Prevention of acute and chronic allograft rejection by a novel retinoic acid receptor-α-selective agonist

International Immunology

Volumn 16, Issue 5, 2004, Pages 665-673

  Seino, Ken Ichiro ^a,b,c   Yamauchi, Toshihiko ^d   Shikata, Kohdoh ^d   Kobayashi, Seiichi ^e   Nagai, Mitsuo ^d   Taniguchi, Masaru ^a,f   Fukao, Katashi ^c  

^a RIKEN   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d EISAI CO LTD   (Japan)

^e EISAI RESEARCH INSTITUTE   (United States)

^f CHIBA UNIVERSITY   (Japan)

Author keywords

Arteriosclerosis; Cell differentiation; Retinoid; Th1 Th2; Transplantation

Indexed keywords

4 [5 (4,7 DIMETHYLBENZO[B]FURAN 2 YL) 1H 2 PYRROLYL]BENZOIC ACID; ALLOANTIGEN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR; CYCLOSPORIN A; ER 38925; GAMMA INTERFERON; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 12; INTERLEUKIN 2; PROTEIN P27; RETINOIC ACID DERIVATIVE; RETINOIC ACID RECEPTOR ALPHA; TACROLIMUS; UNCLASSIFIED DRUG;

ACUTE GRAFT REJECTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA MEDIA; ARTERIOSCLEROSIS; ARTICLE; CELL PROLIFERATION; CHRONIC GRAFT REJECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DISEASE MODEL; DRUG POTENCY; DRUG POTENTIATION; DRUG SELECTIVITY; HEART GRAFT; HEART TRANSPLANTATION; IMMUNOSTIMULATION; IN VITRO STUDY; INCIDENCE; MONOTHERAPY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER;

ACUTE DISEASE; ANIMALS; ARTERIOSCLEROSIS OBLITERANS; CHRONIC DISEASE; CYCLIN-DEPENDENT KINASE INHIBITOR PROTEINS; CYTOKINES; FURANS; GRAFT ENHANCEMENT, IMMUNOLOGIC; GRAFT REJECTION; HEART TRANSPLANTATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED STRAINS; MICROTUBULE-ASSOCIATED PROTEINS; MYOCYTES, SMOOTH MUSCLE; PYRROLES; RATS; RECEPTORS, RETINOIC ACID; RETINOIDS; SPLEEN; T-LYMPHOCYTES, CYTOTOXIC;

EID: 2442563721     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxh066     Document Type: Article

References (46)

