional repression: evidence for transrepression and active repression. Mol Cell Biol. 1996;16:2332-2340.
31. 3, thyroid hormone, and retinoic acid receptors. Mol Cell Biol. 1992;12:4153-4163.
32. Lee MO, Liu Y, Zhang XK. A retinoic acid response element that overlaps an estrogen response element mediates multihormonal sensitivity in transcriptional activation of the lactoferrin gene. Mol Cell Biol. 1995;15:4194-4207.
33. Tran P, Zhang XK, Salbert G, Hermann T, Lehmann JM, Pfahl M. COUP orphan receptors are negative regulators of retinoic acid response pathways. Mol Cell Biol. 1992;12:4666-4676.
34. Widom RL, Rhee M, Karathanasis SK. Repression by ARP-1 sensitizes apolipoprotein AI gene responsiveness to RXR α and retinoic acid. Mol Cell Biol. 1992;12:3380-3389.
35. Lu XP, Salbert G, Pfahl M. An evolutionary conserved COUP-TF binding element in a neural-specific gene and COUP-TF expression patterns support a major role for COUP-TF in neural development. Mol Endocrinol. 1994;8:1774-1788.
36. Hall RK, Sladek FM, Granner DK. The orphan receptors COUP-TF and HNF-4 serve as accessory factors required for induction of phosphoenolpyruvate carboxykinase gene transcription by glucocorticoids. Proc Natl Acad Sci USA. 1995;92:412-416.
37. Power SC, Cereghini S. Positive regulation of the vHNF1 promoter by the orphan receptors COUP-TF1/Ear3 and COUP-TFII/Arp1. Mol Cell Biol. 1996;16:778-791.
38. Rohr O, Aunis D, Schaeffer E. COUP-TF and Sp1 interact and cooperate in the transcriptional activation of the human immunodeficiency virus type 1 long terminal repeat in human microglial cells. J Biol Chem. 1997;272:31149-31155.
39. 3. J Clin Invest. 2002;110:155-156.
40. Jones CA, Hurley MI, Black TA, Kane CM, Pan L, Pruitt SC, Gross KW. Expression of a renin-green fluorescent protein transgene in mouse embryonic, extra-embryonic and adult tissues. Physiol Genomics. 2000; 4:75-81.
41. Sigmund CD, Jones CA, Fabian JR, Mullins JJ, Gross KW. Tissue and cell-specific expression of a renin promoter-T antigen reporter gene construct in transgenic mice. Biochem Biophys Res Commun. 1990;170:344-350.
42. Sola C, Tronik D, Dreyfus M, Babinet C, Rougeon F. Renin-promoter SV40 large T-antigen transgenes induce tumors irrespective of normal cellular expression of renin genes. Oncogene Res. 1989;5:149-153.
43. Sinn PL, Sigmund CD. Transgenic models as tools for studying the regulation of human renin expression. Regul Pept. 2000;86:77-82.
44. Sinn PL, Zhang X, Sigmund CD. Juxtaglomerular cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter. Am J Physiol. 1999;277:F634-F642.
45. Yan Y, Chen R, Pitarresi T, Sigmund CD, Gross KW, Sealey JE, Laragh JH, Catanzaro DF. Kidney is the only source of human plasma renin in 45-kb human renin transgenic mice. Circ Res. 1998;83:1279-1288.
46. Nistala R, Sigmund CD. A reliable and efficient method for deleting operational sequences in PACs and BACs. Nucleic Acids Res. 2002; 30:e41.