Limited repertoire of HLA-DRB1*0401-restricted MBP111-129-specific T cells in HLA-DRB1*0401 Tg mice and their pathogenic potential

Journal of Neuroimmunology

Volumn 151, Issue 1-2, 2004, Pages 94-102

  Huh, Jaebong ^a   Yao, Karen ^a   Quigley, Laura ^a   Ludwin, Samuel K ^b   McFarland, Henry F ^a   Muraro, Paolo A ^a   Martin, Roland ^a   Ito, Kouichi ^a,c  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b QUEEN S UNIVERSITY   (Canada)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

0401; Experimental autoimmune encephalomyelitis; HLA DRB1; Multiple sclerosis; Myelin basic protein; Transgenic mouse

Indexed keywords

EPITOPE; HLA DR ANTIGEN; MYELIN BASIC PROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ARTICLE; BRAIN STEM; CELL LINE; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; HUMAN; IMMUNIZATION; INFLAMMATION; LYMPH NODE CELL; MOUSE; MULTIPLE SCLEROSIS; NERVE ROOT; NONHUMAN; PATHOGENICITY; PERIPHERAL NERVE; PRIORITY JOURNAL; SPINAL CORD; T LYMPHOCYTE; TRANSFER CELL; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; CENTRAL NERVOUS SYSTEM; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES, T-LYMPHOCYTE; FLOW CYTOMETRY; HLA-DR ANTIGENS; HUMANS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

EID: 2442602368     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2004.02.015     Document Type: Article

References (17)

1. Asnagli H., Murphy K.M. Stability and commitment in T helper cell development. Curr. Opin. Immunol. 13(2):2001;242-247
2. Bettelli E., Pagany M., Weiner H.L., Linington C., Sobel R.A., Kuchroo V.K. Myelin oligodendrocyte glycoprotein specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J. Exp. Med. 197:2003;1073-1081
3. Chou Y.K., Henderikx P., Vainiene M., Whitham R., Bourdette D., Chou C.H., Hashim G., Offner H., Vandenbark A.A. Specificity of human T cell clones reactive to immunodominant epitopes of myelin basic protein. J. Neurosci. Res. 28(2):1991;280-290
4. Forrester C., Lascelles R.G. Association between polyneuritis and multiple sclerosis. J. Neurol. Neurosurg. Psychiatry. 42:1979;864-866
5. Forsthuber T.G., Shive C.L., Wienhold W., de Graaf K., Spack E.G., Sublett R., Melms A., Kort J., Racke M.K., Weissert R. T cell epitopes of human myelin oligodendrocyte glycoprotein identified in HLA-DR4 (DRB1*0401) transgenic mice are encephalitogenic and are presented by human B cells. J. Immunol. 167(12):2001;7119-7125
6. Ito K., Bian H.J., Molina M., Han J., Magram J., Saar E., Belunis C., Bolin D.R., Arceo R., Campbell R., Falcioni F., Vidovic D., Hammer J., Nagy Z.A. HLA-DR4-IE chimeric class II Tg, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J. Exp. Med. 183:1996;2635-2644
7. Kawamura K., Yamamura T., Yokoyama K., Chui D.H., Fukui Y., Sasazuki T., Inoko H., David C.S., Tabira T. Hla-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice. J. Clin. Invest. 105(7):2000;977-984
8. Kurdi A., Ayesh I., Abdallat A., Maayta U. Different B lymphocyte alloantigens associated with multiple sclerosis in Arabs and North Europeans. Lancet. 1(8022):1977;1123-1125
9. Lassmann H., Budka H., Schnaberth G. Inflammatory demyelinating polyradiculitis in a patient with multiple sclerosis. Arch. Neurol. 38(2):1981;99-102
10. Madsen L.S., Andersson E.C., Jansson L., Krogsgaard M., Andersen C.B., Engberg J., Strominger J.L., Svejgaard A., Hjorth J.P., Holmdahl R., Wucherpfennig K.W., Fugger L. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat. Genet. 23:1999;343-347
11. Marrosu M.G., Muntoni F., Murru M.R., Spinicci G., Pischedda M.P., Goddi F., Cossu P., Pirastu M. Sardinian multiple sclerosis is associated with HLA-DR4: a serologic and molecular analysis. Neurology. 38(11):1988;1749-1753
12. Martin R., Vogt A.B., Kropshofer H., Lichtenfels R. Association of HLA and multiple sclerosis. Behring-Inst.-Mitt. 94:1994;158-170
13. Muraro P.A., Vergelli M., Kalbus M., Banks D.E., Nagle J.W., Tranquill L.R., Nepom G.T., Biddison W.E., McFarland H.F., Martin R. Immunodominance of a low-affinity major histocompatibility complex-binding myelin basic protein epitope (residues 111-129) in HLA-DR4 (B1*0401) subjects is associated with a restricted T cell receptor repertoire. J. Clin. Invest. 100:1997;339-349
14. Ota K., Matsui M., Milford E.L., Mackin G.A., Weiner H.L., Hafler D.A. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature. 346(6280):1990;183-187
15. Pender M.P., Tabi Z., Nguyen K.B., McCombe P.A. The proximal peripheral nervous system is a major site of demyelination in experimental autoimmune encephalomyelitis induced in the Lewis rat by a myelin basic protein-specific T cell clone. Acta Neuropathol. (Berl). 89(6):1995;527-531
16. Sobel R.A. Genetic and epigenetic influence on EAE phenotypes induced with different encephalitogenic peptides. J. Neuroimmunol. 108:2000;45-52
17. Vandenbark A.A., Rich C., Mooney J., Zamora A., Wang C., Huan J., Fugger L., Offner H., Jones R., Burrows G.G. Recombinant TCR ligand induces tolerance to myelin oligodendrocyte glycoprotein 35-55 peptide and reverses clinical and histological signs of chronic experimental autoimmune encephalomyelitis in HLA-DR2 transgenic mice. J. Immunol. 171(1):2003;127-133