Differential responses of invariant Vα24JαQ T cells and MHC class II- restricted CD4+ T cells to dexamethasone

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2522-2529

  Milner, Joshua D ^a,c   Kent, Sally C ^a   Ashley, Timothy A ^a   Wilson, S Brian ^a,b   Strominger, Jack L ^a,b   Hafler, David A ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD UNIVERSITY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d Center for Neurologic Diseases   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIGEN; DEXAMETHASONE; FAS LIGAND; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR;

ARTICLE; AUTOCRINE EFFECT; CELL DEATH; CELL PROLIFERATION; HELPER CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; LYMPHOCYTE CLONE; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTIGENS, CD1; ANTIGENS, CD3; ANTIGENS, CD95; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; APOPTOSIS; AUTOCRINE COMMUNICATION; CD4-POSITIVE T-LYMPHOCYTES; CLONE CELLS; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS;

EID: 0033198113     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. + T lymphocytes. Science 268:863.
2. - α/β T cells demonstrates preferential use of several Vβ genes and an invariant TCR α chain. J. Exp. Med. 178:1.
3. Rooney, J., T. Hoey, and L. Glimcher. 1995. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 2:473.
4. +) T cells established from murine tumor-infiltrating lymphocytes. J. Immunol. 158:4846.
5. + T cells in a Th2 response and in immunoglobulin E production. Science 270:1845.
6. + T cells that promptly produce interleukin 4. Proc. Nalt. Acad. Sci. USA 92:11931.
7. + T cells are not essential for T helper cell 2 immune responses. J. Exp. Med. 184:1295.
8. Sumida, T., A. Sakamoto, H. Murata, Y. Makino, H. Takahashi, S. Yoshida, K. Nishioka, I. Iwamoto, and M. Taniguchi. 1995. Selective reduction of T cells bearing invariant Vα24JαQ antigen receptor in patients with systemic sclerosis. J. Exp. Med. 182:1163.
9. Wilson, S. B., S. C. Kent, K. T. Patton, T. Orban, R. A. Jackson, M. Exley, S. Porcelli, D. A. Schatz, M. A. Atkinson, S. P. Balk, et al. 1998. Extreme Th1 bias of invariant Vα24JαQ T cells in type 1 diabetes. Nature 391:177.
10. + NK T cells associated with disease development in autoimmune-prone mice. J. Immunol. 156:4035.
11. - (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. J. Exp. Med. 187:1047.
12. - T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 46:572.
13. Padgett, D., J. Sheridan, and R. Loria. 1995. Steroid hormone regulation of a polyclonal TH2 immune response. Am. NY Acad. Sci. 774:323.
14. + T cells in vitro. J. Immunol. 156:2406.
15. Dozmorov, I., and R. Miller. 1998. Generation of antigen-specific TH2 cells from unprimed mice in vitro: effects of dexamethasone and anti-IL-10 antibody. J. Immunol. 160:2700.
16. Rook, G., R. Hernandez-Pando, and S. Lightman. 1994. Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance. Immunol. Today 15:301.
17. Gillis, S., G. Crabtree, and K. Smith. 1979. Glucocorticoid-induced inhibition of T cell growth factor production. 1. The effect on mitogen-induced lymphocyte proliferation. J. Immunol. 123:1624.
18. Almawi, W., M. Lipman, A. Stevens, B. Zanker, E. Hadro, and T. Strom. 1991. Abrogation of glucocorticoid-mediated inhibition of T cell proliferation by the synergistic action of IL-1, IL-6 and IFN-γ. J. Immunol. 146:3523.
19. Wilder, R. 1995. Neuroendocrine-immune system interactions and autoimmunity. Annu. Rev. Immunol. 13:307.
20. MacPhee, I., F. Antoni, and D. Mason. 1989. Spontaneous recovery of rats from experimental allergic encephalomyelitis is dependent on regulation of the immune system by endogenous adrenal corticosteroids. J. Exp. Med. 169:431.
21. Mason, D., I. Macphee, and F. Antoni. 1990. The role of the neuroendocrine system in determining genetic susceptibility to experimental allergic encephalomyelitis in the rat. Immunology 70:1.
22. Wyllie, A. 1980. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555.
