α-Galactosylceramide-driven expansion of human natural killer T cells is inhibited by prednisolone treatment

British Journal of Haematology

Volumn 125, Issue 3, 2004, Pages 400-404

  Johansson, Ulrika ^a,b   Macey, Marion G ^a   Kenny, Deborah ^a   Provan, Drew ^a   Newland, Adrian C ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

Autoimmunity; Immune thrombocytopenia; Immunosuppression; Natural killer cells

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CELL ANTIGEN; PREDNISOLONE;

ADULT; ARTICLE; AUTOIMMUNE DISEASE; CELL ACTIVITY; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MARKER; DRUG MECHANISM; EX VIVO STUDY; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; KILLER CELL; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; REMISSION; T LYMPHOCYTE; THROMBOCYTOPENIA; TREATMENT OUTCOME;

ADULT; ANTI-INFLAMMATORY AGENTS; CELL DIVISION; CELLS, CULTURED; FEMALE; GALACTOSYLCERAMIDES; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KILLER CELLS, NATURAL; MALE; MIDDLE AGED; PREDNISOLONE; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; T-LYMPHOCYTE SUBSETS;

EID: 2442600354     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2004.04896.x     Document Type: Article

References (12)

1. Briggs, W.A., Han, S.H., Miyakawa, H., Burdick, J.F. & Kwon, H.M. (1999) Effects of glucocorticoids and cyclosporine on IL-2 and I kappa B alpha mRNA expression in human peripheral blood mononuclear cells. Journal of Clinical Pharmacology, 39, 119-124.
2. Johansson, U., Ivanyi, J. & Londei, M. (2001) Inhibition of IL-12 production in human dendritic cells matured in the presence of Bacillus Calmette-Guerin or lipoarabinomannan. Immunology Letters, 77, 63-66.
3. Kronenberg, M. & Gapin, L. (2002) The unconventional lifestyle of NKT cells. Nature Reviews Immunology, 2, 557-568.
4. Macey, M.G., McCarthy, D.A., Vogiatzi, D., Brown, K.A. & Newland, A.C. (1998) Rapid flow cytometric identification of putative CD14- and CD64-dendritic cells in whole blood. Cytometry, 31, 199-207.
5. Metelitsa, L.S., Naidenko, O.V., Kant, A., Wu, H.W., Loza, M.J., Perussia, B., Kronenberg, M. & Seeger, R.C. (2001) Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells. Journal of Immunology, 167, 3114-3122.
6. + T cells to dexamethasone. Journal of Immunology, 163, 2522-2529.
7. Provan, D. & Newland, A. (2002) Fifty years of idiopathic thrombocytopenic purpura (ITP): management of refractory itp in adults. British Journal of Haematology, 118, 933-944.
8. Randazzo, B., Hirschberg, T. & Hirschberg, H. (1984) Inhibition of the antigen activated T cell response by methylprednisolone is caused by inhibition of interleukin-2 (IL-2) production. International Journal of Immunopharmacology, 6, 419-423.
9. Spada, F.M., Borriello, F., Sugita, M., Watts, G.J., Koezuka, Y. & Porcelli, S.A. (2000) Low expression level but potent antigen presenting function of CD1d on monocyte lineage cells. European Journal of Immunology, 30, 3468-3477.
10. Vanderheyde, N., Verhasselt, V., Goldman, M. & Willems, F. (1999) Inhibition of human dendritic cell functions by methylprednisolone. Transplantation, 67, 1342-1347.
11. van der Vliet, H.J., Nishi, N., Koezuka, Y., von Blomberg, B.M., van den Eertwegh, A.J., Porcelli, S.A., Pinedo, H.M., Scheper, R.J. & Giaccone, G. (2001) Potent expansion of human natural killer T cells using alpha-galactosylceramide (KRN7000)-loaded monocyte-derived dendritic cells, cultured in the presence of IL-7 and IL-15. Journal of Immunology Methods, 247, 61-72.
12. Wilson, B.S. & Delovitch, T.L. (2003) Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity. Nature Reviews Immunology, 3, 211-222.