1. Hong, W. K. and Itri, L. M. 1994. Retinoids and human cancer. In Sporn, M. B., Roberts, A. B. and Goodman, D. S., eds, The Retinoids, 2nd edn, p. 597. Raven Press, New York.
2. Mangelsdorf, D. J. and Evans, R. M. 1995. The RXR heterodimers and orphan receptors. Cell 83:841.
3. Ross, A. C. 1992. Vitamin A status: relationship to immunity and antibody response. Proc. Soc. Exp. Biol. Med. 178:303.
4. Brinckerhoff, C. E., Coffey, J. W. and Sullivan, A. C. 1983. Inflammation and collagenase production in rats with adjuvant arthritis reduced with 13-cis-retinoic acid. Science 221:756.
5. Racke, M. K., Burnett, D., Pak, S. H., Albert, P. S., Cannella, B., Raine, C. S., McFarlin, D. E. and Scott, D. E. 1995. Retinoid treatment of experimental allergic encephalomyelitis. IL-4 production correlates with improved disease course. J. Immunol. 154:450.
6. Kuwabara, K., Shudo, K. and Hori, Y. 1996. Novel synthetic retinoic acid inhibits rat collagen arthritis and differentially affects serum immunoglobulin subclass levels. FEBS Lett. 378:153.
7. Nagai, H., Matsuura, S., Bouda, K., Takaoka, Y., Wang, T., Niwa, S. and Shudo, K. 1999. Effect of Am-80, a synthetic derivative of retinoid, on experimental arthritis in mice. Pharmacology 58:101.
8. Wang, T., Niwa, S., Bouda, K., Matsuura, S., Homma, T., Shudo, K. and Nagai, H. 2000. The effect of Am-80, one of retinoids derivatives on experimental allergic encephalomyelitis in rats. Life Sci. 67:1869.
9. Yoshimura, H., Kikuchi, K., Hibi, S., Tagami, K., Satoh, T., Yamauchi, T., Ishibashi, A., Tai, K., Hida, T., Tokuhara, N. and Nagai, M. 2000. Discovery of novel and potent retinoic acid receptor α agonists: Syntheses and evaluation of benzofuranyl-pyrrole and benzothiophenyl-pyrrole derivatives. J. Med. Chem. 43:2929.
10. Ishaq, M., Fan, M. and Natarajan, V. 2000. Accumulation of RXR alpha during activation of cycling human T lymphocytes: modulation of RXRE transactivation function by mitogen-activated protein kinase pathways. J. Immunol. 165: 4217.
11. Delescluse, C., Cavey, M. T., Bernard, B. A., Reichert, U., Maignan, J., Darmon, M. and Shroot, B. 1991. Selectively high affinity retinoic acid receptor α or β-γ ligands. Mol. Pharmacol. 40:556.
12. Bernard, B. A., Bernardon, J.-M., Delescluse, C., Martin, B., Lenoir, M.-C., Maignan, J., Charpentier, B., Pilgrim, W. R., Reicher, U. and Shroot, B. 1992. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor γ. Biochem. Biophys. Res. Commun. 186:977.
13. Boehm, E., Suto, C. M., Goldman, M. E. and Heyman, R. A. 1994. Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. J. Med. Chem. 37:2930.
14. Ono, K. and Lindsey, E. S. 1969. Improved technique of heart transplantation in rats. J. Thorac. Cardiovasc. Surg. 57:225.
15. Billingham, M. E. 1981. Diagnosis of cardiac rejection by endomyocardial biopsy. Heart Transplant. 2:25.
16. Nomoto, K., Saeki, T., Kogushi, M., Kobayashi, H., Fujimori, T. and Yamatsu, I. 1993. Inhibitory effects of a novel anti-platelet agent, E5510, on collagen-induced platelet-derived growth factor release and aggregation of human platelets in vivo. Jpn. J. Pharmacol. 61:7.
17. kip1. Eur. J. Immunol. 30:1154.
18. Kawa, S., Nikaido, T., Aoki, Y., Zhai, Y., Kumagaya, T., Furihata, K. and Fujii, S. 1997. Arotinoid mofarotene (RO40-8757) up-regulates p21 and p27 during growth inhibition of pancreatic cancer cell lines. Int. J. Cancer 72:906.
19. Fujimoto, K., Hosotani, R., Doi, R., Wada, M., Lee, J.-U., Koshiba, T., Miyamoto, Y., Tsuji, S., Nakajima, S. and Imamura, M. 1999. Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells. Int. J. Cancer 81:637.
20. kip1 up-regulation is a relevant early event. Oncogene 17:1827.
21. Pomponi, F., Cariati, R., Zancai, P., Paoli, P. D., Rizzo, S., Tedeschi, R. M., Pivetta, B., Vita, S. D., Boiocchi, M. and Dolcetti, R. 1996. Retinoids irreversibly inhibit in vitro growth of Epstein-Barr virus-immortalized B lymphocytes. Blood 88:3147.
22. ink4 on vascular smooth muscle cell proliferation. Circulation 101:2022.
23. Apfel, C., Bauer, F., Crettaz, M., Forni, L., Kamber, M., Kaufmann, F., LeMotte, P., Pirson, W. and Klaus, M. A. 1992. Retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proc. Natl Acad. Sci. USA 89:7129.
