Genetics and visceral leishmaniasis in the Sudan: Seeking a link

Trends in Parasitology

Volumn 20, Issue 6, 2004, Pages 268-274

  Blackwell, Jenefer M ^a   Mohamed, Hiba S ^a,b   Ibrahim, Muntaser E ^b  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF KHARTOUM   (Sudan)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4;

ALLELE; DNA POLYMORPHISM; FAMILY; GENE SEQUENCE; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENETICS; GENOTYPE; HUMAN; IMMUNITY; LEISHMANIA DONOVANI; LEISHMANIASIS; MACROPHAGE; REVIEW; SKIN LEISHMANIASIS; SUDAN; TH1 CELL; TH2 CELL; VISCERAL LEISHMANIASIS;

LEISHMANIA DONOVANI; NASO HEXACANTHUS; PROTOZOA;

EID: 2442598170     PISSN: 14714922     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pt.2004.04.003     Document Type: Article

References (57)

1. De Beer P., et al. Outbreak of kala-azar in the Sudan. Lancet. 335:1990;224
2. Perea W.A., et al. Epidemic of visceral leishmaniasis in southern Sudan. Lancet. 2:1989;1222-1223
3. Zijlstra E.E., et al. Endemic kala-azar in Eastern Sudan, a longitudinal study on the incidence of clinical and subclinical infection and post-kala-azar dermal leishmaniasis. Am. J. Trop. Med. Hyg. 51:1994;826-836
4. Ibrahim M.E., et al. Kala-azar in a high transmission focus: an ethnic and geographical dimension. Am. J. Trop. Med. Hyg. 61:1999;941-944
5. Mohamed H.S., et al. Genetic susceptibility to visceral leishmaniasis in the Sudan: linkage and association with IL4 and IFNGR1. Genes Immun. 4:2003;351-355
6. Mohamed H.S., et al. SLC11A1 (formerly NRAMP1) and susceptibility to visceral leishmaniasis in the Sudan. Eur. J. Hum. Genet. 12:2004;66-74
7. Bucheton B., et al. Genetic control of visceral leishmaniasis in a Sudanese population: candidate gene testing indicates a linkage to the NRAMP1 region. Genes Immun. 4:2003;104-109
8. Blackwell J.M., et al. SLC11A1 (formerly NRAMP1) and disease. Cell. Microbiol. 3:2001;773-784
9. Vidal S.M., et al. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell. 73:1993;469-485
10. +/bivalent cation antiporter. Biochem. J. 354:2001;511-519
11. Vidal S., et al. The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J. Exp. Med. 182:1995;655-666
12. Searle S., et al. Localization of Nramp1 in macrophages: modulation with activation and infection. J. Cell Sci. 111:1998;2855-2866
13. Blackwell J.M., et al. Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/ Slc11a1 gene story. Immunol. Lett. 85:2003;197-203
14. Bellamy R., et al. Variation in the NRAMP1 gene is associated with susceptibility to tuberculosis in West Africans. N. Engl. J. Med. 338:1998;640-644
15. Marquet S., et al. Variants of the human NRAMP1 gene and altered human immunodeficiency virus infection susceptibility. J. Infect. Dis. 180:1999;1521-1525
16. Cordell H.J., Clayton D.G. A unified stepwise regression procedure for evaluating the relative effects of polymorphisms within a gene using case/control or family data: application to HLA in type 1 diabetes. Am. J. Hum. Genet. 70:2002;124-141
17. Searle S., Blackwell J.M. Evidence for a functional repeat polymorphism in the promoter of the human NRAMP1 gene that correlates with autoimmune versus infectious disease susceptibility. J. Med. Genet. 36:1999;295-299
18. Blackwell J.M., et al. Genomic organization and sequence of the human NRAMP gene: identification and mapping of a promoter region polymorphism. Mol. Med. 1:1995;194-205
19. Liu J., et al. Identification of polymorphisms and sequence variants in human homologue of the mouse natural resistance-associated macrophage protein gene. Am. J. Hum. Genet. 56:1995;845-853
20. Buu N.T., et al. Identification of a highly polymorphic length variant in the 3′UTR of NRAMP1. Immunogenetics. 42:1995;428-429
21. White J.K., et al. Genetic and physical mapping of 2q35 in the region of NRAMP and IL8R genes: Identification of a polymorphic repeat in exon 2 of NRAMP. Genomics. 24:1994;295-302
22. Lewis L.-A., et al. Identification of a C to T mutation at position -236 bp in the human NRAMP1 promoter. Immunogenetics. 44:1996;309-311
23. Lenardo M.J., Baltimore D. NF-κB: a pleiotropic mediator of inducible and tissue-specific gene control. Cell. 58:1989;227-229
24. Yip S.P., et al. Extent and distribution of linkage disequilibrium around the SLC11A1 locus. Genes Immun. 4:2003;212-221
25. Zaahl, M.G. et al. Analysis of the SLC11A1 5′-(GT)n repeat polymorphism in patients with inflammatory bowel disease: in vivo and in vitro evidence for a protective allelic effect in the presence of the -237C/T polymorphism. Blood Cells Mol.Dis. (in press).
26. Awomoyi A.A., et al. Interleukin-10, polymorphism in SLC11A1 (formerly NRAMP1), and susceptibility to tuberculosis. J. Infect. Dis. 186:2002;1808-1814
