Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells

Nucleic Acids Research

Volumn 32, Issue 8, 2004, Pages 2508-2519

  Doan, Loretta L ^a   Porter, Susan D ^b   Duan, Zhijun ^c   Flubacher, Marcella M ^d   Montoya, Diego ^a   Tsichlis, Philip N ^e   Horwitz, Marshall ^c   Gilks, C Blake ^b,f   Grimes, H Leighton ^a,g  

^a UNIVERSITY OF LOUISVILLE   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d FOX CHASE CANCER CENTER   (United States)

^e TUFTS MEDICAL CENTER   (United States)

^f VANCOUVER GENERAL HOSPITAL   (Canada)

^g University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; ONCOPROTEIN; REPRESSOR PROTEIN; DNA; DNA BINDING PROTEIN; GFI1 PROTEIN, HUMAN; GFI1 PROTEIN, MOUSE; GFI1 PROTEIN, RAT; GFI1B PROTEIN, HUMAN; GFI1B PROTEIN, MOUSE; MESSENGER RNA; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; AUTOREGULATION; CELL LINE; CONTROLLED STUDY; DNA BINDING; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; LYMPHOID CELL; LYMPHOPOIESIS; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; STEM CELL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; THYMOCYTE; TRANSCRIPTION REGULATION; TRANSGENE; UPREGULATION; ANIMAL; CELL CULTURE; CYTOLOGY; DNA RESPONSIVE ELEMENT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; LEUKEMIA CELL LINE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROMOTER REGION; RAT; SEQUENCE HOMOLOGY; THYMUS;

ANIMALS; BASE SEQUENCE; CELL LINE; CELLS, CULTURED; CONSERVED SEQUENCE; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; JURKAT CELLS; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RATS; REPRESSOR PROTEINS; RESPONSE ELEMENTS; RNA, MESSENGER; SEQUENCE HOMOLOGY, NUCLEIC ACID; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 2442599107     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh570     Document Type: Article

References (34)

