Lack of association between Alzheimer's disease and the promoter region polymorphisms of the nicastrin gene

Neuroscience Letters

Volumn 363, Issue 1, 2004, Pages 49-53

  Orlacchio, Antonio ^a,b   Kawarai, Toshitaka ^c   Polidoro, Mario ^d   Paterson, Andrew D ^e   Rogaeva, Ekaterina ^c   Orlacchio, Aldo ^d   St George Hyslop, Peter H ^c,f   Bernardi, Giorgio ^a,b  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF PERUGIA   (Italy)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

^f TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

Alzheimer's disease; Association study; Nicastrin gene; Promoter region; Single nucleotide polymorphisms

Indexed keywords

AMYLOID PRECURSOR PROTEIN; NICASTRIN;

ALZHEIMER DISEASE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DNA POLYMORPHISM; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; NUCLEOTIDE SEQUENCE; ONSET AGE; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

ADULT; AGE OF ONSET; AGED; ALANINE; ALLELES; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; APOLIPOPROTEINS E; CYSTEINE; FEMALE; GENE FREQUENCY; GLYCINE; HAPLOTYPES; HUMANS; LOGISTIC MODELS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); THREONINE;

EID: 2442557125     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.03.044     Document Type: Article

References (19)

1. Abecasis G.R., Cookson W.O. GOLD - graphical overview of linkage disequilibrium. Bioinformatics. 16:(2):2000;182-183
2. Chen F., Yu G., Arawaka S., Nishimura M., Kawarai T., Yu H., Tandon A., Supala A., Song Y.Q., Rogaeva E., Milman P., Sato C., Yu C., Janus C., Lee J., Song L., Zhang L., Fraser P.E., St George-Hyslop P.H. Nicastrin binds to membrane-tethered Notch. Nat. Cell Biol. 3:2001;751-754
3. Delwel R., Funabiki T., Kreider B.L., Morishita K., Ihle J.N. Four of the seven zinc fingers of the Evi-1 myeloid-transforming gene are required for sequence-specific binding to GA(C/T)AAGA(T/C)AAGATAA. Mol. Cell. Biol. 13:1993;4291-4300
4. Dermaut B., Theuns J., Sleegers K., Hasegawa H., Van den Broeck M., Vennekens K., Corsmit E., St George-Hyslop P., Cruts M., van Duijn C.M., Van Broeckhoven C. The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample. Am. J. Hum. Genet. 70:2002;1568-1574
5. Devlin B., Risch N.A. Comparison of linkage disequilibrium measures for fine-scale mapping. Genomics. 29:1995;311-322
6. Edbauer D., Winkler E., Haass C., Steiner H. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proc. Natl. Acad. Sci. USA. 99:2002;8666-8671
7. Farrer L.A., Cupples L.A., Haines J.L., Hyman B., Kukull W.A., Mayeux R., Myers R.H., Pericak-Vance M.A., Risch N., van Duijn C.M. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. J. Am. Med. Assoc. 278:1997;1349-1356
8. Hiltunen M., Mannermaa A., Thompson D., Easton D., Pirskanen M., Helisalmi S., Koivisto A.M., Lehtovirta M., Ryynanen M., Soininen H. Genome-wide linkage disequilibrium mapping of late-onset Alzheimer's disease in Finland. Neurology. 57:2001;1663-1668
9. Hollenberg S.M., Sternglanz R., Cheng P.F., Weintraub H. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol. 15:1995;3813-3822
10. Kehoe P., Wavrant-De Vrieze F., Crook R., Wu W.S., Holmans P., Fenton I., Spurlock G., Norton N., Williams H., Williams N., Lovestone S., Perez-Tur J., Hutton M., Chartier-Harlin M.C., Shears S., Roehl K., Booth J., Van Voorst W., Ramic D., Williams J., Goate A., Hardy J., Owen M.J. A full genome scan for late onset Alzheimer's disease. Hum. Mol. Genet. 8:1999;237-245
11. Mangalam H.J., Albert V.R., Ingraham H.A., Kapiloff M., Wilson L., Nelson C., Elsholtz H., Rosenfeld M.G. A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally. Genes Dev. 3:1989;946-958
12. McKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 34:1984;939-944
13. Murphy M.P., Das P., Nyborg A.C., Rochette M.J., Dodson M.W., Loosbrock N.M., Souder T.M., McLendon C., Merit S.L., Piper S.C., Jansen K.R., Golde T.E. Overexpression of nicastrin increases Abeta production. FASEB J. 8:2003;8
14. Ohlsson H., Karlsson K., Edlund T. IPF1, a homeodomain-containing transactivator of the insulin gene. EMBO J. 12:1993;4251-4259
15. Orlacchio A., Kawarai T., Paciotti E., Stefani A., Sorbi S., St George-Hyslop P.H., Bernardi G. Association study of the 5-hydroxytryptamine(6) receptor gene in Alzheimer's disease. Neurosci. Lett. 325:2002;13-16
16. Orlacchio A., Kawarai T., Polidoro M., Stefani A., Orlacchio A., St George-Hyslop P.H., Bernardi G. Association analysis between Alzheimer's disease and the Nicastrin gene polymorphisms. Neurosci. Lett. 333:2002;115-118
17. Verrijzer C.P., Alkema M.J., van Weperen W.W., Van Leeuwen H.C., Strating M.J., van der Vliet P.C. The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J. 11:1992;4993-5003
18. Xie X., Ott J. Testing linkage disequilibrium between a disease gene and karmer loci. Am. J. Hum. Genet. 70:1993;1107
19. Yu G., Nishimura M., Arawaka S., Levitan D., Zhang L., Tandon A., Song Y.Q., Rogaeva E., Chen F., Kawarai T., Supala A., Levesque L., Yu H., Yang D.S., Holmes E., Milman P., Liang Y., Zhang D.M., Xu D.H., Sato C., Rogaev E., Smith M., Janus C., Zhang Y., Aebersold R., Farrer L.S., Sorbi S., Bruni A., Fraser P., St George-Hyslop P. Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature. 407:2000;48-54