27. Blackwell J., et al. Influence of H-2 complex on acquired resistance to Leishmania donovani infection in mice. Nature. 283:1980;72-74
28. Peacock C.S., et al. Genetic analysis of multicase families of visceral leishmaniasis in northeastern Brazil: no major role for class II or class III regions of HLA. Genes Immun. 3:2002;350-358
29. Locksley R.M., Scott P. Helper T-cell subsets in mouse leishmaniasis induction, expansion and effector function. Immunol. Today. 12:1991;A58-A61
30. Mohamed, H.S. et al. SLC11A1 (formerly NRAMP1) and susceptibility to visceral leishmaniasis in the Sudan. Eur. J. Hum. Genet. 12, 66-74.
31. Kemp M., et al. Leishmania donovani-reactive Th1- and Th2-like T-cell clones from individuals who have recovered from visceral leishmaniasis. Infect. Immun. 61:1993;1069-1073
32. Sundar S., et al. Circulating T helper 1 (Th1) cell- and Th2 cell-associated cytokines in Indian patients with visceral leishmaniasis. Am. J. Trop. Med. Hyg. 56:1997;522-525
33. Zwingenberger K., et al. Determinants of the immune response in visceral leishmaniasis: evidence for predominance of endogenous interleukin 4 over interferon-gamma production. Clin. Immunol. Immunopathol. 57:1990;242-249
34. Kemp K., et al. Leishmania-specific T cells expressing interferon-gamma (IFN-gamma) and IL-10 upon activation are expanded in individuals cured of visceral leishmaniasis. Clin. Exp. Immunol. 116:1999;500-504
35. Kharazmi A., et al. T-cell response in human leishmaniasis. Immunol. Lett. 65:1999;105-108
36. Kurtzhals J.A., et al. Interleukin-4 and interferon-gamma production by Leishmania stimulated peripheral blood mononuclear cells from nonexposed individuals. Scand. J. Immunol. 41:1995;343-349
37. Gessner A., et al. Differential regulation of IL-9-expression after infection with Leishmania major in susceptible and resistant mice. Immunobiology. 189:1993;419-435
38. Roberts M., et al. Mapping of genes controlling Leishmania major infection in CXS recombinant inbred mice. Eur. J. Immunogenet. 20:1993;349-362
39. Zijlstra E.E., el-Hassan A.M. Leishmaniasis in Sudan. Post kala-azar dermal leishmaniasis. Trans. R. Soc. Trop. Med. Hyg. 95:(Suppl 1):2001;S59-S76
40. Musa A.M., et al. The natural history of Sudanese post-kala-azar dermal leishmaniasis: clinical, immunological and prognostic features. Trans. R. Soc. Trop. Med. Hyg. 96:2002;765-772
41. Newport M.J., et al. A mutation in the interferon-γ-receptor gene and susceptibility to mycobacterial infection. N. Engl. J. Med. 335:1996;1941-1949
42. Jouanguy E., et al. Interferon-gamma-receptor deficiency in an infant with fatal bacille Calmette-Guerin infection. N. Engl. J. Med. 335:1996;1956-1961
43. Altare F., et al. Impairmant of mycobacterial immunity in human interleukin-12 receptor deficiency. Science. 280:1998;1432-1435
44. De Jong R., et al. Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science. 280:1998;1435-1438
45. Dupuis S., et al. Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation. Science. 293:2001;300-303
46. Peacock C.S., et al. Genetic epidemiology of visceral leishmaniasis in northeastern Brazil. Genet. Epidemiol. 20:2001;383-396
47. Kruglyak L., Lander E.S. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am. J. Hum. Genet. 57:1995;439-454
48. Kruglyak L., et al. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am. J. Hum. Genet. 58:1996;1347-1363
49. Gudbjartsson D.F., et al. Allegro, a new computer program for multipoint linkage analysis. Nat. Genet. 25:2000;12-13
50. Kong A., Cox N.J. Allele-sharing models: LOD scores and accurate linkage tests. Am. J. Hum. Genet. 61:1997;1179-1188
51. Spielman R.S., et al. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52:1993;506-516
52. Sham P.C., Curtis D. An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann. Hum. Genet. 59:1995;323-336
53. Dudbridge F., et al. Unbiased application of the transmission disequilibrium test to multilocus haplotypes. Am. J. Hum. Genet. 66:2000;2009-2012
54. Hedrick P.W. Gametic disequilibrium measures: proceed with caution. Genetics. 117:1987;331-341
55. Abecasis G.R., Cookson W.O. GOLD-graphical overview of linkage disequilibrium. Bioinformatics. 16:2000;182-183
56. Graham A.M., et al. Identification of novel alleles at a polymorphic microsatellite repeat region in the human NRAMP1 gene promoter: analysis of allele frequencies in primary biliary cirrhosis. J. Med. Genet. 37:2000;150-152
57. Kojima Y., et al. Inflammatory bowel disease is associated with a novel promoter polymorphism of natural resistance-associated macrophage protein 1 (NRAMP1) gene. Tissue Antigens. 58:2001;379-384