24. Seino, K., Yamauchi, T., Ishibashi, A., Tokuhara, N., Kobayashi, S., Fukunaga, K., Taniguchi, H., Takada, Y., Yuzawa, K., Otsuka, M., Todoroki, T. and Fukao, K. 2000. Prolongation of mouse skin allograft survival by novel agonists selective for retinoic acid receptor-alpha. Transplant. Proc. 32:257.
25. Carman, J. A. and Hayes, C. E. 1991. Abnormal regulation of INF-γ secretion in vitamin A deficiency. J. Immunol. 147:1247.
26. h2 function. J. Immunol. 152:1515.
27. h1 cell development. Eur. J. Immunol. 25:1673.
28. h1 lymphocytes depends on the CD28 costimulatory pathway. J. Immunol. 156:2676.
29. + T cell in vitro. Clin. Immunol. 32:222.
30. Cippitelli, M. 1996. Retinoic acid-induced transcriptional modulation of the human interferon-γ promoter. J. Biol. Chem. 271:26783.
31. Felli, M. P., Vacca, A., Meco, D., Screpanti, I., Farina, A. R., Maroder, M., Martinotti, S., Petrangeli, E., Frati, L. and Gulino, A. 1991. Retinoic acid-induced down regulation of the interleukin-2 promoter via cis-regulatory sequences containing an octamer motif. Mol. Cell Biol. 11:4771.
32. Na, S., Kang, B. Y., Chung, S. W., Han, S., Ma, X., Trinchieri, G., Im, S., Lee, J. W. and Kim, T. S. 1999. Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFκB. J. Biol. Chem. 274:7674.
33. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
34. + lymphocytes by inhibiting IL-12 production. J. Immunol. 160:2231.
35. Ueda, H., Cheung, Y. C., Masetti, P., Diaco, M., McCarter, M., Kupiec-Weglinski, J. W., Tilney, N. L. and Martin, M. 1991. Synergy between cyclosporine and anti-IL-2 receptor monoclonal antibodies in rats. Functional studies of heart and kidney allografts. Transplantation 52:437.
36. Piccotti, J. R., Li, K., Chan, S. Y., Eichwald, E. J. and Bishop, D. K. 1999. Interleukin-12 (IL-12)-driven alloimmune responses in vitro and in vivo. Requirement for B1 subunit of the IL-12 receptor. Transplantation 67:1453.
37. + T cell-mediated rejection of pancreatic islet allografts. J. Immunol. 165:247.
38. Miano, J. M., Topouzis, S., Majesky, M. W. and Olson, E. N. 1996. Retinoid receptor expression and all-trans retinoic acid-mediated growth inhibition in vascular smooth muscle cells. Circulation 93:1886.
39. Neuville, P., Yan, Z.-Q., Gidlöf, A., Pepper, M. S., Hansson, G. K., Gabbiani, G. and Sirsjö, A. 1999. Retinoic acid regulates arterial smooth muscle cell proliferation and phenotypic features in vivo and in vitro through an RARα-dependent signaling pathway. Artherioscler. Thromb. Vesc. Biol. 19:1430.
40. Weigman, P. J., Barry, E. L., McPherson, J. A., McNamara, C. A., Gimple, L. W., Sanders, J. M., Bishop, G. G., Powers, E. R., Ragosta, M., Owens, G. K. and Sarembock, I. J. 2000. All-trans-retinoic acid limits restenosis after balloon angioplasty in the focally atherosclerotic rabbit. A favorable effect on vessel remodeling. Artherioscler. Thromb. Vesc. Biol. 20:89.
41. Miano, J. M., Topouzis, S., Morimatsu, M. W. and Olson, E. N. 1996. Retinoid receptor expression and all-trans retinoic acid-mediated growth inhibition in vascular smooth muscle cells. Circulation 93:1886.
42. Grimm, P. C., Nickerson, P., Jeffery, J., Savani, R. C., Gough, J., Mckenna, R. M., Stern, E. and Rush, D. N. 2001. Neointimal and tubulointestitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection. N. Engl. J. Med. 345:93.
43. Shimizu, K., Sugiura, S., Aikawa, M., Fukumoto, Y., Rabkin, E., Libby, P. and Mitchell, R. N. 2001. Host bone-marrow cells are a source of donor intimal smooth-muscle-like cells in murine aortic transplant arteriopathy. Nat. Med. 7:738.
44. Suzuki, J., Isobe, M., Morishita, R., Aoki, M., Horie, S., Okubo, Y., Kaneda, Y., Sawa, Y., Matsuda, H., Ogihara, T. and Sekiguchi, M. 1997. Prevention of graft coronary arteriosclerosis by antisense cdk2 kinase oligonucleotide. Nat. Med. 3:900.
45. Boussiotis, V. A., Freeman, G. J., Taylor, P. A., Berezovskaya, A., Grass, I., Blazar, B. R. and Nadler, L. E. 2000. p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Nat. Med. 6:290.
46. Hibi, S., Kikuchi, K., Yoshimura, H., Nagai, M., Tai, K. and Hida, T. 1998. Syntheses and structure-activity relationships of novel retinoid X receptor agonists. J. Med. Chem. 41:3245.