1. Yucel,R., Karsunky,H., Klein-Hitpass,L. and Moroy,T. (2003) The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J. Exp. Med., 197, 831-844.
2. Karsunky,H., Zeng,H., Schmidt,T., Zevnik,B., Kluge,R., Schmid,K.W., Duhrsen,U. and Moroy,T. (2002) Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nature Genet., 30, 295-300.
3. Hock,H., Hamblen,M.J., Rooke,H.M., Traver,D., Bronson,R.T., Cameron,S. and Orkin,S.H. (2003) Intrinsic requirement for zinc finger transcription factor gfi-1 in neutrophil differentiation. Immunity, 18, 109-120.
4. Person,R.E., Li.F.Q., Duan,Z., Benson,K.F., Wechsler,J., Papadaki,H.A., Eliopoulos,G., Kaufman,C.L., Bertolone,S.J., Nakamoto,B. et al. (2003) Gfi1 proto-oncogene mutation causes human neutropenia and targets neutrophil elastase. Nature Genet., 34, 308-312.
5. Saleque,S., Cameron,S. and Orkin,S.H. (2002) The zinc-finger proto-oncogene Gfi-1b is essential for development of the erythroid and megakaryocytic lineages. Genes Dev., 16, 301-306.
6. Doan,L.L., Kitay,M.K., Yu,Q., Singer,A., Herblot,S., Hoang,T., Bear,S.E., Morse,H.C., III, Tsichlis,P.N. and Grimes,H.L. (2003) Growth factor independence-1B expression leads to defects in T cell activation, IL-7 receptor alpha expression, and T cell lineage commitment. J. Immunol., 170, 2356-2366.
7. Tong,B., Grimes,H.L., Yang,T.Y., Bear,S.E., Qin,Z., Du,K., El-Deiry,W.S. and Tsichlis,P.N. (1998) The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation. Mol. Cell. Biol., 18, 2462-2473.
8. Grimes,H.L., Chan,T.O., Zweidler-McKay,P.A., Tong,B. and Tsichlis,P.N. (1996) The Gfi-1 proto-oncoprotein contains a novel transcriptional repressor domain, SNAG, and inhibits G1 arrest induced by interleukin-2 withdrawal. Mol. Cell. Biol., 16, 6263-6272.
9. Zweidler-McKay,P.A., Grimes,H.L., Flubacher,M.M. and Tsichlis,P.N. (1996) Gfi-1 encodes a nuclear zinc finger protein that binds DNA and functions as a transcriptional repressor. Mol. Cell. Biol., 16, 4024-4034.
10. Rodel,B., Tavassoli,K., Karsunky,H., Schmidt,T., Bachmann,M., Schaper,F., Heinrich,P., Shuai,K., Elsasser,H.P. and Moroy,T. (2000) The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3. EMBO J., 19, 5845-5855.
11. Karsunky,H., Mende,I., Schmidt,T. and Moroy,T. (2002) High levels of the onco-protein Gfi-1 accelerate T-cell proliferation and inhibit activation induced T-cell death in Jurkat T-cells. Oncogene, 21, 1571-1579.
12. Akagi,K., Suzuki,T., Stephens,R.M., Jenkins,N.A. and Copeland,N.G. (2004) RTCGD: retroviral tagged cancer gene database. Nucleic Acids Res., 32, D523-D527.
13. Hawley,T.S., Telford,W.G., Ramezani,A. and Hawley,R.G. (2001) Four-color flow cytometric detection of retrovirally expressed red, yellow, green, and cyan fluorescent proteins. Biotechniques, 30, 1028-1034.
14. Kinoshita,S., Chen,B.K., Kaneshima,H. and Nolan,G.P. (1998) Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells. Cell, 95, 595-604.
15. Jordan,M., Schallhorn,A. and Wurm,F.M. (1996) Transfecting mammalian cells: optimization of critical parameters affecting calcium-phosphate precipitate formation. Nucleic Acids Res., 24, 596-601.
16. Gilks,C.B., Bear,S.E., Grimes,H.L. and Tsichlis,P.N. (1993) Progression of interleukin-2 (IL-2)-dependent rat T cell lymphoma lines to IL-2-independent growth following activation of a gene (Gfi-1) encoding a novel zinc finger protein. Mol. Cell. Biol., 13, 1759-1768.
17. Porter,S., Larue,L. and Mintz,B. (1991) Mosaicism of tyrosinase-locus transcription and chromatin structure in dark vs. light melanocyte clones of homozygous chinchilla-mottled mice. Dev. Genet., 12, 393-402.
18. Jegalian,A.G. and Wu,H. (2002) Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin. J. Biol. Chem., 277, 2345-2352.
19. Dignam,J.D., Lebovitz,R.M. and Roeder,R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res., 11, 1475-1489.
20. Duan,Z. and Horwitz,M. (2003) Targets of the transcriptional repressor oncoprotein Gfi-1. Proc. Natl Acad. Sci. USA, 100, 5932-5937.
21. Scheijen,B., Jonkers,J., Acton,D. and Berns,A. (1997) Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice. J. Virol., 71, 9-16.
22. Javahery,R., Khachi,A., Lo,K., Zenzie-Gregory,B. and Smale,S.T. (1994) DNA sequence requirements for transcriptional initiator activity in mammalian cells. Mol. Cell. Biol., 14, 116-127.
23. Smale,S.T., Jain,A., Kaufmann,J., Emami,K.H., Lo,K. and Garraway,I.P. (1998) The initiator element: a paradigm for core promoter heterogeneity within metazoan protein-coding genes. Cold Spring Harb. Symp. Quant. Biol., 63, 21-31.
24. Liu,S. and Cowell,J.K. (2000) Cloning and characterization of the TATA-less promoter from the human GFI1 proto-oncogene. Ann. Hum. Genet., 64, 83-86.
25. Quandt,K., Frech,K., Karas,H., Wingender,E. and Werner,T. (1995) MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucleic Acids Res., 23, 4878-4884.
26. Macian,F., Lopez-Rodriguez,C. and Rao,A. (2001) Partners in transcription: NFAT and AP-1. Oncogene, 20, 2476-2489.
27. Taniguchi,T. (1997) Transcription factors IRF-1 and IRF-2: Linking the immune responses and tumor suppression. J. Cell. Physiol., 173, 128-130.
28. Warren,L.A. and Rothenberg,E.V. (2003) Regulatory coding of lymphoid lineage choice by hematopoietic transcription factors. Curr. Opin. Immunol., 15, 166-175.
29. Wallis,D., Hamblen,M., Zhou,Y., Venken,K.J., Schumacher,A., Grimes,H.L., Zoghbi,H.Y., Orkin,S.H. and Bellen,H.J. (2003) The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development, 130, 221-232.
30. Schmidt,T., Karsunky,H., Gau,E., Zevnik,B., Elsasser,H.P. and Moroy,T. (1998) Zinc finger protein GFI-1 has low oncogenic potential but cooperates strongly with pim and myc genes in T-cell lymphomagenesis. Oncogene, 17, 2661-2667.
31. Jia,Y., Xie,G., McDermott,J.B. and Aamodt,E. (1997) The C. elegans gene pag-3 is homologous to the zinc finger proto-oncogene gfi-1. Development, 124, 2063-2073.
32. Schmidt,T., Karsunky,H., Rodel,B., Zevnik,B., Elsasser,H.P. and Moroy,T. (1998) Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection. EMBO J., 17, 5349-5359.
33. Aamodt,E., Shen,L., Marra,M., Schein,J., Rose,B. and McDermott,J.B. (2000) Conservation of sequence and function of the pag-3 genes from C.elegans and C.briggsae. Gene, 243, 67-74.
34. Perez,P., Lira,S.A. and Bravo,R. (1995) Overexpression of RelA in transgenic mouse thymocytes: specific increase in levels of the inhibitor protein I kappa B alpha. Mol. Cell. Biol., 15, 3523-3530.