Conditional activation of RhoA suppresses the epithelial to mesenchymal transition at the primitive streak during mouse gastrulation

Biochemical and Biophysical Research Communications

Volumn 318, Issue 3, 2004, Pages 665-672

  Fuse, Toshimitsu ^a   Kanai, Yoshiakira ^b   Kanai Azuma, Masami ^c,e   Suzuki, Misao ^d   Nakamura, Kazuhiro ^a,f   Mori, Hisashi ^a,g   Hayashi, Yoshihiro ^b   Mishina, Masayoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

^e KYORIN UNIVERSITY   (Japan)

^f JUNTENDO UNIVERSITY   (Japan)

^g UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Cre recombinase; E cadherin; Epithelial mesenchymal transition; Gastrulation; Mouse embryogenesis; Rho

Indexed keywords

CRE RECOMBINASE; PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TELENCEPHALIN; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; EPITHELIUM CELL; GASTRULATION; GENE INDUCTION; IMMUNOHISTOCHEMISTRY; INNER CELL MASS; MARKER GENE; MESENCHYME CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ALLANTOIS; ANIMALS; BETA-GALACTOSIDASE; CADHERINS; ENZYME ACTIVATION; EPITHELIUM; FEMALE; GASTRULA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INTEGRASES; MALE; MEMBRANE GLYCOPROTEINS; MESODERM; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; VIRAL PROTEINS;

EID: 2442539256     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.04.076     Document Type: Article

References (38)