23. Zacharchuk, C. M., M. Mercep, P. K. Chakraborti, S. S. Simons, and J. D. Ashwell. 1990. Programmed T lymphocyte death: cell activation- and steroid-induced pathways are mutually antagonistic. J. Immunol. 145:4037.
24. Iwata, M., S. Hanaoka, and K. Sato. 1991. Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possible in vitro model for positive selection of the T cell repertoire. Eur. J. Immunol. 21:643.
25. Pelfrey, C. M., L. R. Tranquill, S. A. Boehme, H. F. McFarland, and M. J. Lenardo. 1995. Two mechanisms of antigen-specific apoptosis of myelin basic protein (MBP)-specific T lymphocytes derived from multiple sclerosis patients and normal individuals. J. Immunol. 154:6191.
26. Wiegers, G. J., M. S. Labeur, I. E. M. Stec, W. E. F. Klinkert, F. Holsboer, and J. M. H. M. Reul. 1995. Glucocorticoids accelerate anti-T cell receptor-induced T cell growth. J. Immunol. 155:1893.
27. Piccolella, E., D. Vismara, G. Lombardi, D. Guerritore, M. Piantelli, and F. Ranelletti. 1985. Effect of glucocorticoids on the development of suppressive activity in human lymphocyte response to a polysaccharide purified from Candida albicans. J. Immunol. 134:1166.
28. 2 modulate T-cell receptor signaling through a cAMP-independent mechanism. Cell. Immunol. 169:117.
29. 2: a novel paradigm for the induction of T-cell anergy. Cell. Immunol. 180:124.
30. Nijhuis, E., B. Hinloopen, J. Odding, and L. Nagelkerken. 1994. Abrogation of the suppressive effects of dexamethasone by PKC activation or CD28 triggering. Cell. Immunol. 156:438.
31. Cui, H., D. H. Sherr, M. El-Khatib, K. Matsui, D. J. Panka, A. Marshak-Rothstein, and S.-T. Ju. 1996. Regulation of T-cell death genes: selective inhibition of FasL- but not Fas-mediated function. Cell. Immunol. 167: 276.
32. Yang, Y., M. Mercep, C. F. Ware, and J. D. Ashwell. 1995. Fas and activation-induced Fas ligand mediate apoptosis of T cell hybridomas: inhibition of Fas ligand expression by retinoic acid and glucocorticoids. J. Exp. Med. 181:1673.
33. D'Adamio, F., O. Zollo, R. Moraca, E. Ayroldi, S. Bruscoli, A. Bartoli, L. Cannarile, G. Migliorati, and C. Riccardi. 1997. A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. Immunity 7:803.
34. Wucherpfennig, K. W., J. Zhang, C. Witek, M. Matsui, Y. Modabber, K. Ota, and D. A. Hafler. 1994. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol. 152:5581.
35. Van Parijs, L., A. Biuckians, and A. Abbas. 1998. Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes. J. Immunol. 160:2065.
36. Aggarwal, S., and S. Gupta. 1998. Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-2, and Bax. J. Immunol. 160:1627.
37. Nieto, M., and A. Lopez-Rivas. 1989. IL-2 protects T lymphocytes from glucocorticoid-induced DNA fragmentation and cell death. J. Immunol. 143:4166.
38. Kam, J., S. J. Szefler, W. Surs, E. R. Sher, and D. Y. M. Leung. 1993. Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. J. Immunol. 151:3460.
39. Mor, F., and I. Cohen. 1996. IL-2 rescues antigen-specific T cells from radiation or dexamethasone-induced apoptosis. J. Immunol. 156:515.
40. pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J. Exp. Med. 179:1285.
41. + T cells: a new family of T cells. Immunol. Today 17:71.
42. Sternberg, E., G. Chrousos, R. Wilder, and P. Gold. 1992. The stress response and the regulation of inflammatory disease. Ann. Intern. Med. 117:854.
43. Mittelstadt, P. R., and J. D. Ashwell. 1998. Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression. Mol. Cell. Biol. 18:3744.
44. Mittelstadt, P. R., and J. D. Ashwell. 1999. Role of Egr-2 in up-regulalion of Fas ligand in normal T cells and aberrant double-negative Ipr and gld T cells. J. Biol. Chem. 274:3222.
45. + NK T cells. J. Immunol. 158:2076.
46. + T cells by non-major histocompatibility complex-encoded class I-like molecules expressed on bone marrow-derived cells. Proc. Natl. Acad. Sci. USA 92:1200.
47. + T cells are resistant to glucocorticoid-induced apoptosis: implications for the Th1/Th2 balance. J. Immunol. 161:1239.