Gene therapy for ischemic heart disease: Therapeutic potential

American Journal of Cardiovascular Drugs

Volumn 1, Issue 3, 2001, Pages 159-166

  Symes, James F ^a,b  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN;

CLINICAL TRIAL; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; HEART MUSCLE ISCHEMIA; HUMAN; NEOVASCULARIZATION (PATHOLOGY); REVIEW;

CLINICAL TRIALS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HUMANS; MYOCARDIAL ISCHEMIA; NEOVASCULARIZATION, PATHOLOGIC; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 2442576840     PISSN: 11753277     EISSN: 1179187X     Source Type: Journal    
DOI: 10.2165/00129784-200101030-00001     Document Type: Review

References (54)

1. Das DK, Engleman RM, Maulik N, et al. Molecular targets of gene therapy. Ann Thorac Surg 1999; 68: 1929-33
2. Zoldhelyi P, Eichstaedt H, Jax T, et al. The emerging clinical potential of cardiovascular gene therapy. Semin Interv Cardiol 1999; 4: 151-65
3. Isner JM. Tissue responses to ischemia: local and remote responses for preserving perfusion of ischemic muscle. J Clin Invest 2000; 1046: 615-19
4. Couffinhal T, Silver M, Zheng LP et al. A mouse model of angiogenesis. Am J Pathol 1998; 152: 1667-79
5. Lee SH, Wolf PL, Escudero R et al. Early expression of angiogenesis factors in acute myocardial ischemia and infarction. New Engl J Med 2000; 342: 626-33
6. Forsythe JA, Jiang BH, Iyer NV et al. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Moll Cell Biol 1996; 16: 4604-13
7. Levy AP, et al. Regulation of vascular endothelial growth factor in cardiac myocytes. Circ Res 1995; 76: 758-66
8. Couffinhal T, Silver M, Kearney M, et al. Impaired collateral vessel development associated with reduced expression of vascular endothelial growth factor in ApoE-/-mice. Circulation 1999; 99: 3188-98
9. Arras M, Ho WD, Scholz D, et al. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin Invest 1998; 101: 40-50
10. Brogi E, Schatteman G, Wu T, et al. Hypoxia-induced paracrine regulation of VEGF receptor expression. J Clin Invest 1996; 97: 469-76
11. Li J, Brown LF, Hibberd MG, et al. VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am J Physiol 1996; 270: H1803-11
12. Schultz A, Lavie L, Hochberg I, et al. Interindividual heterogeneity in the hypoxic regulation of VEGF: significance for the development of the coronary artery collateral circulation. Circulation 1999; 100: 547-2
13. Rivard A, Fabre JE, Silver M, et al. Age-dependent impairment of angiogenesis. Circulation 1999; 99: 111-20
14. VanBelle E, Rivard A, Chen D, et al. Hypercholesterolemia attenuates angiogenesis but does not preclude augmentation by angiogenic cytokines. Circulation 1997; 96: 2667-74
15. Rivard A, Silver M, Chen D, et al. Rescue of diabetes related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF. Am J Pathol 1999; 154: 355-64
16. Hamawy AH, Lee LY, Crystal RG, et al. Cardiac angiogenesis and gene therapy: a strategy for myocardial revascularization. Curr Opin Cardiol 1999; 14: 515-22
17. Enholm B, Paavonen K, Ristimaki A, et al. Comparison of VEGF, VEGF-B, BEGF-C and Ang 1 mRNA regulation by serum growth factors, oncoproteins and hypoxia. Oncogene 1997; 1: 2475-83
18. Takeshita S, Zheng LP, Brogi E, et al. Therapeutic angiogenesis: a single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hindlimb model. J Clin Invest 1994; 93: 662-70
19. Hariawala M, Horowitz JR, Esakof D, et al. VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts. J Surg Res 1996; 63: 77-82
20. Hayashi S, Morishita R, Nakamura S, et al. Potential role of hepatocyte growth factor, a novel angiogenic growth factor, in peripheral arterial disease downregulation of HGF in response to hypoxia in vascular cells. Circulation 1999; 100: (II) 301-8
21. VanBelle E, Chen D, Zheng LP, et al. Scatter factor stimulates angiogenesis in a rabbit model of hindlimb ischemia [abstract]. Circulation 1995; 92: (I)-78
22. Shyu KG, Manor O, Magner M, et al. Direct intramuscular injection of plasmid DNA encoding angiopoietin-1 but not angiopoietin-2 augments revascularization in the rabbit ischemic hindlimb. Circulation 1998; 98: 2081-87
23. Vincent KA, Shyu KG, Luo Y, et al. Angiogenesis is induced in a rabbit model of hindlimb ischemia by naked DNA encoding an HIF-1(/VP16 hybrid transcription factor. Circulation 2000; 102: 2255-61
24. Alexander MY, Webster KA, McDonald PH, et al. Gene transfer and models of gene therapy for the myocardium. Clin Exp Pharmacol Physiol 1999; 26: 661-8
25. Duckers HJ, Nabel EG. Prospects for genetic therapy of cardiovascular disease. Med Clin North Am 2000; 84 (1): 199-213
26. Tio RA, Tkebuchava T, Scheuermann TH, et al. Intramyocardial gene therapy with naked DNA encoding vascular endothelial growth factor improves collateral flow to ischemic myocardium. Hum Gene Ther 1999; 10-2953-60
27. Tsurumi Y, Takeshita S, Chen D, et al. Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion. Circulation 1996; 94: 3281-90
28. Isner JM, Pieczek A, Schainfeld R, et al. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patients with ischaemic limb. Lancet 1996; 348: 370-74
