Accumulation of RXRα during activation of cycling human T lymphocytes: Modulation of RXRE transactivation function by mitogen-activated protein kinase pathways

Journal of Immunology

Volumn 165, Issue 8, 2000, Pages 4217-4225

  Ishaq, M ^a   Fan, M ^a   Natarajan, V ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALITRETINOIN; CYCLOSPORIN A; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; RETINOID X RECEPTOR; STRESS ACTIVATED PROTEIN KINASE;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GENE CONTROL; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSACTIVATION;

EID: 0034667914     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.8.4217     Document Type: Article

References (55)

1. Overview of vitamin A metabolism and function
2. The retinoid signaling pathway: Molecular and genetic analysis
3. A decade of molecular biology of retinoic acid receptors
4. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia
5. The retinoid receptors
6. The RXR heterodimers and orphan receptors
7. Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation
8. Inhibition of activation-induced apoptosis of thymocytes by all-trans- and 9-cis-retinoic acid is mediated via retinoic acid receptor α
9. 9-Cis retinoic acid inhibition of activation-induced apoptosis is mediated via regulation of Fas ligand and requires retinoic acid receptor and retinoic X receptor activation
10. Retinoic acids inhibit activation-induced apoptosis in T cell hybridomas and thymocytes
11. Induction of apoptosis by retinoids and retinoic acid receptor γ-selective compounds in mouse thymocytes through a novel apoptosis pathway
12. 9-Cis-retinoic acid inhibits activation-driven T-cell apoptosis: Implications for retinoid X receptor involvement in thymocyte development
13. Fas and activation-induced Fas ligand mediated apoptosis of T cell hybridomas: Inhibition of Fas ligand expression by retinoic acid and glucocorticoids
14. Retinoic acid inhibition of ex vivo human immunodeficiency virus-associated apoptosis of peripheral blood cells
15. T cell antigen receptor signal transduction pathways
16. JNK is involved in signal integration during costimulation of T lymphocytes
17. A cytoplasmic inhibitor of the JNK signal transduction pathway
18. Different mitogen-activated protein kinase signaling pathways cooperate to regulate tumor necrosis factor α gene expression in T lymphocytes
19. The ins and outs of Raf kinases
20. Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase
21. Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues
22. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2
23. MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases
24. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
25. Induction of activation-driven (apoptosis) in activated but not resting peripheral blood T cells
26. Cell-autonomous Fas (CD95)/Fas ligand interaction mediates activation-induced apoptosis in T cell hybridomas
27. Autocrine T cell-suicide mediated by APO-1/(Fas/CD95)
28. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance
29. Activation-induced down-regulation of retinoid receptor RXRα expression in human T lymphocytes. Role of cell cycle regulation
30. A direct repeat in the cellular retinol-binding protein type II gene confers differential regulation by RXR and RAR
31. Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation
32. Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer
33. Extracellular signal-regulated kinases in T cells. Anti-CD3 and 4β-phorbol 12-myristate 13-acetate-induced phosphorylation and activation
34. p38 Mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells
35. Differential activation of MAP kinase family members triggered by CD99 engagement
36. RXRβ: A coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements
37. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors
38. Convergence of 9-cis retinoic acid and peroxisome proliferator signaling pathways through heterodimer formation of their receptors
39. Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling
40. Nuclear association of a T cell transcription factor blocked by FK-506 and cyclosporin A
41. Regulation of T-cell-derived protein kinase C activity by vitamin A derivatives
42. Retinoic acid-induced down-regulation of the interleukin-2 promoter via cis-regulatory sequences containing an octamer motif
43. + T cells
44. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
45. Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes
46. 2-terminal kinases
47. Cross-coupling of signal transduction pathways: Zinc finger meets leucine zipper
48. Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor
49. Nuclear receptor/AP-1 interaction
50. A CBP integrator complex mediates transcriptional activation and AP-inhibition by nuclear receptors
51. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway
52. Phosphorylation of c-jun mediated by MAP kinases
53. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
54. Transcription factor ATF2 regulation by the JNK signal transduction pathway
55. Induction of c-fos expression through JNK-mediated TCF/Elk-1 phosphorylation