1. Tam P.P.L., Behringer R.R. Mouse gastrulation: the formation of a mammalian body plan. Mech. Dev. 68:1997;3-25
2. Bellairs R. The primitive streak. Anat. Embryol. 174:1986;1-14
3. Hashimoto K., Nakatsuji N. Formation of the primitive streak and mesoderm cells in mouse embryos-detailed scanning electron microscopical study. Dev. Growth Differ. 31:1989;209-218
4. Tam P.P.L., Williams E.A., Chan W.Y. Gastrulation in the mouse embryo: ultrastructural and molecular aspects of germ layer morphogenesis. Microsc. Res. Tech. 26:1993;301-328
5. Lawson K.A., Meneses J.J., Pedersen R.A. Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development. 113:1991;891-911
6. Tam P.P.L., Gad J.M., Kinder S.J., Tsang T.E., Behringer R.R. Morphogenetic tissue movement and the establishment of body plan during development from blastocyst to gastrula in the mouse. Bioessays. 23:2001;508-517
7. Ciruna B.G., Schwartz L., Harpal K., Yamaguchi T.P., Rossant J. Chimeric analysis of fibroblast growth factor receptor-1 (Fgfr1) function: a role for FGFR1 in morphogenetic movement through the primitive streak. Development. 124:1997;2829-2841
8. Deng C.-X., Wynshaw-Boris A., Shen M.M., Daugherty C., Ornitz D.M., Leder P. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 8:1994;3045-3057
9. Yamaguchi T.P., Harpal K., Henkemeyer M., Rossant J. fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev. 8:1994;3032-3044
10. Sun X., Meyers E.N., Lewandoski M., Martin G.R. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev. 13:1999;1834-1846
11. Burdsal C.A., Damsky C.H., Pedersen R.A. The role of E-cadherin and integrins in mesoderm differentiation and migration at the mammalian primitive streak. Development. 118:1993;829-844
12. Ciruna B., Rossant J. FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev. Cell. 1:2001;37-49
13. Viebahn C. Epithelio-mesenchymal transformation during formation of the mesoderm in the mammalian embryo. Acta Anat. 154:1995;79-97
14. Haegel H., Larue L., Ohsugi M., Fedorov L., Herrenknecht K., Kemler R. Lack of β-catenin affects mouse development at gastrulation. Development. 121:1995;3529-3537
15. Monkley S.J., Zhou X.-H., Kinston S.J., Giblett S.M., Hemmings L., Priddle H., Brown J.E., Pritchard C.A., Critchley D.R., Fässler R. Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev. Dyn. 219:2000;560-574
16. Nakamura K., Manabe T., Watanabe M., Mamiya T., Ichikawa R., Kiyama Y., Sanbo M., Yagi T., Inoue Y., Nabeshima T., Mori H., Mishina M. Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule. Eur. J. Neurosci. 13:2001;179-189
17. Hall A. Rho GTPases and the actin cytoskeleton. Science. 279:1998;509-514
18. Ridley A.J. Rho GTPases and cell migration. J. Cell Sci. 114:2001;2713-2722
19. Niwa H., Yamamura K., Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene. 108:1991;193-199
20. Kozak M. The scanning model for translation: an update. J. Cell Biol. 108:1989;229-241
21. Kalderon D., Roberts B.L., Richardson W.D., Smith A.E. A short amino acid sequence able to specify nuclear location. Cell. 39:1984;499-509
22. Kothary R., Clapoff S., Darling S., Perry M.D., Moran L.A., Rossant J. Inducible expression of an hsp68-lacZ hybrid gene in transgenic mice. Development. 105:1989;707-714
23. 2+-dependent exocytosis from PC12 cells. Genes Cells. 1:1996;943-951
24. Tsujita M., Mori H., Watanabe M., Suzuki M., Miyazaki J., Mishina M. Cerebellar granule cell-specific and inducible expression of Cre recombinase in the mouse. J. Neurosci. 19:1999;10318-10323
25. Hogan B., Beddington R., Costantini F., Lacy E. Manipulating the Mouse Embryo: a Laboratory Manual. second ed. 1994;Cold Spring Harbor Laboratory Press, Plainview, New York
26. Araki K., Araki M., Miyazaki J., Vassalli P. Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase. Proc. Natl. Acad. Sci. USA. 92:1995;160-164
27. Allen N.D., Cran D.G., Barton S.C., Hettle S., Reik W., Surani M.A. Transgenes as probes for active chromosomal domains in mouse development. Nature. 333:1988;852-855
28. Kanai Y., Kanai-Azuma M., Tajima Y., Birk O.S., Hayashi Y., Sanai Y. Identification of a stromal cell type characterized by the secretion of a soluble integrin-binding protein, MFG-E8, in mouse early gonadogenesis. Mech. Dev. 96:2000;223-227
29. Saijoh Y., Fujii H., Meno C., Sato M., Hirota Y., Nagamatsu S., Ikeda M., Hamada H. Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor. Genes Cells. 1:1996;239-252
30. Wilkinson D.G., Nieto M.A. Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol. 225:1993;361-373
31. Sakai K., Miyazaki J. A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. Biochem. Biophys. Res. Commun. 237:1997;318-324
32. Rosner M.H., Vigano M.A., Ozato K., Timmons P.M., Poirier F., Rigby P.W.J., Staudt L.M. A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature. 345:1990;686-692
33. Wilkinson D.G., Bhatt S., Herrmann B.G. Expression pattern of the mouse. T gene and its role in mesoderm formation Nature. 343:1990;657-659
34. Smith J. Brachyury and the T-box genes. Curr. Opin. Genet. Dev. 7:1997;474-480
35. Kavka A.I., Green J.B.A. Tales of tails: Brachyury and the T-box genes. Biochim. Biophys. Acta. 1333:1997;F73-F84
36. Braga V.M.M., Machesky L.M., Hall A., Hotchin N.A. The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J. Cell Biol. 137:1997;1421-1431
37. Takaishi K., Kikuchi A., Kuroda S., Kotani K., Sasaki T., Takai Y. Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility. Mol. Cell. Biol. 13:1993;72-79
38. Damjanov I., Damjanov A., Damsky C.H. Developmentally regulated expression of the cell-cell adhesion glycoprotein cell-CAM 120/80 in peri-implantation mouse embryos and extraembryonic membranes. Dev. Biol. 116:1986;194-202