29. Baumgartner I, Pieczek A, Manor O, et al. Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia. Circulation 1998; 97: 1114-23
30. Isner JM, Baumgartner I, Rauh G, et al. Treatment of thromboangiitis obliterans (Buerger s disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical results. J Vasc Surg 1998; 28: 964-75
31. Vale PR, Losordo DW, Tkebuchava T, et al. Catheter-based myocardial gene transfer utilizing nonfluoroscopic electromechanical left ventricular mapping. J Am Coll Cardiol 1999; 34: 246-54
32. Lee LY, Patel SR, Hackett NR, et al. Focal angiogen therapy using intramyocardial delivery of an adenovirus vector coding for vascular endothelial growth factor, Ann Thor Surg, 2000, 69, 14-24.
33. Logeart D, Hatem SN, Martin CR, et al. Highly efficient adenovirus-mediated gene transfer to cardiac myocytes after single-pass coronary delivery. Hum Gene Ther 2000; 11: 1015-22
34. Davidson MJ, Shah AS, Jaggers J, et al. Intracoronary transgene delivery during cardiopulmonary bypass results in transmural cardiac-specific gene expression in neonatal pigs. Surg Forum 2000; LI: 90-2
35. Boekstegers P, Degenfeld G, Giehrl W, et al. Myocardial gene transfer by selective pressure-regulated retroinfusion of coronary veins. Gene Ther 2000; 7-232-40
36. Schumacher B, Pecher P, von Specht BU, et al. Induction of neoangiogenesis in ischemic myocardium by human growth factor first clinical results of a new treatment of coronary heart disease. Circulation 1998; 97: 645-50
37. Laham RJ, Sellke FW, Edelman ER, et al. Local perivascular delivery of basic fibroblast growth factor in patients undergoing coronary bypass surgery. Circulation 1999; 100: 1865-71
38. Henry TD, McKendall GR, Azrin MA, et al. VIVA trial: One year followup [abstract]. Circulation 2000; 102: II-309
39. Udelson JE, Dilsizian V, Laham RJ, et al. Therapeutic angiogenesis with recombinant fibroblast growth factor-2 improves stress and rest myocardial perfusion abnormalities in patients with severe symptomatic chronic coronary artery disease. Circulation 2000; 102: 1605-0
40. Rosengart TK, Lee LY, Patel SR, et al. Six-month assessment of a phase 1 trial of angiogenic gene therapy for the treatment of coronary artery disease using direct intramyocardial administration of an adenovirus vector expressing the VEGF121 cDNA. Ann Surg 1999; 230: 466-72
41. Symes JF, Losordo DW, Vale PR, et al. Gene therapy with vascular endothelial growth factor for inoperable coronary artery disease. Ann Thor Surg 1999; 68: 830-7
42. Vale PR, Lossordo DW, Milliken CE, et al. Left ventricular electromechanical mapping to assess efficacy of phVEGF165 gene transfer for therapeutic angiogenesis in chronic myocardial ischemia. Circulation 2000; 102: 965-74
43. Fortuin Jr FD, Vale P, Losordo DW, et al. Direct myocardial gene transfer of vascular endothelin growth factor-2 (VEGF-2) naked DNA via thoracotomy relieves angina pectoris and increase exercise time: one-year follow-up of a completed dose-escalating phase I study. J Am Coll Cardiol 2001; 37:2 285A
44. Kleiman NS, Califf RN. Results from late-breaking clinical trials sessions at ACCIS 2000 and ACC 2000. J Am Coll Cardiol 2000; 36: 310-1
45. Kornowski R, Baim DS, Moses JW et al. Short and intermediate term clinical outcomes from direct myocardial laser revascularization guided by Biosense left ventricular electromechanical mapping. Circulation 2000; 102:10, 1120-5
46. Aaberge L, Nordstrand K, Dragsund M, et al. Transmyocardial revascularization with CO2 laser in patients with refractory angina pectoris: clinical results from the Norwegian randomized trial. J Am Coll Cardiol 2000; 35:5, 1170-7
47. Vale PR, Losordo DW, Milliken CE, et al. Randomized, placebo-controlled clinical study of percutaneous catheter-based left ventricular endocardial gene transfer of VEGF-2 for myocardial angiogenesis in patients with chronic myocardial ischemia [abstract]. Circulation 2001; 103: 2138-43
48. Malekan R, Reynolds C, Narula N, et al. Angiogenesis in transmyocardial laser revascularization: a nonspecific response to injury. Circulation 1998; 98: II-62-66
49. Sayeed-Shah U, Mann MJ, Martin J, et al. Complete reversal of ischemic wall motion abnormalities by combined use of gene therapy with transmyocardial laser revascularization. J Thorac Cardiovasc Surg 1998; 116: 763-69
50. Hughes C, Annex B, Yin B, et al. Transmyocardial laser revascularization (TMR) limits in vivo adenoviral-mediated gene transfer in porcine myocardium. J Am Coll Cardiol 1999; 33: 355A
51. Chu VF, Giaid A, Kuang J, et al. Angiogenesis in transmyocardial revascularization: comparison of laser versus mechanical punctures. Ann Thorac Surg 1999; 68: 301-08
52. Doukas J, Ma C, Craig D, et al. Therapeutic angiogenesis induced by FGF2 gene delivery combined with laser transmyocardial revascularization [abstract]. Circulation 2000; 102: II-245
53. Reinlib LJ. Cardiac cell transplantation to patch up the heart. Card Vasc Regeneration 2000; 1: 2-4
54. Yau TM, Sarjeant J, Fung K, et al. Enhanced myocardial angiogenesis by gene transfer using transplanted cells [abstract]. Circulation 2000; 102: II-682